| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| César J Carranza-Aguilar, Araceli Hernández-Mendoza, Carlos Mejias-Aponte, Kenner C Rice, Marisela Morales, Claudia González-Espinosa, Silvia L Cru. Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors. Cellular and molecular neurobiology. 2020-09-14. PMID:32926257. |
the opioid receptor antagonist (-)-naloxone, but not the tlr4 receptor antagonist (+)-naloxone, prevented microglia activation and nlrp3 oligomerization. |
2020-09-14 |
2023-08-13 |
rat |
| Xiaobo Li, Yanshu Zhang, Bin Li, Hongbao Yang, Jian Cui, Xiaoyan Li, Xinwei Zhang, Hao Sun, Qingtao Meng, Shenshen Wu, Shuang Li, Jianbo Wang, Michael Aschner, Rui Che. Activation of NLRP3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice. Environment international. vol 136. 2020-09-10. PMID:31999974. |
activation of nlrp3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice. |
2020-09-10 |
2023-08-13 |
mouse |
| Veni Bharti, Hua Tan, Hong Zhou, Jun-Feng Wan. Txnip mediates glucocorticoid-activated NLRP3 inflammatory signaling in mouse microglia. Neurochemistry international. vol 131. 2020-09-03. PMID:31586460. |
txnip mediates glucocorticoid-activated nlrp3 inflammatory signaling in mouse microglia. |
2020-09-03 |
2023-08-13 |
mouse |
| Veni Bharti, Hua Tan, Hong Zhou, Jun-Feng Wan. Txnip mediates glucocorticoid-activated NLRP3 inflammatory signaling in mouse microglia. Neurochemistry international. vol 131. 2020-09-03. PMID:31586460. |
the purpose of this study is to investigate the effect of chronic stress hormone treatment on txnip and nlrp3 inflammasome signaling in cultured microglia cells. |
2020-09-03 |
2023-08-13 |
mouse |
| Jialing Peng, Hongxuan Wang, Zhe Gong, Xiangpen Li, Lei He, Qingyu Shen, Jingrui Pan, Ying Pen. Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity. Molecular immunology. vol 123. 2020-08-18. PMID:32438202. |
it raises questions how exactly nlrp3 inflammasom was activated in microglia and neuron and whether idebenone reverses the process in i/r. |
2020-08-18 |
2023-08-13 |
Not clear |
| Silvia L Cruz, Monserrat Armenta-Reséndiz, César J Carranza-Aguilar, Emilio J Galvá. Minocycline prevents neuronal hyperexcitability and neuroinflammation in medial prefrontal cortex, as well as memory impairment caused by repeated toluene inhalation in adolescent rats. Toxicology and applied pharmacology. vol 395. 2020-08-17. PMID:32234516. |
these effects are accompanied by significant decreased expression of astrocytes and activated microglia in the mpfc, reduced nlrp3 inflammasome activation and mrna expression levels of the pro-inflammatory cytokine interleukin 1β (il-1β), as well as increased mrna expression of the anti-inflammatory cytokine transforming growth factor β (tgf-β). |
2020-08-17 |
2023-08-13 |
rat |
| Xiaojuan Han, Sifan Sun, Yiming Sun, Qiqi Song, Jialei Zhu, Nanshan Song, Miaomiao Chen, Ting Sun, Meiling Xia, Jianhua Ding, Ming Lu, Honghong Yao, Gang H. Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease. Autophagy. vol 15. issue 11. 2020-08-05. PMID:30966861. |
mechanically, ka promoted macroautophagy/autophagy in microglia, leading to reduced nlrp3 protein expression, which in turn deactivated the nlrp3 inflammasome. |
2020-08-05 |
2023-08-13 |
mouse |
| Mariusz Z Ratajczak, Aaron Mack, Kamila Bujko, Alison Domingues, Daniel Pedziwiatr, Magda Kucia, Janina Ratajczak, Henning Ulrich, Jolanta Kucharska-Mazur, Jerzy Samochowie. ATP-Nlrp3 Inflammasome-Complement Cascade Axis in Sterile Brain Inflammation in Psychiatric Patients and its Impact on Stem Cell Trafficking. Stem cell reviews and reports. vol 15. issue 4. 2020-07-23. PMID:31020518. |
in this review we will present a concept that aberrant purinergic signaling and increases in extracellular level of adenosine triphosphate (atp) in the brain parenchyma may lead to activation of nlrp3 inflammasome in microglia cells and as a consequence microglia released danger associated molecular pattern (damp) proteins activate complement cascade (comc) in mannan binding lectin (mbl) - dependent manner. |
2020-07-23 |
2023-08-13 |
Not clear |
| Burak I Arioz, Bora Tastan, Emre Tarakcioglu, Kemal Ugur Tufekci, Melis Olcum, Nevin Ersoy, Alper Bagriyanik, Kursad Genc, Sermin Gen. Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway. Frontiers in immunology. vol 10. 2020-07-15. PMID:31327964. |
we assessed the effects of melatonin on behavioral changes and inflammatory cytokine expression in hippocampus of mice in lps-induced dlb, as well as its effects on nlr family pyrin domain containing 3 (nlrp3) inflammasome activation, oxidative stress and pyroptotic cell death in murine microglia |
2020-07-15 |
2023-08-13 |
mouse |
| Cai Zong, Rieka Hasegawa, Makoto Urushitani, Lingyi Zhang, Daichi Nagashima, Toshihiro Sakurai, Sahoko Ichihara, Seiichiroh Ohsako, Gaku Ichihar. Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro. Archives of toxicology. vol 93. issue 7. 2020-07-01. PMID:31073625. |
