| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Yii Huang, Chia-En Tu, Shu-Chi Wang, Yung-Li Hung, Chia-Cheng Su, Shih-Hua Fang, Chi-Shuo Chen, Po-Len Liu, Wei-Chung Cheng, Yu-Wei Huang, Chia-Yang L. Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia. BMC complementary and alternative medicine. vol 18. issue 1. 2018-10-01. PMID:30107806. |
corylin inhibits lps-induced inflammatory response and attenuates the activation of nlrp3 inflammasome in microglia. |
2018-10-01 |
2023-08-13 |
Not clear |
| Hua Bai, Bo Yang, Wenfeng Yu, Yan Xiao, Dejun Yu, Qifang Zhan. Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome. Experimental cell research. vol 362. issue 1. 2018-09-07. PMID:29196167. |
oxidative stress-mediated activation of nlrp3 inflammasome in microglia is critical in the development of neurodegerative diseases such as alzheimer's disease (ad), parkinson disease (pd). |
2018-09-07 |
2023-08-13 |
Not clear |
| C Dempsey, A Rubio Araiz, K J Bryson, O Finucane, C Larkin, E L Mills, A A B Robertson, M A Cooper, L A J O'Neill, M A Lync. Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain, behavior, and immunity. vol 61. 2018-08-10. PMID:28003153. |
here, we examined the effect of the small molecule inhibitor of the nlrp3 inflammasome, mcc950, on microglia in vitro and in vivo. |
2018-08-10 |
2023-08-13 |
mouse |
| Zheng Fan, Zhigang Liang, Hui Yang, Yuting Pan, Yan Zheng, Xiaomin Wan. Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia. Journal of neuroinflammation. vol 14. issue 1. 2018-07-27. PMID:29262843. |
tenuigenin protects dopaminergic neurons from inflammation via suppressing nlrp3 inflammasome activation in microglia. |
2018-07-27 |
2023-08-13 |
Not clear |
| Roya Aryanpour, Parichehr Pasbakhsh, Kazem Zibara, Zeinab Namjoo, Fatemeh Beigi Boroujeni, Saeed Shahbeigi, Iraj Ragerdi Kashani, Cordian Beyer, Adib Zendehde. Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model. International immunopharmacology. vol 51. 2018-05-10. PMID:28830026. |
progesterone therapy induces an m1 to m2 switch in microglia phenotype and suppresses nlrp3 inflammasome in a cuprizone-induced demyelination mouse model. |
2018-05-10 |
2023-08-13 |
mouse |
| M E Brocca, L Pietranera, M Meyer, A Lima, P Roig, E R de Kloet, A F De Nicol. Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats. Journal of neuroendocrinology. vol 29. issue 7. 2018-04-23. PMID:28523794. |
we also measured serum-glucocorticoid-activated kinase 1 (sgk1 mrna), the number and phenotype of iba1+ microglia, as well as mrna expression levels of the pro-inflammatory factors cyclo-oxygenase 2 (cox2), nlrp3 inflammasome and tumour necrosis factor α (tnfα). |
2018-04-23 |
2023-08-13 |
rat |
| Diya Wang, Jianbin Zhang, Wenkai Jiang, Zipeng Cao, Fang Zhao, Tongjian Cai, Michael Aschner, Wenjing Lu. The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability. Autophagy. vol 13. issue 5. 2018-03-29. PMID:28318352. |
nlrp3 (nlr family, pyrin domain containing 3)- casp1 (caspase 1) inflammasome-mediated neuroinflammation in microglia has specific relevance to neurological diseases. |
2018-03-29 |
2023-08-13 |
mouse |
| Manmeet K Mamik, Elizabeth Hui, William G Branton, Brienne A McKenzie, Jesse Chisholm, Eric A Cohen, Christopher Powe. HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 12. issue 2. 2018-03-02. PMID:27726055. |
hiv-1 viral protein r activates nlrp3 inflammasome in microglia: implications for hiv-1 associated neuroinflammation. |
2018-03-02 |
2023-08-13 |
mouse |
| Matthew G Frank, Michael D Weber, Laura K Fonken, Sarah A Hershman, Linda R Watkins, Steven F Maie. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26482581. |
we found that ds-hmgb1 increased expression of nf-κbiα mrna and nlrp3 mrna in isolated microglia, and potentiated the microglial pro-inflammatory response (tnfα mrna, il-1β mrna and il-1β protein) to lps. |
2017-12-29 |
2023-08-13 |
Not clear |
| Hong-Mei Wang, Ting Zhang, Jian-Kang Huang, Jing-Yan Xiang, Jing-Jiong Chen, Jian-Liang Fu, Yu-Wu Zha. Edaravone Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 43. issue 3. 2017-12-26. PMID:28977782. |
edaravone attenuates the proinflammatory response in amyloid-β-treated microglia by inhibiting nlrp3 inflammasome-mediated il-1β secretion. |
