| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Devlina Ghosh, Gajendra Singh, Prabhaker Mishra, Aditi Singh, Alok Kumar, Neeraj Sinh. Alteration in mitochondrial dynamics promotes the proinflammatory response of microglia and is involved in cerebellar dysfunction of young and aged mice following LPS exposure. Neuroscience letters. 2023-04-28. PMID:37116576. |
following lps stimulation, we observed microglia activation and subsequent elevation in proinflammatory cytokines (m1; tnf-α, ifn-γ) with nlrp3 activationand a concomitant reduction in the expression of anti-inflammatory markers (m2; ym1, tgf-β1) in the cerebellar tissue of aged mice compared with the young lps and aged controls. |
2023-04-28 |
2023-08-14 |
mouse |
| Guohao Wang, Weiqin Yin, Hyunhee Shin, Qingjun Tian, Wei Lu, Steven X Ho. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nature aging. vol 1. issue 11. 2023-04-28. PMID:37118341. |
ablation of arf1 in cultured primary neurons led to an increase in peroxidated lipids in co-cultured microglia, activation of the microglial nlrp3 inflammasome and release of inflammatory cytokines in an apolipoprotein e-dependent manner. |
2023-04-28 |
2023-08-14 |
mouse |
| Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qi. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072933. |
degradation of nlrp3 by p62-dependent-autophagy improves cognitive function in alzheimer's disease by maintaining the phagocytic function of microglia. |
2023-04-19 |
2023-08-14 |
Not clear |
| Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qi. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072933. |
activation of the nlrp3 inflammasome promotes microglia to secrete inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and clearance functions of microglia in alzheimer's disease (ad). |
2023-04-19 |
2023-08-14 |
Not clear |
| Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qi. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072933. |
thus, we aimed to prove that the degradation of nlrp3 occurs through the autophagy-lysosome pathway (alp) and also demonstrate its effects on the function of microglia and pathological changes in ad. |
2023-04-19 |
2023-08-14 |
Not clear |
| Edward Pajarillo, Sang Hoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son, Michael Aschner, Eunsook Le. The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066140. |
rab10 played a critical role in lrrk2-mediated mn toxicity by dysregulating the autophagy-lysosome pathway, and nlrp3 inflammasome in microglia. |
2023-04-17 |
2023-08-14 |
mouse |
| Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li P. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging cell. 2023-04-08. PMID:37029500. |
however, the role of parkin in nlrp3 inflammasome activation in microglia remains unclear. |
2023-04-08 |
2023-08-14 |
mouse |
| Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li P. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging cell. 2023-04-08. PMID:37029500. |
thus, we aimed to investigate whether parkin regulates nlrp3 in microglia. |
2023-04-08 |
2023-08-14 |
mouse |
| Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li P. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging cell. 2023-04-08. PMID:37029500. |
we investigated the role of parkin in nlrp3 inflammasome activation through the overexpression of parkin in bv2 microglial cells and knockout of parkin in primary microglia after lipopolysaccharide (lps) treatment. |
2023-04-08 |
2023-08-14 |
mouse |
| Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li P. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging cell. 2023-04-08. PMID:37029500. |
overexpression of parkin mediated nlrp3 degradation via k48-linked polyubiquitination in microglia. |
2023-04-08 |
2023-08-14 |
mouse |
| Hung-Li Wang, Yi-Chuan Cheng, Tu-Hsueh Yeh, Han-Fang Liu, Yi-Hsin Weng, Rou-Shayn Chen, Yi-Chun Chen, Juu-Chin Lu, Tsong-Long Hwang, Kuo-Chen Wei, Yu-Chuan Liu, Yu-Ting Wang, Chia-Chen Hsu, Tai-Ju Chiu, Ching-Chi Chi. HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease. Biochemical pharmacology. 2023-03-31. PMID:37001680. |
fpr1 agonist fmlf induced activation of microglia cells by causing activation of nlrp3 inflammasome and upregulation and secretion of il-1β, il-6 or tnf-α. |
2023-03-31 |
2023-08-14 |
mouse |
| Chloe G McKee, Madison Hoffos, Haley A Vecchiarelli, Marie-Ève Trembla. Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease. Frontiers in pharmacology. vol 14. 2023-03-27. PMID:36969855. |
preclinical and early phase clinical trials investigating the therapeutic effects of pharmacological agents acting on microglia, including reactive oxygen species, trem2, fractalkine signaling, the complement cascade, and the nlrp3 inflammasome, are currently underway; however, important questions remain unanswered. |
2023-03-27 |
2023-08-14 |
Not clear |
| Ilkcan Ercan, Serap Cilaker Micili, Sila Soy, Defne Engur, Kemal Ugur Tufekci, Abdullah Kumral, Sermin Gen. Bilirubin induces microglial NLRP3 inflammasome activation in vitro and in vivo. Molecular and cellular neurosciences. 2023-03-25. PMID:36965549. |
following injection of bilirubin into the cisterna magna of a neonatal mouse, activation of the nlrp3 inflammasome and microglia were determined by double staining with iba1-nlrp3 and iba1-caspase-1. |
2023-03-25 |
2023-08-14 |
mouse |
| Minghui Wang, Hu Zhang, Jiling Liang, Jielun Huang, Ning Che. Exercise suppresses neuroinflammation for alleviating Alzheimer's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-03-20. PMID:36935511. |
herein, based on animal experiments and a few clinical trials, neuroinflammation in ad is characterized by long-term activation of pro-inflammatory microglia and the nod-, lrr- and pyrin domain-containing protein 3 (nlrp3) inflammasomes. |
2023-03-20 |
2023-08-14 |
Not clear |
| Zhongyan Wu, Fan Mei, Yangyang Gan, Anhang Liu, Jiapan Hu, Yan Jin, Yuxin Yi. FAM69C functions as a kinase for eIF2α and promotes stress granule assembly. EMBO reports. 2023-03-17. PMID:36929224. |
defective stress granule assembly in microglia correlates with the formation of asc specks and nlrp3 inflammasome activation, whereas induction of stress granule precludes inflammasome formation. |
2023-03-17 |
2023-08-14 |
mouse |
| Possemato Elena, La Barbera Livia, Nobili Annalisa, Krashia Paraskevi, D'Amelio Marcell. The role of dopamine in NLRP3 inflammasome inhibition: implications for neurodegenerative diseases. Ageing research reviews. 2023-03-09. PMID:36893920. |
the neurotransmitter dopamine (da) is one of the players that negatively modulate nlrp3 inflammasome activation through da receptors expressed in both microglia and astrocytes. |
2023-03-09 |
2023-08-14 |
Not clear |
| Jinqing Lai, Genwang Chen, Zhe Wu, Shaoyang Yu, Rongfu Huang, Yile Zeng, Weibin Lin, Chunmei Fan, Xiangrong Che. PHLDA1 modulates microglial response and NLRP3 inflammasome signaling following experimental subarachnoid hemorrhage. Frontiers in immunology. vol 14. 2023-03-06. PMID:36875102. |
concomitant with phlda1 activation, nod-like receptor pyrin domain-containing protein 3 (nlrp3) inflammasome expression in microglia was also evidently enhanced after sah. |
2023-03-06 |
2023-08-14 |
mouse |
| Li-Ping Huang, Long-Hui Lu, Xi-Yang Yang, Yong-Yan Xie, Zi-Wei Xu, Xu-Dong Zhu, Jing-Jing Wang, Zhi-Xin Wu, Jian-Fu Tang, Yi Wu, Yao-Hui Che. [Effect of Erjing Pills on alleviating neuroinflammation of AD rats based on TLR4/NF-κB/NLRP3 pathway and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872241. |
compared with the model control group, the erjing pill groups enhanced the new object recognition index of rats, decreased the deposition of aβ_(1-42) and the expression of p-tau~(404) positive protein in the hippocampus, inhibited the activation of microglia in the dentate gyrus, reduced the levels of inflammatory factors il-1β, tnf-α, and il-6 in the hippocampus, and down-regulated the expression levels of tlr4, p-nf-κb p65/nf-κb p65, p-iκbα/iκbα, and nlrp3 proteins in the hippocampus. |
2023-03-05 |
2023-08-14 |
rat |
| Muthukumar Kannan, Seema Singh, Divya T Chemparathy, Abiola A Oladapo, Dinesh Y Gawande, Shashank M Dravid, Shilpa Buch, Susmita Si. HIV-1 Tat induced microglial EVs leads to neuronal synaptodendritic injury: microglia-neuron cross-talk in NeuroHIV. Extracellular vesicles and circulating nucleic acids. vol 3. issue 2. 2023-02-22. PMID:36812097. |
we hypothesized that hiv-1 tat mediated microglia evs carrying significant levels of nlrp3 contribute to the synaptodendritic injury, thereby affecting the maturation of neurons. |
2023-02-22 |
2023-08-14 |
Not clear |
| Charlotte Braatz, Max P Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Róisín M McManus, Michael T Henek. NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. Journal of neurochemistry. 2023-02-17. PMID:36799439. |
nlrp3 mrna degradation was achieved at 72 hours of aso treatment in primary murine microglia. |
2023-02-17 |
2023-08-14 |
human |