| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Burak I Arioz, Bora Tastan, Emre Tarakcioglu, Kemal Ugur Tufekci, Melis Olcum, Nevin Ersoy, Alper Bagriyanik, Kursad Genc, Sermin Gen. Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway. Frontiers in immunology. vol 10. 2020-07-15. PMID:31327964. |
we assessed the effects of melatonin on behavioral changes and inflammatory cytokine expression in hippocampus of mice in lps-induced dlb, as well as its effects on nlr family pyrin domain containing 3 (nlrp3) inflammasome activation, oxidative stress and pyroptotic cell death in murine microglia |
2020-07-15 |
2023-08-13 |
mouse |
| Cai Zong, Rieka Hasegawa, Makoto Urushitani, Lingyi Zhang, Daichi Nagashima, Toshihiro Sakurai, Sahoko Ichihara, Seiichiroh Ohsako, Gaku Ichihar. Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro. Archives of toxicology. vol 93. issue 7. 2020-07-01. PMID:31073625. |
furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the nlrp3 inflammasome pathway, as evident by increased expression of nlrp3, caspase 1, and asc in the rat cerebral cortex, and by the inhibitory effects of nlrp3 inflammasome inhibitor on the acrylamide-induced upregulation of nlrp3, caspase 1, il-1β, and il-18 in bv-2 microglia. |
2020-07-01 |
2023-08-13 |
rat |
| Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Leonardo Bonilha, Gayenell S Magwood, Daniel Lackland, Robert J Adams, Mark S Kind. Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 47. 2020-07-01. PMID:31611307. |
inhibition or ko of the nlrp3 in microglia prevented the increase in il-1β. |
2020-07-01 |
2023-08-13 |
mouse |
| Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K Adlakha, Anirban Bas. Correction to: HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway. Journal of neuroinflammation. vol 15. issue 1. 2020-05-11. PMID:30442172. |
correction to: hsp60 critically regulates endogenous il-1β production in activated microglia by stimulating nlrp3 inflammasome pathway. |
2020-05-11 |
2023-08-13 |
Not clear |
| Aline L Pacheco, Gabriella Vicentini, Kely C Matteucci, Rafaela Rosa Ribeiro, Ricardo Weinlich, Karina R Bortoluc. The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication. Journal of leukocyte biology. vol 106. issue 1. 2020-05-11. PMID:30997938. |
in this article, we described an effector response mediated by nlrp3 that works on microglia but not on astrocytes to control t. cruzi infection. |
2020-05-11 |
2023-08-13 |
Not clear |
| Aline L Pacheco, Gabriella Vicentini, Kely C Matteucci, Rafaela Rosa Ribeiro, Ricardo Weinlich, Karina R Bortoluc. The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication. Journal of leukocyte biology. vol 106. issue 1. 2020-05-11. PMID:30997938. |
moreover, the absence of nlrp3 renders microglia but not astrocytes more permissive to t. cruzi replication. |
2020-05-11 |
2023-08-13 |
Not clear |
| Aline L Pacheco, Gabriella Vicentini, Kely C Matteucci, Rafaela Rosa Ribeiro, Ricardo Weinlich, Karina R Bortoluc. The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication. Journal of leukocyte biology. vol 106. issue 1. 2020-05-11. PMID:30997938. |
importantly, the pharmacological inhibition of inos with aminoguanidine resulted in a significant increase in the numbers of amastigotes found in microglia from wild-type but not from nlrp3 |
2020-05-11 |
2023-08-13 |
Not clear |
| Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purve. Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. American journal of physiology. Renal physiology. vol 318. issue 2. 2020-05-11. PMID:31869244. |
moreover, the mechanism of neuroinflammation elicited by other peripheral diseases involves the nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome, which is present in microglia in the brain and cleaves and activates proinflammatory cytokines such as il-1β. |
2020-05-11 |
2023-08-13 |
rat |
| Agnese Taticchi, Stefania Urbani, Elisabetta Albi, Maurizio Servili, Michela Codini, Giovanna Traina, Stefania Balloni, Federica Filomena Patria, Luana Perioli, Tommaso Beccari, Carmela Cont. In Vitro Anti-Inflammatory Effects of Phenolic Compounds from Moraiolo Virgin Olive Oil (MVOO) in Brain Cells via Regulating the TLR4/NLRP3 Axis. Molecules (Basel, Switzerland). vol 24. issue 24. 2020-05-01. PMID:31835609. |
the results showed that low concentration of mvoo-pe prevented microglia cell death and attenuated the lps-induced activation of toll-like receptor 4 (tlr4)/nod-like receptor pyrin domain-containing-3 (nlrp3) signaling cascade. |
2020-05-01 |
2023-08-13 |
Not clear |
| Hua Kong, Li Yang, Can He, Jing-Wei Zhou, Wei-Zu Li, Wen-Ning Wu, Han-Qing Chen, Yan-Yan Yi. Chronic unpredictable mild stress accelerates lipopolysaccharide- induced microglia activation and damage of dopaminergic neurons in rats. Pharmacology, biochemistry, and behavior. vol 179. 2020-04-20. PMID:30658122. |
