| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melis Olcum, Bora Tastan, Cagla Kiser, Sermin Genc, Kursad Gen. Microglial NLRP3 inflammasome activation in multiple sclerosis. Advances in protein chemistry and structural biology. vol 119. 2021-01-01. PMID:31997770. |
in this review, we focus on microglial nlrp3 inflammasome activation in ms. first, we overview the basic knowledge about ms, microglia and the nlrp3 inflammasome. |
2021-01-01 |
2023-08-13 |
Not clear |
| Ya-Shuo Feng, Zi-Xuan Tan, Lin-Yu Wu, Fang Dong, Feng Zhan. The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease. Ageing research reviews. vol 64. 2020-12-30. PMID:33059089. |
the activation of the nlrp3 inflammasome causes the generation of caspase-1-mediated interleukin (il)-1β and il-18 in microglia cells, where neuroinflammation is involved in the development and progression of ad. |
2020-12-30 |
2023-08-13 |
Not clear |
| Bernát Nógrádi, Ádám Nyúl-Tóth, Mihály Kozma, Kinga Molnár, Roland Patai, László Siklós, Imola Wilhelm, István A Krizba. Upregulation of Nucleotide-Binding Oligomerization Domain-, LRR- and Pyrin Domain-Containing Protein 3 in Motoneurons Following Peripheral Nerve Injury in Mice. Frontiers in pharmacology. vol 11. 2020-12-18. PMID:33328988. |
although basal expression of nlrp3 was observed in microglia, astroglia and neurons as well, its upregulation and co-localization with apoptosis-associated speck-like protein containing a caspase activation and recruitment domain, suggesting inflammasome activation, was only detected in neurons. |
2020-12-18 |
2023-08-13 |
mouse |
| Yijun Cheng, Bin Chen, Wanqun Xie, Zhenghong Chen, Guoyuan Yang, Yu Cai, Hanbing Shang, Weiguo Zha. Ghrelin attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling pathway in mice. International immunopharmacology. vol 79. 2020-12-07. PMID:31926478. |
ghrelin inhibited the nlrp3 inflammasome activation and subsequently suppressed the neuroinflammatory response as evidenced by reduced microglia activation, neutrophil infiltration, and pro-inflammatory mediators release after ich. |
2020-12-07 |
2023-08-13 |
mouse |
| Yue Zhao, Chen-Ye Zeng, Xiao-Hong Li, Ting-Ting Yang, Xi Kuang, Jun-Rong D. Klotho overexpression improves amyloid-β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease. Aging cell. 2020-10-24. PMID:32964663. |
klotho treatment significantly inhibited nacht, lrr, and pyd domain-containing protein 3 (nlrp3) and the subsequent transformation of microglia to the m2 type that may enhance microglia-mediated aβ clearance. |
2020-10-24 |
2023-08-13 |
mouse |
| Kendra L Hanslik, Tyler K Ullan. The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease. Frontiers in neurology. vol 11. 2020-10-22. PMID:33071950. |
the role of microglia and the nlrp3 inflammasome in alzheimer's disease. |
2020-10-22 |
2023-08-13 |
Not clear |
| Kendra L Hanslik, Tyler K Ullan. The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease. Frontiers in neurology. vol 11. 2020-10-22. PMID:33071950. |
several recent reports indicate that the assembly of the multi-protein complex known as the nod, lrr, and pyrin-domain containing 3 (nlrp3) inflammasome by microglia results in apoptosis spec-like protein containing a card (asc) spec formation, which then nucleates new aβ plaques, thus amplifying aβ-associated pathology. |
2020-10-22 |
2023-08-13 |
Not clear |
| Paola Chiozzi, Alba Clara Sarti, Juana M Sanz, Anna Lisa Giuliani, Elena Adinolfi, Valentina Vultaggio-Poma, Simonetta Falzoni, Francesco Di Virgili. Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine. Scientific reports. vol 9. issue 1. 2020-10-19. PMID:31019207. |
in the present study, we used the n13 microglia cell line and mouse primary microglia from wt and p2rx7-deleted mice to test the effect of nimodipine on amyloid β (aβ)-dependent nlrp3 inflammasome expression and function, and on mitochondrial energy metabolism. |