2017-12-26 |
2023-08-13 |
mouse |
| Adib Zendedel, Sonja Johann, Soraya Mehrabi, Mohammad-Taghi Joghataei, Gholamreza Hassanzadeh, Markus Kipp, Cordian Beye. Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25972240. |
immunofluorescence double-labeling demonstrated that microglia and neurons are major sources of the asc and nlrp3 respectivley. |
2017-12-25 |
2023-08-13 |
rat |
| Hannah Scheiblich, Anna Schlütter, Douglas T Golenbock, Eicke Latz, Pilar Martinez-Martinez, Michael T Henek. Activation of the NLRP3 inflammasome in microglia: the role of ceramide. Journal of neurochemistry. vol 143. issue 5. 2017-12-07. PMID:28940479. |
activation of the nlrp3 inflammasome in microglia: the role of ceramide. |
2017-12-07 |
2023-08-13 |
Not clear |
| Hannah Scheiblich, Anna Schlütter, Douglas T Golenbock, Eicke Latz, Pilar Martinez-Martinez, Michael T Henek. Activation of the NLRP3 inflammasome in microglia: the role of ceramide. Journal of neurochemistry. vol 143. issue 5. 2017-12-07. PMID:28940479. |
growing evidence suggests that ceramide plays a critical role in nlrp3 inflammasome assembly, however, the relationship between ceramide and inflammasome activation in microglia remains unknown. |
2017-12-07 |
2023-08-13 |
Not clear |
| Ana S Falcão, Luís A R Carvalho, Gonçalo Lidónio, Ana R Vaz, Susana D Lucas, Rui Moreira, Dora Brite. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. ACS chemical neuroscience. vol 8. issue 1. 2017-10-30. PMID:27797173. |
vs also suppressed aβ-induced expression of inflammatory mediators in microglia, such as matrix metalloproteinase (mmp)-2 and mmp-9, as well as high-mobility group box protein-1 (hmgb1), nod-like receptor protein 3 (nlrp3)-inflammasome, and interleukin (il)-1β. |
2017-10-30 |
2023-08-13 |
mouse |
| Leslie Freeman, Haitao Guo, Clément N David, W June Brickey, Sushmita Jha, Jenny P-Y Tin. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. The Journal of experimental medicine. vol 214. issue 5. 2017-09-12. PMID:28404595. |
nlr members nlrc4 and nlrp3 mediate sterile inflammasome activation in microglia and astrocytes. |
2017-09-12 |
2023-08-13 |
Not clear |
| Leslie Freeman, Haitao Guo, Clément N David, W June Brickey, Sushmita Jha, Jenny P-Y Tin. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. The Journal of experimental medicine. vol 214. issue 5. 2017-09-12. PMID:28404595. |
in this study, we reveal that lysophosphatidylcholine (lpc), a molecule associated with neurodegeneration and demyelination, elicits nlrp3 and nlrc4 inflammasome activation in microglia and astrocytes, which are central players in neuroinflammation. |
2017-09-12 |
2023-08-13 |
Not clear |
| Holger Scholz, Claudia Ede. Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes. Journal of neuroimmunology. vol 310. 2017-08-22. PMID:28778433. |
lpc-induced caspase-1 activation in microglia was found to depend on lps prestimulation, inflammasome nlrp3 and adaptor molecule asc. |
2017-08-22 |
2023-08-13 |
Not clear |
| Ernest T Chivero, Ming-Lei Guo, Palsamy Periyasamy, Ke Liao, Shannon E Callen, Shilpa Buc. HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 13. 2017-08-18. PMID:28270571. |
we found a dose- and time-dependent induction of nlrp3 expression in microglia exposed to tat compared with control. |
2017-08-18 |
2023-08-13 |
Not clear |
| Sheng-Tao Yao, Fang Cao, Jia-Lin Chen, Wei Chen, Rui-Ming Fan, Gang Li, You-Chao Zeng, Song Jiao, Xiang-Ping Xia, Chong Han, Qi-Shan Ra. NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH. Journal of molecular neuroscience : MN. vol 61. issue 3. 2017-06-29. PMID:27933491. |
the nlrp3 inflammasome was activated after ich and was located in the microglial cell of the mouse brain, which exhibits a time-dependent manner. |
2017-06-29 |
2023-08-13 |
mouse |
| Xinchun Ye, Dandan Zuo, Lu Yu, Liang Zhang, Jiao Tang, Chengcheng Cui, Lei Bao, Kun Zan, Zuohui Zhang, Xinxin Yang, Hao Chen, Hai Tang, Jie Zu, Hongjuan Shi, Guiyun Cu. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochemical and biophysical research communications. vol 485. issue 2. 2017-06-13. PMID:28202418. |
ros/txnip pathway contributes to thrombin induced nlrp3 inflammasome activation and cell apoptosis in microglia. |
2017-06-13 |
2023-08-13 |
human |