| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoxing Mo, Ruijie Cheng, Lihui Shen, Nian Liu, Yunhong Sun, Shan Lin, Guanhua Jiang, Xiaoqin Li, Xiaobo Peng, Yan Zhang, Yuxiao Liao, Hong Yan, Liegang Li. Yeast β-glucan alleviates high-fat diet-induced Alzheimer's disease-like pathologies in rats via the gut-brain axis. International journal of biological macromolecules. 2024-08-23. PMID:39179066. |
in the hippocampus, bg alleviated hfd-induced the activation of astrocytes, microglia, nod-like receptor thermal protein domain associated protein 3 (nlrp3) inflammasome pathway, and ad-like pathologies. |
2024-08-23 |
2024-08-27 |
rat |
| Changbai Sui, Ying Liu, Jun Jiang, Jianhua Tang, Ling Yu, Guoying L. Ginsenoside Rg1 ameliorates cerebral ischemia-reperfusion injury by regulating Pink1/ Parkin-mediated mitochondrial autophagy and inhibiting microglia NLRP3 activation. Brain research bulletin. vol 216. 2024-08-13. PMID:39134096. |
ginsenoside rg1 ameliorates cerebral ischemia-reperfusion injury by regulating pink1/ parkin-mediated mitochondrial autophagy and inhibiting microglia nlrp3 activation. |
2024-08-13 |
2024-08-16 |
Not clear |
| Meng-Meng Li, Mei-Juan Shi, Chen-Chen Feng, Zhong-Yu Yu, Xiao-Fei Bai, Lu-L. LncRNA KCNQ1OT1 promotes NLRP3 inflammasome activation in Parkinson's disease by regulating pri-miR-186/mature miR-186/NLRP3 axis. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 8. 2024-08-10. PMID:39122224. |
as kcnq1ot1 located in both cytoplasm and nucleus of microglia, we demonstrated that kcnq1ot1 promoted microglial nlrp3 inflammasome activation by competitive binding with mir-186 in cytoplasm and inhibited pri-mir-186 mediated nlrp3 silencing through recruitment of digeorge syndrome critical region gene 8 (dgcr8) in nucleus, respectively. |
2024-08-10 |
2024-08-13 |
mouse |
| Meng-Meng Li, Mei-Juan Shi, Chen-Chen Feng, Zhong-Yu Yu, Xiao-Fei Bai, Lu-L. LncRNA KCNQ1OT1 promotes NLRP3 inflammasome activation in Parkinson's disease by regulating pri-miR-186/mature miR-186/NLRP3 axis. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 8. 2024-08-10. PMID:39122224. |
our study found a novel lncrna-pri-mirna/mature mirna-mrna regulatory network in microglia mediated nlrp3 inflammasome activation and dopaminergic neuronal loss, provided further insights for the treatment of parkinson's disease. |
2024-08-10 |
2024-08-13 |
mouse |
| Tosin A Olasehinde, Oyinlola O Olaoku. Apigenin and inflammation in the brain: can apigenin inhibit neuroinflammation in preclinical models? Inflammopharmacology. 2024-08-10. PMID:39126572. |
the anti-neuroinflammatory mechanisms exhibited by apigenin include inhibition of overproduction of pro-inflammatory cytokines, attenuation of microglia activation via reduction of cd-11b-positive cells, inhibition of rock-1 expression and upregulation of mir-15a, p-erk1/2, p-creb, and bdnf, downregulation of nlrp3 inflammasome, inos and cox-2 expression, reduction of toll-like receptor-4 expression and inhibition of nuclear factor-kappa b (nf-kb) activation. |
2024-08-10 |
2024-08-13 |
Not clear |
| Nagihan Demirtaş, Büşra Şahin Mazlumoğlu, Şaziye Sezin Palabıyık Yüceli. Role of NLRP3 Inflammasomes in Neurodegenerative Diseases. The Eurasian journal of medicine. vol 55. issue 1. 2024-08-07. PMID:39109852. |
