| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dorit Trudler, Kristopher L Nazor, Yvonne S Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S Goodwin, Yona Levites, Todd E Golde, Jeffery W Kelly, Michael R Sierks, Nicholas J Schork, Michael Karin, Rajesh Ambasudhan, Stuart A Lipto. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 15. 2021-11-29. PMID:33833060. |
heretofore, it remained unknown if oligomeric/fibrillar αsyn could activate the nucleotide-binding oligomerization domain (nod)-like receptor (nlr) family pyrin domain-containing 3 (nlrp3) inflammasome in human microglia and whether anti-αsyn antibodies could prevent this effect. |
2021-11-29 |
2023-08-13 |
mouse |
| Dorit Trudler, Kristopher L Nazor, Yvonne S Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S Goodwin, Yona Levites, Todd E Golde, Jeffery W Kelly, Michael R Sierks, Nicholas J Schork, Michael Karin, Rajesh Ambasudhan, Stuart A Lipto. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 15. 2021-11-29. PMID:33833060. |
here, we show that αsyn activates the nlrp3 inflammasome in human induced pluripotent stem cell (hipsc)-derived microglia (himg) via dual stimulation involving toll-like receptor 2 (tlr2) engagement and mitochondrial damage. |
2021-11-29 |
2023-08-13 |
mouse |
| Maryam Mohammadi, Mahdad Abdi, Mehdi Alidadi, Wael Mohamed, Kazem Zibara, Iraj Ragerdi Kashan. Medroxyprogesterone acetate attenuates demyelination, modulating microglia activation, in a cuprizone neurotoxic demyelinating mouse model. American journal of neurodegenerative disease. vol 10. issue 5. 2021-11-27. PMID:34824899. |
in summary, mpa reduces the level of demyelination and has an anti-inflammatory role in cns demyelination by inducing m2 microglia polarization and suppressing the m1 phenotype through the inhibition of nf-κb and nlrp3 inflammasome. |
2021-11-27 |
2023-08-13 |
mouse |
| Kuan Cheng, Jingjing Wang, Qingxing Chen, Gang Zhao, Yang Pang, Ye Xu, Junbo Ge, Wenqing Zh. Inflammasome-mediated neurodegeneration following heart disease. Annals of translational medicine. vol 9. issue 20. 2021-11-19. PMID:34790766. |
previous studies have shown that nlrp3 activation in brain microglia is required for ad; however, its possible role in mi-induced future development of neurodegeneration is not yet understood. |
2021-11-19 |
2023-08-13 |
Not clear |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
we examined activation of the nlrp3 pathway in microglia exposed to cocaine, followed by validation in mice administered either cocaine or saline for 7 days, with or without pretreatment with the nlrp3 inhibitor, mcc950, and in postmortem cortical brain tissues of chronic cocaine-dependent humans. |
2021-11-18 |
2023-08-13 |
mouse |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
we found that microglia exposed to cocaine exhibited significant induction of nlrp3 and mature il-1β expression. |
2021-11-18 |
2023-08-13 |
mouse |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
collectively, these findings suggest that cocaine activates microglia involving the nlrp3 inflammasome pathway, thereby contributing to neuroinflammation. |
2021-11-18 |
2023-08-13 |
mouse |
| Mayra López-Cervantes, Andrés Quintanar-Stephano, Sarael Alcauter-Solórzano, Rogelio Hernández-Pando, Raúl Aguilar-Roblero, Deisy Gasca-Martínez, Juan J Ortíz, Olivia Vázquez-Martínez, Cecilia Ximénez-Camilli, Mauricio Díaz-Muño. Cerebellar spongiform degeneration is accompanied by metabolic, cellular, and motor disruption in male rats with portacaval anastomosis. Journal of neuroscience research. vol 99. issue 9. 2021-11-18. PMID:34061383. |
the results were as follows: (a) cellular alterations, namely loss of purkinje cells, morphological changes, such as swelling of astrocytes and bergmann glia, and activation of microglia; (b) cytotoxic edema, shown by an increase in aquaporin-4 and n-acetylaspartate and a reduction in taurine and choline-derivate osmolytes; (c) metabolic adjustments, noted by the elevation of circulating ammonium, enhanced presence of glutamine synthetase, and increase in glutamine and creatine/phosphocreatine; (d) inflammasome activation, detected by the elevation of the marker nlrp3 and microglial activation; (e) locomotor deficits in pca rats as assessed by the rotarod and open field tests. |
