| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingchen Wang, Zhiping Yang, Xintong Wu, Xiao Zhang, Feng Geng, Qiaoyun Wang, Zikai Geng, Chen Yu, Zhipeng L. Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn. International immunopharmacology. vol 111. 2022-08-13. PMID:35963156. |
our study demonstrated that chrysin inhibited the activation of microglia and reduced the expression of nlrp3 and il-1β. |
2022-08-13 |
2023-08-14 |
mouse |
| Kristine E Zengeler, John R Luken. Taking the parkin brakes off of neuronal NLRP3 drives inflammasome activation and neurodegeneration in Parkinson's disease. Neuron. vol 110. issue 15. 2022-08-04. PMID:35926449. |
nlrp3 is a central driver of neurodegeneration thought to function mainly in microglia. |
2022-08-04 |
2023-08-14 |
Not clear |
| Si-Yu Wang, Xin-Xin Fu, Rui Duan, Bin Wei, Hai-Ming Cao, E Yan, Shuai-Yu Chen, Ying-Dong Zhang, Teng Jian. The Alzheimer's disease-associated gene Neural regeneration research. vol 18. issue 2. 2022-07-28. PMID:35900442. |
lps stimulation increased the levels of nlrp3 in primary microglia. |
2022-07-28 |
2023-08-14 |
mouse |
| Ana Belen Lopez-Rodriguez, Céline Decouty-Perez, Victor Farré-Alins, Alejandra Palomino-Antolín, Paloma Narros-Fernández, Javier Ege. Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma. Pharmaceutics. vol 14. issue 8. 2022-07-27. PMID:35893807. |
activation of nlrp3 is required for a functional and beneficial microglia response after brain trauma. |
2022-07-27 |
2023-08-14 |
mouse |
| Chenyang Han, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Caiqun Zhang, Li Guo, Yi Yan. Double-negative T cells mediate M1 polarization of microglial cells via TNF-α-NLRP3 to aggravate neuroinflammation and cognitive impairment in Alzheimer's disease mice. Journal of cellular physiology. 2022-07-22. PMID:35866513. |
dnts were later cocultured with mice microglial cell line bv2, then fluorescence staining was conducted to detect nlrp3 expression, and enzyme-linked immunoassay was performed to measure the expression of inflammatory factors. |
2022-07-22 |
2023-08-14 |
mouse |
| Yukitoshi Izumi, Chika Fujii, Kazuko A O'Dell, Charles F Zorumsk. Acrylamide inhibits long-term potentiation and learning involving microglia and pro-inflammatory signaling. Scientific reports. vol 12. issue 1. 2022-07-20. PMID:35858988. |
these results indicate that cognitive impairment by acrylamide is mediated by mechanisms involving microglia and release of cytokines via nlrp3 activation. |
2022-07-20 |
2023-08-14 |
rat |
| Emre Tarakcioglu, Bora Tastan, Burak I Arioz, Kemal Ugur Tufekci, Sermin Gen. Melatonin Alters the miRNA Transcriptome of Inflammasome Activation in Murine Microglial Cells. Neurochemical research. 2022-07-16. PMID:35842554. |
for that purpose, we have performed rna sequencing on a lipopolysaccharide and adenosine triphosphate (lps + atp) induced nlr family pyrin domain containing 3 (nlrp3) inflammasome activation model in the n9 mouse microglial cell line, with and without melatonin pre-treatment. |
2022-07-16 |
2023-08-14 |
mouse |
| Yiping Chen, Chongyao Hao, Wenjie Chen, Wenjing Cheng, Peng Li, Junliang Shen, Tao Tong, Simin Yan, Shuqiong Huang, Tianwei He, Zhiyong Huang, Xianjun Men. Anti-depressant Effects of Acupuncture: the Insights from NLRP3 mediated Pyroptosis and Inflammation. Neuroscience letters. 2022-07-12. PMID:35820551. |
results showed that acupuncture significantly improved the depression-like behavior of cums rat, suppressed the expressions of nlrp3, asc, caspase-1, gsdmd, il-1β, il-18, hmgb1, ifn-γ, il-6 and tnf-α in the serum and hippocampus, restored the %area of microglia, astrocytes and neuronal cells in the hippocampus. |
2022-07-12 |
2023-08-14 |
rat |
| Fan Jie, Xuan Yang, Bowen Yang, Yan Liu, Lipeng Wu, Baiyi L. Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-06-30. PMID:35772378. |
stigmasterol attenuates inflammatory response of microglia via nf-κb and nlrp3 signaling by ampk activation. |
2022-06-30 |
2023-08-14 |
Not clear |
| Yu Cui, Nan-Nan Zhang, Dan Wang, Wei-Hong Meng, Hui-Sheng Che. Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia. Journal of inflammation research. vol 15. 2022-06-16. PMID:35706530. |
modified citrus pectin alleviates cerebral ischemia/reperfusion injury by inhibiting nlrp3 inflammasome activation via tlr4/nf-ĸb signaling pathway in microglia. |
2022-06-16 |
2023-08-14 |
Not clear |
| Shanshan Zhang, Juntao Hu, Guixue Liu, Haoran Wu, Meihui Li, Chenye Shi, Qiong Liu, Wensheng L. Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress. Translational psychiatry. vol 12. issue 1. 2022-06-10. PMID:35688836. |
