| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lanlan Zhong, Xingshu Ren, Yuhang Ai, Zhiyong Li. SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation. Neuromolecular medicine. 2022-11-05. PMID:36333543. |
the increase of nucleotide-binding oligomerization domain 3 (nlrp3) and phosphorylated dynamin-related protein 1 (drp1) ser616 in microglia was attenuated by ss-31. |
2022-11-05 |
2023-08-14 |
mouse |
| Yi Tian, Meihui Li, Shanshan Zhang, Juntao Hu, Haoran Wu, Mitchell Wan, Jingxin Xue, Leilei Wang, Honglei Xiao, Guomin Zhou, Kaidi Wang, Qiong Li. Microglia activation in the hippocampus mediates retinal degeneration-induced depressive-like behaviors via the NLRP3/IL-1β pathway. Brain research bulletin. 2022-11-04. PMID:36332880. |
after tissue collection, we used immunohistochemistry to assess the activation of microglia and real-time polymerase chain reaction to measure the levels of pro-inflammatory cytokines and the nod-, lrr-, and pyrin-domain containing protein 3 (nlrp3) inflammasome. |
2022-11-04 |
2023-08-14 |
mouse |
| Shukai Sun, Wenkai Jiang, Xia Yan, Jing Zhang, Lei Gao, Chunfeng Wu, Bin Zhu, Lian W. Ligand-gated ion channel P2X7 regulates NLRP3/Caspase-1-mediated inflammatory pain caused by pulpitis in the trigeminal ganglion and medullary dorsal horn. Brain research bulletin. 2022-11-03. PMID:36328143. |
moreover, treatment with 130nm kcl, a p2x7 inhibitor, significantly reduced the expression of nlrp3, il-1β, il-18, caspase-1, and p2x7 in microglia after lipopolysaccharide(lps) stimulation. |
2022-11-03 |
2023-08-14 |
rat |
| Eduardo A Albornoz, Alberto A Amarilla, Naphak Modhiran, Sandra Parker, Xaria X Li, Danushka K Wijesundara, Julio Aguado, Adriana Pliego Zamora, Christopher L D McMillan, Benjamin Liang, Nias Y G Peng, Julian D J Sng, Fatema Tuj Saima, Jenny N Fung, John D Lee, Devina Paramitha, Rhys Parry, Michael S Avumegah, Ariel Isaacs, Martin W Lo, Zaray Miranda-Chacon, Daniella Bradshaw, Constanza Salinas-Rebolledo, Niwanthi W Rajapakse, Ernst J Wolvetang, Trent P Munro, Alejandro Rojas-Fernandez, Paul R Young, Katryn J Stacey, Alexander A Khromykh, Keith J Chappell, Daniel Watterson, Trent M Woodruf. SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular psychiatry. 2022-11-01. PMID:36316366. |
sars-cov-2 drives nlrp3 inflammasome activation in human microglia through spike protein. |
2022-11-01 |
2023-08-14 |
mouse |
| Eduardo A Albornoz, Alberto A Amarilla, Naphak Modhiran, Sandra Parker, Xaria X Li, Danushka K Wijesundara, Julio Aguado, Adriana Pliego Zamora, Christopher L D McMillan, Benjamin Liang, Nias Y G Peng, Julian D J Sng, Fatema Tuj Saima, Jenny N Fung, John D Lee, Devina Paramitha, Rhys Parry, Michael S Avumegah, Ariel Isaacs, Martin W Lo, Zaray Miranda-Chacon, Daniella Bradshaw, Constanza Salinas-Rebolledo, Niwanthi W Rajapakse, Ernst J Wolvetang, Trent P Munro, Alejandro Rojas-Fernandez, Paul R Young, Katryn J Stacey, Alexander A Khromykh, Keith J Chappell, Daniel Watterson, Trent M Woodruf. SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular psychiatry. 2022-11-01. PMID:36316366. |
mechanistically, we demonstrated that purified sars-cov-2 spike glycoprotein activated the nlrp3 inflammasome in lps-primed microglia, in a ace2-dependent manner. |
2022-11-01 |
2023-08-14 |
mouse |
| Jiawei Zhu, Fan Zhou, Qin Zhou, Yongjie Xu, Yunting Li, Dingbang Huang, Lixuan Chen, Anfei Liu, Fei Zou, Xiaojing Men. NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2022-10-29. PMID:36308466. |
nlrp3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice. |
2022-10-29 |
2023-08-14 |
mouse |
