| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher Nebel, Alexander Aslanidis, Khalid Rashid, Thomas Langman. Activated microglia trigger inflammasome activation and lysosomal destabilization in human RPE cells. Biochemical and biophysical research communications. vol 484. issue 3. 2017-06-06. PMID:28159556. |
in this study, we investigated whether reactive microglia trigger and sustain nlrp3 inflammasome activation in human retinal pigment epithelium (arpe-19) cells. |
2017-06-06 |
2023-08-13 |
human |
| Ya-Min Liu, Ji-Duo Shen, Li-Ping Xu, Han-Bing Li, Yu-Cheng Li, Li-Tao Y. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. International immunopharmacology. vol 45. 2017-06-01. PMID:28213267. |
considering that depression is an inflammatory related mental disease, our present study was aimed to investigate the role of ferulic acid in the regulation of microglia activation, pro-inflammatory cytokines, nuclear factor kappa b (nf-κb) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome in mice exposed to chronic unpredictable mild stress (cums). |
2017-06-01 |
2023-08-13 |
mouse |
| Ya-Min Liu, Ji-Duo Shen, Li-Ping Xu, Han-Bing Li, Yu-Cheng Li, Li-Tao Y. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. International immunopharmacology. vol 45. 2017-06-01. PMID:28213267. |
then, we found that cums significantly caused interleukin-1β (il-1β), interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α) up-regulation, microglia, nf-κb signaling and nlrp3 inflammasome activation in the prefrontal cortex. |
2017-06-01 |
2023-08-13 |
mouse |
| Leoni Lammerding, Alexander Slowik, Sonja Johann, Cordian Beyer, Adib Zendede. Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain. Neuroendocrinology. vol 103. issue 5. 2017-05-16. PMID:26337121. |
within the limits of antibody availability, immunofluorescence labeling demonstrated that microglia and neurons are major sources of the locally activated inflammasomes nod-like receptor protein-3 (nlrp3) and associated speck-like protein (asc), respectively. |
2017-05-16 |
2023-08-13 |
rat |
| Philippe Leff-Gelman, Ismael Mancilla-Herrera, Mónica Flores-Ramos, Carlos Cruz-Fuentes, Juan Pablo Reyes-Grajeda, María Del Pilar García-Cuétara, Marielle Danitza Bugnot-Pérez, David Ellioth Pulido-Ascenci. The Immune System and the Role of Inflammation in Perinatal Depression. Neuroscience bulletin. vol 32. issue 4. 2017-02-24. PMID:27432060. |
thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during pregnancy, proposing that the same stress-related mechanisms involved in the activation of the nlrp3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. |
2017-02-24 |
2023-08-13 |
Not clear |
| Yang Cai, Hong Kong, Yin-Bing Pan, Lai Jiang, Xiu-Xiu Pan, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Li. Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia. Journal of neuroinflammation. vol 13. issue 1. 2017-02-14. PMID:26931361. |
procyanidins alleviates morphine tolerance by inhibiting activation of nlrp3 inflammasome in microglia. |
2017-02-14 |
2023-08-13 |
Not clear |
| Yang Cai, Hong Kong, Yin-Bing Pan, Lai Jiang, Xiu-Xiu Pan, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Li. Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia. Journal of neuroinflammation. vol 13. issue 1. 2017-02-14. PMID:26931361. |
our present study investigated the effects and possible mechanism of a natural product procyanidins in improving morphine tolerance via its specific inhibition on nod-like receptor protein3 (nlrp3) inflammasome in microglia. |
2017-02-14 |
2023-08-13 |
Not clear |
| Ji-Yun Kim, James C Paton, David E Briles, Dong-Kwon Rhee, Suhkneung Py. Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia. Oncotarget. vol 6. issue 42. 2016-11-07. PMID:26683708. |
thus, the present data demonstrate that s. pneumoniae induces pyroptosis in murine microglia and that nlrp3 inflammasome is critical for caspase-1 activation during the process. |
2016-11-07 |
2023-08-13 |
mouse |
| Yanran Liang, Xiuna Jing, Zhifen Zeng, Wei Bi, Ying Chen, Xia Wu, Lianhong Yang, Jun Liu, Songhua Xiao, Shuqiong Liu, Danyu Lin, Enxiang Ta. Rifampicin attenuates rotenone-induced inflammation via suppressing NLRP3 inflammasome activation in microglia. Brain research. vol 1622. 2016-06-02. PMID:26086368. |
rifampicin attenuates rotenone-induced inflammation via suppressing nlrp3 inflammasome activation in microglia. |