rats exhibited defective behavior and hippocampal neuroinflammation after 12 weeks of cms, which included elevated expression of cleaved interleukin-1β (il-1β) and nlrp3 inflammasome together with the activation of microglia. |
2022-06-10 |
2023-08-14 |
rat |
| Shanshan Zhang, Juntao Hu, Guixue Liu, Haoran Wu, Meihui Li, Chenye Shi, Qiong Liu, Wensheng L. Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress. Translational psychiatry. vol 12. issue 1. 2022-06-10. PMID:35688836. |
all these results indicate that the nlrp3 inflammasome of microglia in the hippocampus is related to the antidepressant effects of clomipramine and cms-induced depressive-like behavior in rats. |
2022-06-10 |
2023-08-14 |
rat |
| Heng Fang, Yirong Wang, Jia Deng, Huidan Zhang, Qingrui Wu, Linling He, Jing Xu, Xin Shao, Xin Ouyang, Zhimei He, Qiuping Zhou, Huifang Wang, Yiyu Deng, Chunbo Che. Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice. mSystems. 2022-06-01. PMID:35642838. |
moreover, ipa markedly inhibited nlrp3 inflammasome activation and interleukin-1β (il-1β) secretion in lipopolysaccharide-stimulated microglia. |
2022-06-01 |
2023-08-13 |
mouse |
| Dylan A Galloway, Samantha J Carew, Stephanie N Blandford, Rochelle Y Benoit, Neva Fudge, Tangyne Berry, G R Wayne Moore, Jane Barron, Craig S Moor. Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination. Journal of neurochemistry. 2022-05-28. PMID:35633501. |
we observed that nlrp3 inflammasome components and microrna-223-3p were upregulated at sites of myelin injury within activated macrophages and microglia. |
2022-05-28 |
2023-08-13 |
mouse |
| Dylan A Galloway, Samantha J Carew, Stephanie N Blandford, Rochelle Y Benoit, Neva Fudge, Tangyne Berry, G R Wayne Moore, Jane Barron, Craig S Moor. Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination. Journal of neurochemistry. 2022-05-28. PMID:35633501. |
both microrna-223-3p and a small-molecule nlrp3 inhibitor, mcc950, supressed inflammasome activation in macrophages and microglia in vitro; compared with microglia, macrophages were more prone to inflammasome activation in vitro. |
2022-05-28 |
2023-08-13 |
mouse |
| Dylan A Galloway, Samantha J Carew, Stephanie N Blandford, Rochelle Y Benoit, Neva Fudge, Tangyne Berry, G R Wayne Moore, Jane Barron, Craig S Moor. Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination. Journal of neurochemistry. 2022-05-28. PMID:35633501. |
in conclusion, we demonstrate that nlrp3 inflammasome activity by macrophages and microglia is a critical component of the inflammatory microenvironment following demyelination and represents a potential therapeutic target for inflammatory-mediated demyelinating diseases, including ms. |
2022-05-28 |
2023-08-13 |
mouse |
| Jia-Mei Li, Ting Hu, Chun-Lei Jiang, Wei Wan. Pinocembrin ameliorates depressive-like behaviors by regulating P2X7/TRL4 receptors expression in mouse hippocampus. Behavioural pharmacology. 2022-05-27. PMID:35621136. |
toll-like receptor 4 (tlr4) and p2x7 receptor (p2x7r) were recently reckoned pivotally to regulate nod-like receptor protein 3 (nlrp3) in microglia. |
2022-05-27 |
2023-08-13 |
mouse |
| Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E Barclay, Ramona M Rodriguiz, William C Wetsel, Ting Yang, Mari L Shinohara, Niccolò Terrand. Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome. Frontiers in immunology. vol 13. 2022-05-23. PMID:35603196. |
surgery triggered asc specks formation in ca1 hippocampal microglia, but without inducing significant morphological changes in nlrp3 and asc knockout mice. |
2022-05-23 |
2023-08-13 |
mouse |
| Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-23. PMID:35605300. |
however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1ß), tumor necrosis factor-alpha (tnfα), and nuclear factor kappa b (nf-κb)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. |
2022-05-23 |
2023-08-13 |
mouse |
| Lin Liu, Tingting Zhou, Tao Li, Zhanhua Liang, Xiaoguang Lu. LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis. Behavioural brain research. 2022-05-13. PMID:35550840. |
meanwhile, the cell number of th+/caspase3+/iba1+ in substantia nigra, cell viability, and apoptosis rate of bv2 microglia, inflammatory levels, and nlr family pyrin domain containing 3 (nlrp3) inflammasome were determined using immunohistochemistry, mtt assay, flow cytometry, elisa assay, and western blot. |
2022-05-13 |
2023-08-13 |
mouse |