| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
microglia, the resident immune cells of the central nervous system (cns), play a dual role in neurotoxicity by releasing the nlr family pyrin domain containing 3 (nlrp3) inflammasome and brain-derived neurotrophic factor (bdnf) in response to environmental stress. |
2024-04-24 |
2024-04-28 |
mouse |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
moreover, msa-activated microglia triggered remarkable tau phosphorylation at multiple sites through nlrp3 inflammasome pathway. |
2024-04-23 |
2024-04-26 |
mouse |
| Debashis Dutta, Jianuo Liu, Enquan Xu, Huangui Xion. Methamphetamine Enhancement of HIV-1 gp120-Mediated NLRP3 Inflammasome Activation and Resultant Proinflammatory Responses in Rat Microglial Cultures. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612400. |
meth also augmented the co-localization of nlrp3 and caspase-1, increased the numbers of nlrp3 puncta and ros production, increased the levels of inos expression and no production, and increased the levels of cleaved gasdermind (gsdmd-n; an executor of pyroptosis) in gp120-primed microglia. |
2024-04-13 |
2024-04-15 |
human |
| Juan Yu, Zhanghong Zhao, Yuanyuan Li, Jian Chen, Nanqu Huang, Yong Lu. Role of NLRP3 in Parkinson's disease: Specific activation especially in dopaminergic neurons. Heliyon. vol 10. issue 7. 2024-04-10. PMID:38596076. |
previous studies have demonstrated that the over-activation of nlrp3 inflammasome in microglia indirectly leads to the loss of dans, which can worsen pd. |
2024-04-10 |
2024-04-12 |
Not clear |
| Xinyue Li, Kai Ma, Tiantian Tian, Huan Pang, Tianxiang Liu, Meng Li, Jiali Li, Zhixuan Luo, Huiyuan Hu, Shanshan Hou, Jing Yu, Qiaohong Hou, Xiuling Song, Chao Zhao, Haiying Du, Jinhua Li, Zhongjun Du, Minghua Ji. Methylmercury induces inflammatory response and autophagy in microglia through the activation of NLRP3 inflammasome. Environment international. vol 186. 2024-04-08. PMID:38588609. |
methylmercury induces inflammatory response and autophagy in microglia through the activation of nlrp3 inflammasome. |
2024-04-08 |
2024-04-11 |
mouse |
| Wenwen Zhu, Haoqiang Zhang, Tong Niu, Kunyu Liu, Huzaifa Fareeduddin Mohammed Farooqui, Ruoyu Sun, Xiu Chen, Yang Yuan, Shaohua Wan. Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation. Brain, behavior, and immunity. 2024-04-03. PMID:38570101. |
these findings indicate an important regulatory axis of microglial responses from scap to the nlrp3 inflammasome pathway in microglia. |
2024-04-03 |
2024-04-06 |
mouse |
| Tahmineh Mokhtari, Elnaz Irandoost, Fatemeh Sheikhbahae. Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation. International immunopharmacology. vol 132. 2024-04-02. PMID:38565045. |
the activation of glial cells, particularly the polarization of microglia, leads to the activation of the nlrp3 inflammasome and the overproduction of inflammatory cytokines. |
2024-04-02 |
2024-04-05 |
Not clear |
| Ya Zhao, Qian Li, Jingyan Niu, Erliang Guo, Chenchen Zhao, Jian Zhang, Xue Liu, Lihua Wang, Lang Rao, Xiaoyuan Chen, Kuikun Yan. Neutrophil Membrane-Camouflaged Polyprodrug Nanomedicine for Inflammation Suppression in Ischemic Stroke Therapy. Advanced materials (Deerfield Beach, Fla.). 2024-03-22. PMID:38519052. |
in addition, single-cell rna-sequencing analysis identifies that the nanomedicine attenuates post-stroke inflammation by reprogramming microglia toward anti-inflammatory phenotypes, which is realized via modulating cebpb-regulated activation of nlrp3 inflammasomes and secretion of cxcl2 chemokine. |
2024-03-22 |
2024-03-25 |
Not clear |
| Ping Gao, Haowei Shi, Xiaofei Jin, Shuhan Guo, Xiaohong Zhou, Weijuan Ga. Mechanism of astragaloside IV regulating NLRP3 through LOC102555978 to attenuate cerebral ischemia reperfusion induced microglia pyroptosis. International immunopharmacology. vol 131. 2024-03-21. PMID:38513574. |
mechanism of astragaloside iv regulating nlrp3 through loc102555978 to attenuate cerebral ischemia reperfusion induced microglia pyroptosis. |
2024-03-21 |
2024-03-24 |
rat |
| Xiao-Mei Xia, Yu Duan, Yue-Ping Wang, Rui-Xue Han, Yin-Feng Dong, Si-Yuan Jiang, Yu Zheng, Chen Qiao, Lei Cao, Xiao Lu, Ming L. Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome. Acta pharmacologica Sinica. 2024-03-20. PMID:38504011. |
we found that tmcao activated microglia in the ischemic core and penumbra regions of the brain, followed by the nlrp3 inflammasome activation-induced neuroinflammation, which finally triggered neuronal death. |
2024-03-20 |
2024-03-23 |
mouse |
| Cagla Kiser, Ceren Perihan Gonul, Sermin Gen. Nrf2 activator Diethyl Maleate attenuates ROS mediated NLRP3 inflammasome activation in murine microglia. Cytotechnology. vol 76. issue 2. 2024-03-18. PMID:38495294. |
nrf2 activator diethyl maleate attenuates ros mediated nlrp3 inflammasome activation in murine microglia. |
2024-03-18 |
2024-03-20 |
Not clear |
| Cagla Kiser, Ceren Perihan Gonul, Sermin Gen. Nrf2 activator Diethyl Maleate attenuates ROS mediated NLRP3 inflammasome activation in murine microglia. Cytotechnology. vol 76. issue 2. 2024-03-18. PMID:38495294. |
