| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Yuan, ShuangXian Guan, Zhen Wang, HongLiang Ni, DongLiang Ding, WenBo Xu, GuoMin L. HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34166779. |
hif-1α was implicated in tbi-induced brain injury, aggravated nlrp3 inflammasome -mediated pyroptosis, and the activation of microglia, which provided a potential target for treating tbi. |
2021-11-10 |
2023-08-13 |
mouse |
| Ana Belen Lopez-Rodriguez, Edel Hennessy, Carol L Murray, Arshed Nazmi, Hugh J Delaney, Dáire Healy, Steven G Fagan, Michael Rooney, Erika Stewart, Anouchka Lewis, Niamh de Barra, Philip Scarry, Louise Riggs-Miller, Delphine Boche, Mark O Cunningham, Colm Cunningha. Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 10. 2021-11-09. PMID:34080771. |
the nlrp3 inflammasome was assembled surrounding amyloid beta, and microglia were primed, facilitating exaggerated interleukin-1β (il-1β) responses to subsequent lps stimulation. |
2021-11-09 |
2023-08-13 |
mouse |
| Su Yang, Xingxing Zhang, Hengli Zhang, Xiangxiang Lin, Xijun Chen, Ying Zhang, Xiao Lin, Lijie Huang, Qichuan Zhug. Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway. Molecular medicine reports. vol 24. issue 3. 2021-11-09. PMID:34296312. |
the present study examined the molecular mechanism of di on nlr family pyrin domain‑containing 3 (nlrp3) inflammasome assembly and nlrp3 inflammasome‑dependent pyroptosis in microglia. |
2021-11-09 |
2023-08-13 |
Not clear |
| Rong Rong, Rongliang Yang, Haibo Li, Mengling You, Zhuotao Liang, Zhou Zeng, Rongrong Zhou, Xiaobo Xia, Dan J. The roles of mitochondrial dynamics and NLRP3 inflammasomes in the pathogenesis of retinal light damage. Annals of the New York Academy of Sciences. 2021-11-06. PMID:34741555. |
further experiments revealed that dynamin-related protein 1 (drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the nlrp3 inflammasome. |
2021-11-06 |
2023-08-13 |
mouse |
| Yun-Ying Feng, Hui Che. [Nucleotide-binding Oligomerization Domain-like Receptor Family Pyrin Domain Containing 3 Inflammasome in Alzheimer's Disease]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 5. 2021-11-04. PMID:34728041. |
alzheimer's disease(ad)is a chronic neurodegenerative disease whose cause remains unclear.the β-amyloid plaques in the brain are one of the major pathological features of ad.however,the drugs targeting extracellular β-amyloid plaques have failed to cure the disease.innate immunity and neuroinflammation play a role in the pathogenesis and progression of ad.as the macrophages existing in the central nervous system,microglia are related with extracellular β-amyloid deposition,intracellular neurofibrillary tangle formation,and neuron injury.accumulating evidence demonstrates that the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3(nlrp3)inflammasome in microglia plays a role in ad,suggesting new therapeutic target for ad in this signaling pathway.this article reviewed the studies about the activation and regulation of nlrp3 inflammasome in the pathogenesis and progression of ad as well as the development of ad therapies targeting this pathway,aiming to provide reference for further studies in this field. |
2021-11-04 |
2023-08-13 |
Not clear |
| Folashade A Ogunrinade, Stephanie T Guetchueng, Folashade O Katola, Mutalib A Aderogba, Idowu S Akande, Satyajit D Sarker, Olumayokun A Olajid. Zanthoxylum zanthoxyloides inhibits lipopolysaccharide- and synthetic hemozoin-induced neuroinflammation in BV-2 microglia: roles of NF-κB transcription factor and NLRP3 inflammasome activation. The Journal of pharmacy and pharmacology. vol 73. issue 1. 2021-11-02. PMID:33791805. |
zanthoxylum zanthoxyloides inhibits lipopolysaccharide- and synthetic hemozoin-induced neuroinflammation in bv-2 microglia: roles of nf-κb transcription factor and nlrp3 inflammasome activation. |
2021-11-02 |
2023-08-13 |
Not clear |
| Olumayokun A Olajide, Victoria U Iwuanyanwu, Oyinkansola D Adegbola, Alaa A Al-Hindaw. SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia. Molecular neurobiology. 2021-10-30. PMID:34709564. |
exposure of s1 to bv-2 microglia also increased the protein levels of nlrp3 inflammasome and enhanced caspase-1 activity. |
2021-10-30 |
2023-08-13 |
Not clear |
| Ming-Lei Guo, Ernest T Chivero, Shannon E Callen, Shilpa Buc. NLRP3 Inflammasome Is Involved in Cocaine-Mediated Potentiation on Behavioral Changes in CX3CR1-Deficient Mice. Journal of personalized medicine. vol 11. issue 10. 2021-10-26. PMID:34683104. |
taken together, our findings demonstrated that the functional status of microglia could have an impact on cocaine-mediated reward effects, and nlrp3 inflammasome activity was associated with this phenomenon. |
2021-10-26 |
2023-08-13 |
mouse |
| Iven-Alex von Muecke-Heim, Clemens Ries, Lidia Urbina, Jan M Deussin. P2X7R antagonists in chronic stress-based depression models: a review. European archives of psychiatry and clinical neuroscience. vol 271. issue 7. 2021-10-25. PMID:34279714. |