in this study, in vivo experiments are used to evaluate the effects of cums on lipopolysaccharide (lps)-induced microglia activation and nlrp3 inflammasome activation. |
2020-04-20 |
2023-08-13 |
rat |
| Hua Kong, Li Yang, Can He, Jing-Wei Zhou, Wei-Zu Li, Wen-Ning Wu, Han-Qing Chen, Yan-Yan Yi. Chronic unpredictable mild stress accelerates lipopolysaccharide- induced microglia activation and damage of dopaminergic neurons in rats. Pharmacology, biochemistry, and behavior. vol 179. 2020-04-20. PMID:30658122. |
our data showed that pretreatment with cums for 14 days increased the microglia activation and the da neurons damage, and the mechanisms may be associated with the acceleration of the inflammatory response and activation of nlrp3 inflammasome. |
2020-04-20 |
2023-08-13 |
rat |
| Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam, Huajun Jin, Hariharan Saminathan, Monica Langley, Adhithiya Charli, Manikandan Samidurai, Dharmin Rokad, Shivani Ghaisas, Olga Pletnikova, Valina L Dawson, Ted M Dawson, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasam. Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of experimental medicine. vol 216. issue 6. 2020-04-14. PMID:31036561. |
fyn kinase regulates misfolded α-synuclein uptake and nlrp3 inflammasome activation in microglia. |
2020-04-14 |
2023-08-13 |
mouse |
| Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
mptp-driven nlrp3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. |
2020-04-07 |
2023-08-13 |
mouse |
| Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
in primary microglia and mixed glial cell cultures, mptp/atp treatment promotes the robust assembly and activation of the nlrp3 inflammasome via producing mitochondrial reactive oxygen species. |
2020-04-07 |
2023-08-13 |
mouse |
| Xiaoling Zhang, Wenmin Huang, Qianhang Shao, Yuan Yang, Zhengxin Xu, Jing Chen, Xiaoyan Zhang, Xiaoqun G. Drp1, a potential therapeutic target for Parkinson's disease, is involved in olfactory bulb pathological alteration in the Rotenone-induced rat model. Toxicology letters. vol 325. 2020-03-30. PMID:32088201. |
additionally, increased nf-κb nuclear translocation and nlrp3 inflammasome components expressions caused by rotenone injection were observed accompanied by the activation of microglia and astrocytes in the olfactory bulb. |
2020-03-30 |
2023-08-13 |
rat |
| Zhenyi Xue, Zimu Zhang, Hongkun Liu, Wen Li, Xiangdong Guo, Zhihui Zhang, Ying Liu, Long Jia, Yan Li, Yinghui Ren, Hongwei Yang, Lijuan Zhang, Qi Zhang, Yurong Da, Junwei Hao, Zhi Yao, Rongxin Zhan. lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. Cell death and differentiation. vol 26. issue 1. 2020-03-11. PMID:29666475. |
elucidation of the link between lincrna-cox2 and the inflammasome-autophagy crosstalk in macrophage and microglia reveals a role for lncrnas in activation of nlrp3 inflammasome and autophagy, and provides new opportunities for therapeutic intervention in neuroinflammation-dependent diseases. |
2020-03-11 |
2023-08-13 |
Not clear |
| Ravikanth Velagapudi, Ayokulehin M Kosoko, Olumayokun A Olajid. Induction of Neuroinflammation and Neurotoxicity by Synthetic Hemozoin. Cellular and molecular neurobiology. vol 39. issue 8. 2020-01-20. PMID:31332667. |
treatment of bv-2 microglia with shz increased protein levels of nlrp3 with accompanying increase in caspase-1 activity. |
2020-01-20 |
2023-08-13 |
Not clear |
| Yujie Luo, Cesar Reis, Sheng Che. NLRP3 Inflammasome in the Pathophysiology of Hemorrhagic Stroke: A Review. Current neuropharmacology. vol 17. issue 7. 2020-01-06. PMID:30592254. |
the nod-like receptor family, pyrin domain containing 3 (nlrp3) inflammasome is predominantly released by microglia and is believed as the main contributor of neuroinflammation. |
2020-01-06 |
2023-08-13 |
Not clear |
| Judith Houtman, Kiara Freitag, Niclas Gimber, Jan Schmoranzer, Frank L Heppner, Marina Jendrac. Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3. The EMBO journal. vol 38. issue 4. 2020-01-06. PMID:30617086. |
beclin1-driven autophagy modulates the inflammatory response of microglia via nlrp3. |
2020-01-06 |
2023-08-13 |
Not clear |
| Deidiane Elisa Ribeiro, Aline Lulho Roncalho, Talita Glaser, Henning Ulrich, Gregers Wegener, Sâmia Joc. P2X7 Receptor Signaling in Stress and Depression. International journal of molecular sciences. vol 20. issue 11. 2019-11-19. PMID:31174279. |
moreover, p2x7r stimulation in microglia modulates the innate immune response by activating the nlr family pyrin domain containing 3 (nlrp3) inflammasome, consistent with the neuroimmune hypothesis of mdd. |
2019-11-19 |
2023-08-13 |
Not clear |