| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baoyu Ma, Yongxin Liu, Xiao Zhang, Rui Zhang, Zhenjiang Zhang, Zhihao Zhang, Jie Liu, Zhaodong Juan, Xiaotong Sun, Lina Sun, Jingyao Huang, Jinpeng Fen. TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation. Oxidative medicine and cellular longevity. vol 2022. 2022-04-11. PMID:35401924. |
and the nlrp3 inflammasome was increased in lps-activated bv-2 microglia cells in the microglia-neuron coculture system; pretreatment with pk11195 and midazolam limited this undesirable situation. |
2022-04-11 |
2023-08-13 |
Not clear |
| Baoyu Ma, Yongxin Liu, Xiao Zhang, Rui Zhang, Zhenjiang Zhang, Zhihao Zhang, Jie Liu, Zhaodong Juan, Xiaotong Sun, Lina Sun, Jingyao Huang, Jinpeng Fen. TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation. Oxidative medicine and cellular longevity. vol 2022. 2022-04-11. PMID:35401924. |
taken together, tspo ligands pk11195 and midazolam showed neuroprotective effects by reducing the inflammatory response of lps-activated microglia, which may be related to the enhancement of mitophagy and the inhibition of nlrp3 inflammasome. |
2022-04-11 |
2023-08-13 |
Not clear |
| Ajay Kumar, Pawan Kumar Singh, Zeeshan Ahmed, Sukhvinder Singh, Ashok Kuma. Essential Role of NLRP3 Inflammasome in Mediating IL-1β Production and the Pathobiology of Staphylococcus aureus Endophthalmitis. Infection and immunity. 2022-04-11. PMID:35404106. |
moreover, we found that both infiltrating neutrophils and retinal microglia contribute toward nlrp3 activation and il-1β production in s. aureus-infected eyes. |
2022-04-11 |
2023-08-13 |
mouse |
| Xiao Hu, Qiongzhen Zeng, Ji Xiao, Shurong Qin, Yuan Wang, Tianhao Shan, Di Hu, Yexuan Zhu, Kaisheng Liu, Kai Zheng, Yifei Wang, Zhe Re. Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome. Frontiers in microbiology. vol 13. 2022-04-07. PMID:35387080. |
in this study, we confirmed for the first time that the dna virus hsv-1 triggers gasdermin d-dependent pyroptosis by activating nlr family pyrin domain containing 3 (nlrp3) inflammasomes in mouse microglia, leading to mature il-1β production and active caspase-1 (p10) release. |
2022-04-07 |
2023-08-13 |
mouse |
| Oualid Sbai, Mehdi Djelloul, Antonia Auletta, Alessandro Ieraci, Carlo Vascotto, L Perron. AGE-TXNIP axis drives inflammation in Alzheimer's by targeting Aβ to mitochondria in microglia. Cell death & disease. vol 13. issue 4. 2022-04-05. PMID:35379773. |
altogether these data shed new light on a novel mechanism of action of rage-txnip axis in microglia, which is intertwined with aβ and ultimately causes mitochondria dysfunction and nlrp3 inflammasome cascade activation, suggesting txnip as a druggable target to be better deepened for ad. |
2022-04-05 |
2023-08-13 |
mouse |
| Sahithi Attaluri, Meenakshi Arora, Leelavathi N Madhu, Maheedhar Kodali, Bing Shuai, Laila Melissari, Raghavendra Upadhya, Xiaolan Rao, Adrian Bates, Eeshika Mitra, Keyhan R Ghahfarouki, M N V Ravikumar, Ashok K Shett. Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression. Aging and disease. vol 13. issue 2. 2022-04-04. PMID:35371600. |
lessened neuroinflammation was noticeable from reductions in astrocyte hypertrophy, nf-kb, activated microglia with nlrp3 inflammasomes, and multiple proinflammatory cytokines. |
2022-04-04 |
2023-08-13 |
rat |
| Ana Catarina Pereira, Jessica De Pascale, Rosa Resende, Susana Cardoso, Isabel Ferreira, Bruno Miguel Neves, Mylène A Carrascal, Mónica Zuzarte, Nuno Madeira, Sofia Morais, António Macedo, Anália do Carmo, Paula I Moreira, Maria Teresa Cruz, Cláudia F Pereir. ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system. Cellular and molecular life sciences : CMLS. vol 79. issue 4. 2022-03-28. PMID:35344105. |
this work aimed to investigate the role of er-mitochondria communication during er stress-induced nlrp3 inflammasome activation in both peripheral and central innate immune systems, by using thp-1 human monocytes and bv2 microglia cells, respectively, as in vitro models. |
2022-03-28 |
2023-08-13 |
human |
| Ya Zheng, Benjamin Reiner, Jianuo Liu, Linda Xu, Huangui Xion. Methamphetamine augments HIV-1 gp120 inhibition of synaptic transmission and plasticity in rat hippocampal slices: Implications for methamphetamine exacerbation of HIV-associated neurocognitive disorders. Neurobiology of disease. 2022-03-26. PMID:35337950. |
further studies revealed an involvement of microglia nlrp3 inflammasome activation in meth augmentation of gp120-mediated attenuation of ltp. |
2022-03-26 |
2023-08-13 |
human |
