| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
p2x4 inhibition reduces microglia inflammation and apoptosis by nlrp3 and improves nervous system defects in rat brain trauma model. |
2022-03-15 |
2023-08-13 |
rat |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
the inhibition of p2x4 effectively reduced the inflammation and apoptosis of microglia, and nlrp3 may be involved in this process. |
2022-03-15 |
2023-08-13 |
rat |
| Ting Xiao, Heyu Ji, Xuejuan Shangguan, Shuangquan Qu, Yulong Cui, Junmei X. NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. Biochemical and biophysical research communications. vol 602. 2022-03-05. PMID:35247698. |
nlrp3 inflammasome of microglia promotes a1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. |
2022-03-05 |
2023-08-13 |
mouse |
| Ting Xiao, Heyu Ji, Xuejuan Shangguan, Shuangquan Qu, Yulong Cui, Junmei X. NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. Biochemical and biophysical research communications. vol 602. 2022-03-05. PMID:35247698. |
taken together, nlrp3 inflammasome of microglia promotes transformation of a1 astrocytes and consequently exacerbates neo-neuron decline, resulting in cognitive impairment after a challenge of lps. |
2022-03-05 |
2023-08-13 |
mouse |
| Adrianne F Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A C Herrebout, Mona M H E Fayed, Michele Sandre, Tatiana Varanita, Charlotte E Teunissen, Jeroen J M Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacc. Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-02-17. PMID:35172843. |
degenerating neurons are surrounded by activated microglia with increased secretion of interleukin-1β (il-1β), driven largely by the nlrp3 inflammasome. |
2022-02-17 |
2023-08-13 |
mouse |
| Adrianne F Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A C Herrebout, Mona M H E Fayed, Michele Sandre, Tatiana Varanita, Charlotte E Teunissen, Jeroen J M Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacc. Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-02-17. PMID:35172843. |
dopamine blocks microglial nlrp3 inflammasome activation in the mptp model, but its effects in this framework, highly relevant to pd, remain unexplored in primary human microglia and in other in vivo parkinsonism models. |
2022-02-17 |
2023-08-13 |
mouse |
| Eun S Park, Sehee Kim, Derek C Yao, Jude P J Savarraj, Huimahn Alex Choi, Peng Roc Chen, Eunhee Ki. Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163148. |
we found that seng increased the gene expression of vegf-a, pro-inflammatory cytokines/inflammasome mediators (tnf-α, il-6, nlrp3, asc, caspase-1, and il-1β), and proteolytic enzyme (mmp-9) in bv2 microglia. |
2022-02-15 |
2023-08-13 |
mouse |
| Hui Yuan, Bo Lu, Yiqin Ji, Bo Meng, Ruichun Wang, Daofan Sun, Rongjun Liu, Xiaojie Zhai, Xiaoyu Li, Jinling Qin, Junping Che. Role of P2X4/NLRP3 Pathway-Mediated Neuroinflammation in Perioperative Neurocognitive Disorders. Mediators of inflammation. vol 2022. 2022-02-14. PMID:35153623. |
the level of p2x4r and nlrp3 was estimated by western blot, the activation of microglia was detected via immunohistochemistry, and the expression of tnf- |
2022-02-14 |
2023-08-13 |
mouse |
| Xinxin Ma, Junnian Hao, Jianrong Wu, Yuehua Li, Xiaojun Cai, Yuanyi Zhen. Prussian blue nanozyme as a pyroptosis inhibitor alleviates neurodegeneration. Advanced materials (Deerfield Beach, Fla.). 2022-02-10. PMID:35143076. |
both in vitro and in vivo results demonstrate that pbzyme reduces the activation of microglial nlrp3 inflammasomes and caspase-1 by scavenging reactive oxygen species, thereby downregulating gsdmd cleavage as well as inflammatory factor production, and eventually leading to the inhibition of microglia pyroptosis. |
2022-02-10 |
2023-08-13 |
mouse |
| Jian Zhou, Faxuan Wang, Leina Jia, Ru Chai, Hengquan Wang, Xiaolan Wang, Jiangping Li, Kai Wang, Pengju Zhang, Huifang Yan. 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide. Environmental toxicology. 2022-01-31. PMID:35099110. |
2,4-dichlorophenoxyacetic acid induces ros activation in nlrp3 inflammatory body-induced autophagy disorder in microglia and the protective effect of lycium barbarum polysaccharide. |
2022-01-31 |
2023-08-13 |
Not clear |
| Jian Zhou, Faxuan Wang, Leina Jia, Ru Chai, Hengquan Wang, Xiaolan Wang, Jiangping Li, Kai Wang, Pengju Zhang, Huifang Yan. 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide. Environmental toxicology. 2022-01-31. PMID:35099110. |
