| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lorena Olivares-González, Sheyla Velasco, José María Millán, Regina Rodrig. Intravitreal administration of adalimumab delays retinal degeneration in rd10 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 10. 2021-04-30. PMID:32816354. |
adalimumab prevented from retinal degeneration without affecting caspase -dependent mechanisms but decreasing parp activation, microglia activation as well as nlrp3 inflammasome. |
2021-04-30 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
consequently, the intestinal expression of nlrp3 was down-regulated, the cognitive ability of mice was improved, the activation of microglia in central hippocampus was suppressed and the expression of neuroinflammatory factors was also down-regulated. |
2021-04-28 |
2023-08-13 |
mouse |
| Michael J Butler, Rachel M Cole, Nicholas P Deems, Martha A Belury, Ruth M Barriento. Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32544595. |
our results indicate that hfd increased gene expression of microglial markers of activation indicative of microglial priming, including cd11b, mhcii, cx3cr1, and nlrp3, as well as the pro-inflammatory marker il-1β in both hippocampus and amygdala-derived microglia. |
2021-04-27 |
2023-08-13 |
rat |
| Ning Zhang, Chunhong Liu, Ruiyan Zhang, Li Jin, Xiaohan Yin, Xuexing Zheng, Hans-Christian Siebert, Yubao Li, Zhengping Wang, Gabriele Loers, Athanasios K Petridi. Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet. Food & function. vol 11. issue 6. 2021-04-26. PMID:32539054. |
in conclusion, these data demonstrate that kd decreased the reactive astrocytes and activated the microglia in the corpus callosum, and that kd inhibited the hadc3 and nlrp3 inflammasome signaling pathway in cpz-treated mice. |
2021-04-26 |
2023-08-13 |
mouse |
| Xiaoqi Chu, Chun Wang, Zheng Wu, Liting Fan, Chunmei Tao, Jiaqi Lin, Shuang Chen, Yongzhong Lin, Yusong G. JNK/c-Jun-driven NLRP3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy. Experimental eye research. vol 202. 2021-04-16. PMID:33141050. |
jnk/c-jun-driven nlrp3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy. |
2021-04-16 |
2023-08-13 |
Not clear |
| Xiaoqi Chu, Chun Wang, Zheng Wu, Liting Fan, Chunmei Tao, Jiaqi Lin, Shuang Chen, Yongzhong Lin, Yusong G. JNK/c-Jun-driven NLRP3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy. Experimental eye research. vol 202. 2021-04-16. PMID:33141050. |
the present study concentrated on jnk/c-jun-driven nlrp3 inflammasome activation in microglia during the degeneration of retinal ganglion cells (rgcs) in iton. |
2021-04-16 |
2023-08-13 |
Not clear |
| Baohua Hou, Yahui Zhang, Peiyu Liang, Yuan He, Biwen Peng, Wanhong Liu, Song Han, Jun Yin, Xiaohua H. Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32415059. |
activation of the nlrp3 inflammasome in microglia is fundamental for subsequent inflammatory events. |
2021-04-07 |
2023-08-13 |
mouse |
| Jibrin Danladi, Hemmen Sabi. Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia. International journal of molecular sciences. vol 22. issue 2. 2021-04-02. PMID:33445791. |
hypothermia stimulates microglia to secret cold-inducible rna-binding protein (cirp), which triggers nf-κb, controlling multiple inflammatory pathways, including nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasomes and cyclooxygenase-2 (cox-2) signaling. |
2021-04-02 |
2023-08-13 |
human |
| Lea L Friker, Hannah Scheiblich, Inga V Hochheiser, Rebecca Brinkschulte, Dietmar Riedel, Eicke Latz, Matthias Geyer, Michael T Henek. β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia. Cell reports. vol 30. issue 11. 2021-03-23. PMID:32187546. |
indeed, asc released by a pyroptotic cell can be functionally built into the neighboring microglia nod-like receptor protein (nlrp3) inflammasome. |
2021-03-23 |
2023-08-13 |
Not clear |
| Dai-Chao Ma, Nan-Nan Zhang, Yi-Na Zhang, Hui-Sheng Che. Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia. Experimental neurology. vol 332. 2021-03-09. PMID:32652099. |
kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping m1/m2 phenotypes and compromising the activation of nlrp3 inflammasome in microglia. |
2021-03-09 |
2023-08-13 |
rat |
| Dai-Chao Ma, Nan-Nan Zhang, Yi-Na Zhang, Hui-Sheng Che. Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia. Experimental neurology. vol 332. 2021-03-09. PMID:32652099. |
after cerebral ischemia/reperfusion injury, pro-inflammatory m1-like and anti-inflammatory m2-like phenotypes of microglia are involved in neuroinflammation, in which nlrp3 inflammasome plays an essential role. |