| Hetao Bian, Feng Yan, Weili Li, Wenjun Tu, Xunming J. Tert-butylhydroquinone prevents neuroinflammation and relieves depression via regulation of NLRP3 signaling in mice. International immunopharmacology. vol 107. 2022-03-26. PMID:35338961. |
these results suggested that, by inhibiting lps-induced neuroinflammation and microglia activation, tbhq could effectively improve lps-induced inflammation-related depression-like behavior through modulating the nlrp3 signaling pathway. |
2022-03-26 |
2023-08-13 |
mouse |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
dopamine, in turn, has been shown to inhibit nlrp3 inflammasome activation in microglia. |
2022-03-25 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
in this review, we provide a literature framework for a hypothesis in which kv1.3 activity-induced nlrp3 inflammasome activation, evoked by stimuli such as α-synuclein, could lead to microglia utilizing dopamine from adjacent dopaminergic neurons to counteract this process and fend off an activated state. |
2022-03-25 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
if this is the case, a sufficient dopamine supply would ensure that microglia remain under control, but as dopamine is gradually siphoned from the neurons by microglial demand, nlrp3 inflammasome activation and kv1.3 activity would progressively intensify to promote each of the three major facets of pd pathology: α-synuclein aggregation, microglia-mediated neuroinflammation, and dopaminergic neurodegeneration. |
2022-03-25 |
2023-08-13 |
Not clear |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
p2x4 inhibition reduces microglia inflammation and apoptosis by nlrp3 and improves nervous system defects in rat brain trauma model. |
2022-03-15 |
2023-08-13 |
rat |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
the inhibition of p2x4 effectively reduced the inflammation and apoptosis of microglia, and nlrp3 may be involved in this process. |
2022-03-15 |
2023-08-13 |
rat |
| Ting Xiao, Heyu Ji, Xuejuan Shangguan, Shuangquan Qu, Yulong Cui, Junmei X. NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. Biochemical and biophysical research communications. vol 602. 2022-03-05. PMID:35247698. |
nlrp3 inflammasome of microglia promotes a1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. |
2022-03-05 |
2023-08-13 |
mouse |
| Ting Xiao, Heyu Ji, Xuejuan Shangguan, Shuangquan Qu, Yulong Cui, Junmei X. NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia. Biochemical and biophysical research communications. vol 602. 2022-03-05. PMID:35247698. |
taken together, nlrp3 inflammasome of microglia promotes transformation of a1 astrocytes and consequently exacerbates neo-neuron decline, resulting in cognitive impairment after a challenge of lps. |
2022-03-05 |
2023-08-13 |
mouse |
| Adrianne F Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A C Herrebout, Mona M H E Fayed, Michele Sandre, Tatiana Varanita, Charlotte E Teunissen, Jeroen J M Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacc. Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-02-17. PMID:35172843. |
degenerating neurons are surrounded by activated microglia with increased secretion of interleukin-1β (il-1β), driven largely by the nlrp3 inflammasome. |
2022-02-17 |
2023-08-13 |
mouse |
| Adrianne F Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A C Herrebout, Mona M H E Fayed, Michele Sandre, Tatiana Varanita, Charlotte E Teunissen, Jeroen J M Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacc. Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-02-17. PMID:35172843. |
dopamine blocks microglial nlrp3 inflammasome activation in the mptp model, but its effects in this framework, highly relevant to pd, remain unexplored in primary human microglia and in other in vivo parkinsonism models. |
2022-02-17 |
2023-08-13 |
mouse |
| Eun S Park, Sehee Kim, Derek C Yao, Jude P J Savarraj, Huimahn Alex Choi, Peng Roc Chen, Eunhee Ki. Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163148. |
we found that seng increased the gene expression of vegf-a, pro-inflammatory cytokines/inflammasome mediators (tnf-α, il-6, nlrp3, asc, caspase-1, and il-1β), and proteolytic enzyme (mmp-9) in bv2 microglia. |
2022-02-15 |
2023-08-13 |
mouse |
| Hui Yuan, Bo Lu, Yiqin Ji, Bo Meng, Ruichun Wang, Daofan Sun, Rongjun Liu, Xiaojie Zhai, Xiaoyu Li, Jinling Qin, Junping Che. Role of P2X4/NLRP3 Pathway-Mediated Neuroinflammation in Perioperative Neurocognitive Disorders. Mediators of inflammation. vol 2022. 2022-02-14. PMID:35153623. |
the level of p2x4r and nlrp3 was estimated by western blot, the activation of microglia was detected via immunohistochemistry, and the expression of tnf- |
2022-02-14 |
2023-08-13 |
mouse |