| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuying Pei, Fafeng Cheng, Wei Li, Qiaoyu Yu, Chongyang Ma, Yan Zou, Tian Xu, Shuling Liu, Shuang Zhang, Qingguo Wan. Enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting NLRP3 inflammasome. Journal of bioscience and bioengineering. 2021-12-10. PMID:34887181. |
enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting nlrp3 inflammasome. |
2021-12-10 |
2023-08-13 |
cattle |
| Arjun Sapkota, Ji Woong Cho. Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation. Biomolecules & therapeutics. 2021-12-08. PMID:34873072. |
oa also attenuated nlrp3 inflammasome activation in activated microglia during the acute phase. |
2021-12-08 |
2023-08-13 |
mouse |
| Rui-Yuan Pan, Xiang-Xi Kong, Yong Cheng, Lu Du, Zhen-Chao Wang, Chao Yuan, Jin-Bo Cheng, Zeng-Qiang Yuan, Hai-Yan Zhang, Ya-Jin Lia. 1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis. Acta pharmacologica Sinica. vol 42. issue 11. 2021-12-07. PMID:33627802. |
we showed that 1,2,4-ttb (1 mm) markedly suppressed nigericin- or atp-induced nlrp3 inflammasome activation, thus decreased caspase-1 activation and il-1β secretion in immortalized murine bone marrow-derived macrophages (ibmdms) and in primary mouse microglia. |
2021-12-07 |
2023-08-13 |
mouse |
| Bora Tastan, Burak I Arioz, Kemal Ugur Tufekci, Emre Tarakcioglu, Ceren Perihan Gonul, Kursad Genc, Sermin Gen. Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice. Frontiers in immunology. vol 12. 2021-12-06. PMID:34858398. |
dimethyl fumarate alleviates nlrp3 inflammasome activation in microglia and sickness behavior in lps-challenged mice. |
2021-12-06 |
2023-08-13 |
mouse |
| Alexander G Marnero. Role of inflammasome activation in neovascular age-related macular degeneration. The FEBS journal. 2021-12-04. PMID:34767301. |
furthermore, inflammasome activation can occur in cnv macrophages and microglia despite lack of nlrp3. |
2021-12-04 |
2023-08-13 |
Not clear |
| Kemal Ugur Tufekci, Bedir Irem Eltutan, Kamer Burak Isci, Sermin Gen. Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34739715. |
resveratrol inhibits nlrp3 inflammasome-induced pyroptosis and mir-155 expression in microglia through sirt1/ampk pathway. |
2021-12-03 |
2023-08-13 |
Not clear |
| Kemal Ugur Tufekci, Bedir Irem Eltutan, Kamer Burak Isci, Sermin Gen. Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34739715. |
to sum up, our results suggest that resveratrol suppresses the nlrp3 inflammasome and mir-155 expression through ampk and sirt1 pathways in microglia. |
2021-12-03 |
2023-08-13 |
Not clear |
| Xian Zhang, Qing Shu, Zhanhui Liu, Chao Gao, Zhenhua Wang, Zhiguo Xing, Jinning Son. Recombinant osteopontin provides protection for cerebral infarction by inhibiting the NLRP3 inflammasome in microglia. Brain research. vol 1751. 2021-11-30. PMID:33157099. |
recombinant osteopontin provides protection for cerebral infarction by inhibiting the nlrp3 inflammasome in microglia. |
2021-11-30 |
2023-08-13 |
rat |
| Xian Zhang, Qing Shu, Zhanhui Liu, Chao Gao, Zhenhua Wang, Zhiguo Xing, Jinning Son. Recombinant osteopontin provides protection for cerebral infarction by inhibiting the NLRP3 inflammasome in microglia. Brain research. vol 1751. 2021-11-30. PMID:33157099. |
the effects of opn on cerebral ischemic injury, neural function, microglia inflammation and nlrp3 inflammasome function were studied by immunofluorescence, staining, enzyme-linked immunosorbent assay and western blot assay. |
2021-11-30 |
2023-08-13 |
rat |
| Xian Zhang, Qing Shu, Zhanhui Liu, Chao Gao, Zhenhua Wang, Zhiguo Xing, Jinning Son. Recombinant osteopontin provides protection for cerebral infarction by inhibiting the NLRP3 inflammasome in microglia. Brain research. vol 1751. 2021-11-30. PMID:33157099. |
we found that opn was also involved in the negative regulation of inflammasome and microglia activity in cerebral ischemic injury, and that opn inhibited the activation of nlrp3 inflammasome and the function of microglia in a lps-induced inflammatory model. |
2021-11-30 |
2023-08-13 |
rat |
| Kishore Aravind Ravichandran, Michael T Henek. Inflammasome activation in neurodegenerative diseases. Essays in biochemistry. 2021-11-30. PMID:34846519. |
molecular sensors within these microglia, such as the nlrp3 inflammasome, are activated by signals that represent the hallmarks of neurodegenerative diseases. |
2021-11-30 |
2023-08-13 |
mouse |
| Dorit Trudler, Kristopher L Nazor, Yvonne S Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S Goodwin, Yona Levites, Todd E Golde, Jeffery W Kelly, Michael R Sierks, Nicholas J Schork, Michael Karin, Rajesh Ambasudhan, Stuart A Lipto. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 15. 2021-11-29. PMID:33833060. |
