| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Wang, Meina Ma, Hong Yu, Hongmei Yu, Shuai Zhang, Rui L. Mirtazapine prevents cell activation, inflammation, and oxidative stress against isoflurane exposure in microglia. Bioengineered. vol 13. issue 1. 2021-12-29. PMID:34964706. |
mirtazapine prevented isoflurane-induced production of the pro-inflammatory factors interleukin (il)-1β and il-18 by inhibiting the activation of the nod-like receptor family protein 3 (nlrp3) inflammasome in bv2 microglia. |
2021-12-29 |
2023-08-13 |
Not clear |
| Jialong Chen, Kanmin Mao, Honglin Yu, Yue Wen, Hua She, He Zhang, Linhua Liu, Mingque Li, Wenjun Li, Fei Zo. p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. Journal of neuroinflammation. vol 18. issue 1. 2021-12-21. PMID:34930303. |
p38-tfeb pathways promote microglia activation through inhibiting cma-mediated nlrp3 degradation in parkinson's disease. |
2021-12-21 |
2023-08-13 |
Not clear |
| Matthew G Frank, Kathy H Nguyen, Jayson B Ball, Shelby Hopkins, Tel Kelley, Michael V Baratta, Monika Fleshner, Steven F Maie. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: evidence of PAMP-like properties. Brain, behavior, and immunity. 2021-12-16. PMID:34915155. |
direct exposure of microglia to s1 resulted in increased gene expression (il1b, il6, tnf, nlrp3) and protein levels (il-1β, il-6, tnf, cxcl1, il-10). |
2021-12-16 |
2023-08-13 |
human |
| Yahui Zhang, Baohua Hou, Peiyu Liang, Xin Lu, Yifan Wu, Xinyi Zhang, Yuanteng Fan, Yumin Liu, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Song Han, Xiaohua H. TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia. Cell death & disease. vol 12. issue 12. 2021-12-15. PMID:34907173. |
trpv1 channel mediates nlrp3 inflammasome-dependent neuroinflammation in microglia. |
2021-12-15 |
2023-08-13 |
Not clear |
| Da-Yong Xia, Jin-Long Yuan, Xiao-Chun Jiang, Min Qi, Nian-Sheng Lai, Ling-Yun Wu, Xiang-Sheng Zhan. SIRT1 Promotes M2 Microglia Polarization Frontiers in immunology. vol 12. 2021-12-13. PMID:34899720. |
in the present study, we first observed that ex527, a potent selective sirt1 inhibitor, enhanced microglial m1 polarization and nod-like receptor pyrin domain-containing 3 (nlrp3) inflammasome activation in microglia after sah. |
2021-12-13 |
2023-08-13 |
Not clear |
| Ting Wang, Bo Ruan, Jinxin Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Haixia Zhao, Yuanjian Yang, Ding Yua. Activation of NLRP3-Caspase-1 pathway contributes to age-related impairments in cognitive function and synaptic plasticity. Neurochemistry international. vol 152. 2021-12-11. PMID:34743016. |
nlrp3 inflammasome in microglia is fundamental for il-1β maturation and subsequent inflammatory events. |
2021-12-11 |
2023-08-13 |
rat |
| Meiyun Cai, Wenxin Zhuang, E Lv, Zhan Liu, Yanqiang Wang, Wenyi Zhang, Wenyu F. Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway. Neurochemistry international. vol 152. 2021-12-11. PMID:34780806. |
the results showed kae could ameliorate the behavioral deficits of parkinson's disease (pd) rats, inhibit the activation of microglia and astrocytes, reduce the loss of th-positive neurons, down-regulate levels of pyroptosis-related nod-like receptor family pyrin domain containing 3 (nlrp3), gasdermind-n term (gsdmd-nt), caspase1, apoptosis-associated speck-like protein containing a caspase-recruitment domain (asc), interleukin (il)-1β, and il-18, and decrease the levels of inflammatory molecules (inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2)) and p38 mitogen-activated protein kinase/nuclear factor-kappab (p38mapk/nf-κb) signaling pathway molecules (p38mapk, p-p38mapk, nf-κb, and p-nf-κb) in the substantia nigra of pd rats. |
2021-12-11 |
2023-08-13 |
rat |
| Kai Wang, Cai Lu, Tong Wang, Chen Qiao, Linyu Lu, Die Wu, Ming Lu, Ruini Chen, Lu Fan, Juanjuan Tan. Hyperoside suppresses NLRP3 inflammasome in Parkinson's disease via Pituitary Adenylate Cyclase-Activating Polypeptide. Neurochemistry international. vol 152. 2021-12-11. PMID:34883151. |
pacap 6-38 reversed the inhibitory effect of hyperoside on the microglia proliferation and activation of the nlrp3 inflammasome. |
2021-12-11 |
2023-08-13 |
mouse |
| Yuying Pei, Fafeng Cheng, Wei Li, Qiaoyu Yu, Chongyang Ma, Yan Zou, Tian Xu, Shuling Liu, Shuang Zhang, Qingguo Wan. Enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting NLRP3 inflammasome. Journal of bioscience and bioengineering. 2021-12-10. PMID:34887181. |
enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting nlrp3 inflammasome. |