in conclusion, 2,4-d enhanced cell migration, promoted oxidative stress, induced excessive release of mitochondrial reactive oxygen species, promoted microglial cell activation, released inflammatory factors, activated nlrp3 inflammasomes, and inhibited autophagy. |
2022-01-31 |
2023-08-13 |
Not clear |
| Krisztina Tóth, Nikolett Lénárt, Péter Berki, Rebeka Fekete, Eszter Szabadits, Balázs Pósfai, Csaba Cserép, Ahmad Alatshan, Szilvia Benkő, Dániel Kiss, Christian A Hübner, Attila Gulyás, Kai Kaila, Zsuzsanna Környei, Ádám Déne. The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner. PLoS biology. vol 20. issue 1. 2022-01-27. PMID:35085235. |
in addition, microglial nkcc1 deficiency results in nlrp3 inflammasome priming and increased production of interleukin-1β (il-1β), rendering microglia prone to exaggerated inflammatory responses. |
2022-01-27 |
2023-08-13 |
mouse |
| Jingru Qiu, Ye Chen, Jing Zhuo, Li Zhang, Jia Liu, Baozhu Wang, Deqing Sun, Shuyan Yu, Haiyan Lo. Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model. Neuropharmacology. 2022-01-22. PMID:35065082. |
the mechanism may be related with its inhibition of nlrp3 inflammasome activation via promoting mitophagy in microglia. |
2022-01-22 |
2023-08-13 |
mouse |
| Jian Lai, Jie-Mei Ji, Mei-Yun-Zi Chen, Yun-Peng Luo, Yue Yu, Gang Zhou, Li-Ling Wei, Lan-Shan Huang, Jing-Chen Li. Melatonin ameliorates bupivacaine-induced spinal neurotoxicity in rats by suppressing neuronal NLRP3 inflammasome activation. Neuroscience letters. 2022-01-22. PMID:35065245. |
nlrp3 was expressed mainly in neurons and microglia. |
2022-01-22 |
2023-08-13 |
rat |
| Yao Lin, Tingting Huang, Weimin Shen, Qiongyi Pang, Qingfeng Xie, Xiang Chen, Fengxia T. TRPV1 Suppressed NLRP3 Through Regulating Autophagy in Microglia After Ischemia-Reperfusion Injury. Journal of molecular neuroscience : MN. 2022-01-18. PMID:35041191. |
trpv1 suppressed nlrp3 through regulating autophagy in microglia after ischemia-reperfusion injury. |
2022-01-18 |
2023-08-13 |
Not clear |
| Xueyuan Yu, Jiajia Lv, Jun Wu, Yong Chen, Fei Chen, Li Wan. The autoimmune encephalitis-related cytokine TSLP in the brain primes neuroinflammation by activating the JAK2-NLRP3 axis. Clinical and experimental immunology. 2022-01-12. PMID:35020848. |
in vitro experiments using bv-2murine microglia revealed that tslp directly induced nlrp3 expression, phosphorylation of jak2 but not jak1orjak3, and il-1β release, which were markedly inhibited by ruxolitinib. |
2022-01-12 |
2023-08-13 |
mouse |
| Airu Huang, Ling Ji, Yilong Huang, Qian Yu, Yufeng L. miR-185-5p alleviates CCI-induced neuropathic pain by repressing NLRP3 inflammasome through dual targeting MyD88 and CXCR4. International immunopharmacology. vol 104. 2022-01-09. PMID:34999395. |
increasing mir-185-5p expression notably impeded the expression of myd88, cxcr4 and nlrp3 inflammasome in bv2 microglia, while attenuating mir-185-5p expression exerted the opposite effects. |
2022-01-09 |
2023-08-13 |
rat |
| Jie Liu, Wei Ma, Cheng-Hao Zang, Guo-Dong Wang, Si-Jia Zhang, Hong-Jie Wu, Ke-Wei Zhu, Xiang-Lin Xiang, Chun-Yan Li, Kuang-Pin Liu, Jian-Hui Guo, Li-Yan L. Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway. Annals of translational medicine. vol 9. issue 22. 2022-01-06. PMID:34988203. |
salidroside inhibits nlrp3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the tlr4/nf-κb signaling pathway. |
2022-01-06 |
2023-08-13 |
Not clear |
| Qing Liu, Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Na-Zhi Li, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu, Li-Tao Y. Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2022-01-03. PMID:34978026. |
in addition, nlrp3 inhibition decreased the number of microglia and changed the activated state of microglia to a resting state by morphology 3d reconstruction. |
2022-01-03 |
2023-08-13 |
mouse |
| Qing Liu, Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Na-Zhi Li, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu, Li-Tao Y. Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2022-01-03. PMID:34978026. |
the results from immunofluorescence demonstrated that nlrp3 and il-1β expression was decreased in microglia in response to mcc950 treatment. |
2022-01-03 |
2023-08-13 |
mouse |