| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei He, Ting Long, Qi Pan, Shanshan Zhang, Yixin Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen, Jiying Zho. Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model. Journal of neuroinflammation. vol 16. issue 1. 2019-08-12. PMID:30971286. |
the nod-like receptor protein 3 (nlrp3) inflammasome may regulate the inflammatory process of microglia in several neurological diseases, but its role in cm is largely unknown. |
2019-08-12 |
2023-08-13 |
Not clear |
| Francis J Herman, Giulio Maria Pasinett. Principles of inflammasome priming and inhibition: Implications for psychiatric disorders. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:29902514. |
a recent focus on why primed microglia cells are susceptible to environmental insults has been the nlrp3 inflammasome. |
2019-07-31 |
2023-08-13 |
Not clear |
| Francis J Herman, Giulio Maria Pasinett. Principles of inflammasome priming and inhibition: Implications for psychiatric disorders. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:29902514. |
the activation of nlrp3 inflammasome in microglia results in the cleavage of zymogen inflammatory interleukins into functional forms that elicit a number of consequential effects in the local neuronal environment. |
2019-07-31 |
2023-08-13 |
Not clear |
| Lang Zhang, Rahul Previn, Liang Lu, Ri-Fang Liao, Yi Jin, Ri-Kang Wan. Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway. Brain research bulletin. vol 142. 2019-07-30. PMID:30179677. |
the effect was found to be due to inhibition of nlrp3 inflammasome and nf-κb and its promoted m1 to m2 phenotypic conversion of microglia. |
2019-07-30 |
2023-08-13 |
mouse |
| Pratima Rawat, Carmen Teodorof-Diedrich, Stephen A Specto. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. vol 67. issue 5. 2019-07-29. PMID:30582668. |
human immunodeficiency virus type-1 single-stranded rna activates the nlrp3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. |
2019-07-29 |
2023-08-13 |
human |
| Pratima Rawat, Carmen Teodorof-Diedrich, Stephen A Specto. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. vol 67. issue 5. 2019-07-29. PMID:30582668. |
our findings show that exposure of human primary microglia to ssrna40 activates the nlr family pyrin domain containing 3 (nlrp3) inflammasome. |
2019-07-29 |
2023-08-13 |
human |
| Pratima Rawat, Carmen Teodorof-Diedrich, Stephen A Specto. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. vol 67. issue 5. 2019-07-29. PMID:30582668. |
treatment with ssrna40 resulted in a blockade of autophagy/mitophagy mediated negative regulation of nlrp3 inflammasome activity with the release of inflammatory cytokines, caspase-1 activation, and pyroptotic microglial cell death. |
2019-07-29 |
2023-08-13 |
human |
| Fu-Qun Liu, Qi Gao, Dan-Dan Wang, Zhi-Xiong Zhan. [Effects of GBE50 on LPS/ATP induced NLRP3 inflammasome activation in primary rat microglia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 16. 2019-07-19. PMID:30200740. |
[effects of gbe50 on lps/atp induced nlrp3 inflammasome activation in primary rat microglia]. |
2019-07-19 |
2023-08-13 |
rat |
| Fu-Qun Liu, Qi Gao, Dan-Dan Wang, Zhi-Xiong Zhan. [Effects of GBE50 on LPS/ATP induced NLRP3 inflammasome activation in primary rat microglia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 16. 2019-07-19. PMID:30200740. |
in this study, the anti-inflammatory mechanism of ginkgo biloba extract 50 (gbe50) and its mechanism of action on nlrp3 inflammatory corpuscles were observed by primary microglia cells. |
2019-07-19 |
2023-08-13 |
rat |
| François Mouton-Liger, Thibault Rosazza, Julia Sepulveda-Diaz, Amélie Ieang, Sidi-Mohamed Hassoun, Emilie Claire, Graziella Mangone, Alexis Brice, Patrick P Michel, Jean-Christophe Corvol, Olga Cort. Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. Glia. vol 66. issue 8. 2019-07-18. PMID:29665074. |
we report here an exacerbation of nlrp3 inflammasome activation by specific inducers in microglia and bone marrow-derived macrophages from park2 |
2019-07-18 |
2023-08-13 |
Not clear |
| Bin Zheng, Shuncai Zhang, Yanlu Ying, Xinying Guo, Hengchang Li, Lixin Xu, Xiangcai Rua. Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats. Bioscience reports. vol 38. issue 5. 2019-05-17. PMID:30232232. |