soluble α-synuclein-antibody complexes activate the nlrp3 inflammasome in hipsc-derived microglia. |
2021-11-29 |
2023-08-13 |
mouse |
| Dorit Trudler, Kristopher L Nazor, Yvonne S Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S Goodwin, Yona Levites, Todd E Golde, Jeffery W Kelly, Michael R Sierks, Nicholas J Schork, Michael Karin, Rajesh Ambasudhan, Stuart A Lipto. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 15. 2021-11-29. PMID:33833060. |
heretofore, it remained unknown if oligomeric/fibrillar αsyn could activate the nucleotide-binding oligomerization domain (nod)-like receptor (nlr) family pyrin domain-containing 3 (nlrp3) inflammasome in human microglia and whether anti-αsyn antibodies could prevent this effect. |
2021-11-29 |
2023-08-13 |
mouse |
| Dorit Trudler, Kristopher L Nazor, Yvonne S Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S Goodwin, Yona Levites, Todd E Golde, Jeffery W Kelly, Michael R Sierks, Nicholas J Schork, Michael Karin, Rajesh Ambasudhan, Stuart A Lipto. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 15. 2021-11-29. PMID:33833060. |
here, we show that αsyn activates the nlrp3 inflammasome in human induced pluripotent stem cell (hipsc)-derived microglia (himg) via dual stimulation involving toll-like receptor 2 (tlr2) engagement and mitochondrial damage. |
2021-11-29 |
2023-08-13 |
mouse |
| Maryam Mohammadi, Mahdad Abdi, Mehdi Alidadi, Wael Mohamed, Kazem Zibara, Iraj Ragerdi Kashan. Medroxyprogesterone acetate attenuates demyelination, modulating microglia activation, in a cuprizone neurotoxic demyelinating mouse model. American journal of neurodegenerative disease. vol 10. issue 5. 2021-11-27. PMID:34824899. |
in summary, mpa reduces the level of demyelination and has an anti-inflammatory role in cns demyelination by inducing m2 microglia polarization and suppressing the m1 phenotype through the inhibition of nf-κb and nlrp3 inflammasome. |
2021-11-27 |
2023-08-13 |
mouse |
| Kuan Cheng, Jingjing Wang, Qingxing Chen, Gang Zhao, Yang Pang, Ye Xu, Junbo Ge, Wenqing Zh. Inflammasome-mediated neurodegeneration following heart disease. Annals of translational medicine. vol 9. issue 20. 2021-11-19. PMID:34790766. |
previous studies have shown that nlrp3 activation in brain microglia is required for ad; however, its possible role in mi-induced future development of neurodegeneration is not yet understood. |
2021-11-19 |
2023-08-13 |
Not clear |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
we examined activation of the nlrp3 pathway in microglia exposed to cocaine, followed by validation in mice administered either cocaine or saline for 7 days, with or without pretreatment with the nlrp3 inhibitor, mcc950, and in postmortem cortical brain tissues of chronic cocaine-dependent humans. |
2021-11-18 |
2023-08-13 |
mouse |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
we found that microglia exposed to cocaine exhibited significant induction of nlrp3 and mature il-1β expression. |
2021-11-18 |
2023-08-13 |
mouse |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
collectively, these findings suggest that cocaine activates microglia involving the nlrp3 inflammasome pathway, thereby contributing to neuroinflammation. |
2021-11-18 |
2023-08-13 |
mouse |
| Mayra López-Cervantes, Andrés Quintanar-Stephano, Sarael Alcauter-Solórzano, Rogelio Hernández-Pando, Raúl Aguilar-Roblero, Deisy Gasca-Martínez, Juan J Ortíz, Olivia Vázquez-Martínez, Cecilia Ximénez-Camilli, Mauricio Díaz-Muño. Cerebellar spongiform degeneration is accompanied by metabolic, cellular, and motor disruption in male rats with portacaval anastomosis. Journal of neuroscience research. vol 99. issue 9. 2021-11-18. PMID:34061383. |
the results were as follows: (a) cellular alterations, namely loss of purkinje cells, morphological changes, such as swelling of astrocytes and bergmann glia, and activation of microglia; (b) cytotoxic edema, shown by an increase in aquaporin-4 and n-acetylaspartate and a reduction in taurine and choline-derivate osmolytes; (c) metabolic adjustments, noted by the elevation of circulating ammonium, enhanced presence of glutamine synthetase, and increase in glutamine and creatine/phosphocreatine; (d) inflammasome activation, detected by the elevation of the marker nlrp3 and microglial activation; (e) locomotor deficits in pca rats as assessed by the rotarod and open field tests. |
2021-11-18 |
2023-08-13 |
rat |