| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maheedhar Kodali, Leelavathi N Madhu, Roxanne L Reger, Bojana Milutinovic, Raghavendra Upadhya, Jenny J Gonzalez, Sahithi Attaluri, Bing Shuai, Daniel L G Gitai, Shama Rao, Jong M Choi, Sung Y Jung, Ashok K Shett. Intranasally Administered Human MSC-derived Extracellular Vesicles Inhibit NLRP3-p38/MAPK Signaling after TBI and Prevent Chronic Brain Dysfunction. Brain, behavior, and immunity. 2022-11-25. PMID:36427808. |
such inhibition in the acute phase of tbi endured in the chronic phase, which could also be gleaned from diminished nlrp3 inflammasome activation in microglia of tbi mice receiving hmsc-evs. |
2022-11-25 |
2023-08-14 |
mouse |
| Simeng Gu, Yumeng Li, Yao Jiang, Jason H Huang, Fushun Wan. Glymphatic Dysfunction Induced Oxidative Stress and Neuro-Inflammation in Major Depression Disorders. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2022-11-24. PMID:36421482. |
glymphatic impairment can lead to ros accumulation in the microenvironment, inducing cellular injury signaling and activating nlrp3 in microglia to induce inflammation and, thus, many brain diseases, including psychiatric disorders. |
2022-11-24 |
2023-08-14 |
Not clear |
| Yu Wang, Yi-Jie Liu, Man-Man Zhang, Han Zhou, Yi-Han Gao, Wen-Jing Cheng, Zi-Wei Ye, Zhong-Yu Yuan, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Y. CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice. ACS chemical neuroscience. 2022-11-18. PMID:36399525. |
in conclusion, the results of the study showed that the antidepressant-like effects of nlrp3 inhibitor cy-09 were mediated by alleviating neuroinflammation in microglia and independent of the neurotrophic function in the hippocampus. |
2022-11-18 |
2023-08-14 |
mouse |
| Minghao Yan, Haibo Jin, Chun Pan, Xiaodong Ha. Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia. Molecular neurobiology. 2022-11-17. PMID:36385231. |
chronic microcystin-lr-induced α-synuclein promotes neuroinflammation through activation of the nlrp3 inflammasome in microglia. |
2022-11-17 |
2023-08-14 |
mouse |
| Minghao Yan, Haibo Jin, Chun Pan, Xiaodong Ha. Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia. Molecular neurobiology. 2022-11-17. PMID:36385231. |
in the mouse models of chronic mc-lr exposure, a large number of inflammatory factors (il-6, il-1β, and tnf-α) were deposited in brain tissue, and activation of nlrp3 in microglia was also observed in the midbrain. |
2022-11-17 |
2023-08-14 |
mouse |
| Minghao Yan, Haibo Jin, Chun Pan, Xiaodong Ha. Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia. Molecular neurobiology. 2022-11-17. PMID:36385231. |
collectively, mc-lr exposure promoted the pathological spread of α-syn from cell to cell, activated nlrp3 inflammasome in microglia, and generated neuroinflammation, in which the tlr4 receptor played a substantial effect. |
2022-11-17 |
2023-08-14 |
mouse |
| Shanshan Hou, Chao Li, Yihua Wang, Jiayin Sun, Yutong Guo, Xiaofan Ning, Kai Ma, Xinyue Li, Hua Shao, Guanqun Cui, Minghua Jin, Zhongjun D. Silica Nanoparticles Cause Activation of NLRP3 Inflammasome in-vitro Model-Using Microglia. International journal of nanomedicine. vol 17. 2022-11-17. PMID:36388872. |
silica nanoparticles cause activation of nlrp3 inflammasome in-vitro model-using microglia. |
2022-11-17 |
2023-08-14 |
Not clear |