in this study, nlrp3 inflammasome was activated in n9 murine microglia via 1 µg/ml lps (lipopolysaccharide) for 4 h and 5 mm atp (adenosine 5'-triphosphate) for 1 h, respectively. |
2024-03-18 |
2024-03-20 |
Not clear |
| Nan-Shi-Yu Yang, Wen-Jing Zhong, Han-Xi Sha, Chen-Yu Zhang, Ling Jin, Jia-Xi Duan, Jian-Bing Xiong, Zhi-Jian You, Yong Zhou, Cha-Xiang Gua. mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice. International journal of biological sciences. vol 20. issue 5. 2024-03-14. PMID:38481801. |
the activation of nlrp3 inflammasome in microglia is critical for neuroinflammation during postoperative cognitive dysfunction (pocd) induced by sevoflurane. |
2024-03-14 |
2024-03-16 |
mouse |
| Nan-Shi-Yu Yang, Wen-Jing Zhong, Han-Xi Sha, Chen-Yu Zhang, Ling Jin, Jia-Xi Duan, Jian-Bing Xiong, Zhi-Jian You, Yong Zhou, Cha-Xiang Gua. mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice. International journal of biological sciences. vol 20. issue 5. 2024-03-14. PMID:38481801. |
however, the molecular mechanism by which sevoflurane activates the nlrp3 inflammasome in microglia remains unclear. |
2024-03-14 |
2024-03-16 |
mouse |
| Ruonan Dang, Xuyang Hou, Xinglan Huang, Caifeng Huang, Xiaoqing Zhao, Xingrong Wang, Ning Zhang, Yuqi Yang, Nan Li, Sheng Liu, Peng Yan, Ping Fan, Xinghua Song, Suiying Zhang, Yuqiong Deng, Xiping Cheng, Xinhua Xi. Effects of the Glucocorticoid-Mediated Mitochondrial Translocation of Glucocorticoid Receptors on Oxidative Stress and Pyroptosis in BV-2 Microglia. Journal of molecular neuroscience : MN. vol 74. issue 1. 2024-03-13. PMID:38478195. |
bv-2 microglia were stimulated with dexamethasone (dex) and treated with either tubastatin-a or mitoquinone (mitoq) for 24 h. our results showed that dex increased the translocation of grs to mitochondria, and this effect was accompanied by decreases in the expression of mitochondrially encoded cytochrome c oxidase 1 (mt-co1) and mitochondrially encoded cytochrome c oxidase 3 (mt-co3) and increases in the expression of nod-like receptor thermal protein domain-associated protein 3 (nlrp3), caspase-1, and gasdermin d (gsdmd). |
2024-03-13 |
2024-03-16 |
Not clear |
| Paige E Anton, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. NF-κB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464118. |
studies utilizing rodent models of neurodegenerative disease reveal heightened activation of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) and nod like receptor 3 (nlrp3) mediate microglia activation and associated neuronal injury. |
2024-03-11 |
2024-03-14 |
Not clear |
| Ali Rifat, Bernardino Ossola, Roland W Bürli, Lee A Dawson, Nicola L Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L Heppner, Jörg R P Geiger, Christian Madr. Differential contribution of THIK-1 K Journal of neuroinflammation. vol 21. issue 1. 2024-02-28. PMID:38409076. |
differential contribution of thik-1 k neuroinflammation is highly influenced by microglia, particularly through activation of the nlrp3 inflammasome and subsequent release of il-1β. |
2024-02-28 |
2024-03-01 |
Not clear |
| Jie Cao, Lanqin Li, Runge Zhang, Zhou Shu, Yaxin Zhang, Weiguang Sun, Yonghui Zhang, Zhengxi H. Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition. Natural products and bioprospecting. vol 14. issue 1. 2024-02-26. PMID:38407685. |
our results provide a new understanding of how lc inhibits the nlrp3 inflammasome in microglia, providing neuroprotection. |
2024-02-26 |
2024-02-28 |
Not clear |
| Jinsong Xue, Keju Tao, Weijia Wang, Xiaofei Wan. What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson's Disease? International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338925. |
additionally, we describe the potential anti-inflammatory therapies, including nod-like receptor pyrin domain containing protein 3 (nlrp3) inflammasome inhibition, nuclear factor κb (nf-κb) inhibition, microglia inhibition, astrocyte inhibition, nicotinamide adenine dinucleotide phosphate (nadph) oxidase inhibition, the peroxisome proliferator-activated receptor γ (pparγ) agonist, targeting the mitogen-activated protein kinase (mapk) pathway, targeting the adenosine monophosphate-activated protein kinase (ampk)-dependent pathway, targeting α-synuclein, targeting mirna, acupuncture, and exercise. |
2024-02-10 |
2024-02-12 |
Not clear |
| Emily McMahon, Sherihan El-Sayed, Jack Green, Christopher Hoyle, Lorna FitzPatrick, Emma V Jones, Eve Corrie, Rebecca L Kelly, Mairi Challinor, Sally Freeman, Richard A Bryce, Catherine B Lawrence, David Brough, Paul R Kashe. Brazilin is a natural product inhibitor of the NLRP3 inflammasome. iScience. vol 27. issue 2. 2024-02-08. PMID:38327788. |
here we have identified that the natural product brazilin effectively inhibits both priming and activation of the nlrp3 inflammasome in cultured murine macrophages, a human ipsc microglial cell line and in a mouse model of acute peritoneal inflammation. |
2024-02-08 |
2024-02-10 |
mouse |