| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Qiang Su, Xiang-Yang Wang, Fu-Tai Gong, Min Feng, Jing-Jing Bai, Rui-Rui Zhang, Xiao-Qian Dan. Oral treatment with glycyrrhizin inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization after traumatic spinal cord injury. Brain research bulletin. vol 158. 2021-08-31. PMID:32092434. |
the inflammatory response induced by traumatic spinal cord injury (sci) involves the activation of nlrp3 inflammasomes, which are closely related to the activation of microglia. |
2021-08-31 |
2023-08-13 |
rat |
| Xiao-Li Si, Yuan-Jian Fang, Ling-Fei Li, Lu-Yan Gu, Xin-Zhen Yin, Jun-Tian, Ya-Ping Yan, Jia-Li Pu, Bao-Rong Zhan. From inflammasome to Parkinson's disease: Does the NLRP3 inflammasome facilitate exosome secretion and exosomal alpha-synuclein transmission in Parkinson's disease? Experimental neurology. vol 336. 2021-08-30. PMID:33161049. |
the nlr family pyrin domain containing 3 protein (nlrp3) inflammasome activation in microglia, and the subsequent release of proinflammatory cytokines, are two crucial pathological events involved in neuroinflammation and pd progression. |
2021-08-30 |
2023-08-13 |
Not clear |
| Jack Rivers-Auty, Victor S Tapia, Claire S White, Michael J D Daniels, Samuel Drinkall, Paul T Kennedy, Harry G Spence, Shi Yu, Jack P Green, Christopher Hoyle, James Cook, Amy Bradley, Alison E Mather, Ruth Peters, Te-Chen Tzeng, Margaret J Gordon, John H Beattie, David Brough, Catherine B Lawrenc. Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 13. 2021-08-17. PMID:33597269. |
the nlrp3-inflammasome complex is one of the most important regulators of inflammation, and we show here that zinc deficiency in immune cells, including microglia, potentiated nlrp3 responses to inflammatory stimuli |
2021-08-17 |
2023-08-13 |
mouse |
| Yu-Qin Li, Ji-Xiang Chen, Quan-Wei Li, Zheng-Jun Xiao, Tao Yuan, Zhao-Hui Xi. Targeting NLRP3 inflammasome improved the neurogenesis and post-stroke cognition in a mouse model of photothrombotic stroke. Neuroreport. vol 31. issue 11. 2021-08-16. PMID:32576768. |
intraperitoneal injection of mcc950 inhibited the nlrp3 activation, decreased the number of microglia, increased the number of neurons and promoted the hippocampal neurogenesis, eventually improved psci. |
2021-08-16 |
2023-08-13 |
mouse |
| Yujie Jia, Yu Tong, Lianqiu Min, Yanrong Li, Yan Chen. Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation. Tissue & cell. vol 71. 2021-08-09. PMID:33676236. |
furthermore, we indicated that ori suppressed the activation of nlrp3 inflammasome in ogd/r induced bv2 microglia cells by inhibiting nf-κb signaling. |
2021-08-09 |
2023-08-13 |
mouse |
| Xiaoxue Du, Yuzhen Xu, Shijia Chen, Marong Fan. Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway. Neural plasticity. vol 2020. 2021-08-03. PMID:32908485. |
inhibited csf1r alleviates ischemia injury via inhibition of microglia m1 polarization and nlrp3 pathway. |
2021-08-03 |
2023-08-13 |
mouse |
| Hirofumi Matsuyama, Akihiro Shindo, Takuya Shimada, Kenichiro Yata, Hideaki Wakita, Ryosuke Takahashi, Hidekazu Tomimot. Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome. Brain research. vol 1736. 2021-08-02. PMID:32171704. |
these results suggest that chronic cerebral hypoperfusion induces upregulation of nlrp3 and aim2 inflammasomes; therefore, inflammasomes may play an important role in the sterile inflammatory response in astrocytes and microglia during chronic cerebral hypoperfusion. |