| Xvlei Hu, Yifan Zhang, Lei Wang, Jiangwei Ding, Mei Li, Hailiang Li, Liang Wu, Zhong Zeng, Hechun Xi. Microglial activation in the motor cortex mediated NLRP3-related neuroinflammation and neuronal damage following spinal cord injury. Frontiers in cellular neuroscience. vol 16. 2022-11-07. PMID:36339822. |
in this study, we found that microglia were activated in m1 after sci, which triggered nod-like receptor protein 3 (nlrp3) related chronic neuroinflammation and neuronal damage |
2022-11-07 |
2023-08-14 |
Not clear |
| Lanlan Zhong, Xingshu Ren, Yuhang Ai, Zhiyong Li. SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation. Neuromolecular medicine. 2022-11-05. PMID:36333543. |
the increase of nucleotide-binding oligomerization domain 3 (nlrp3) and phosphorylated dynamin-related protein 1 (drp1) ser616 in microglia was attenuated by ss-31. |
2022-11-05 |
2023-08-14 |
mouse |
| Yi Tian, Meihui Li, Shanshan Zhang, Juntao Hu, Haoran Wu, Mitchell Wan, Jingxin Xue, Leilei Wang, Honglei Xiao, Guomin Zhou, Kaidi Wang, Qiong Li. Microglia activation in the hippocampus mediates retinal degeneration-induced depressive-like behaviors via the NLRP3/IL-1β pathway. Brain research bulletin. 2022-11-04. PMID:36332880. |
after tissue collection, we used immunohistochemistry to assess the activation of microglia and real-time polymerase chain reaction to measure the levels of pro-inflammatory cytokines and the nod-, lrr-, and pyrin-domain containing protein 3 (nlrp3) inflammasome. |
2022-11-04 |
2023-08-14 |
mouse |
| Shukai Sun, Wenkai Jiang, Xia Yan, Jing Zhang, Lei Gao, Chunfeng Wu, Bin Zhu, Lian W. Ligand-gated ion channel P2X7 regulates NLRP3/Caspase-1-mediated inflammatory pain caused by pulpitis in the trigeminal ganglion and medullary dorsal horn. Brain research bulletin. 2022-11-03. PMID:36328143. |
moreover, treatment with 130nm kcl, a p2x7 inhibitor, significantly reduced the expression of nlrp3, il-1β, il-18, caspase-1, and p2x7 in microglia after lipopolysaccharide(lps) stimulation. |
2022-11-03 |
2023-08-14 |
rat |
| Eduardo A Albornoz, Alberto A Amarilla, Naphak Modhiran, Sandra Parker, Xaria X Li, Danushka K Wijesundara, Julio Aguado, Adriana Pliego Zamora, Christopher L D McMillan, Benjamin Liang, Nias Y G Peng, Julian D J Sng, Fatema Tuj Saima, Jenny N Fung, John D Lee, Devina Paramitha, Rhys Parry, Michael S Avumegah, Ariel Isaacs, Martin W Lo, Zaray Miranda-Chacon, Daniella Bradshaw, Constanza Salinas-Rebolledo, Niwanthi W Rajapakse, Ernst J Wolvetang, Trent P Munro, Alejandro Rojas-Fernandez, Paul R Young, Katryn J Stacey, Alexander A Khromykh, Keith J Chappell, Daniel Watterson, Trent M Woodruf. SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular psychiatry. 2022-11-01. PMID:36316366. |
sars-cov-2 drives nlrp3 inflammasome activation in human microglia through spike protein. |
2022-11-01 |
2023-08-14 |
mouse |
| Eduardo A Albornoz, Alberto A Amarilla, Naphak Modhiran, Sandra Parker, Xaria X Li, Danushka K Wijesundara, Julio Aguado, Adriana Pliego Zamora, Christopher L D McMillan, Benjamin Liang, Nias Y G Peng, Julian D J Sng, Fatema Tuj Saima, Jenny N Fung, John D Lee, Devina Paramitha, Rhys Parry, Michael S Avumegah, Ariel Isaacs, Martin W Lo, Zaray Miranda-Chacon, Daniella Bradshaw, Constanza Salinas-Rebolledo, Niwanthi W Rajapakse, Ernst J Wolvetang, Trent P Munro, Alejandro Rojas-Fernandez, Paul R Young, Katryn J Stacey, Alexander A Khromykh, Keith J Chappell, Daniel Watterson, Trent M Woodruf. SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular psychiatry. 2022-11-01. PMID:36316366. |
