| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan Jie, Xuan Yang, Bowen Yang, Yan Liu, Lipeng Wu, Baiyi L. Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-06-30. PMID:35772378. |
stigmasterol attenuates inflammatory response of microglia via nf-κb and nlrp3 signaling by ampk activation. |
2022-06-30 |
2023-08-14 |
Not clear |
| Yu Cui, Nan-Nan Zhang, Dan Wang, Wei-Hong Meng, Hui-Sheng Che. Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia. Journal of inflammation research. vol 15. 2022-06-16. PMID:35706530. |
modified citrus pectin alleviates cerebral ischemia/reperfusion injury by inhibiting nlrp3 inflammasome activation via tlr4/nf-ĸb signaling pathway in microglia. |
2022-06-16 |
2023-08-14 |
Not clear |
| Shanshan Zhang, Juntao Hu, Guixue Liu, Haoran Wu, Meihui Li, Chenye Shi, Qiong Liu, Wensheng L. Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress. Translational psychiatry. vol 12. issue 1. 2022-06-10. PMID:35688836. |
rats exhibited defective behavior and hippocampal neuroinflammation after 12 weeks of cms, which included elevated expression of cleaved interleukin-1β (il-1β) and nlrp3 inflammasome together with the activation of microglia. |
2022-06-10 |
2023-08-14 |
rat |
| Shanshan Zhang, Juntao Hu, Guixue Liu, Haoran Wu, Meihui Li, Chenye Shi, Qiong Liu, Wensheng L. Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress. Translational psychiatry. vol 12. issue 1. 2022-06-10. PMID:35688836. |
all these results indicate that the nlrp3 inflammasome of microglia in the hippocampus is related to the antidepressant effects of clomipramine and cms-induced depressive-like behavior in rats. |
2022-06-10 |
2023-08-14 |
rat |
| Heng Fang, Yirong Wang, Jia Deng, Huidan Zhang, Qingrui Wu, Linling He, Jing Xu, Xin Shao, Xin Ouyang, Zhimei He, Qiuping Zhou, Huifang Wang, Yiyu Deng, Chunbo Che. Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice. mSystems. 2022-06-01. PMID:35642838. |
moreover, ipa markedly inhibited nlrp3 inflammasome activation and interleukin-1β (il-1β) secretion in lipopolysaccharide-stimulated microglia. |
2022-06-01 |
2023-08-13 |
mouse |
| Dylan A Galloway, Samantha J Carew, Stephanie N Blandford, Rochelle Y Benoit, Neva Fudge, Tangyne Berry, G R Wayne Moore, Jane Barron, Craig S Moor. Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination. Journal of neurochemistry. 2022-05-28. PMID:35633501. |
we observed that nlrp3 inflammasome components and microrna-223-3p were upregulated at sites of myelin injury within activated macrophages and microglia. |
2022-05-28 |
2023-08-13 |
mouse |
| Dylan A Galloway, Samantha J Carew, Stephanie N Blandford, Rochelle Y Benoit, Neva Fudge, Tangyne Berry, G R Wayne Moore, Jane Barron, Craig S Moor. Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination. Journal of neurochemistry. 2022-05-28. PMID:35633501. |
both microrna-223-3p and a small-molecule nlrp3 inhibitor, mcc950, supressed inflammasome activation in macrophages and microglia in vitro; compared with microglia, macrophages were more prone to inflammasome activation in vitro. |
2022-05-28 |
2023-08-13 |
mouse |
| Dylan A Galloway, Samantha J Carew, Stephanie N Blandford, Rochelle Y Benoit, Neva Fudge, Tangyne Berry, G R Wayne Moore, Jane Barron, Craig S Moor. Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination. Journal of neurochemistry. 2022-05-28. PMID:35633501. |
in conclusion, we demonstrate that nlrp3 inflammasome activity by macrophages and microglia is a critical component of the inflammatory microenvironment following demyelination and represents a potential therapeutic target for inflammatory-mediated demyelinating diseases, including ms. |
2022-05-28 |
2023-08-13 |
mouse |
| Jia-Mei Li, Ting Hu, Chun-Lei Jiang, Wei Wan. Pinocembrin ameliorates depressive-like behaviors by regulating P2X7/TRL4 receptors expression in mouse hippocampus. Behavioural pharmacology. 2022-05-27. PMID:35621136. |
toll-like receptor 4 (tlr4) and p2x7 receptor (p2x7r) were recently reckoned pivotally to regulate nod-like receptor protein 3 (nlrp3) in microglia. |
2022-05-27 |
2023-08-13 |
mouse |
| Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E Barclay, Ramona M Rodriguiz, William C Wetsel, Ting Yang, Mari L Shinohara, Niccolò Terrand. Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome. Frontiers in immunology. vol 13. 2022-05-23. PMID:35603196. |
surgery triggered asc specks formation in ca1 hippocampal microglia, but without inducing significant morphological changes in nlrp3 and asc knockout mice. |
2022-05-23 |
2023-08-13 |
mouse |
| Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-23. PMID:35605300. |
however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1ß), tumor necrosis factor-alpha (tnfα), and nuclear factor kappa b (nf-κb)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. |
2022-05-23 |
2023-08-13 |
mouse |
| Lin Liu, Tingting Zhou, Tao Li, Zhanhua Liang, Xiaoguang Lu. LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis. Behavioural brain research. 2022-05-13. PMID:35550840. |
meanwhile, the cell number of th+/caspase3+/iba1+ in substantia nigra, cell viability, and apoptosis rate of bv2 microglia, inflammatory levels, and nlr family pyrin domain containing 3 (nlrp3) inflammasome were determined using immunohistochemistry, mtt assay, flow cytometry, elisa assay, and western blot. |
2022-05-13 |
2023-08-13 |
mouse |
| Eun Sun Jung, Kyujin Suh, Jihui Han, Heyyoung Kim, Hyung-Sik Kang, Won-Seok Choi, Inhee Mook-Jun. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging cell. 2022-04-27. PMID:35474599. |
in particular, inflammasome activation, including nlrp3 inflammasome in microglia, is regarded as fundamental for the pro-inflammatory response of immune cells. |
2022-04-27 |
2023-08-13 |
Not clear |
| Eun Sun Jung, Kyujin Suh, Jihui Han, Heyyoung Kim, Hyung-Sik Kang, Won-Seok Choi, Inhee Mook-Jun. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging cell. 2022-04-27. PMID:35474599. |
here, we show that amyloid-β activates the nlrp3 inflammasome in microglia by activating syk and inhibiting ampk. |
2022-04-27 |
2023-08-13 |
Not clear |
| Yu Ren, Qing Wang, Zexian Yang, Linyin Feng, Yu Zhan. MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation. Biochemical and biophysical research communications. vol 611. 2022-04-26. PMID:35472607. |
furthermore, immunostaining or immunoblotting experiments on the hippocampal tissue were performed, and the results suggested that mcc950 not only inhibited the expression of nlrp3, and suppressed the activation of astrocytes and microglia, but also promoted the mtor-mediated autophagy pathway to reduce human α-synuclein accumulation. |
2022-04-26 |
2023-08-13 |
mouse |
| Jahirul Islam, Jung-Ah Cho, Ju-Yong Kim, Kyung-Sun Park, Young-Jae Koh, Chu Young Chung, Eun-Jae Lee, Soo Jeong Nam, Kyoungyul Lee, Seoung-Heon Kim, Sung-Hye Park, Dong Young Lee, Byeong C Kim, Kyung-Hwa Lee, Seung-Yong Seon. GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-04-25. PMID:35464490. |
gpcr19 regulates p2x7r-mediated nlrp3 inflammasomal activation of microglia by amyloid β in a mouse model of alzheimer's disease. |
2022-04-25 |
2023-08-13 |
mouse |
| Zhi-Wen Zhou, Xiang Ren, Wen-Sheng Zhou, Ai-Ping Li, Li-Jun Zhen. LncRNA NEAT1 alleviates ischemic stroke via transcriptional inhibition of NLRP3 mediated by the miR‑10b‑5p/BCL6 axis. Acta neurobiologiae experimentalis. vol 82. issue 1. 2022-04-22. PMID:35451420. |
thus, lncrna neat1 inhibited inflammasome activation by nlrp3 in microglia via the neat1/ mir‑10b‑5p/bcl6/nlrp3 regulatory axis, which alleviated deleterious outcomes of ischemic stroke. |
2022-04-22 |
2023-08-13 |
Not clear |
| Alice Hartmann, Carla Vila-Verde, Francisco S Guimarães, Sâmia R Joca, Sabrina F Lisbo. The NLRP3 inflammasome in stress response: another target for the promiscuous cannabidiol? Current neuropharmacology. 2022-04-12. PMID:35410608. |
the mechanisms are still unclear, but one pathway in microglia has received increased attention in the last 8 years: the nlrp3 inflammasome pathway. |
2022-04-12 |
2023-08-13 |
Not clear |
| Alice Hartmann, Carla Vila-Verde, Francisco S Guimarães, Sâmia R Joca, Sabrina F Lisbo. The NLRP3 inflammasome in stress response: another target for the promiscuous cannabidiol? Current neuropharmacology. 2022-04-12. PMID:35410608. |
this review will highlight some findings for neuroinflammation and microglia involvement in stress-related psychiatric disorders, particularly addressing the nlrp3 inflammasome pathway. |
2022-04-12 |
2023-08-13 |
Not clear |
| Baoyu Ma, Yongxin Liu, Xiao Zhang, Rui Zhang, Zhenjiang Zhang, Zhihao Zhang, Jie Liu, Zhaodong Juan, Xiaotong Sun, Lina Sun, Jingyao Huang, Jinpeng Fen. TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation. Oxidative medicine and cellular longevity. vol 2022. 2022-04-11. PMID:35401924. |
in this study, we evaluated the role of tspo and its ligands pk11195 and midazolam in lps-activated bv-2 microglia cells involving mitophagy process and the nucleotide-binding domain-like receptor protein 3 (nlrp3) inflammasome activation. |
2022-04-11 |
2023-08-13 |
Not clear |