behavioural testing was performed during or after the last week of stress application and resulted in depressive-like behaviours, immune changes (nlrp3 assembly, interleukin-1β level increase, microglia activation) and neuroplasticity impairment. |
2021-10-25 |
2023-08-13 |
mouse |
| Yuan Li, Haifeng Zhang, Mingyuan Liu, Weiying Guo, Lu Y. Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflammation in Diabetic Mice and BV2 Cells. Current pharmaceutical design. vol 27. issue 24. 2021-10-22. PMID:34279193. |
microglia nlrp3 inflammasomes activation involving diabetic neuroinflammation in diabetic mice and bv2 cells. |
2021-10-22 |
2023-08-13 |
mouse |
| Liuna Yang, Kanming Mao, Honglin Yu, Jialong Che. Neuroinflammatory Responses and Parkinson' Disease: Pathogenic Mechanisms and Therapeutic Targets. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 4. 2021-10-20. PMID:32529463. |
graphical abstract various mechanismsparticipate in nlrp3 activation,causing microglia activation inpd. |
2021-10-20 |
2023-08-13 |
Not clear |
| Rui Ding, Weiyang Ou, Chengwei Chen, Yaqi Liu, Haiyan Li, Xifang Zhang, Huihui Chai, Xiaowen Ding, Qiujing Wan. Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation. Neurochemistry international. vol 141. 2021-10-18. PMID:32980492. |
the levels of 3-nitrotyrosine (3-nt, as a footprint of peroxynitrite), nlrp3, caspase p20, il-1β, and gsdmd were distinctly elevated post-cvst and cellular localization of peroxynitrite, nlrp3, caspase p20, and il-1β was largely observed in neurons and/or microglia. |
2021-10-18 |
2023-08-13 |
rat |
| Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua O. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:34265833. |
the nod-like receptor 3 (nlrp3) inflammasome assembles inside of microglia on activation, which plays an important role in neurodegeneration such as alzheimer disease. |
2021-10-18 |
2023-08-13 |
rat |
| Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua O. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:34265833. |
although nlrp3 inflammasome assembles inside of microglia on activation has been shown to be essential for the development and progression of amyloid pathology, its whether it mediates the neurodegeneration caused by np is currently unclear. |
2021-10-18 |
2023-08-13 |
rat |
| Shanya Jiang, Nicole M Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A Mandell, Stephen D Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P Weick, Gary A Rosenberg, Eicke Latz, Michael T Heneka, Kiran Bhaska. Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell reports. vol 36. issue 12. 2021-10-06. PMID:34551296. |
treating microglia with ptau-containing neuronal media, exosomes, or phfs causes il-1β activation, which is nlrp3, asc, and caspase-1 dependent. |
2021-10-06 |
2023-08-13 |
mouse |
| Lung-Chih Li, Wei-Yu Chen, Jin-Bor Chen, Wen-Chin Lee, Chiung-Chih Chang, Hong-Tai Tzeng, Chiang-Chi Huang, Ya-Jen Chang, Jenq-Lin Yan. The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572437. |
the ast-120 recovers uremic toxin-induced cognitive deficit via nlrp3 inflammasome pathway in astrocytes and microglia. |
2021-10-01 |
2023-08-13 |
mouse |
| Lung-Chih Li, Wei-Yu Chen, Jin-Bor Chen, Wen-Chin Lee, Chiung-Chih Chang, Hong-Tai Tzeng, Chiang-Chi Huang, Ya-Jen Chang, Jenq-Lin Yan. The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572437. |
these findings suggested that is is an important uremic toxin that induces nlrp3 inflammasome-mediated not only in microglia, but it also occurred in astrocytic inflammation, which subsequently causes cognitive impairment. |
2021-10-01 |
2023-08-13 |
mouse |
| Jianjian Dong, Xun Wang, Chenchen Xu, Manli Gao, Shijing Wang, Jin Zhang, Haiyang Tong, Lulu Wang, Yongzhu Han, Nan Cheng, Yongsheng Ha. Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson's disease. Cell death & disease. vol 12. issue 1. 2021-09-29. PMID:33462188. |
furthermore, the activation of nlrp3 inflammasome was noted in primary microglia treated with cucl |
2021-09-29 |
2023-08-13 |
mouse |
| Xiaolong Yao, Shengbo Wang, Yingchun Chen, Liuqing Sheng, Huanhuan Li, Huichao You, Jianfeng Ye, Qing Zhang, Jun L. Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34405489. |
meanwhile, nod-like receptor with pyrin domain containing-3 (nlrp3) inflammasomes in microglia may play a central role in tbi. |
2021-09-29 |
2023-08-13 |
mouse |
| Xiaolong Yao, Shengbo Wang, Yingchun Chen, Liuqing Sheng, Huanhuan Li, Huichao You, Jianfeng Ye, Qing Zhang, Jun L. Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34405489. |
to gain an insight into this possibility, we conducted cell culture and biochemical studies on the effect of sh on nlrp3 inflammasome in microglia. |
2021-09-29 |
2023-08-13 |
mouse |