2016-06-02 |
2023-08-13 |
Not clear |
| Audrey Gustin, Mélanie Kirchmeyer, Eric Koncina, Paul Felten, Sophie Losciuto, Tony Heurtaux, Aubry Tardivel, Paul Heuschling, Catherine Doster. NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes. PloS one. vol 10. issue 6. 2016-05-10. PMID:26091541. |
nlrp3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes. |
2016-05-10 |
2023-08-13 |
mouse |
| Audrey Gustin, Mélanie Kirchmeyer, Eric Koncina, Paul Felten, Sophie Losciuto, Tony Heurtaux, Aubry Tardivel, Paul Heuschling, Catherine Doster. NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes. PloS one. vol 10. issue 6. 2016-05-10. PMID:26091541. |
amyloid-β peptides were able to activate the nlrp3 inflammasome in microglia and il-1β secretion occurred in a p2x7 receptor-independent manner. |
2016-05-10 |
2023-08-13 |
mouse |
| Matthew G Frank, Michael D Weber, Linda R Watkins, Steven F Maie. Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming. Brain, behavior, and immunity. vol 48. 2016-04-13. PMID:25816800. |
a model of neuroinflammatory priming is developed wherein glucocorticoids induce synthesis and release of hmgb1 from microglia, which signals through tlr2/tlr4, thereby priming the nlrp3 inflammasome. |
2016-04-13 |
2023-08-13 |
Not clear |
| Weihua Zhao, David R Beers, Shaughn Bell, Jinghong Wang, Shixiang Wen, Robert H Baloh, Stanley H Appe. TDP-43 activates microglia through NF-κB and NLRP3 inflammasome. Experimental neurology. vol 273. 2016-02-18. PMID:26222336. |
tdp-43 activates microglia through nf-κb and nlrp3 inflammasome. |
2016-02-18 |
2023-08-13 |
Not clear |
| Xu Liu, Wenlin Hao, Yiren Qin, Yann Decker, Xuan Wang, Martin Burkart, Karl Schötz, Michael D Menger, Klaus Fassbender, Yang Li. Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer's disease. Brain, behavior, and immunity. vol 46. 2016-02-04. PMID:25637484. |
treatment with egb 761 also reduced the concentrations of nlrp3 protein that colocalized with lc3-positive autophagosomes or autolysosomes in microglia. |
2016-02-04 |
2023-08-13 |
mouse |
| Ying Pan, Xu-Yang Chen, Qing-Yu Zhang, Ling-Dong Kon. Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24859041. |
the increased co-location of nlrp3 and ionized calcium binding adaptor molecule 1 (iba1) protein expression supported that microglia in glial cells was the primary contributor for cums-induced pfc nlrp3 inflammasome activation in rats. |
2015-06-09 |
2023-08-13 |
rat |
| Mi-Hyang Cho, Kwangmin Cho, Hoe-Jin Kang, Eun-Young Jeon, Hun-Sik Kim, Hyung-Joon Kwon, Hong-Mi Kim, Dong-Hou Kim, Seung-Yong Yoo. Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy. vol 10. issue 10. 2015-05-19. PMID:25126727. |
autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the nlrp3 inflammasome. |
2015-05-19 |
2023-08-13 |
mouse |
| Mi-Hyang Cho, Kwangmin Cho, Hoe-Jin Kang, Eun-Young Jeon, Hun-Sik Kim, Hyung-Joon Kwon, Hong-Mi Kim, Dong-Hou Kim, Seung-Yong Yoo. Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy. vol 10. issue 10. 2015-05-19. PMID:25126727. |
here we demonstrate a novel role for autophagy in the clearance of extracellular aβ fibrils by microglia and in the regulation of the aβ-induced nlrp3 (nlr family, pyrin domain containing 3) inflammasome using microglia specific atg7 knockout mice and cell cultures. |
2015-05-19 |
2023-08-13 |
mouse |
| Michael D Weber, Matthew G Frank, Kevin J Tracey, Linda R Watkins, Steven F Maie. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568124. |
stress induces the danger-associated molecular pattern hmgb-1 in the hippocampus of male sprague dawley rats: a priming stimulus of microglia and the nlrp3 inflammasome. |
2015-03-20 |
2023-08-13 |
rat |
| Michael D Weber, Matthew G Frank, Kevin J Tracey, Linda R Watkins, Steven F Maie. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568124. |
exposure to 100 inescapable tail shocks (iss) increased hmgb-1 and nlrp3 protein in the hippocampus and led isolated microglia to release hmgb-1 ex vivo. |
2015-03-20 |
2023-08-13 |
rat |
| Michael D Weber, Matthew G Frank, Kevin J Tracey, Linda R Watkins, Steven F Maie. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568124. |
previous is potentiated gene expression of nlrp3 and proinflammatory cytokines to lps, that is, microglia were sensitized. |
2015-03-20 |
2023-08-13 |
rat |