2021-12-10 |
2023-08-13 |
cattle |
| Arjun Sapkota, Ji Woong Cho. Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation. Biomolecules & therapeutics. 2021-12-08. PMID:34873072. |
oa also attenuated nlrp3 inflammasome activation in activated microglia during the acute phase. |
2021-12-08 |
2023-08-13 |
mouse |
| Rui-Yuan Pan, Xiang-Xi Kong, Yong Cheng, Lu Du, Zhen-Chao Wang, Chao Yuan, Jin-Bo Cheng, Zeng-Qiang Yuan, Hai-Yan Zhang, Ya-Jin Lia. 1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis. Acta pharmacologica Sinica. vol 42. issue 11. 2021-12-07. PMID:33627802. |
we showed that 1,2,4-ttb (1 mm) markedly suppressed nigericin- or atp-induced nlrp3 inflammasome activation, thus decreased caspase-1 activation and il-1β secretion in immortalized murine bone marrow-derived macrophages (ibmdms) and in primary mouse microglia. |
2021-12-07 |
2023-08-13 |
mouse |
| Bora Tastan, Burak I Arioz, Kemal Ugur Tufekci, Emre Tarakcioglu, Ceren Perihan Gonul, Kursad Genc, Sermin Gen. Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice. Frontiers in immunology. vol 12. 2021-12-06. PMID:34858398. |
dimethyl fumarate alleviates nlrp3 inflammasome activation in microglia and sickness behavior in lps-challenged mice. |
2021-12-06 |
2023-08-13 |
mouse |
| Alexander G Marnero. Role of inflammasome activation in neovascular age-related macular degeneration. The FEBS journal. 2021-12-04. PMID:34767301. |
furthermore, inflammasome activation can occur in cnv macrophages and microglia despite lack of nlrp3. |
2021-12-04 |
2023-08-13 |
Not clear |
| Kemal Ugur Tufekci, Bedir Irem Eltutan, Kamer Burak Isci, Sermin Gen. Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34739715. |
resveratrol inhibits nlrp3 inflammasome-induced pyroptosis and mir-155 expression in microglia through sirt1/ampk pathway. |
2021-12-03 |
2023-08-13 |
Not clear |
| Kemal Ugur Tufekci, Bedir Irem Eltutan, Kamer Burak Isci, Sermin Gen. Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34739715. |
to sum up, our results suggest that resveratrol suppresses the nlrp3 inflammasome and mir-155 expression through ampk and sirt1 pathways in microglia. |
2021-12-03 |
2023-08-13 |
Not clear |
| Xian Zhang, Qing Shu, Zhanhui Liu, Chao Gao, Zhenhua Wang, Zhiguo Xing, Jinning Son. Recombinant osteopontin provides protection for cerebral infarction by inhibiting the NLRP3 inflammasome in microglia. Brain research. vol 1751. 2021-11-30. PMID:33157099. |
recombinant osteopontin provides protection for cerebral infarction by inhibiting the nlrp3 inflammasome in microglia. |
2021-11-30 |
2023-08-13 |
rat |
| Xian Zhang, Qing Shu, Zhanhui Liu, Chao Gao, Zhenhua Wang, Zhiguo Xing, Jinning Son. Recombinant osteopontin provides protection for cerebral infarction by inhibiting the NLRP3 inflammasome in microglia. Brain research. vol 1751. 2021-11-30. PMID:33157099. |
the effects of opn on cerebral ischemic injury, neural function, microglia inflammation and nlrp3 inflammasome function were studied by immunofluorescence, staining, enzyme-linked immunosorbent assay and western blot assay. |
2021-11-30 |
2023-08-13 |
rat |
| Xian Zhang, Qing Shu, Zhanhui Liu, Chao Gao, Zhenhua Wang, Zhiguo Xing, Jinning Son. Recombinant osteopontin provides protection for cerebral infarction by inhibiting the NLRP3 inflammasome in microglia. Brain research. vol 1751. 2021-11-30. PMID:33157099. |
we found that opn was also involved in the negative regulation of inflammasome and microglia activity in cerebral ischemic injury, and that opn inhibited the activation of nlrp3 inflammasome and the function of microglia in a lps-induced inflammatory model. |
2021-11-30 |
2023-08-13 |
rat |
| Kishore Aravind Ravichandran, Michael T Henek. Inflammasome activation in neurodegenerative diseases. Essays in biochemistry. 2021-11-30. PMID:34846519. |
molecular sensors within these microglia, such as the nlrp3 inflammasome, are activated by signals that represent the hallmarks of neurodegenerative diseases. |
2021-11-30 |
2023-08-13 |
mouse |
| Dorit Trudler, Kristopher L Nazor, Yvonne S Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S Goodwin, Yona Levites, Todd E Golde, Jeffery W Kelly, Michael R Sierks, Nicholas J Schork, Michael Karin, Rajesh Ambasudhan, Stuart A Lipto. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 15. 2021-11-29. PMID:33833060. |
soluble α-synuclein-antibody complexes activate the nlrp3 inflammasome in hipsc-derived microglia. |
2021-11-29 |
2023-08-13 |
mouse |