| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ngoc Minh Hong Hoang, Wonhee Jo, Min-Sun Ki. Protective effect of Prolactin releasing peptide against 1,2-diacetylbenzene -induced neuroinflammation. Neuropeptides. vol 100. 2023-06-03. PMID:37269608. |
we observed that prrp modulated nadph oxidase - regulated nlrp3 inflammasome and prl signaling pathways differently between physical and toxic conditions in microglia. |
2023-06-03 |
2023-08-14 |
Not clear |
| Edward Pajarillo, Sang Hoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son, Michael Aschner, Eunsook Le. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. The Journal of biological chemistry. 2023-06-03. PMID:37269951. |
rab10 played a critical role in lrrk2-mediated mn toxicity by dysregulating the autophagy-lysosome pathway, and nlrp3 inflammasome in microglia. |
2023-06-03 |
2023-08-14 |
mouse |
| Cheng-Qiang Wang, Zou Su, Chun-Guang Dai, Jia-Le Song, Bo Qia. Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis. Ecotoxicology and environmental safety. vol 259. 2023-05-24. PMID:37224780. |
meanwhile, bde47 exposure reduced protein levels of tyrosine hydroxylase (th) and dopamine transporter (dat), activated astrocytes and microglia cells, and increased protein levels of nlrp3, il-6, il-1β, and tnf-α in the brain of mice. |
2023-05-24 |
2023-08-14 |
mouse |
| Seema Singh, Annadurai Thangaraj, Ernest T Chivero, Ming-Lei Guo, Palsamy Periyasamy, Shilpa Buc. Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-06. PMID:37148425. |
role of dysregulated autophagy in hiv tat, cocaine, and cart mediated nlrp3 activation in microglia. |
2023-05-06 |
2023-08-14 |
mouse |
| Seema Singh, Annadurai Thangaraj, Ernest T Chivero, Ming-Lei Guo, Palsamy Periyasamy, Shilpa Buc. Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-06. PMID:37148425. |
our findings also demonstrated activation of the nlrp3 signaling in microglia exposed to these agents. |
2023-05-06 |
2023-08-14 |
mouse |
| Weam W Ibrahim, Krystyna Skalicka-Woźniak, Barbara Budzyńska, Nesrine S El Saye. NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via scoparone-inhibited TLR4 axis in ovariectomy/D-galactose Alzheimer's disease rat model. International immunopharmacology. vol 119. 2023-05-03. PMID:37137264. |
this study investigated the neuroprotective potential of sco in ad animal model focusing on determining its effect on m1/m2 microglia polarization and exploring the plausible mechanism involved via investigating its modulatory role on tlr4/myd88/nf-κb and nlrp3 inflammasome. |
2023-05-03 |
2023-08-14 |
rat |
| Jung Lo, Hsin-En Wu, Ching-Chih Liu, Kun-Che Chang, Po-Yen Lee, Po-Len Liu, Shu-Pin Huang, Pei-Chang Wu, Tzu-Chieh Lin, Yu-Hung Lai, Yo-Chen Chang, Yuan-Ru Chen, Sheng-I Lee, Yu-Kai Huang, Shu-Chi Wang, Chia-Yang L. Nordalbergin Exerts Anti-Neuroinflammatory Effects by Attenuating MAPK Signaling Pathway, NLRP3 Inflammasome Activation and ROS Production in LPS-Stimulated BV2 Microglia. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108458. |
nordalbergin exerts anti-neuroinflammatory effects by attenuating mapk signaling pathway, nlrp3 inflammasome activation and ros production in lps-stimulated bv2 microglia. |
2023-04-28 |
2023-08-14 |
Not clear |
| Xingru Chen, Xiaolan Zhou, Xiaoqing Cheng, Liting Lin, Qi Wang, Ruoting Zhan, Qingguang Wu, Sijun Li. Protective Effect of Ferulic Acid on Lipopolysaccharide-Induced BV2 Microglia Inflammation via AMPK/mTOR Signaling Pathway. Molecules (Basel, Switzerland). vol 28. issue 8. 2023-04-28. PMID:37110714. |
we further studied the mechanism of fa's regulation of lps-induced bv2 neuroinflammation and found that fa can significantly reduce the expression of mtor in bv2 microglia induced by lps, and significantly increase the expression of ampk, indicating that fa may have an anti-inflammatory effect by activating the ampk/mtor signaling pathway to regulate the release of inflammatory mediators (such as nlrp3, caspase-1 p20 and il-1β). |
2023-04-28 |
2023-08-14 |
Not clear |
| Devlina Ghosh, Gajendra Singh, Prabhaker Mishra, Aditi Singh, Alok Kumar, Neeraj Sinh. Alteration in mitochondrial dynamics promotes the proinflammatory response of microglia and is involved in cerebellar dysfunction of young and aged mice following LPS exposure. Neuroscience letters. 2023-04-28. PMID:37116576. |
