| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojuan Han, Tianshu Xu, Qijun Fang, Huajun Zhang, Lijun Yue, Gang Hu, Lingyun Su. Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy. Redox biology. vol 44. 2021-07-05. PMID:34082381. |
this work illustrated that qu prevents neuronal injury via inhibition of mtros-mediated nlrp3 inflammasome activation in microglia through promoting mitophagy, which provides a potential novel therapeutic strategy for neuroinflammation-related diseases. |
2021-07-05 |
2023-08-13 |
mouse |
| Linglong Xiao, Huaping Zheng, Jing Li, Qinghua Wang, Haitao Su. Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32856203. |
furthermore, previous studies have reported that nlrp3 inflammasome is mainly present in microglia, so we speculate that its activation may be strongly associated with microglial polarization. |
2021-07-01 |
2023-08-13 |
human |
| Shanshan Zhang, Ying Zong, Zhonggan Ren, Juntao Hu, Xinyuan Wu, Honglei Xiao, Song Qin, Guomin Zhou, Yuanyuan Ma, Yaodong Zhang, Jin Yu, Kaidi Wang, Guocai Lu, Qiong Li. Regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by NLRP3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. The European journal of neuroscience. vol 52. issue 11. 2021-06-21. PMID:33098156. |
regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by nlrp3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. |
2021-06-21 |
2023-08-13 |
mouse |
| Shanshan Zhang, Ying Zong, Zhonggan Ren, Juntao Hu, Xinyuan Wu, Honglei Xiao, Song Qin, Guomin Zhou, Yuanyuan Ma, Yaodong Zhang, Jin Yu, Kaidi Wang, Guocai Lu, Qiong Li. Regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by NLRP3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. The European journal of neuroscience. vol 52. issue 11. 2021-06-21. PMID:33098156. |
in the brain, nlrp3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin-domain-containing 3) inflammasome is mainly expressed in microglia located in the hippocampus and other mood-regulated regions, which are particularly susceptible to stress. |
2021-06-21 |
2023-08-13 |
mouse |
| Shanshan Zhang, Ying Zong, Zhonggan Ren, Juntao Hu, Xinyuan Wu, Honglei Xiao, Song Qin, Guomin Zhou, Yuanyuan Ma, Yaodong Zhang, Jin Yu, Kaidi Wang, Guocai Lu, Qiong Li. Regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by NLRP3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. The European journal of neuroscience. vol 52. issue 11. 2021-06-21. PMID:33098156. |
in conclusion, nlrp3 inflammasome is involved in lps-induced depressive-like behaviors, and that nlrp3 and asc may play roles in regulating ido expression in microglia. |
2021-06-21 |
2023-08-13 |
mouse |
| Jiping Li, Xinping Dai, Liuyi Zhou, Xinxiu Li, Dongxiao Pa. Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation. Frontiers in pharmacology. vol 12. 2021-06-19. PMID:34135761. |
edaravone plays protective effects on lps-induced microglia by switching m1/m2 phenotypes and regulating nlrp3 inflammasome activation. |
2021-06-19 |
2023-08-13 |
rat |
| Wei-Sheng Lin, Ting-Rong Hs. Hypothesis: Febrile infection-related epilepsy syndrome is a microglial NLRP3 inflammasome/IL-1 axis-driven autoinflammatory syndrome. Clinical & translational immunology. vol 10. issue 6. 2021-06-19. PMID:34141434. |
a closer analysis of current literature suggests that microglia and the nlrp3 inflammasome might be the pivotal cellular and molecular players in fires pathogenesis, respectively. |
2021-06-19 |
2023-08-13 |
Not clear |
| Longyun Zhou, Min Yao, Zirui Tian, Yongjia Song, Yueli Sun, Jie Ye, Gan Li, Kim Sia Sng, Leqin Xu, Xuejun Cui, Yongjun Wan. Echinacoside attenuates inflammatory response in a rat model of cervical spondylotic myelopathy via inhibition of excessive mitochondrial fission. Free radical biology & medicine. vol 152. 2021-06-18. PMID:32014501. |
in vitro data suggested that ech suppressed activated microglia by modulating activation of the nlrp3 inflammasome and nf-κb signaling. |
2021-06-18 |
2023-08-13 |
rat |
| Ruixue Huang, Liyan Hou, Xingyue Zhai, Zhengzheng Ruan, Wei Sun, Dongdong Zhang, Xiulan Zhao, Qingshan Wan. 2,5-hexanedione induces NLRP3 inflammasome activation and neurotoxicity through NADPH oxidase-dependent pathway. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33212186. |
blocking activation of p38-mapk and nf-κb significantly reduced hd-induced capase-1 activation and interleukin-1β maturation, indicating a critical role of nadph oxidase and downstream mapk and nf-κb pathways in regulating activation of nlrp3 inflammasome, in hd-treated microglia. |
