| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruixue Huang, Liyan Hou, Xingyue Zhai, Zhengzheng Ruan, Wei Sun, Dongdong Zhang, Xiulan Zhao, Qingshan Wan. 2,5-hexanedione induces NLRP3 inflammasome activation and neurotoxicity through NADPH oxidase-dependent pathway. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33212186. |
blocking activation of p38-mapk and nf-κb significantly reduced hd-induced capase-1 activation and interleukin-1β maturation, indicating a critical role of nadph oxidase and downstream mapk and nf-κb pathways in regulating activation of nlrp3 inflammasome, in hd-treated microglia. |
2021-06-18 |
2023-08-13 |
rat |
| Chad Smith, Kyle J Trageser, Henry Wu, Francis J Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinett. Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446652. |
the results show a flavanol-rich dietary preparation (fdp) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included il-1β upregulation, nlrp3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Chad Smith, Kyle J Trageser, Henry Wu, Francis J Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinett. Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446652. |
production of il-1β and nlrp3 were critical for both anxiety phenotypes and microglia activation. |
2021-06-18 |
2023-08-13 |
mouse |
| Chad Smith, Kyle J Trageser, Henry Wu, Francis J Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinett. Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446652. |
individual fdp metabolites potently inhibited il-1β production from microglia following stimulation with nlrp3-specific agonists, supporting anxiolytic properties of fdp observed in models of sleep deprivation involve inhibition of the nlrp3 inflammasome. |
2021-06-18 |
2023-08-13 |
mouse |
| Chao Ren, Ling-Xi Li, An-Qi Dong, Yu-Ting Zhang, Hua Hu, Cheng-Jie Mao, Fen Wang, Chun-Feng Li. Depression Induced by Chronic Unpredictable Mild Stress Increases Susceptibility to Parkinson's Disease in Mice via Neuroinflammation Mediated by P2X7 Receptor. ACS chemical neuroscience. vol 12. issue 7. 2021-06-18. PMID:33734697. |
with behavioral changes, neuroinflammatory markers, such as caspase-1, nlrp3 and il-1β increased, and microglia were activated as well as expression of p2x7r increased. |
2021-06-18 |
2023-08-13 |
mouse |
| Melis Olcum, Kemal Ugur Tufekci, Devrim Yagmur Durur, Bora Tastan, Irem Nur Gokbayrak, Kursad Genc, Sermin Gen. Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-κB/miR-223 Signaling. Antioxidants (Basel, Switzerland). vol 10. issue 5. 2021-06-15. PMID:34066647. |
our study aimed to investigate the mechanism of the impact of ethyl pyruvate on nlrp3 inflammasome activation in the n9 microglial cell line. |
2021-06-15 |
2023-08-13 |
Not clear |
| Xiong Wang, Li Ma, Qiao-Yan Ding, Wen-Yu Zhang, Yong-Gang Chen, Jin-Hu Wu, Hong-Feng Zhang, Xiu-Li Gu. Microglial NLRP3 inflammasome activation-mediated inflammation promotes prolactinoma development. Endocrine-related cancer. vol 28. issue 7. 2021-06-11. PMID:33974557. |
immunohistochemistry results also confirmed that the nlrp3 expression was elevated in human prolactinoma tissues, and the microglia marker-ionised calcium binding adaptor molecule-1 was co-located with the nlrp3 protein in prolactinomas by immunofluorescence assay. |
2021-06-11 |
2023-08-13 |
mouse |
| Xue-Mei He, Yan-Zhen Zhou, Shuo Sheng, Jing-Jie Li, Guo-Qing Wang, Feng Zhan. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:33294118. |
ellagic acid protects dopamine neurons via inhibition of nlrp3 inflammasome activation in microglia. |
2021-06-08 |
2023-08-13 |
rat |
| Xue-Mei He, Yan-Zhen Zhou, Shuo Sheng, Jing-Jie Li, Guo-Qing Wang, Feng Zhan. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:33294118. |
nod-like receptor protein 3 (nlrp3) inflammasome was highly located in microglia and involved in the process of neuroinflammation. |
2021-06-08 |
2023-08-13 |
rat |
| Xue-Mei He, Yan-Zhen Zhou, Shuo Sheng, Jing-Jie Li, Guo-Qing Wang, Feng Zhan. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:33294118. |
first, ea reduced nlrp3 inflammasome signaling activation in microglia and subsequent proinflammatory cytokines' excretion. |
2021-06-08 |