following lps stimulation, we observed microglia activation and subsequent elevation in proinflammatory cytokines (m1; tnf-α, ifn-γ) with nlrp3 activationand a concomitant reduction in the expression of anti-inflammatory markers (m2; ym1, tgf-β1) in the cerebellar tissue of aged mice compared with the young lps and aged controls. |
2023-04-28 |
2023-08-14 |
mouse |
| Guohao Wang, Weiqin Yin, Hyunhee Shin, Qingjun Tian, Wei Lu, Steven X Ho. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nature aging. vol 1. issue 11. 2023-04-28. PMID:37118341. |
ablation of arf1 in cultured primary neurons led to an increase in peroxidated lipids in co-cultured microglia, activation of the microglial nlrp3 inflammasome and release of inflammatory cytokines in an apolipoprotein e-dependent manner. |
2023-04-28 |
2023-08-14 |
mouse |
| Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qi. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072933. |
degradation of nlrp3 by p62-dependent-autophagy improves cognitive function in alzheimer's disease by maintaining the phagocytic function of microglia. |
2023-04-19 |
2023-08-14 |
Not clear |
| Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qi. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072933. |
activation of the nlrp3 inflammasome promotes microglia to secrete inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and clearance functions of microglia in alzheimer's disease (ad). |
2023-04-19 |
2023-08-14 |
Not clear |
| Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qi. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. CNS neuroscience & therapeutics. 2023-04-19. PMID:37072933. |
thus, we aimed to prove that the degradation of nlrp3 occurs through the autophagy-lysosome pathway (alp) and also demonstrate its effects on the function of microglia and pathological changes in ad. |
2023-04-19 |
2023-08-14 |
Not clear |
| Edward Pajarillo, Sang Hoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son, Michael Aschner, Eunsook Le. The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066140. |
rab10 played a critical role in lrrk2-mediated mn toxicity by dysregulating the autophagy-lysosome pathway, and nlrp3 inflammasome in microglia. |
2023-04-17 |
2023-08-14 |
mouse |
| Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li P. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging cell. 2023-04-08. PMID:37029500. |
however, the role of parkin in nlrp3 inflammasome activation in microglia remains unclear. |
2023-04-08 |
2023-08-14 |
mouse |
| Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li P. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging cell. 2023-04-08. PMID:37029500. |
thus, we aimed to investigate whether parkin regulates nlrp3 in microglia. |
2023-04-08 |
2023-08-14 |
mouse |
| Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li P. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging cell. 2023-04-08. PMID:37029500. |
we investigated the role of parkin in nlrp3 inflammasome activation through the overexpression of parkin in bv2 microglial cells and knockout of parkin in primary microglia after lipopolysaccharide (lps) treatment. |
2023-04-08 |
2023-08-14 |
mouse |
| Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li P. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging cell. 2023-04-08. PMID:37029500. |
overexpression of parkin mediated nlrp3 degradation via k48-linked polyubiquitination in microglia. |
2023-04-08 |
2023-08-14 |
mouse |
| Hung-Li Wang, Yi-Chuan Cheng, Tu-Hsueh Yeh, Han-Fang Liu, Yi-Hsin Weng, Rou-Shayn Chen, Yi-Chun Chen, Juu-Chin Lu, Tsong-Long Hwang, Kuo-Chen Wei, Yu-Chuan Liu, Yu-Ting Wang, Chia-Chen Hsu, Tai-Ju Chiu, Ching-Chi Chi. HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease. Biochemical pharmacology. 2023-03-31. PMID:37001680. |
fpr1 agonist fmlf induced activation of microglia cells by causing activation of nlrp3 inflammasome and upregulation and secretion of il-1β, il-6 or tnf-α. |
2023-03-31 |
2023-08-14 |
mouse |
| Chloe G McKee, Madison Hoffos, Haley A Vecchiarelli, Marie-Ève Trembla. Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease. Frontiers in pharmacology. vol 14. 2023-03-27. PMID:36969855. |
preclinical and early phase clinical trials investigating the therapeutic effects of pharmacological agents acting on microglia, including reactive oxygen species, trem2, fractalkine signaling, the complement cascade, and the nlrp3 inflammasome, are currently underway; however, important questions remain unanswered. |
2023-03-27 |
2023-08-14 |
Not clear |