| Jiawei Zhu, Fan Zhou, Qin Zhou, Yongjie Xu, Yunting Li, Dingbang Huang, Lixuan Chen, Anfei Liu, Fei Zou, Xiaojing Men. NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2022-10-29. PMID:36308466. |
our results showed that chronic pb exposure induce learning and memory impairment in mice, mainly related to the activation of microglia and nlrp3 inflammasome. |
2022-10-29 |
2023-08-14 |
mouse |
| Jiawei Zhu, Fan Zhou, Qin Zhou, Yongjie Xu, Yunting Li, Dingbang Huang, Lixuan Chen, Anfei Liu, Fei Zou, Xiaojing Men. NLRP3 activation in microglia contributes to learning and memory impairment induced by chronic lead exposure in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2022-10-29. PMID:36308466. |
in conclusion, nlrp3 inflammasome activation in microglia plays a vital role in pb neurotoxicity, by a novel mechanism of enhancing mtros production and ca2+ redistribution. |
2022-10-29 |
2023-08-14 |
mouse |
| Shanshan Li, Yinquan Fang, Yihe Zhang, Mengmeng Song, Xilin Zhang, Xiao Ding, Hang Yao, Miaomiao Chen, Yiming Sun, Jianhua Ding, Qin Wang, Ming Lu, Guangyu Wu, Gang H. Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice. Cell reports. vol 41. issue 4. 2022-10-26. PMID:36288697. |
we further show that in microglia the nf-κb pathway activates the nlrp3 inflammasome which in turn activates caspase-1 to induce the secretion of a1 inductors, leading to the production of a1-like astrocytes. |
2022-10-26 |
2023-08-14 |
mouse |
| Carolina A Moraes, Eugenio D Hottz, Débora Dos Santos Ornellas, Daniel Adesse, Carolina T de Azevedo, Joana C d'Avila, Camila Zaverucha-do-Valle, Tatiana Maron-Gutierrez, Helene Santos Barbosa, Patricia Torres Bozza, Fernando Augusto Bozz. Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy. Molecular neurobiology. 2022-10-24. PMID:36280654. |
meanwhile, an in vitro model of primary microglia stimulated with lps exhibited an increase in mitochondrial reactive oxygen species (ros) production, nlrp3 complex recruitment, and il-1β release. |
2022-10-24 |
2023-08-14 |
mouse |
| Ru-Huei Fu, Chia-Wen Tsai, Shao-Chih Chiu, Shih-Ping Liu, Yu-Ting Chiang, Yun-Hua Kuo, Woei-Cherng Shyu, Shinn-Zong Li. C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect. Cells. vol 11. issue 19. 2022-10-14. PMID:36231090. |
c9-als-associated proline-arginine dipeptide repeat protein induces activation of nlrp3 inflammasome of hmc3 microglia cells by binding of complement component 1 q subcomponent-binding protein (c1qbp), and syringin prevents this effect. |
2022-10-14 |
2023-08-14 |
Not clear |
| Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Caroline Zanotto, Larissa Daniele Bobermin, Ana Cristina Roginski, Moacir Wajner, André Quincozes-Santos, Carlos Alberto Gonçalve. Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. Journal of neuroinflammation. vol 19. issue 1. 2022-10-11. PMID:36221097. |
moreover, the inhibition of s100b, a protein predominantly synthesized and secreted by astrocytes, inhibition of microglia activation and abrogation of nlrp3 inflammasome assembly confirmed the role of neuroinflammation in the upregulation of glycolysis in the hippocampus. |
2022-10-11 |
2023-08-14 |
rat |
| Ya Gao, Shuyue Li, Yidan Zhang, Jian Zhang, Yuan Zhao, Cui Chang, Xuan Gao, Guofeng Yan. Cattle Encephalon Glycoside and Ignotin Attenuates Aβ1-42-Mediated Neurotoxicity by Preventing NLRP3 Inflammasome Activation and Modulating Microglial Polarization via TLR4/NF-κB Signaling Pathway. Neurotoxicity research. 2022-10-10. PMID:36214996. |
however, it is not clear whether cegi can inhibit nlrp3 inflammasome activation and regulate the polarization of microglia in ad and whether its effects rely on tlr4/nf-κb signaling pathway. |
2022-10-10 |
2023-08-14 |
mouse |