administration of dexmedetomidine inhibited nlrp3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats. |
2019-05-17 |
2023-08-13 |
rat |
| Shuo Wang, Yu-He Yuan, Nai-Hong Chen, Hong-Bo Wan. The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease. International immunopharmacology. vol 67. 2019-05-09. PMID:30594776. |
the nucleotide-binding oligomerization domain-, leucine-rich repeat and pyrin domain-containing 3 (nlrp3) inflammasome is an inflammatory complex existing in microglia. |
2019-05-09 |
2023-08-13 |
Not clear |
| Anindya Bhattacharya, Declan N C Jone. Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders. Psychoneuroendocrinology. vol 98. 2019-05-08. PMID:30121550. |
within the brain tissue, microglia are the myeloid cells that express the p2x7 ion channel that is connected through the nlrp3 inflammasome complex leading to release of il-1β and il-18. |
2019-05-08 |
2023-08-13 |
Not clear |
| Wangying Dai, Xingguo Wang, Honglin Teng, Chi Li, Bin Wang, Jing Wan. Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats. International immunopharmacology. vol 66. 2019-05-03. PMID:30472522. |
celastrol simultaneously reduced the activation of microglia (especially m1 microglia) in the spinal cord, inhibited the pyroptosis-related proteins (nlrp3 asc caspase-1 gsdmd), reduced the release of tnf-α il-1β and il-18 inflammatory factors, and increased the release of il10 cytokines. |
2019-05-03 |
2023-08-13 |
rat |
| Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K Adlakha, Anirban Bas. HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway. Journal of neuroinflammation. vol 15. issue 1. 2019-04-10. PMID:29885667. |
hsp60 critically regulates endogenous il-1β production in activated microglia by stimulating nlrp3 inflammasome pathway. |
2019-04-10 |
2023-08-13 |
Not clear |
| Bingqing Cao, Tao Wang, Qiumin Qu, Tao Kang, Qian Yan. Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson's Disease via Regulating miR-7/NLRP3 Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30031125. |
downregulation of snhg1 elevated mir-7 expression, suppressed the activation of microglia and nlrp3 inflammasome as well as dopaminergic neuron loss in the midbrain substantia nigra pars compacta in mptp-treated mice. |
2019-03-29 |
2023-08-13 |
mouse |
| Xiuli Yang, Jing Sun, Tae Jung Kim, Young-Ju Kim, Sang-Bae Ko, Chi Kyung Kim, Xiaofeng Jia, Byung-Woo Yoo. Pretreatment with low-dose fimasartan ameliorates NLRP3 inflammasome-mediated neuroinflammation and brain injury after intracerebral hemorrhage. Experimental neurology. vol 310. 2019-03-21. PMID:30171865. |
the double immunofluorescence staining of brain cells showed a significant decrease in the co-localization of nlrp3 with iba1 (microglia marker) positive cells by fimasartan treatment. |
2019-03-21 |
2023-08-13 |
rat |
| Elaine Wan Ling Chan, Sangeetha Krishnansamy, Cindy Wong, Sook Yee Ga. The NLRP3 inflammasome is involved in the neuroprotective mechanism of neural stem cells against microglia-mediated toxicity in SH-SY5Y cells via the attenuation of tau hyperphosphorylation and amyloidogenesis. Neurotoxicology. vol 70. 2019-03-18. PMID:30408495. |
nscs regulate nlrp3 activation and il-1β secretion, which are critical in the initiation of the inflammatory responses, hence preventing the release of neurotoxic pro-inflammatory factors by microglia. |
2019-03-18 |
2023-08-13 |
Not clear |
| Xiang Li, Tianyi Wang, Dongping Zhang, Haiying Li, Haitao Shen, Xin Ding, Gang Che. Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction. Neuropharmacology. vol 141. 2019-02-13. PMID:30218674. |
meanwhile, andro decreased the levels of il-1β and ldh, as well as microglia pyroptosis induced by ich by suppressing the assembly of the nucleotide-binding oligomerization domain like receptor protein 3 (nlrp3) inflammasome. |
2019-02-13 |
2023-08-13 |
Not clear |
| Xin-Xin Chen, Zhenhua Guo, Qianyue Jin, Songlin Qiao, Rui Li, Xuewu Li, Ruiguang Deng, Wen-Hai Feng, Gai-Ping Zhan. Porcine reproductive and respiratory syndrome virus induces interleukin-1β through MyD88/ERK/AP-1 and NLRP3 inflammasome in microglia. Veterinary microbiology. vol 227. 2019-01-31. PMID:30473357. |
porcine reproductive and respiratory syndrome virus induces interleukin-1β through myd88/erk/ap-1 and nlrp3 inflammasome in microglia. |
2019-01-31 |
2023-08-13 |
Not clear |