2021-03-09 |
2023-08-13 |
rat |
| Asta Lučiūnaitė, Róisín M McManus, Marija Jankunec, Ildikó Rácz, Cira Dansokho, Indrė Dalgėdienė, Stephanie Schwartz, Frederic Brosseron, Michael T Henek. Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia. Journal of neurochemistry. vol 155. issue 6. 2021-03-02. PMID:31872431. |
soluble aβ oligomers and protofibrils induce nlrp3 inflammasome activation in microglia. |
2021-03-02 |
2023-08-13 |
mouse |
| Asta Lučiūnaitė, Róisín M McManus, Marija Jankunec, Ildikó Rácz, Cira Dansokho, Indrė Dalgėdienė, Stephanie Schwartz, Frederic Brosseron, Michael T Henek. Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia. Journal of neurochemistry. vol 155. issue 6. 2021-03-02. PMID:31872431. |
here, we investigated whether aβ oligomers or protofibrils that represent lower molecular aggregates prior to aβ deposition are able to activate the nlrp3 inflammasome and subsequent interleukin-1 beta (il-1β) release by microglia. |
2021-03-02 |
2023-08-13 |
mouse |
| An-Guo Wu, Xiao-Gang Zhou, Gan Qiao, Lu Yu, Yong Tang, Lu Yan, Wen-Qiao Qiu, Rong Pan, Chong-Lin Yu, Betty Yuen-Kwan Law, Da-Lian Qin, Jian-Ming W. Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases. Ageing research reviews. vol 65. 2021-02-22. PMID:33161129. |
nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (nlrp3), the most well-studied inflammasome, is abundantly expressed in microglia and has gained considerable attention. |
2021-02-22 |
2023-08-13 |
Not clear |
| An-Guo Wu, Xiao-Gang Zhou, Gan Qiao, Lu Yu, Yong Tang, Lu Yan, Wen-Qiao Qiu, Rong Pan, Chong-Lin Yu, Betty Yuen-Kwan Law, Da-Lian Qin, Jian-Ming W. Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases. Ageing research reviews. vol 65. 2021-02-22. PMID:33161129. |
misfolded proteins are characterized as the common hallmarks of neurodegenerative diseases due to not only their induced neuronal toxicity but also their effects in over-activating microglia and the nlrp3 inflammasome. |
2021-02-22 |
2023-08-13 |
Not clear |
| An-Guo Wu, Xiao-Gang Zhou, Gan Qiao, Lu Yu, Yong Tang, Lu Yan, Wen-Qiao Qiu, Rong Pan, Chong-Lin Yu, Betty Yuen-Kwan Law, Da-Lian Qin, Jian-Ming W. Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases. Ageing research reviews. vol 65. 2021-02-22. PMID:33161129. |
in this review article, we summarize and discuss the nlrp3 inflammasome and its specific inhibitors in microglia. |
2021-02-22 |
2023-08-13 |
Not clear |
| Jie Zhao, Xiangyu Piao, Yue Wu, Shanshan Liang, Fang Han, Qian Liang, Shujuan Shao, Dewei Zha. Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-02-16. PMID:32559840. |
immunofluorescence staining showed an up-regulation in nlr family pyrin domain containing 3 (nlrp3) immunoreactivity in iba1-labled microglia together with total iba1 and nlrp3 expression in the brain following tmcao, while down-regulated by cep treatment. |
2021-02-16 |
2023-08-13 |
mouse |
| Jie Zhao, Xiangyu Piao, Yue Wu, Shanshan Liang, Fang Han, Qian Liang, Shujuan Shao, Dewei Zha. Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-02-16. PMID:32559840. |
taken together, we demonstrate that cep attenuates cerebral i/r injury probably by inhibiting microglia activation and nlrp3 inflammasome-induced inflammation and reducing oxidative stress via suppressing 12/15-lox signaling. |
2021-02-16 |
2023-08-13 |
mouse |
| Yue Qu, Jun-Yan Wu, Qing Yua. [Effect of acupuncture on hippocampal inflammation in rats with intrauterine distress induced hypoxic-ischemic brain injury]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 1. 2021-02-10. PMID:33559420. |
to observe the effects of acupuncture on the behavior, serum inflammatory cytokines, hippocampal nod-like receptor protein 3(nlrp3) inflammasome-related proteins and microglia activation in rats with intrauterine distress induced ischemia-hypoxic brain injury (hibd), so as to explore the mechanism of acupuncture underlying treatment of hibd by regulating hippocampal inflammation. |
2021-02-10 |
2023-08-13 |
rat |
| Chuan He, Zhong-Sheng Huang, Hong-Ru Chen, Chao-Chao Yu, Xue-Song Wang, Tao Jiang, Li-Hong Kon. [Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 12. 2021-02-01. PMID:33415876. |
to observe the effect of pretreatment of acupuncture on the expression of nucleotide-binding oligomerization domain-like receptor 3(nlrp3), caspase-1, interleukin1β(il-1β) and the number of activated microglia (mg) in the hippocampus in alzheimer's disease (ad) like rats, so as to explore the mechanism of pretreatment of acupuncture in preventing and treating ad. |
2021-02-01 |
2023-08-13 |
rat |