| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yulin Huang, Jing Hao, Xuli Yang, Li Xu, Yue Liu, Yu'e Sun, Xiaoping Gu, Wei Zhang, Zhengliang M. Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord. Neurochemical research. 2022-09-14. PMID:36104611. |
pretreatment of the ros inhibitor phenyl-n-tert-butylnitrone alleviates sleep deprivation-induced hyperalgesia by suppressing microglia activation and nlrp3 inflammasome activity in the spinal dorsal cord. |
2022-09-14 |
2023-08-14 |
mouse |
| Zhou Hong, Jiaqi Cheng, Yong Ye, Xiaoqing Chen, Feng Zhan. MicroRNA-451 attenuates the inflammatory response of activated microglia by downregulating NLRP3. World neurosurgery. 2022-09-10. PMID:36087911. |
microrna-451 attenuates the inflammatory response of activated microglia by downregulating nlrp3. |
2022-09-10 |
2023-08-14 |
Not clear |
| Liping Zhou, Xingzhe Wang, Xueyao Wang, Jing An, Xin Zheng, Deqiang Han, Zhiguo Che. Neuroprotective effects of human umbilical cord mesenchymal stromal cells in PD mice via centrally and peripherally suppressing NLRP3 inflammasome-mediated inflammatory responses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076517. |
subsequently, the striatal content of dopamine (da) and its metabolites, tyrosine hydroxylase (th)-positive neurons and activated microglia, circulating inflammatory cytokines, gene expression of cytokines, and nod-like receptor protein 3 (nlrp3) inflammasome molecules were measured using high-performance liquid chromatography, flow cytometry, immunohistochemistry, immunofluorescent staining, and real-time polymerase chain reaction assays, respectively. |
2022-09-09 |
2023-08-14 |
mouse |
| Linglong Xiao, Mengqi Wang, Yifeng Shi, Yangyang Xu, Yuan Gao, Wei Zhang, Yang Wu, Hao Deng, Wei Pan, Wei Wang, Haitao Su. Secondary White Matter Injury Mediated by Neuroinflammation After Intracerebral Hemorrhage and Promising Therapeutic Strategies of Targeting the NLRP3 Inflammasome. Current neuropharmacology. 2022-08-31. PMID:36043798. |
moreover, nlrp3 inflammasome is activated in microglia and astrocytes and exerts a vital role in microglia and astrocytes-mediated neuroinflammation. |
2022-08-31 |
2023-08-14 |
Not clear |
| Linglong Xiao, Mengqi Wang, Yifeng Shi, Yangyang Xu, Yuan Gao, Wei Zhang, Yang Wu, Hao Deng, Wei Pan, Wei Wang, Haitao Su. Secondary White Matter Injury Mediated by Neuroinflammation After Intracerebral Hemorrhage and Promising Therapeutic Strategies of Targeting the NLRP3 Inflammasome. Current neuropharmacology. 2022-08-31. PMID:36043798. |
we speculate that nlrp3 inflammasome activation is closely related to the polarization of microglia and astrocytes and that nlrp3 inflammasome activation may exacerbate wmi by polarizing microglia and astrocytes to the pro-inflammatory phenotype after ich, while nlrp3 inflammasome inhibition may attenuate wmi by polarizing microglia and astrocytes to the anti-inflammatory phenotype following ich. |
2022-08-31 |
2023-08-14 |
Not clear |
| Linglong Xiao, Mengqi Wang, Yifeng Shi, Yangyang Xu, Yuan Gao, Wei Zhang, Yang Wu, Hao Deng, Wei Pan, Wei Wang, Haitao Su. Secondary White Matter Injury Mediated by Neuroinflammation After Intracerebral Hemorrhage and Promising Therapeutic Strategies of Targeting the NLRP3 Inflammasome. Current neuropharmacology. 2022-08-31. PMID:36043798. |
therefore, nlrp3 inflammasome may act as leveraged regulatory fulcrums for microglia and astrocytes polarization to modulate wmi and wm repair after ich. |
2022-08-31 |
2023-08-14 |
Not clear |
| Hao Jiang, Ying Zhang, Juan Yue, Yuchen Shi, Bo Xiao, Wenbiao Xiao, Zhaohui Lu. Non-coding RNAs: The Neuroinflammatory Regulators in Neurodegenerative Diseases. Frontiers in neurology. vol 13. 2022-08-29. PMID:36034298. |
in this study, we summarize four main mechanisms of lncrnas and mirnas involved in neuroinflammation in neurodegenerative diseases, including the imbalance between proinflammatory and neuroprotective cells in microglia and astrocytes, nlrp3 inflammasome, oxidative stress, and mitochondrial dysfunction, and inflammatory mediators. |
2022-08-29 |
2023-08-14 |
Not clear |
| Mengdi Liu, Haoran Zheng, Ze Liu, Yiyan Guo, Shuhong Wang, Yaohui Tang, Hengli Tian, Zhijun Zhang, Guoyuan Yan. Dl-3-n-Butylphthalide Reduced Neuroinflammation by Inhibiting Inflammasome in Microglia in Mice after Middle Cerebral Artery Occlusion. Life (Basel, Switzerland). vol 12. issue 8. 2022-08-26. PMID:36013423. |
brain infarct volume, neurological deficits, nlrp3, microglia, and neuronal death were examined in sacrificed mice to explore the correction between nbp effects and nlrp3 expression. |
2022-08-26 |
2023-08-14 |
mouse |
| Zhi-Qiang Cui, Xiao-Ying Hu, Tuo Yang, Jing-Wei Guan, Ying Gu, Hui-Yuan Li, Hui-Yu Zhang, Qing-Huan Xiao, Xiao-Hong Su. TMEM16F may be a new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018189. |
we performed a morris water maze test to evaluate the spatial memory ability of animals and detected markers for the microglia m1/m2 phenotype and nlrp3 inflammasome. |
2022-08-26 |
2023-08-14 |
mouse |
| Zhi-Qiang Cui, Xiao-Ying Hu, Tuo Yang, Jing-Wei Guan, Ying Gu, Hui-Yuan Li, Hui-Yu Zhang, Qing-Huan Xiao, Xiao-Hong Su. TMEM16F may be a new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018189. |
after tmem16f knockdown in mice, spatial memory ability was improved, microglia polarization to the m2 phenotype was promoted, nlrp3 inflammasome activation was inhibited, cell apoptosis and aβ plaque deposition in brain tissue were reduced, and brain injury was alleviated. |
2022-08-26 |
2023-08-14 |
mouse |
| Linh Thi Nhat Nguyen, Huu Dat Nguyen, Yun Joong Kim, Tinh Thi Nguyen, Thuy Thi Lai, Yoon Kyoung Lee, Hyeo-Il Ma, Young Eun Ki. Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations. Journal of Parkinson's disease. 2022-08-21. PMID:35988226. |
afterward, activated nlrp3 triggers local microglia and astrocytes to release additional il-1β. |
2022-08-21 |
2023-08-14 |
Not clear |
| Yihua He, Yuan Chang, Yuqin Peng, Juan Zhu, Kewei Liu, Jiancong Chen, Yongming Wu, Zhong Ji, Zhenzhou Lin, Shengnan Wang, Sohan Gupta, Nailiang Zang, Suyue Pan, Kaibin Huan. Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation In Microglia. Molecular neurobiology. 2022-08-16. PMID:35972671. |
glibenclamide directly prevents neuroinflammation by targeting sur1-trpm4-mediated nlrp3 inflammasome activation in microglia. |
2022-08-16 |
2023-08-14 |
rat |
| Qingchen Wang, Zhiping Yang, Xintong Wu, Xiao Zhang, Feng Geng, Qiaoyun Wang, Zikai Geng, Chen Yu, Zhipeng L. Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn. International immunopharmacology. vol 111. 2022-08-13. PMID:35963156. |
our study demonstrated that chrysin inhibited the activation of microglia and reduced the expression of nlrp3 and il-1β. |