2021-08-02 |
2023-08-13 |
mouse |
| Hua Bai, Qifang Zhan. Role of N4-acetylcytidine for continuously activating NLRP3 inflammosome by HMGB1 pathway in microglia. Neural regeneration research. vol 16. issue 7. 2021-07-28. PMID:33318439. |
role of n4-acetylcytidine for continuously activating nlrp3 inflammosome by hmgb1 pathway in microglia. |
2021-07-28 |
2023-08-13 |
Not clear |
| H Huang, Y Gao, K Nie, L Wan. [Macrophage migration inhibitory factor meditates MPP+/MPTP-induced NLRP3 inflammasome activation in microglia cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 41. issue 7. 2021-07-27. PMID:34308845. |
[macrophage migration inhibitory factor meditates mpp+/mptp-induced nlrp3 inflammasome activation in microglia cells]. |
2021-07-27 |
2023-08-13 |
Not clear |
| Dai-Chao Ma, Nan-Nan Zhang, Yi-Na Zhang, Hui-Sheng Che. Salvianolic Acids for Injection alleviates cerebral ischemia/reperfusion injury by switching M1/M2 phenotypes and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia in vivo and in vitro. Journal of ethnopharmacology. vol 270. 2021-07-26. PMID:33421597. |
salvianolic acids for injection alleviates cerebral ischemia/reperfusion injury by switching m1/m2 phenotypes and inhibiting nlrp3 inflammasome/pyroptosis axis in microglia in vivo and in vitro. |
2021-07-26 |
2023-08-13 |
Not clear |
| Dai-Chao Ma, Nan-Nan Zhang, Yi-Na Zhang, Hui-Sheng Che. Salvianolic Acids for Injection alleviates cerebral ischemia/reperfusion injury by switching M1/M2 phenotypes and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia in vivo and in vitro. Journal of ethnopharmacology. vol 270. 2021-07-26. PMID:33421597. |
after cerebral ischemia/reperfusion injury, pro-inflammatory m1 and anti-inflammatory m2 phenotypes of microglia are involved in neuroinflammation, in which activation of nlrp3 inflammasome and subsequent pyroptosis play essential roles. |
2021-07-26 |
2023-08-13 |
Not clear |
| William S Dodd, Imaray Noda, Melanie Martinez, Koji Hosaka, Brian L Ho. NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage. Journal of neuroinflammation. vol 18. issue 1. 2021-07-24. PMID:34284798. |
nlrp3 activation is known to drive il-1β production and stimulate microglia reactivity, both hallmarks of sah pathology; thus, we hypothesized that inhibition of nlrp3 could alleviate sah-induced vascular dysfunction and functional deficits. |
2021-07-24 |
2023-08-13 |
Not clear |
| Hongguang Ding, Ya Li, Miaoyun Wen, Xinqiang Liu, Yongli Han, Hongke Zen. Elevated intracranial pressure induces IL‑1β and IL‑18 overproduction via activation of the NLRP3 inflammasome in microglia of ischemic adult rats. International journal of molecular medicine. vol 47. issue 1. 2021-07-15. PMID:33236152. |
elevated intracranial pressure induces il‑1β and il‑18 overproduction via activation of the nlrp3 inflammasome in microglia of ischemic adult rats. |
2021-07-15 |
2023-08-13 |
rat |
| Hongguang Ding, Ya Li, Miaoyun Wen, Xinqiang Liu, Yongli Han, Hongke Zen. Elevated intracranial pressure induces IL‑1β and IL‑18 overproduction via activation of the NLRP3 inflammasome in microglia of ischemic adult rats. International journal of molecular medicine. vol 47. issue 1. 2021-07-15. PMID:33236152. |