2023-08-13 |
rat |
| Yidan Zhang, Yuan Zhao, Jian Zhang, Guofeng Yan. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32929691. |
stimulated by aβ deposition, nlrp3 assembles and activates within microglia in the ad brain, leading to caspase-1 activation along with downstream interleukin (il)-1β secretion, and subsequent inflammatory events. |
2021-06-02 |
2023-08-13 |
mouse |
| Yidan Zhang, Yuan Zhao, Jian Zhang, Guofeng Yan. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32929691. |
activation of the nlrp3 inflammasome mediates microglia to exhibit inflammatory m1 phenotype, with high expression of caspase-1 and il-1β. |
2021-06-02 |
2023-08-13 |
mouse |
| Yidan Zhang, Yuan Zhao, Jian Zhang, Guofeng Yan. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32929691. |
however, nlrp3 or caspase-1 deletion in app/ps1 mice promotes microglia to transform to an anti-inflammatory m2 phenotype, with decreased secretion of caspase-1 and il-1β. |
2021-06-02 |
2023-08-13 |
mouse |
| Juliana Helena Dos Santos de Toledo, Thais Fernanda de Campos Fraga-Silva, Patrícia Aparecida Borim, Larissa Ragozo Cardoso de Oliveira, Evelyn da Silva Oliveira, Larissa Lucena Périco, Clélia Akiko Hiruma-Lima, Adriana Aparecida Lopes de Souza, Carlos Alberto Ferreira de Oliveira, Pedro de Magalhães Padilha, Marcos Felipe Pinatto-Botelho, Alcindo Aparecido Dos Santos, Alexandrina Sartori, Sofia Fernanda Gonçalves Zorzella-Pezavent. Organic Selenium Reaches the Central Nervous System and Downmodulates Local Inflammation: A Complementary Therapy for Multiple Sclerosis? Frontiers in immunology. vol 11. 2021-05-31. PMID:33193354. |
in addition of a tolerogenic profile in dendritic cells from the mesenteric lymph nodes, lad-βse also downregulated cell amount, activation status of macrophages and microglia, nlrp3 (nod-like receptors) inflammasome activation and other pro-inflammatory parameters in the cns. |
2021-05-31 |
2023-08-13 |
mouse |
| Sahabuddin Ahmed, Mohit Kwatra, Samir Ranjan Panda, U S N Murty, V G M Naid. Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:32971182. |
andrographolide suppresses nlrp3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of parkinson disease. |
2021-05-27 |
2023-08-13 |
Not clear |
| Yue Qin, Jingru Qiu, Ping Wang, Jia Liu, Yong Zhao, Fan Jiang, Haiyan Lo. Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson's disease. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33039664. |
impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating nlrp3 inflammasome activation in experimental models of parkinson's disease. |
2021-05-27 |
2023-08-13 |
Not clear |
| Limin Lang, Bin Xu, Jianbin Yuan, Shize Li, Shuai Lian, Yan Chen, Jingru Guo, Huanmin Yan. GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33166810. |
gaba-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the nlrp3 inflammasome and nf-κb signaling pathways. |
2021-05-25 |
2023-08-13 |
mouse |
| Limin Lang, Bin Xu, Jianbin Yuan, Shize Li, Shuai Lian, Yan Chen, Jingru Guo, Huanmin Yan. GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33166810. |
we demonstrated that chronic cold stress induced the activation of microglia, the emergence of neuroinflammation, and the impairment of neurons in the hippocampus, which might be the result of gaba-mediated activation of nod-like receptor protein 3 (nlrp3) inflammasome and the nuclear factor kappa b (nf-κb) signaling pathway. |
2021-05-25 |
2023-08-13 |
mouse |
| Christopher Hoyle, Elena Redondo-Castro, James Cook, Te-Chen Tzeng, Stuart M Allan, David Brough, Eloise Lemarchan. Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture. Immunology. vol 161. issue 1. 2021-05-24. PMID:32445196. |
most mechanistic studies on nlrp3 activation use two-dimensional pure microglial cell culture systems. |
2021-05-24 |
2023-08-13 |
Not clear |
| Christopher Hoyle, Elena Redondo-Castro, James Cook, Te-Chen Tzeng, Stuart M Allan, David Brough, Eloise Lemarchan. Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture. Immunology. vol 161. issue 1. 2021-05-24. PMID:32445196. |
nigericin-induced nlrp3 inflammasome activation was dynamically visualized in microglia through asc speck formation. |
2021-05-24 |
2023-08-13 |
Not clear |