the nlrp3 inflammasome is the most researched inflammasome and also located in microglia, its activation mediates the maturation and secretion of the inflammatory cytokines interleukin1beta (il-1β) and il-18, thus exerting its efects in the central nervous system. |
2024-08-07 |
2024-08-09 |
human |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy. bioRxiv : the preprint server for biology. 2024-07-29. PMID:39071343. |
residual microglia following short-term plx5622 treatment in 5xfad mice exhibit diminished nlrp3 inflammasome and mtor signaling, and enhanced autophagy. |
2024-07-29 |
2024-08-02 |
mouse |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy. bioRxiv : the preprint server for biology. 2024-07-29. PMID:39071343. |
the leftover microglia demonstrated a noninflammatory phenotype, with highly branched and ramified processes and reduced nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome complexes. |
2024-07-29 |
2024-08-02 |
mouse |
| Walaa Bayoumie El Gazzar, Amina A Farag, Mohamed Samir, Heba Bayoumi, Heba S Youssef, Yasmin Mohammed Marei, Shimaa K Mohamed, Azza M Marei, Reham M Abdelfatah, Manal Moustafa Mahmoud, Elshaimaa Ahmed Fahmy Aboelkomsan, Eman Kamel M Khalfallah, Hala Magdy Anwe. Berberine chloride loaded nano-PEGylated liposomes attenuates imidacloprid-induced neurotoxicity by inhibiting NLRP3/Caspase-1/GSDMD-mediated pyroptosis. BioFactors (Oxford, England). 2024-07-29. PMID:39074847. |
the histopathological changes, anti-oxidant and oxidative stress markers (gsh, sod, and mda), proinflammatory cytokines (il1β and tnf-α), microglia phenotype markers (cd86 and inos for m1; cd163 for m2), the canonical pyroptotic pathway markers (nlrp3, caspase-1, gsdmd, and il-18) and alzheimer's disease markers (neprilysin and beta amyloid [aβ] deposits) were assessed. |
2024-07-29 |
2024-08-02 |
rat |
| Walaa Bayoumie El Gazzar, Amina A Farag, Mohamed Samir, Heba Bayoumi, Heba S Youssef, Yasmin Mohammed Marei, Shimaa K Mohamed, Azza M Marei, Reham M Abdelfatah, Manal Moustafa Mahmoud, Elshaimaa Ahmed Fahmy Aboelkomsan, Eman Kamel M Khalfallah, Hala Magdy Anwe. Berberine chloride loaded nano-PEGylated liposomes attenuates imidacloprid-induced neurotoxicity by inhibiting NLRP3/Caspase-1/GSDMD-mediated pyroptosis. BioFactors (Oxford, England). 2024-07-29. PMID:39074847. |
oral administration of imi resulted in apparent cerebellar histopathological alterations, oxidative stress, predominance of m1 microglia phenotype, significantly upregulated nlrp3, caspase-1, gsdmd, il-18 and aβ deposits and significantly decreased neprilysin expression. |
2024-07-29 |
2024-08-02 |
rat |
| Alaa H Shehata, Aliaa F Anter, Sara Mohamed Naguib Abdel Hafez, Ahmed Rn Ibrahim, Eman S Kamel, Al-Shaimaa F Ahme. Pioglitazone ameliorates sepsis-associated encephalopathy through SIRT1 signaling pathway. International immunopharmacology. vol 139. 2024-07-27. PMID:39067401. |
pio also promoted cerebral sirt1 expression and reduced cerebral activation of microglia, oxidative stress, hmgb, inos, nlrp3 and caspase-3 along with an obvious improvement in behavioral deficits and cerebral pathological damage induced by lps. |
2024-07-27 |
2024-08-02 |
mouse |
| Yousef Mohamadi, Maryam Borhani-Haghigh. Retraction notice to "TGN020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and NLRP3 inflammasome in a cuprizone mouse model" [J. Chem. Neuroanat. 132 (2023) 102306]. Journal of chemical neuroanatomy. 2024-07-25. PMID:39054199. |