the aim of the present study was to examine whether elevated icp may increase il‑1β and il‑18 secretion by activating the nod‑like receptor protein 3 (nlrp3) inflammasome in microglia of ischemic adult rats. |
2021-07-15 |
2023-08-13 |
rat |
| Hongguang Ding, Ya Li, Miaoyun Wen, Xinqiang Liu, Yongli Han, Hongke Zen. Elevated intracranial pressure induces IL‑1β and IL‑18 overproduction via activation of the NLRP3 inflammasome in microglia of ischemic adult rats. International journal of molecular medicine. vol 47. issue 1. 2021-07-15. PMID:33236152. |
these results suggested that elevated icp‑induced il‑1β and il‑18 overproduction via activation of the nlrp3 inflammasome by ischemia‑activated microglia may augment neuroinflammation. |
2021-07-15 |
2023-08-13 |
rat |
| Xiangliang Zeng, Yanchun Li, Sicong Ma, Yidan Tang, Hanwen L. Phoenixin-20 Ameliorates Lipopolysaccharide-Induced Activation of Microglial NLRP3 Inflammasome. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32651843. |
this study investigated whether pnx-20 possesses a protective effect against lipopolysaccharide (lps)-induced activation of the nlrp3 inflammasome in microglia. |
2021-07-09 |
2023-08-13 |
Not clear |
| Zhen Xie, Hao Hui, Qian Yao, Yan Duan, Wu Li, Ye Cheng, Meng Zhang, Ye Tian, Gang Zha. By Regulating the NLRP3 Inflammasome Can Reduce the Release of Inflammatory Factors in the Co-Culture Model of Tuberculosis H37Ra Strain and Rat Microglia. Frontiers in cellular and infection microbiology. vol 11. 2021-07-05. PMID:33928044. |
by regulating the nlrp3 inflammasome can reduce the release of inflammatory factors in the co-culture model of tuberculosis h37ra strain and rat microglia. |
2021-07-05 |
2023-08-13 |
rat |
| Zhen Xie, Hao Hui, Qian Yao, Yan Duan, Wu Li, Ye Cheng, Meng Zhang, Ye Tian, Gang Zha. By Regulating the NLRP3 Inflammasome Can Reduce the Release of Inflammatory Factors in the Co-Culture Model of Tuberculosis H37Ra Strain and Rat Microglia. Frontiers in cellular and infection microbiology. vol 11. 2021-07-05. PMID:33928044. |
tuberculosis infection of the central nervous system can cause severe inflammation in microglia, and nlrp3 inflammasome is also an important source of inflammation in microglia. |
2021-07-05 |
2023-08-13 |
rat |
| Zhen Xie, Hao Hui, Qian Yao, Yan Duan, Wu Li, Ye Cheng, Meng Zhang, Ye Tian, Gang Zha. By Regulating the NLRP3 Inflammasome Can Reduce the Release of Inflammatory Factors in the Co-Culture Model of Tuberculosis H37Ra Strain and Rat Microglia. Frontiers in cellular and infection microbiology. vol 11. 2021-07-05. PMID:33928044. |
therefore, in this study, we used a co-culture model of rat microglia and tuberculosis h37ra strain to explore the influence of tuberculosis infection on the nlrp3 inflammasome in microglia and its regulation mechanism. |
2021-07-05 |
2023-08-13 |
rat |
| Leelavathi N Madhu, Maheedhar Kodali, Sahithi Attaluri, Bing Shuai, Laila Melissari, Xiaolan Rao, Ashok K Shett. Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox biology. vol 43. 2021-07-05. PMID:33933884. |
behavioral tests revealed cognitive and mood dysfunction in gwi rats receiving vehicle, which were associated with elevated oxidative stress, reduced nrf2, catalase and mitochondrial complex proteins, astrocyte hypertrophy, activated microglia with nlrp3 inflammasomes, elevated proinflammatory cytokines, waned neurogenesis, and synapse loss in the hippocampus. |
2021-07-05 |
2023-08-13 |
rat |