| Ya Gao, Shuyue Li, Yidan Zhang, Jian Zhang, Yuan Zhao, Cui Chang, Xuan Gao, Guofeng Yan. Cattle Encephalon Glycoside and Ignotin Attenuates Aβ1-42-Mediated Neurotoxicity by Preventing NLRP3 Inflammasome Activation and Modulating Microglial Polarization via TLR4/NF-κB Signaling Pathway. Neurotoxicity research. 2022-10-10. PMID:36214996. |
furthermore, the roles of cegi in inhibiting nlrp3 inflammasome activation, modulating microglia m1/m2 polarization, and increasing aβ degrading enzyme expression were further validated in vivo using app/ps1 mice. |
2022-10-10 |
2023-08-14 |
mouse |
| Ya Gao, Shuyue Li, Yidan Zhang, Jian Zhang, Yuan Zhao, Cui Chang, Xuan Gao, Guofeng Yan. Cattle Encephalon Glycoside and Ignotin Attenuates Aβ1-42-Mediated Neurotoxicity by Preventing NLRP3 Inflammasome Activation and Modulating Microglial Polarization via TLR4/NF-κB Signaling Pathway. Neurotoxicity research. 2022-10-10. PMID:36214996. |
in conclusion, cegi promotes aβ degradation and protects microglia against aβ1-42-induced neurotoxicity by preventing nlrp3 inflammasome activation and regulating m1/m2 polarization via tlr4/nf-κb pathways. |
2022-10-10 |
2023-08-14 |
mouse |
| Janeli Viil, Kelli Somelar-Duracz, Külli Jaako, Kaili Anier, Alexander Zharkovsk. Characterization of IMG Microglial Cell Line as a Valuable In Vitro Tool for NLRP3 Inflammasome Studies. Cellular and molecular neurobiology. 2022-09-27. PMID:36163404. |
characterization of img microglial cell line as a valuable in vitro tool for nlrp3 inflammasome studies. |
2022-09-27 |
2023-08-14 |
mouse |
| Janeli Viil, Kelli Somelar-Duracz, Külli Jaako, Kaili Anier, Alexander Zharkovsk. Characterization of IMG Microglial Cell Line as a Valuable In Vitro Tool for NLRP3 Inflammasome Studies. Cellular and molecular neurobiology. 2022-09-27. PMID:36163404. |
here, we investigated whether the mouse microglial cell line img is suitable to study nlrp3 inflammasome by incubating cells with different concentrations of nlrp3 inflammasome priming and activating agents lipopolysaccharide (lps) and atp, respectively, and applying short (4 h) or long (24 h) lps incubation times. |
2022-09-27 |
2023-08-14 |
mouse |
| Xiu Chen, Juan-Ling He, Xue-Ting Liu, Na Zhao, Fan Geng, Meng-Meng Zhu, Gong-Ping Liu, Qing-Guo Re. DI-3-n-butylphthalide mitigates stress-induced cognitive deficits in mice through inhibition of NLRP3-Mediated neuroinflammation. Neurobiology of stress. vol 20. 2022-09-26. PMID:36160816. |
activated microglia and nlrp3 inflammasome were found after 8-week chronic stress. |
2022-09-26 |
2023-08-14 |
mouse |
| Jung Lo, Ching-Chih Liu, Yueh-Shan Li, Po-Yen Lee, Po-Len Liu, Pei-Chang Wu, Tzu-Chieh Lin, Chi-Shuo Chen, Chien-Chih Chiu, Yu-Hung Lai, Yo-Chen Chang, Hsin-En Wu, Yuan-Ru Chen, Yu-Kai Huang, Shu-Pin Huang, Shu-Chi Wang, Chia-Yang L. Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation. Journal of inflammation research. vol 15. 2022-09-22. PMID:36131784. |
punicalagin attenuates lps-induced inflammation and ros production in microglia by inhibiting the mapk/nf-κb signaling pathway and nlrp3 inflammasome activation. |
2022-09-22 |
2023-08-14 |
Not clear |
| Jung Lo, Ching-Chih Liu, Yueh-Shan Li, Po-Yen Lee, Po-Len Liu, Pei-Chang Wu, Tzu-Chieh Lin, Chi-Shuo Chen, Chien-Chih Chiu, Yu-Hung Lai, Yo-Chen Chang, Hsin-En Wu, Yuan-Ru Chen, Yu-Kai Huang, Shu-Pin Huang, Shu-Chi Wang, Chia-Yang L. Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation. Journal of inflammation research. vol 15. 2022-09-22. PMID:36131784. |
this study aimed to investigate the effects of punicalagin on lps-induced inflammatory responses, nlrp3 inflammasome activation, and the production of ros using murine microglia bv2 cells. |
2022-09-22 |
2023-08-14 |
Not clear |