furthermore, acrylamide-induced upregulation of pro-inflammatory cytokines was mediated through the nlrp3 inflammasome pathway, as evident by increased expression of nlrp3, caspase 1, and asc in the rat cerebral cortex, and by the inhibitory effects of nlrp3 inflammasome inhibitor on the acrylamide-induced upregulation of nlrp3, caspase 1, il-1β, and il-18 in bv-2 microglia. |
2020-07-01 |
2023-08-13 |
rat |
| Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Leonardo Bonilha, Gayenell S Magwood, Daniel Lackland, Robert J Adams, Mark S Kind. Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 47. 2020-07-01. PMID:31611307. |
inhibition or ko of the nlrp3 in microglia prevented the increase in il-1β. |
2020-07-01 |
2023-08-13 |
mouse |
| Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K Adlakha, Anirban Bas. Correction to: HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway. Journal of neuroinflammation. vol 15. issue 1. 2020-05-11. PMID:30442172. |
correction to: hsp60 critically regulates endogenous il-1β production in activated microglia by stimulating nlrp3 inflammasome pathway. |
2020-05-11 |
2023-08-13 |
Not clear |
| Aline L Pacheco, Gabriella Vicentini, Kely C Matteucci, Rafaela Rosa Ribeiro, Ricardo Weinlich, Karina R Bortoluc. The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication. Journal of leukocyte biology. vol 106. issue 1. 2020-05-11. PMID:30997938. |
in this article, we described an effector response mediated by nlrp3 that works on microglia but not on astrocytes to control t. cruzi infection. |
2020-05-11 |
2023-08-13 |
Not clear |
| Aline L Pacheco, Gabriella Vicentini, Kely C Matteucci, Rafaela Rosa Ribeiro, Ricardo Weinlich, Karina R Bortoluc. The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication. Journal of leukocyte biology. vol 106. issue 1. 2020-05-11. PMID:30997938. |
moreover, the absence of nlrp3 renders microglia but not astrocytes more permissive to t. cruzi replication. |
2020-05-11 |
2023-08-13 |
Not clear |
| Aline L Pacheco, Gabriella Vicentini, Kely C Matteucci, Rafaela Rosa Ribeiro, Ricardo Weinlich, Karina R Bortoluc. The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication. Journal of leukocyte biology. vol 106. issue 1. 2020-05-11. PMID:30997938. |
importantly, the pharmacological inhibition of inos with aminoguanidine resulted in a significant increase in the numbers of amastigotes found in microglia from wild-type but not from nlrp3 |
2020-05-11 |
2023-08-13 |
Not clear |
| Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purve. Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. American journal of physiology. Renal physiology. vol 318. issue 2. 2020-05-11. PMID:31869244. |
moreover, the mechanism of neuroinflammation elicited by other peripheral diseases involves the nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasome, which is present in microglia in the brain and cleaves and activates proinflammatory cytokines such as il-1β. |
2020-05-11 |
2023-08-13 |
rat |
| Agnese Taticchi, Stefania Urbani, Elisabetta Albi, Maurizio Servili, Michela Codini, Giovanna Traina, Stefania Balloni, Federica Filomena Patria, Luana Perioli, Tommaso Beccari, Carmela Cont. In Vitro Anti-Inflammatory Effects of Phenolic Compounds from Moraiolo Virgin Olive Oil (MVOO) in Brain Cells via Regulating the TLR4/NLRP3 Axis. Molecules (Basel, Switzerland). vol 24. issue 24. 2020-05-01. PMID:31835609. |
the results showed that low concentration of mvoo-pe prevented microglia cell death and attenuated the lps-induced activation of toll-like receptor 4 (tlr4)/nod-like receptor pyrin domain-containing-3 (nlrp3) signaling cascade. |
2020-05-01 |
2023-08-13 |
Not clear |
| Hua Kong, Li Yang, Can He, Jing-Wei Zhou, Wei-Zu Li, Wen-Ning Wu, Han-Qing Chen, Yan-Yan Yi. Chronic unpredictable mild stress accelerates lipopolysaccharide- induced microglia activation and damage of dopaminergic neurons in rats. Pharmacology, biochemistry, and behavior. vol 179. 2020-04-20. PMID:30658122. |
in this study, in vivo experiments are used to evaluate the effects of cums on lipopolysaccharide (lps)-induced microglia activation and nlrp3 inflammasome activation. |
2020-04-20 |
2023-08-13 |
rat |
| Hua Kong, Li Yang, Can He, Jing-Wei Zhou, Wei-Zu Li, Wen-Ning Wu, Han-Qing Chen, Yan-Yan Yi. Chronic unpredictable mild stress accelerates lipopolysaccharide- induced microglia activation and damage of dopaminergic neurons in rats. Pharmacology, biochemistry, and behavior. vol 179. 2020-04-20. PMID:30658122. |
our data showed that pretreatment with cums for 14 days increased the microglia activation and the da neurons damage, and the mechanisms may be associated with the acceleration of the inflammatory response and activation of nlrp3 inflammasome. |
2020-04-20 |
2023-08-13 |
rat |
| Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam, Huajun Jin, Hariharan Saminathan, Monica Langley, Adhithiya Charli, Manikandan Samidurai, Dharmin Rokad, Shivani Ghaisas, Olga Pletnikova, Valina L Dawson, Ted M Dawson, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasam. Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of experimental medicine. vol 216. issue 6. 2020-04-14. PMID:31036561. |
fyn kinase regulates misfolded α-synuclein uptake and nlrp3 inflammasome activation in microglia. |
2020-04-14 |
2023-08-13 |
mouse |