2021-06-18 |
2023-08-13 |
rat |
| Chad Smith, Kyle J Trageser, Henry Wu, Francis J Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinett. Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446652. |
the results show a flavanol-rich dietary preparation (fdp) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included il-1β upregulation, nlrp3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Chad Smith, Kyle J Trageser, Henry Wu, Francis J Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinett. Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446652. |
production of il-1β and nlrp3 were critical for both anxiety phenotypes and microglia activation. |
2021-06-18 |
2023-08-13 |
mouse |
| Chad Smith, Kyle J Trageser, Henry Wu, Francis J Herman, Umar Haris Iqbal, Maria Sebastian-Valverde, Tal Frolinger, Emma Zeng, Giulio Maria Pasinett. Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446652. |
individual fdp metabolites potently inhibited il-1β production from microglia following stimulation with nlrp3-specific agonists, supporting anxiolytic properties of fdp observed in models of sleep deprivation involve inhibition of the nlrp3 inflammasome. |
2021-06-18 |
2023-08-13 |
mouse |
| Chao Ren, Ling-Xi Li, An-Qi Dong, Yu-Ting Zhang, Hua Hu, Cheng-Jie Mao, Fen Wang, Chun-Feng Li. Depression Induced by Chronic Unpredictable Mild Stress Increases Susceptibility to Parkinson's Disease in Mice via Neuroinflammation Mediated by P2X7 Receptor. ACS chemical neuroscience. vol 12. issue 7. 2021-06-18. PMID:33734697. |
with behavioral changes, neuroinflammatory markers, such as caspase-1, nlrp3 and il-1β increased, and microglia were activated as well as expression of p2x7r increased. |
2021-06-18 |
2023-08-13 |
mouse |
| Melis Olcum, Kemal Ugur Tufekci, Devrim Yagmur Durur, Bora Tastan, Irem Nur Gokbayrak, Kursad Genc, Sermin Gen. Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-κB/miR-223 Signaling. Antioxidants (Basel, Switzerland). vol 10. issue 5. 2021-06-15. PMID:34066647. |
our study aimed to investigate the mechanism of the impact of ethyl pyruvate on nlrp3 inflammasome activation in the n9 microglial cell line. |
2021-06-15 |
2023-08-13 |
Not clear |
| Xiong Wang, Li Ma, Qiao-Yan Ding, Wen-Yu Zhang, Yong-Gang Chen, Jin-Hu Wu, Hong-Feng Zhang, Xiu-Li Gu. Microglial NLRP3 inflammasome activation-mediated inflammation promotes prolactinoma development. Endocrine-related cancer. vol 28. issue 7. 2021-06-11. PMID:33974557. |
immunohistochemistry results also confirmed that the nlrp3 expression was elevated in human prolactinoma tissues, and the microglia marker-ionised calcium binding adaptor molecule-1 was co-located with the nlrp3 protein in prolactinomas by immunofluorescence assay. |
2021-06-11 |
2023-08-13 |
mouse |
| Xue-Mei He, Yan-Zhen Zhou, Shuo Sheng, Jing-Jie Li, Guo-Qing Wang, Feng Zhan. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:33294118. |
ellagic acid protects dopamine neurons via inhibition of nlrp3 inflammasome activation in microglia. |
2021-06-08 |
2023-08-13 |
rat |
| Xue-Mei He, Yan-Zhen Zhou, Shuo Sheng, Jing-Jie Li, Guo-Qing Wang, Feng Zhan. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:33294118. |
nod-like receptor protein 3 (nlrp3) inflammasome was highly located in microglia and involved in the process of neuroinflammation. |
2021-06-08 |
2023-08-13 |
rat |
| Xue-Mei He, Yan-Zhen Zhou, Shuo Sheng, Jing-Jie Li, Guo-Qing Wang, Feng Zhan. Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:33294118. |
first, ea reduced nlrp3 inflammasome signaling activation in microglia and subsequent proinflammatory cytokines' excretion. |
2021-06-08 |
2023-08-13 |
rat |
| Yidan Zhang, Yuan Zhao, Jian Zhang, Guofeng Yan. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32929691. |
stimulated by aβ deposition, nlrp3 assembles and activates within microglia in the ad brain, leading to caspase-1 activation along with downstream interleukin (il)-1β secretion, and subsequent inflammatory events. |
2021-06-02 |
2023-08-13 |
mouse |
| Yidan Zhang, Yuan Zhao, Jian Zhang, Guofeng Yan. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32929691. |
activation of the nlrp3 inflammasome mediates microglia to exhibit inflammatory m1 phenotype, with high expression of caspase-1 and il-1β. |
2021-06-02 |
2023-08-13 |
mouse |