2020-10-19 |
2023-08-13 |
mouse |
| Paola Chiozzi, Alba Clara Sarti, Juana M Sanz, Anna Lisa Giuliani, Elena Adinolfi, Valentina Vultaggio-Poma, Simonetta Falzoni, Francesco Di Virgili. Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine. Scientific reports. vol 9. issue 1. 2020-10-19. PMID:31019207. |
our data show that in microglia aβ causes p2x7r-dependent a) nfκb activation; b) nlrp3 inflammasome expression and function; c) mitochondria toxicity; and these changes are fully inhibited by nimodipine. |
2020-10-19 |
2023-08-13 |
mouse |
| Hu Li, Xueping Zhang, Mingfu Chen, Jianyan Chen, Tao Gao, Shanglong Ya. Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades. EXCLI journal. vol 17. 2020-10-01. PMID:29743866. |
nod-like receptor 3 (nlrp3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
human |
| Hu Li, Xueping Zhang, Mingfu Chen, Jianyan Chen, Tao Gao, Shanglong Ya. Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades. EXCLI journal. vol 17. 2020-10-01. PMID:29743866. |
the present study was aimed to investigate effect of dex on nlrp3 activity in activated microglia and reveal the underlying mechanisms. |
2020-10-01 |
2023-08-13 |
human |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
mitochondrial impairment in microglia amplifies nlrp3 inflammasome proinflammatory signaling in cell culture and animal models of parkinson's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
in the present study, we show that impaired mitochondrial function can augment the nlrp3 inflammasome-driven proinflammatory cascade in microglia. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
primary mouse microglia treated with the common inflammogen lps increased nlrp3 and pro-il-1β expression. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
interestingly, exposure of lps-primed microglial cells to the mitochondrial complex-i inhibitory pesticides rotenone and tebufenpyrad specifically potentiated the nlrp3 induction, asc speck formation and pro-il-1β processing to il-1β in a dose-dependent manner, indicating that mitochondrial impairment heightened the nlrp3 inflammasome-mediated proinflammatory response in microglia. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
the neurotoxic pesticide-induced nlrp3 inflammasome activation was accompanied by bioenergetic defects and lysosomal dysfunction in microglia. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
furthermore, the pesticides enhanced mitochondrial ros generation in primary microglia, while amelioration of mitochondria-derived ros by the mitochondria-targeted antioxidant mito-apocynin completely abolished il-1β release, indicating mitochondrial ros drives potentiation of the nlrp3 inflammasome in microglia. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
collectively, our results demonstrate that mitochondrial impairment in microglia can amplify nlrp3 inflammasome signaling, which augments the dopaminergic neurodegenerative process. |
2020-09-30 |
2023-08-13 |
mouse |
| Zhi-Hang Lin, Si-Yuan Wang, Li-Li Chen, Jia-Yuan Zhuang, Qing-Feng Ke, Dan-Rui Xiao, Wen-Ping Li. Methylene Blue Mitigates Acute Neuroinflammation after Spinal Cord Injury through Inhibiting NLRP3 Inflammasome Activation in Microglia. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29311826. |
methylene blue mitigates acute neuroinflammation after spinal cord injury through inhibiting nlrp3 inflammasome activation in microglia. |
2020-09-30 |
2023-08-13 |
Not clear |
| Katharine M von Herrmann, Lucas A Salas, Eileen M Martinez, Alison L Young, Joseph M Howard, Mary S Feldman, Brock C Christensen, Owen M Wilkins, Stephen L Lee, William F Hickey, Matthew C Havrd. NPJ Parkinson's disease. vol 4. 2020-09-30. PMID:30131971. |
these cellular complexes are well characterized in the innate immune system and activity of the nlrp3 inflammasome has been reported in microglia. |
2020-09-30 |
2023-08-13 |
Not clear |