2021-11-18 |
2023-08-13 |
rat |
| Chenyang Han, Qiaohong Hu, Anqi Yu, Qingcai Jiao, Yi Yan. Mafenide derivatives inhibit neuroinflammation in Alzheimer's disease by regulating pyroptosis. Journal of cellular and molecular medicine. vol 25. issue 22. 2021-11-18. PMID:34632701. |
as a result, the administration of sulfa-4 and sulfa-22 could significantly inhibit the activation of microglia, decrease the expression of inflammatory factors in the central nervous system and simultaneously suppress the production of p30-gsdmd as well as the expression of upstream nlrp3 inflammasome and caspase-1 protein. |
2021-11-18 |
2023-08-13 |
Not clear |
| Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wan. Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease. Frontiers in immunology. vol 12. 2021-11-17. PMID:34691027. |
findings demonstrate an elevated level of nlrp3 inflammasome in activated microglia in the substantia nigra of pd patients. |
2021-11-17 |
2023-08-13 |
Not clear |
| Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wan. Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease. Frontiers in immunology. vol 12. 2021-11-17. PMID:34691027. |
abnormal protein aggregation of α-synuclein (α-syn), a pathologically relevant protein of pd, were reported to activate the nlrp3 inflammasome of microglia through interaction with toll-like receptors (tlrs). |
2021-11-17 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
α-synuclein evokes nlrp3 inflammasome-mediated il-1β secretion from primary human microglia. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
the main driver of il-1β secretion from microglia is the nlrp3 inflammasome. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
α-syn is known to activate the microglial nlrp3 inflammasome in murine models, but its relationship to this inflammasome in human microglia has not been established. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
in this study, il-1β secretion from primary mouse microglia induced by α-syn fibrils was dependent on nlrp3 inflammasome assembly and caspase-1 activity, as previously reported. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
this work presents similarities between primary human and mouse microglia in the mechanisms of activation of the nlrp3 inflammasome by α-syn, but also highlights evidence to suggest that there may be a difference in the requirement for caspase-1 activity in il-1β output. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
the data represent a novel characterization of pd-related nlrp3 inflammasome activation in primary human microglia and further implicate this mechanism in the pathology underlying pd. |
2021-11-16 |
2023-08-13 |
mouse |
| Lin Yuan, Yurong Zhu, Shuang Huang, Lin Lin, Xugan Jiang, Shengxia Che. NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells. Journal of microbiology (Seoul, Korea). vol 59. issue 8. 2021-11-16. PMID:34061343. |
nf-κb/ros and erk pathways regulate nlrp3 inflammasome activation in listeria monocytogenes infected bv2 microglia cells. |
2021-11-16 |
2023-08-13 |
Not clear |
| Dong Yuan, ShuangXian Guan, Zhen Wang, HongLiang Ni, DongLiang Ding, WenBo Xu, GuoMin L. HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34166779. |
hif-1α aggravated traumatic brain injury by nlrp3 inflammasome-mediated pyroptosis and activation of microglia. |
2021-11-10 |
2023-08-13 |
mouse |
| Dong Yuan, ShuangXian Guan, Zhen Wang, HongLiang Ni, DongLiang Ding, WenBo Xu, GuoMin L. HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34166779. |
in addition, hif-1α accumulated nlrp3 inflammasome-mediated pyroptosis and activation of microglia. |
2021-11-10 |
2023-08-13 |
mouse |