| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Luis Marcos, Rossy Olivares-Barraza, Karina Ceballo, Melisa Wastavino, Víctor Ortiz, Julio Riquelme, Jonathan Martínez-Pinto, Pablo Muñoz, Gonzalo Cruz, Ramón Sotomayor-Zárat. Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674982. |
obesity-induced neuroinflammation is a chronic aseptic central nervous system inflammation that presents systemic characteristics associated with increased pro-inflammatory cytokines such as interleukin 1 beta (il-1β) and interleukin 18 (il-18) and the presence of microglia and reactive astrogliosis as well as the activation of the nlrp3 inflammasome. |
2023-01-21 |
2023-08-14 |
Not clear |
| A D Roseborough, Y Zhu, L Zhao, S R Laviolette, S H Pasternak, S N Whitehea. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implications for blood-brain barrier dysfunction. Neurobiology of disease. 2023-01-16. PMID:36646389. |
at the same time, in response to injury, microglia demonstrate increased nlrp3 inflammasome activity and heightened release of pro-inflammatory cytokines. |
2023-01-16 |
2023-08-14 |
Not clear |
| A D Roseborough, Y Zhu, L Zhao, S R Laviolette, S H Pasternak, S N Whitehea. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implications for blood-brain barrier dysfunction. Neurobiology of disease. 2023-01-16. PMID:36646389. |
in this work, we investigate fibrinogen mediated nlrp3 inflammasome priming of bv-2 cells and primary adult microglia and propose a role for extracellular vesicles (evs) as propagators of this interaction. |
2023-01-16 |
2023-08-14 |
Not clear |
| A D Roseborough, Y Zhu, L Zhao, S R Laviolette, S H Pasternak, S N Whitehea. Fibrinogen primes the microglial NLRP3 inflammasome and propagates pro-inflammatory signaling via extracellular vesicles: Implications for blood-brain barrier dysfunction. Neurobiology of disease. 2023-01-16. PMID:36646389. |
following exposure to fibrinogen microglia significantly upregulate transcription of il-1β, il-6, nlrp3 and other pro-inflammatory cytokines which was sustained by repeated fibrinogen exposure. |
2023-01-16 |
2023-08-14 |
Not clear |
| Heping Shen, Hongyan Pei, Liping Zhai, Qiaobing Guan, Genghuan Wan. Aurantiamide suppresses the activation of NLRP3 inflammasome to improve the cognitive function and central inflammation in mice with Alzheimer's disease. CNS neuroscience & therapeutics. 2023-01-11. PMID:36627760. |
this study was aimed at exploring the mechanism by which aurantiamide (aur) targeted nlrp3 to suppress microglial cell polarization. |
2023-01-11 |
2023-08-14 |
mouse |
| Qian-Kun Lv, Kang-Xin Tao, Xiao-Bo Wang, Xiao-Yu Yao, Meng-Zhu Pang, Jun-Yi Liu, Fen Wang, Chun-Feng Li. Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2023-01-04. PMID:36598534. |
α-syn is a crucial marker of pd, and its accumulation leads to microglia m1-like phenotype polarization, activation of nlrp3 inflammasomes, and impaired autophagy and phagocytosis in microglia. |
2023-01-04 |
2023-08-14 |
Not clear |
| Qian-Kun Lv, Kang-Xin Tao, Xiao-Bo Wang, Xiao-Yu Yao, Meng-Zhu Pang, Jun-Yi Liu, Fen Wang, Chun-Feng Li. Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2023-01-04. PMID:36598534. |
autophagy of microglia is related to degradation of α-syn and nlrp3 inflammasome blockage to relieve neuroinflammation. |
2023-01-04 |
2023-08-14 |
Not clear |
| Ke Xue, Mian Qi, Tongping She, Zhenglin Jiang, Yunfeng Zhang, Xueting Wang, Guohua Wang, Lihua Xu, Bin Peng, Jiayi Liu, Xinjian Song, Yuan Yuan, Xia L. Argon mitigates post-stroke neuroinflammation by regulating M1/M2 polarization and inhibiting NF-κB/NLRP3 inflammasome signaling. Journal of molecular cell biology. 2022-12-27. PMID:36574951. |
in this study, we analyzed the activation and polarization of microglia after i/r injury with or without argon administration and explored the effects of argon on nlrp3 inflammasome-mediated inflammation in microglia in vitro and in vivo. |
2022-12-27 |
2023-08-14 |
Not clear |
| Ke Xue, Mian Qi, Tongping She, Zhenglin Jiang, Yunfeng Zhang, Xueting Wang, Guohua Wang, Lihua Xu, Bin Peng, Jiayi Liu, Xinjian Song, Yuan Yuan, Xia L. Argon mitigates post-stroke neuroinflammation by regulating M1/M2 polarization and inhibiting NF-κB/NLRP3 inflammasome signaling. Journal of molecular cell biology. 2022-12-27. PMID:36574951. |
the results showed that argon application inhibited the activation of m1 microglia/macrophage in the ischemic penumbra and the expression of proteins related to nlrp3 inflammasome and pyroptosis in microglia. |
2022-12-27 |
2023-08-14 |
Not clear |
| Yue-Ran Cui, Zhong-Qi Bu, Hai-Yang Yu, Li-Li Yan, Juan Fen. Emodin attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis. Neural regeneration research. vol 18. issue 7. 2022-12-26. PMID:36571359. |