retraction notice to "tgn020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and nlrp3 inflammasome in a cuprizone mouse model" [j. chem. |
2024-07-25 |
2024-07-28 |
mouse |
| Brice Ayissi Owona, Arnaud Mary, Angelique N Messi, Kishore Aravind Ravichandran, Josephine Ngo Mbing, Emmanuel Pegnyemb, Paul F Moundipa, Michael T Henek. Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation. Molecular neurobiology. 2024-07-16. PMID:39012444. |
neuroinflammation is a common hallmark of alzheimer's disease (ad), with nlrp3 inflammasome proven to be activated in microglia of ad patients' brains. |
2024-07-16 |
2024-07-18 |
human |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
activation of the nlrp3 inflammasome, situated within microglia, can be triggered by diverse danger signals, leading to cell pyroptosis, apoptosis, and tauopathy. |
2024-07-14 |
2024-07-18 |
Not clear |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
in this review, we focus on elucidating the inhibitory regulatory mechanism of the nlrp3 inflammasome in microglia, which ultimately manifests as suppression of the inflammatory response. |
2024-07-14 |
2024-07-18 |
Not clear |
| Wenjing Ning, Shi Lv, Qian Wang, Yuzhen X. The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage. Neural regeneration research. 2024-07-12. PMID:38993136. |
currently, microglia in subarachnoid hemorrhage are targeted with tlr inhibitors, nuclear factor-κb and stat3 pathway inhibitors, glycine/tyrosine kinases, nlrp3 signaling pathway inhibitors, gasdermin d inhibitors, vincristine receptor α receptor agonists, ferroptosis inhibitors, genetic modification techniques, stem cell therapies, and traditional chinese medicine. |
2024-07-12 |
2024-07-14 |
Not clear |
| Daniel C Shippy, Abigail H Evered, Tyler K Ullan. Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease. Immunological reviews. 2024-07-11. PMID:38989642. |
nlrp3 inflammasome activation in microglia, the primary immune effector cells of the brain, results in caspase-1 activation and secretion of il-1β and il-18. |
2024-07-11 |
2024-07-13 |
Not clear |
| Hilal Cihankaya, Verian Bader, Konstanze F Winklhofer, Matthias Vorgerd, Johann Matschke, Sarah Stahlke, Carsten Theiss, Veronika Matschk. Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS. Cells. vol 13. issue 12. 2024-06-26. PMID:38920626. |
additionally, we showed the upregulation of protein levels and the colocalization of nlrp3, c-casp1, and gsdmd in neurons, as well as in microglia and astrocytes. |
2024-06-26 |
2024-06-29 |
mouse |
| FangFang Qian, RenHong He, XiaoHui Du, Yi Wei, Zhou Zhou, JianZhong Fan, YouHua H. Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury. Neurochemical research. 2024-06-23. PMID:38909329. |
rtms also reduced the levels of pyroptosis within microglia and pyroptosis-related proteins (nlrp3, caspase-1, gsdmd, il-1β and il-18). |
2024-06-23 |
2024-06-25 |
rat |
| Jing-Hao Liang, Heng Yu, Chuan-Peng Xia, Yue-Hui Zheng, Zhe Zhang, Yu Chen, Mazhar Ali Raza, Long Wu, Hede Ya. Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908197. |
in the in vivo study, we adopted the rat chronic constriction injury model, and the results showed that gb(4 mg/kg) treatment effectively reduced pain sensation in rats and decreased the expressions of iba-1 (a microglia marker), nlrp3 inflammasome, and inflammatory factors, such as interleukin (il)-1β, in the spinal cord 7 days post-surgery. |
2024-06-22 |
2024-06-25 |
rat |