| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nagihan Demirtaş, Büşra Şahin Mazlumoğlu, Şaziye Sezin Palabıyık Yüceli. Role of NLRP3 Inflammasomes in Neurodegenerative Diseases. The Eurasian journal of medicine. vol 55. issue 1. 2024-08-07. PMID:39109852. |
the nlrp3 inflammasome is the most researched inflammasome and also located in microglia, its activation mediates the maturation and secretion of the inflammatory cytokines interleukin1beta (il-1β) and il-18, thus exerting its efects in the central nervous system. |
2024-08-07 |
2024-08-09 |
human |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy. bioRxiv : the preprint server for biology. 2024-07-29. PMID:39071343. |
residual microglia following short-term plx5622 treatment in 5xfad mice exhibit diminished nlrp3 inflammasome and mtor signaling, and enhanced autophagy. |
2024-07-29 |
2024-08-02 |
mouse |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy. bioRxiv : the preprint server for biology. 2024-07-29. PMID:39071343. |
the leftover microglia demonstrated a noninflammatory phenotype, with highly branched and ramified processes and reduced nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome complexes. |
2024-07-29 |
2024-08-02 |
mouse |
| Walaa Bayoumie El Gazzar, Amina A Farag, Mohamed Samir, Heba Bayoumi, Heba S Youssef, Yasmin Mohammed Marei, Shimaa K Mohamed, Azza M Marei, Reham M Abdelfatah, Manal Moustafa Mahmoud, Elshaimaa Ahmed Fahmy Aboelkomsan, Eman Kamel M Khalfallah, Hala Magdy Anwe. Berberine chloride loaded nano-PEGylated liposomes attenuates imidacloprid-induced neurotoxicity by inhibiting NLRP3/Caspase-1/GSDMD-mediated pyroptosis. BioFactors (Oxford, England). 2024-07-29. PMID:39074847. |
the histopathological changes, anti-oxidant and oxidative stress markers (gsh, sod, and mda), proinflammatory cytokines (il1β and tnf-α), microglia phenotype markers (cd86 and inos for m1; cd163 for m2), the canonical pyroptotic pathway markers (nlrp3, caspase-1, gsdmd, and il-18) and alzheimer's disease markers (neprilysin and beta amyloid [aβ] deposits) were assessed. |
2024-07-29 |
2024-08-02 |
rat |
| Walaa Bayoumie El Gazzar, Amina A Farag, Mohamed Samir, Heba Bayoumi, Heba S Youssef, Yasmin Mohammed Marei, Shimaa K Mohamed, Azza M Marei, Reham M Abdelfatah, Manal Moustafa Mahmoud, Elshaimaa Ahmed Fahmy Aboelkomsan, