| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun Sun Jung, Kyujin Suh, Jihui Han, Heyyoung Kim, Hyung-Sik Kang, Won-Seok Choi, Inhee Mook-Jun. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging cell. 2022-04-27. PMID:35474599. |
in particular, inflammasome activation, including nlrp3 inflammasome in microglia, is regarded as fundamental for the pro-inflammatory response of immune cells. |
2022-04-27 |
2023-08-13 |
Not clear |
| Eun Sun Jung, Kyujin Suh, Jihui Han, Heyyoung Kim, Hyung-Sik Kang, Won-Seok Choi, Inhee Mook-Jun. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging cell. 2022-04-27. PMID:35474599. |
here, we show that amyloid-β activates the nlrp3 inflammasome in microglia by activating syk and inhibiting ampk. |
2022-04-27 |
2023-08-13 |
Not clear |
| Yu Ren, Qing Wang, Zexian Yang, Linyin Feng, Yu Zhan. MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation. Biochemical and biophysical research communications. vol 611. 2022-04-26. PMID:35472607. |
furthermore, immunostaining or immunoblotting experiments on the hippocampal tissue were performed, and the results suggested that mcc950 not only inhibited the expression of nlrp3, and suppressed the activation of astrocytes and microglia, but also promoted the mtor-mediated autophagy pathway to reduce human α-synuclein accumulation. |
2022-04-26 |
2023-08-13 |
mouse |
| Jahirul Islam, Jung-Ah Cho, Ju-Yong Kim, Kyung-Sun Park, Young-Jae Koh, Chu Young Chung, Eun-Jae Lee, Soo Jeong Nam, Kyoungyul Lee, Seoung-Heon Kim, Sung-Hye Park, Dong Young Lee, Byeong C Kim, Kyung-Hwa Lee, Seung-Yong Seon. GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-04-25. PMID:35464490. |
gpcr19 regulates p2x7r-mediated nlrp3 inflammasomal activation of microglia by amyloid β in a mouse model of alzheimer's disease. |
2022-04-25 |
2023-08-13 |
mouse |
| Zhi-Wen Zhou, Xiang Ren, Wen-Sheng Zhou, Ai-Ping Li, Li-Jun Zhen. LncRNA NEAT1 alleviates ischemic stroke via transcriptional inhibition of NLRP3 mediated by the miR‑10b‑5p/BCL6 axis. Acta neurobiologiae experimentalis. vol 82. issue 1. 2022-04-22. PMID:35451420. |
thus, lncrna neat1 inhibited inflammasome activation by nlrp3 in microglia via the neat1/ mir‑10b‑5p/bcl6/nlrp3 regulatory axis, which alleviated deleterious outcomes of ischemic stroke. |
2022-04-22 |
2023-08-13 |
Not clear |
| Alice Hartmann, Carla Vila-Verde, Francisco S Guimarães, Sâmia R Joca, Sabrina F Lisbo. The NLRP3 inflammasome in stress response: another target for the promiscuous cannabidiol? Current neuropharmacology. 2022-04-12. PMID:35410608. |
the mechanisms are still unclear, but one pathway in microglia has received increased attention in the last 8 years: the nlrp3 inflammasome pathway. |
2022-04-12 |
2023-08-13 |
Not clear |
| Alice Hartmann, Carla Vila-Verde, Francisco S Guimarães, Sâmia R Joca, Sabrina F Lisbo. The NLRP3 inflammasome in stress response: another target for the promiscuous cannabidiol? Current neuropharmacology. 2022-04-12. PMID:35410608. |
this review will highlight some findings for neuroinflammation and microglia involvement in stress-related psychiatric disorders, particularly addressing the nlrp3 inflammasome pathway. |
2022-04-12 |
2023-08-13 |
Not clear |
| Baoyu Ma, Yongxin Liu, Xiao Zhang, Rui Zhang, Zhenjiang Zhang, Zhihao Zhang, Jie Liu, Zhaodong Juan, Xiaotong Sun, Lina Sun, Jingyao Huang, Jinpeng Fen. TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation. Oxidative medicine and cellular longevity. vol 2022. 2022-04-11. PMID:35401924. |
in this study, we evaluated the role of tspo and its ligands pk11195 and midazolam in lps-activated bv-2 microglia cells involving mitophagy process and the nucleotide-binding domain-like receptor protein 3 (nlrp3) inflammasome activation. |
2022-04-11 |
2023-08-13 |
Not clear |
| Baoyu Ma, Yongxin Liu, Xiao Zhang, Rui Zhang, Zhenjiang Zhang, Zhihao Zhang, Jie Liu, Zhaodong Juan, Xiaotong Sun, Lina Sun, Jingyao Huang, Jinpeng Fen. TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation. Oxidative medicine and cellular longevity. vol 2022. 2022-04-11. PMID:35401924. |
and the nlrp3 inflammasome was increased in lps-activated bv-2 microglia cells in the microglia-neuron coculture system; pretreatment with pk11195 and midazolam limited this undesirable situation. |
2022-04-11 |
2023-08-13 |
Not clear |
| Baoyu Ma, Yongxin Liu, Xiao Zhang, Rui Zhang, Zhenjiang Zhang, Zhihao Zhang, Jie Liu, Zhaodong Juan, Xiaotong Sun, Lina Sun, Jingyao Huang, Jinpeng Fen. TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation. Oxidative medicine and cellular longevity. vol 2022. 2022-04-11. PMID:35401924. |
taken together, tspo ligands pk11195 and midazolam showed neuroprotective effects by reducing the inflammatory response of lps-activated microglia, which may be related to the enhancement of mitophagy and the inhibition of nlrp3 inflammasome. |
2022-04-11 |
2023-08-13 |
Not clear |
| Ajay Kumar, Pawan Kumar Singh, Zeeshan Ahmed, Sukhvinder Singh, Ashok Kuma. Essential Role of NLRP3 Inflammasome in Mediating IL-1β Production and the Pathobiology of Staphylococcus aureus Endophthalmitis. Infection and immunity. 2022-04-11. PMID:35404106. |
moreover, we found that both infiltrating neutrophils and retinal microglia contribute toward nlrp3 activation and il-1β production in s. aureus-infected eyes. |
2022-04-11 |
2023-08-13 |
mouse |
| Xiao Hu, Qiongzhen Zeng, Ji Xiao, Shurong Qin, Yuan Wang, Tianhao Shan, Di Hu, Yexuan Zhu, Kaisheng Liu, Kai Zheng, Yifei Wang, Zhe Re. Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome. Frontiers in microbiology. vol 13. 2022-04-07. PMID:35387080. |
in this study, we confirmed for the first time that the dna virus hsv-1 triggers gasdermin d-dependent pyroptosis by activating nlr family pyrin domain containing 3 (nlrp3) inflammasomes in mouse microglia, leading to mature il-1β production and active caspase-1 (p10) release. |
2022-04-07 |
2023-08-13 |
mouse |
| Oualid Sbai, Mehdi Djelloul, Antonia Auletta, Alessandro Ieraci, Carlo Vascotto, L Perron. AGE-TXNIP axis drives inflammation in Alzheimer's by targeting Aβ to mitochondria in microglia. Cell death & disease. vol 13. issue 4. 2022-04-05. PMID:35379773. |
altogether these data shed new light on a novel mechanism of action of rage-txnip axis in microglia, which is intertwined with aβ and ultimately causes mitochondria dysfunction and nlrp3 inflammasome cascade activation, suggesting txnip as a druggable target to be better deepened for ad. |
2022-04-05 |
2023-08-13 |
mouse |
| Sahithi Attaluri, Meenakshi Arora, Leelavathi N Madhu, Maheedhar Kodali, Bing Shuai, Laila Melissari, Raghavendra Upadhya, Xiaolan Rao, Adrian Bates, Eeshika Mitra, Keyhan R Ghahfarouki, M N V Ravikumar, Ashok K Shett. Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression. Aging and disease. vol 13. issue 2. 2022-04-04. PMID:35371600. |
lessened neuroinflammation was noticeable from reductions in astrocyte hypertrophy, nf-kb, activated microglia with nlrp3 inflammasomes, and multiple proinflammatory cytokines. |
2022-04-04 |
2023-08-13 |
rat |
| Ana Catarina Pereira, Jessica De Pascale, Rosa Resende, Susana Cardoso, Isabel Ferreira, Bruno Miguel Neves, Mylène A Carrascal, Mónica Zuzarte, Nuno Madeira, Sofia Morais, António Macedo, Anália do Carmo, Paula I Moreira, Maria Teresa Cruz, Cláudia F Pereir. ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system. Cellular and molecular life sciences : CMLS. vol 79. issue 4. 2022-03-28. PMID:35344105. |
this work aimed to investigate the role of er-mitochondria communication during er stress-induced nlrp3 inflammasome activation in both peripheral and central innate immune systems, by using thp-1 human monocytes and bv2 microglia cells, respectively, as in vitro models. |
2022-03-28 |
2023-08-13 |
human |
| Ya Zheng, Benjamin Reiner, Jianuo Liu, Linda Xu, Huangui Xion. Methamphetamine augments HIV-1 gp120 inhibition of synaptic transmission and plasticity in rat hippocampal slices: Implications for methamphetamine exacerbation of HIV-associated neurocognitive disorders. Neurobiology of disease. 2022-03-26. PMID:35337950. |
further studies revealed an involvement of microglia nlrp3 inflammasome activation in meth augmentation of gp120-mediated attenuation of ltp. |
2022-03-26 |
2023-08-13 |
human |
| Hetao Bian, Feng Yan, Weili Li, Wenjun Tu, Xunming J. Tert-butylhydroquinone prevents neuroinflammation and relieves depression via regulation of NLRP3 signaling in mice. International immunopharmacology. vol 107. 2022-03-26. PMID:35338961. |
these results suggested that, by inhibiting lps-induced neuroinflammation and microglia activation, tbhq could effectively improve lps-induced inflammation-related depression-like behavior through modulating the nlrp3 signaling pathway. |
2022-03-26 |
2023-08-13 |
mouse |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
dopamine, in turn, has been shown to inhibit nlrp3 inflammasome activation in microglia. |
2022-03-25 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
in this review, we provide a literature framework for a hypothesis in which kv1.3 activity-induced nlrp3 inflammasome activation, evoked by stimuli such as α-synuclein, could lead to microglia utilizing dopamine from adjacent dopaminergic neurons to counteract this process and fend off an activated state. |
2022-03-25 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
if this is the case, a sufficient dopamine supply would ensure that microglia remain under control, but as dopamine is gradually siphoned from the neurons by microglial demand, nlrp3 inflammasome activation and kv1.3 activity would progressively intensify to promote each of the three major facets of pd pathology: α-synuclein aggregation, microglia-mediated neuroinflammation, and dopaminergic neurodegeneration. |
2022-03-25 |
2023-08-13 |
Not clear |