| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinxin Ma, Junnian Hao, Jianrong Wu, Yuehua Li, Xiaojun Cai, Yuanyi Zhen. Prussian blue nanozyme as a pyroptosis inhibitor alleviates neurodegeneration. Advanced materials (Deerfield Beach, Fla.). 2022-02-10. PMID:35143076. |
both in vitro and in vivo results demonstrate that pbzyme reduces the activation of microglial nlrp3 inflammasomes and caspase-1 by scavenging reactive oxygen species, thereby downregulating gsdmd cleavage as well as inflammatory factor production, and eventually leading to the inhibition of microglia pyroptosis. |
2022-02-10 |
2023-08-13 |
mouse |
| Jian Zhou, Faxuan Wang, Leina Jia, Ru Chai, Hengquan Wang, Xiaolan Wang, Jiangping Li, Kai Wang, Pengju Zhang, Huifang Yan. 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide. Environmental toxicology. 2022-01-31. PMID:35099110. |
2,4-dichlorophenoxyacetic acid induces ros activation in nlrp3 inflammatory body-induced autophagy disorder in microglia and the protective effect of lycium barbarum polysaccharide. |
2022-01-31 |
2023-08-13 |
Not clear |
| Jian Zhou, Faxuan Wang, Leina Jia, Ru Chai, Hengquan Wang, Xiaolan Wang, Jiangping Li, Kai Wang, Pengju Zhang, Huifang Yan. 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide. Environmental toxicology. 2022-01-31. PMID:35099110. |
in conclusion, 2,4-d enhanced cell migration, promoted oxidative stress, induced excessive release of mitochondrial reactive oxygen species, promoted microglial cell activation, released inflammatory factors, activated nlrp3 inflammasomes, and inhibited autophagy. |
2022-01-31 |
2023-08-13 |
Not clear |
| Krisztina Tóth, Nikolett Lénárt, Péter Berki, Rebeka Fekete, Eszter Szabadits, Balázs Pósfai, Csaba Cserép, Ahmad Alatshan, Szilvia Benkő, Dániel Kiss, Christian A Hübner, Attila Gulyás, Kai Kaila, Zsuzsanna Környei, Ádám Déne. The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner. PLoS biology. vol 20. issue 1. 2022-01-27. PMID:35085235. |
in addition, microglial nkcc1 deficiency results in nlrp3 inflammasome priming and increased production of interleukin-1β (il-1β), rendering microglia prone to exaggerated inflammatory responses. |
2022-01-27 |
2023-08-13 |
mouse |
| Jingru Qiu, Ye Chen, Jing Zhuo, Li Zhang, Jia Liu, Baozhu Wang, Deqing Sun, Shuyan Yu, Haiyan Lo. Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model. Neuropharmacology. 2022-01-22. PMID:35065082. |
the mechanism may be related with its inhibition of nlrp3 inflammasome activation via promoting mitophagy in microglia. |
2022-01-22 |
2023-08-13 |
mouse |
| Jian Lai, Jie-Mei Ji, Mei-Yun-Zi Chen, Yun-Peng Luo, Yue Yu, Gang Zhou, Li-Ling Wei, Lan-Shan Huang, Jing-Chen Li. Melatonin ameliorates bupivacaine-induced spinal neurotoxicity in rats by suppressing neuronal NLRP3 inflammasome activation. Neuroscience letters. 2022-01-22. PMID:35065245. |
nlrp3 was expressed mainly in neurons and microglia. |
2022-01-22 |
2023-08-13 |
rat |
| Yao Lin, Tingting Huang, Weimin Shen, Qiongyi Pang, Qingfeng Xie, Xiang Chen, Fengxia T. TRPV1 Suppressed NLRP3 Through Regulating Autophagy in Microglia After Ischemia-Reperfusion Injury. Journal of molecular neuroscience : MN. 2022-01-18. PMID:35041191. |
trpv1 suppressed nlrp3 through regulating autophagy in microglia after ischemia-reperfusion injury. |
2022-01-18 |
2023-08-13 |
Not clear |
| Xueyuan Yu, Jiajia Lv, Jun Wu, Yong Chen, Fei Chen, Li Wan. The autoimmune encephalitis-related cytokine TSLP in the brain primes neuroinflammation by activating the JAK2-NLRP3 axis. Clinical and experimental immunology. 2022-01-12. PMID:35020848. |
in vitro experiments using bv-2murine microglia revealed that tslp directly induced nlrp3 expression, phosphorylation of jak2 but not jak1orjak3, and il-1β release, which were markedly inhibited by ruxolitinib. |
2022-01-12 |
2023-08-13 |
mouse |
| Airu Huang, Ling Ji, Yilong Huang, Qian Yu, Yufeng L. miR-185-5p alleviates CCI-induced neuropathic pain by repressing NLRP3 inflammasome through dual targeting MyD88 and CXCR4. International immunopharmacology. vol 104. 2022-01-09. PMID:34999395. |
increasing mir-185-5p expression notably impeded the expression of myd88, cxcr4 and nlrp3 inflammasome in bv2 microglia, while attenuating mir-185-5p expression exerted the opposite effects. |
2022-01-09 |
2023-08-13 |
rat |
| Jie Liu, Wei Ma, Cheng-Hao Zang, Guo-Dong Wang, Si-Jia Zhang, Hong-Jie Wu, Ke-Wei Zhu, Xiang-Lin Xiang, Chun-Yan Li, Kuang-Pin Liu, Jian-Hui Guo, Li-Yan L. Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway. Annals of translational medicine. vol 9. issue 22. 2022-01-06. PMID:34988203. |
salidroside inhibits nlrp3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the tlr4/nf-κb signaling pathway. |
2022-01-06 |
2023-08-13 |
Not clear |
