| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charlotte Braatz, Max P Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Róisín M McManus, Michael T Henek. NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. Journal of neurochemistry. 2023-02-17. PMID:36799439. |
together nlrp3-directed asos can suppress nlrp3 inflammasome activity and subsequent release of il-1β in primary murine microglia and thp-1 cells. |
2023-02-17 |
2023-08-14 |
human |
| Pin-Yu Chen, Jiin-Cherng Yen, Tzu-Ting Liu, Szu-Ting Chen, Shuu-Jiun Wang, Shih-Pin Che. Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation. Brain : a journal of neurology. 2023-02-16. PMID:36795624. |
the sd-evoked nlrp3 inflammasome activation was observed exclusively in neurons but not microglia or astrocytes. |
2023-02-16 |
2023-08-14 |
Not clear |
| Pin-Yu Chen, Jiin-Cherng Yen, Tzu-Ting Liu, Szu-Ting Chen, Shuu-Jiun Wang, Shih-Pin Che. Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation. Brain : a journal of neurology. 2023-02-16. PMID:36795624. |
moreover, multiple sds induced microglial activation subsequent to neuronal nlrp3 inflammasome activation, which in turn orchestrated with neurons to mediate cortical neuroinflammation, as demonstrated by decreased neuronal inflammation after pharmacological inhibition of microglia activation or blockade of the tlr2/4 receptors. |
2023-02-16 |
2023-08-14 |
Not clear |
| Xintong Zheng, Mingwei Wang, Shuting Liu, Haiqiao Chen, Yifei Li, Fa Yuan, Ludong Yang, Suo Qiu, Hongwei Wang, Zhi Xie, Mengqing Xian. A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury. Cell death & disease. vol 14. issue 2. 2023-02-15. PMID:36792584. |
its deficiency in mice protected retinal ganglion cells from retinal ir injury by attenuating the activation of microglia and the nlrp3 inflammasome pathway. |
2023-02-15 |
2023-08-14 |
mouse |
| Jiande Li, Hongxuan Wang, Dandan Liu, Xiangpen Li, Lei He, Jingrui Pan, Qingyu Shen, Ying Pen. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in the microglia of the prefrontal cortex in mice. Brain, behavior, and immunity. 2023-02-08. PMID:36754245. |
cb2r activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing nlrp3 inflammasome activation in the microglia of the prefrontal cortex in mice. |
2023-02-08 |
2023-08-14 |
mouse |
| Jiande Li, Hongxuan Wang, Dandan Liu, Xiangpen Li, Lei He, Jingrui Pan, Qingyu Shen, Ying Pen. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in the microglia of the prefrontal cortex in mice. Brain, behavior, and immunity. 2023-02-08. PMID:36754245. |
alcohol exposure increases nlrp3 inflammasome expression, increasing cytokine secretion by activated microglia. |
2023-02-08 |
2023-08-14 |
mouse |
| Jianqiang Wei, Jing Yin, Ying Cui, Kaijie Wang, Mingyan Hong, Jianzhong Cu. FERMT1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLRP3/NF-κB pathway. Experimental animals. 2023-02-05. PMID:36740252. |
fermt1 knockdown reduced microglia activity, inhibited nlr family pyrin domain containing 3 (nlrp3) inflammasome activity and decreased the expression of inflammatory factors including interleukin-1β (il-1β) and interleukin 18 (il-18) in the peri-hematoma tissues. |
2023-02-05 |
2023-08-14 |
rat |
| Jianqiang Wei, Jing Yin, Ying Cui, Kaijie Wang, Mingyan Hong, Jianzhong Cu. FERMT1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLRP3/NF-κB pathway. Experimental animals. 2023-02-05. PMID:36740252. |
bv2 microglial cells were transfected with fermt1 sirna and incubated with 60 μm hemin for 24 h. activation of nlrp3 inflammasome induced by hemin were reduced in microglia when fermt1 was knocked down, leading to decreased production of inflammatory factors il-1β and il-18. |
2023-02-05 |
2023-08-14 |
rat |
| Dan Gao, Ceng-Ceng Zheng, Jin-Ping Hao, Cui-Cui Yang, Chao-Ying H. Icariin Ameliorates Behavioral Deficits and Neuropathology in a Mouse Model of Multiple Sclerosis. Brain research. 2023-02-02. PMID:36731819. |
meanwhile, it was observed that the activation of microglia in cerebral cortex and hippocampus were inhibited followed by the neuroinflammatory cytokines downregulation such as il-1β, il-6 and tnf-α after ica treatment, which was probably attributable to the suppression of microglial nlrp3 inflammasome activation. |
2023-02-02 |
2023-08-14 |
mouse |
| Jingrui Pan, Jialing Peng, Xiangpen Li, Hongxuan Wang, Xiaoming Rong, Ying Pen. Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6. Molecular neurobiology. 2023-01-30. PMID:36717480. |
in addition, ruptured lysosomes engulfing asc specks which were possibly secreted from microglia triggered the enhanced nlrp3 expression. |
2023-01-30 |
2023-08-14 |
rat |
| Jingrui Pan, Jialing Peng, Xiangpen Li, Hongxuan Wang, Xiaoming Rong, Ying Pen. Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6. Molecular neurobiology. 2023-01-30. PMID:36717480. |