in this model, the nucleotide-binding domain-like receptor family pyrin domain containing 3 (nlrp3) inflammasome and the microglia exacerbated neuroinflammation, playing an important role in the development of multiple sclerosis. |
2022-12-26 |
2023-08-14 |
rat |
| b' Yunzhu Yang, Jiafa Zhang, Canhong Yang, Bo Dong, Yanhong Fu, Yuanyuan Wang, Ming Gong, Tao Liu, Pingming Qiu, Weibing Xie, Tianming L\\xc3\\xb. Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/Autophagy/NLRP3 signal axis in fibrillar A\\xce\\xb2-activated microglia. Brain research. 2022-12-20. PMID:36539049.' |
the neuroinflammatory hypothesis of alzheimer's disease (ad) posits that amyloid-beta (aβ) phagocytosis along with subsequent lysosomal damage and nlrp3 inflammasome activation plays important roles in aβ-induced microglia activation and microglia-induced neurotoxicity. |
2022-12-20 |
2023-08-14 |
Not clear |
| b' Yunzhu Yang, Jiafa Zhang, Canhong Yang, Bo Dong, Yanhong Fu, Yuanyuan Wang, Ming Gong, Tao Liu, Pingming Qiu, Weibing Xie, Tianming L\\xc3\\xb. Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/Autophagy/NLRP3 signal axis in fibrillar A\\xce\\xb2-activated microglia. Brain research. 2022-12-20. PMID:36539049.' |
however, whether sfn can inhibit its cytotoxic autophagy and nlrp3 inflammasome activation in microglia remain unknown. |
2022-12-20 |
2023-08-14 |
Not clear |
| b' Yunzhu Yang, Jiafa Zhang, Canhong Yang, Bo Dong, Yanhong Fu, Yuanyuan Wang, Ming Gong, Tao Liu, Pingming Qiu, Weibing Xie, Tianming L\\xc3\\xb. Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/Autophagy/NLRP3 signal axis in fibrillar A\\xce\\xb2-activated microglia. Brain research. 2022-12-20. PMID:36539049.' |
our results demonstrated that sfn could inhibit the cytostatic autophagy-induced nlrp3 signaling pathway in aβ-activated microglia by decreasing reactive oxygen species (ros) production. |
2022-12-20 |
2023-08-14 |
Not clear |
| Peng Wang, Jing Zhan. Persistent expression of NLRP3 in spinal microglia promotes development of lumbar disc degeneration. Frontiers in immunology. vol 13. 2022-12-12. PMID:36505450. |
persistent expression of nlrp3 in spinal microglia promotes development of lumbar disc degeneration. |
2022-12-12 |
2023-08-14 |
Not clear |
| Peng Wang, Jing Zhan. Persistent expression of NLRP3 in spinal microglia promotes development of lumbar disc degeneration. Frontiers in immunology. vol 13. 2022-12-12. PMID:36505450. |
however, the importance of nlrp3 in spinal microglia in ldd is not known and thus addressed in the current study. |
2022-12-12 |
2023-08-14 |
Not clear |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
only microglia expressed all nlrp3 inflammasome-forming proteins (i.e., asc, nlrp3, caspase-1). |
2022-12-09 |
2023-08-14 |
human |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
in ca1, nlrp3-positive microglia and cleaved gsdmd-positive neurons were associated with local neuronal loss, indicating a possible contribution of nlrp3 inflammasome and pyroptosis activation to ad-related neurodegeneration. |
2022-12-09 |
2023-08-14 |
human |
| Dahlia Palevski, Gil Ben-David, Yehonatan Weinberger, Rabeei Haj Daood, José A Fernández, Ivan Budnik, Sarina Levy-Mendelovich, Gili Kenet, Yael Nisgav, Dov Weinberger, John H Griffin, Tami Livna. 3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430674. |
3k3a-activated protein c prevents microglia activation, inhibits nlrp3 inflammasome and limits ocular inflammation. |
2022-11-26 |
2023-08-14 |
Not clear |
| Dahlia Palevski, Gil Ben-David, Yehonatan Weinberger, Rabeei Haj Daood, José A Fernández, Ivan Budnik, Sarina Levy-Mendelovich, Gili Kenet, Yael Nisgav, Dov Weinberger, John H Griffin, Tami Livna. 3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430674. |
leukocyte recruitment, microglia activation, nlrp3 inflammasome and il-1β levels were assessed using flow cytometry, retinal cryosection histology, retinal flatmount immunohistochemistry and vascular imaging, with and without 3k3a-apc treatment. |
2022-11-26 |
2023-08-14 |
Not clear |
| Maheedhar Kodali, Leelavathi N Madhu, Roxanne L Reger, Bojana Milutinovic, Raghavendra Upadhya, Jenny J Gonzalez, Sahithi Attaluri, Bing Shuai, Daniel L G Gitai, Shama Rao, Jong M Choi, Sung Y Jung, Ashok K Shett. Intranasally Administered Human MSC-derived Extracellular Vesicles Inhibit NLRP3-p38/MAPK Signaling after TBI and Prevent Chronic Brain Dysfunction. Brain, behavior, and immunity. 2022-11-25. PMID:36427808. |
traumatic brain injury (tbi) leads to lasting brain dysfunction with chronic neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 (nlrp3) inflammasome activation in microglia. |
2022-11-25 |
2023-08-14 |
mouse |