| Qing Liu, Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Na-Zhi Li, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu, Li-Tao Y. Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2022-01-03. PMID:34978026. |
in addition, nlrp3 inhibition decreased the number of microglia and changed the activated state of microglia to a resting state by morphology 3d reconstruction. |
2022-01-03 |
2023-08-13 |
mouse |
| Qing Liu, Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Na-Zhi Li, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu, Li-Tao Y. Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2022-01-03. PMID:34978026. |
the results from immunofluorescence demonstrated that nlrp3 and il-1β expression was decreased in microglia in response to mcc950 treatment. |
2022-01-03 |
2023-08-13 |
mouse |
| Qi Wang, Meina Ma, Hong Yu, Hongmei Yu, Shuai Zhang, Rui L. Mirtazapine prevents cell activation, inflammation, and oxidative stress against isoflurane exposure in microglia. Bioengineered. vol 13. issue 1. 2021-12-29. PMID:34964706. |
mirtazapine prevented isoflurane-induced production of the pro-inflammatory factors interleukin (il)-1β and il-18 by inhibiting the activation of the nod-like receptor family protein 3 (nlrp3) inflammasome in bv2 microglia. |
2021-12-29 |
2023-08-13 |
Not clear |
| Jialong Chen, Kanmin Mao, Honglin Yu, Yue Wen, Hua She, He Zhang, Linhua Liu, Mingque Li, Wenjun Li, Fei Zo. p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. Journal of neuroinflammation. vol 18. issue 1. 2021-12-21. PMID:34930303. |
p38-tfeb pathways promote microglia activation through inhibiting cma-mediated nlrp3 degradation in parkinson's disease. |
2021-12-21 |
2023-08-13 |
Not clear |
| Matthew G Frank, Kathy H Nguyen, Jayson B Ball, Shelby Hopkins, Tel Kelley, Michael V Baratta, Monika Fleshner, Steven F Maie. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: evidence of PAMP-like properties. Brain, behavior, and immunity. 2021-12-16. PMID:34915155. |
direct exposure of microglia to s1 resulted in increased gene expression (il1b, il6, tnf, nlrp3) and protein levels (il-1β, il-6, tnf, cxcl1, il-10). |
2021-12-16 |
2023-08-13 |
human |
| Yahui Zhang, Baohua Hou, Peiyu Liang, Xin Lu, Yifan Wu, Xinyi Zhang, Yuanteng Fan, Yumin Liu, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Song Han, Xiaohua H. TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia. Cell death & disease. vol 12. issue 12. 2021-12-15. PMID:34907173. |
trpv1 channel mediates nlrp3 inflammasome-dependent neuroinflammation in microglia. |
2021-12-15 |
2023-08-13 |
Not clear |
| Da-Yong Xia, Jin-Long Yuan, Xiao-Chun Jiang, Min Qi, Nian-Sheng Lai, Ling-Yun Wu, Xiang-Sheng Zhan. SIRT1 Promotes M2 Microglia Polarization Frontiers in immunology. vol 12. 2021-12-13. PMID:34899720. |
in the present study, we first observed that ex527, a potent selective sirt1 inhibitor, enhanced microglial m1 polarization and nod-like receptor pyrin domain-containing 3 (nlrp3) inflammasome activation in microglia after sah. |
2021-12-13 |
2023-08-13 |
Not clear |
| Ting Wang, Bo Ruan, Jinxin Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Haixia Zhao, Yuanjian Yang, Ding Yua. Activation of NLRP3-Caspase-1 pathway contributes to age-related impairments in cognitive function and synaptic plasticity. Neurochemistry international. vol 152. 2021-12-11. PMID:34743016. |
nlrp3 inflammasome in microglia is fundamental for il-1β maturation and subsequent inflammatory events. |
2021-12-11 |
2023-08-13 |
rat |
| Meiyun Cai, Wenxin Zhuang, E Lv, Zhan Liu, Yanqiang Wang, Wenyi Zhang, Wenyu F. Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway. Neurochemistry international. vol 152. 2021-12-11. PMID:34780806. |
the results showed kae could ameliorate the behavioral deficits of parkinson's disease (pd) rats, inhibit the activation of microglia and astrocytes, reduce the loss of th-positive neurons, down-regulate levels of pyroptosis-related nod-like receptor family pyrin domain containing 3 (nlrp3), gasdermind-n term (gsdmd-nt), caspase1, apoptosis-associated speck-like protein containing a caspase-recruitment domain (asc), interleukin (il)-1β, and il-18, and decrease the levels of inflammatory molecules (inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2)) and p38 mitogen-activated protein kinase/nuclear factor-kappab (p38mapk/nf-κb) signaling pathway molecules (p38mapk, p-p38mapk, nf-κb, and p-nf-κb) in the substantia nigra of pd rats. |
2021-12-11 |
2023-08-13 |
rat |
| Kai Wang, Cai Lu, Tong Wang, Chen Qiao, Linyu Lu, Die Wu, Ming Lu, Ruini Chen, Lu Fan, Juanjuan Tan. Hyperoside suppresses NLRP3 inflammasome in Parkinson's disease via Pituitary Adenylate Cyclase-Activating Polypeptide. Neurochemistry international. vol 152. 2021-12-11. PMID:34883151. |
pacap 6-38 reversed the inhibitory effect of hyperoside on the microglia proliferation and activation of the nlrp3 inflammasome. |
2021-12-11 |
2023-08-13 |
mouse |