neuronal and endothelial nlrp3 inflammasomes were activated by microglia in cerebral ischemia and reperfusion injury mainly via il-1β/il-1r1/traf6 signaling, which might be therapeutically targetable. |
2023-01-30 |
2023-08-14 |
rat |
| Zhiyou Yang, Junxin Liu, Shuai Wei, Jiahang Deng, Xinyue Feng, Shucheng Liu, Mingxin Li. A novel strategy for bioactive natural products targeting NLRP3 inflammasome in Alzheimer's disease. Frontiers in pharmacology. vol 13. 2023-01-26. PMID:36699095. |
in response to a wide range of stimuli like aβ, nlrp3 assembles apoptosis-associated speck-like protein (asc) and procaspase-1 into an inflammasome complex to induce the caspase-1 mediated secretion of interleukin (il)-1β/il-18 in m1 polarized microglia, triggering the pathophysiological changes and cognitive decline of ad. |
2023-01-26 |
2023-08-14 |
Not clear |
| José Luis Marcos, Rossy Olivares-Barraza, Karina Ceballo, Melisa Wastavino, Víctor Ortiz, Julio Riquelme, Jonathan Martínez-Pinto, Pablo Muñoz, Gonzalo Cruz, Ramón Sotomayor-Zárat. Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674982. |
obesity-induced neuroinflammation is a chronic aseptic central nervous system inflammation that presents systemic characteristics associated with increased pro-inflammatory cytokines such as interleukin 1 beta (il-1β) and interleukin 18 (il-18) and the presence of microglia and reactive astrogliosis as well as the activation of the nlrp3 inflammasome. |
2023-01-21 |
2023-08-14 |
Not clear |
| A D Roseborough, Y Zhu, L Zhao, S R Laviolette, S H Pasternak, S N Whitehea. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implications for blood-brain barrier dysfunction. Neurobiology of disease. 2023-01-16. PMID:36646389. |
at the same time, in response to injury, microglia demonstrate increased nlrp3 inflammasome activity and heightened release of pro-inflammatory cytokines. |
2023-01-16 |
2023-08-14 |
Not clear |
| A D Roseborough, Y Zhu, L Zhao, S R Laviolette, S H Pasternak, S N Whitehea. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implications for blood-brain barrier dysfunction. Neurobiology of disease. 2023-01-16. PMID:36646389. |
in this work, we investigate fibrinogen mediated nlrp3 inflammasome priming of bv-2 cells and primary adult microglia and propose a role for extracellular vesicles (evs) as propagators of this interaction. |
2023-01-16 |
2023-08-14 |
Not clear |
| A D Roseborough, Y Zhu, L Zhao, S R Laviolette, S H Pasternak, S N Whitehea. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implications for blood-brain barrier dysfunction. Neurobiology of disease. 2023-01-16. PMID:36646389. |
following exposure to fibrinogen microglia significantly upregulate transcription of il-1β, il-6, nlrp3 and other pro-inflammatory cytokines which was sustained by repeated fibrinogen exposure. |
2023-01-16 |
2023-08-14 |
Not clear |
| Heping Shen, Hongyan Pei, Liping Zhai, Qiaobing Guan, Genghuan Wan. Aurantiamide suppresses the activation of NLRP3 inflammasome to improve the cognitive function and central inflammation in mice with Alzheimer's disease. CNS neuroscience & therapeutics. 2023-01-11. PMID:36627760. |
this study was aimed at exploring the mechanism by which aurantiamide (aur) targeted nlrp3 to suppress microglial cell polarization. |
2023-01-11 |
2023-08-14 |
mouse |
| Qian-Kun Lv, Kang-Xin Tao, Xiao-Bo Wang, Xiao-Yu Yao, Meng-Zhu Pang, Jun-Yi Liu, Fen Wang, Chun-Feng Li. Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2023-01-04. PMID:36598534. |
α-syn is a crucial marker of pd, and its accumulation leads to microglia m1-like phenotype polarization, activation of nlrp3 inflammasomes, and impaired autophagy and phagocytosis in microglia. |
2023-01-04 |
2023-08-14 |
Not clear |
| Qian-Kun Lv, Kang-Xin Tao, Xiao-Bo Wang, Xiao-Yu Yao, Meng-Zhu Pang, Jun-Yi Liu, Fen Wang, Chun-Feng Li. Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2023-01-04. PMID:36598534. |
autophagy of microglia is related to degradation of α-syn and nlrp3 inflammasome blockage to relieve neuroinflammation. |
2023-01-04 |
2023-08-14 |
Not clear |
| Ke Xue, Mian Qi, Tongping She, Zhenglin Jiang, Yunfeng Zhang, Xueting Wang, Guohua Wang, Lihua Xu, Bin Peng, Jiayi Liu, Xinjian Song, Yuan Yuan, Xia L. Argon mitigates post-stroke neuroinflammation by regulating M1/M2 polarization and inhibiting NF-κB/NLRP3 inflammasome signaling. Journal of molecular cell biology. 2022-12-27. PMID:36574951. |
in this study, we analyzed the activation and polarization of microglia after i/r injury with or without argon administration and explored the effects of argon on nlrp3 inflammasome-mediated inflammation in microglia in vitro and in vivo. |
2022-12-27 |
2023-08-14 |
Not clear |