mechanistically, we demonstrated that purified sars-cov-2 spike glycoprotein activated the nlrp3 inflammasome in lps-primed microglia, in a ace2-dependent manner. |
2022-11-01 |
2023-08-14 |
mouse |
| Jiawei Zhu, Fan Zhou, Qin Zhou, Yongjie Xu, Yunting Li, Dingbang Huang, Lixuan Chen, Anfei Liu, Fei Zou, Xiaojing Men. NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2022-10-29. PMID:36308466. |
nlrp3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice. |
2022-10-29 |
2023-08-14 |
mouse |
| Jiawei Zhu, Fan Zhou, Qin Zhou, Yongjie Xu, Yunting Li, Dingbang Huang, Lixuan Chen, Anfei Liu, Fei Zou, Xiaojing Men. NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2022-10-29. PMID:36308466. |
our results showed that chronic pb exposure induce learning and memory impairment in mice, mainly related to the activation of microglia and nlrp3 inflammasome. |
2022-10-29 |
2023-08-14 |
mouse |
| Jiawei Zhu, Fan Zhou, Qin Zhou, Yongjie Xu, Yunting Li, Dingbang Huang, Lixuan Chen, Anfei Liu, Fei Zou, Xiaojing Men. NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2022-10-29. PMID:36308466. |
in conclusion, nlrp3 inflammasome activation in microglia plays a vital role in pb neurotoxicity, by a novel mechanism of enhancing mtros production and ca2+ redistribution. |
2022-10-29 |
2023-08-14 |
mouse |
| Shanshan Li, Yinquan Fang, Yihe Zhang, Mengmeng Song, Xilin Zhang, Xiao Ding, Hang Yao, Miaomiao Chen, Yiming Sun, Jianhua Ding, Qin Wang, Ming Lu, Guangyu Wu, Gang H. Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice. Cell reports. vol 41. issue 4. 2022-10-26. PMID:36288697. |
we further show that in microglia the nf-κb pathway activates the nlrp3 inflammasome which in turn activates caspase-1 to induce the secretion of a1 inductors, leading to the production of a1-like astrocytes. |
2022-10-26 |
2023-08-14 |
mouse |
| Carolina A Moraes, Eugenio D Hottz, Débora Dos Santos Ornellas, Daniel Adesse, Carolina T de Azevedo, Joana C d'Avila, Camila Zaverucha-do-Valle, Tatiana Maron-Gutierrez, Helene Santos Barbosa, Patricia Torres Bozza, Fernando Augusto Bozz. Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy. Molecular neurobiology. 2022-10-24. PMID:36280654. |
meanwhile, an in vitro model of primary microglia stimulated with lps exhibited an increase in mitochondrial reactive oxygen species (ros) production, nlrp3 complex recruitment, and il-1β release. |
2022-10-24 |
2023-08-14 |
mouse |
| Ru-Huei Fu, Chia-Wen Tsai, Shao-Chih Chiu, Shih-Ping Liu, Yu-Ting Chiang, Yun-Hua Kuo, Woei-Cherng Shyu, Shinn-Zong Li. C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect. Cells. vol 11. issue 19. 2022-10-14. PMID:36231090. |
c9-als-associated proline-arginine dipeptide repeat protein induces activation of nlrp3 inflammasome of hmc3 microglia cells by binding of complement component 1 q subcomponent-binding protein (c1qbp), and syringin prevents this effect. |
2022-10-14 |
2023-08-14 |
Not clear |
| Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Caroline Zanotto, Larissa Daniele Bobermin, Ana Cristina Roginski, Moacir Wajner, André Quincozes-Santos, Carlos Alberto Gonçalve. Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. Journal of neuroinflammation. vol 19. issue 1. 2022-10-11. PMID:36221097. |
moreover, the inhibition of s100b, a protein predominantly synthesized and secreted by astrocytes, inhibition of microglia activation and abrogation of nlrp3 inflammasome assembly confirmed the role of neuroinflammation in the upregulation of glycolysis in the hippocampus. |
2022-10-11 |
2023-08-14 |
rat |