2022-08-13 |
2023-08-14 |
mouse |
| Kristine E Zengeler, John R Luken. Taking the parkin brakes off of neuronal NLRP3 drives inflammasome activation and neurodegeneration in Parkinson's disease. Neuron. vol 110. issue 15. 2022-08-04. PMID:35926449. |
nlrp3 is a central driver of neurodegeneration thought to function mainly in microglia. |
2022-08-04 |
2023-08-14 |
Not clear |
| Si-Yu Wang, Xin-Xin Fu, Rui Duan, Bin Wei, Hai-Ming Cao, E Yan, Shuai-Yu Chen, Ying-Dong Zhang, Teng Jian. The Alzheimer's disease-associated gene Neural regeneration research. vol 18. issue 2. 2022-07-28. PMID:35900442. |
lps stimulation increased the levels of nlrp3 in primary microglia. |
2022-07-28 |
2023-08-14 |
mouse |
| Ana Belen Lopez-Rodriguez, Céline Decouty-Perez, Victor Farré-Alins, Alejandra Palomino-Antolín, Paloma Narros-Fernández, Javier Ege. Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma. Pharmaceutics. vol 14. issue 8. 2022-07-27. PMID:35893807. |
activation of nlrp3 is required for a functional and beneficial microglia response after brain trauma. |
2022-07-27 |
2023-08-14 |
mouse |
| Chenyang Han, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Caiqun Zhang, Li Guo, Yi Yan. Double-negative T cells mediate M1 polarization of microglial cells via TNF-α-NLRP3 to aggravate neuroinflammation and cognitive impairment in Alzheimer's disease mice. Journal of cellular physiology. 2022-07-22. PMID:35866513. |
dnts were later cocultured with mice microglial cell line bv2, then fluorescence staining was conducted to detect nlrp3 expression, and enzyme-linked immunoassay was performed to measure the expression of inflammatory factors. |
2022-07-22 |
2023-08-14 |
mouse |
| Yukitoshi Izumi, Chika Fujii, Kazuko A O'Dell, Charles F Zorumsk. Acrylamide inhibits long-term potentiation and learning involving microglia and pro-inflammatory signaling. Scientific reports. vol 12. issue 1. 2022-07-20. PMID:35858988. |
these results indicate that cognitive impairment by acrylamide is mediated by mechanisms involving microglia and release of cytokines via nlrp3 activation. |
2022-07-20 |
2023-08-14 |
rat |
| Emre Tarakcioglu, Bora Tastan, Burak I Arioz, Kemal Ugur Tufekci, Sermin Gen. Melatonin Alters the miRNA Transcriptome of Inflammasome Activation in Murine Microglial Cells. Neurochemical research. 2022-07-16. PMID:35842554. |
for that purpose, we have performed rna sequencing on a lipopolysaccharide and adenosine triphosphate (lps + atp) induced nlr family pyrin domain containing 3 (nlrp3) inflammasome activation model in the n9 mouse microglial cell line, with and without melatonin pre-treatment. |
2022-07-16 |
2023-08-14 |
mouse |
| Yiping Chen, Chongyao Hao, Wenjie Chen, Wenjing Cheng, Peng Li, Junliang Shen, Tao Tong, Simin Yan, Shuqiong Huang, Tianwei He, Zhiyong Huang, Xianjun Men. Anti-depressant Effects of Acupuncture: the Insights from NLRP3 mediated Pyroptosis and Inflammation. Neuroscience letters. 2022-07-12. PMID:35820551. |
results showed that acupuncture significantly improved the depression-like behavior of cums rat, suppressed the expressions of nlrp3, asc, caspase-1, gsdmd, il-1β, il-18, hmgb1, ifn-γ, il-6 and tnf-α in the serum and hippocampus, restored the %area of microglia, astrocytes and neuronal cells in the hippocampus. |
2022-07-12 |
2023-08-14 |
rat |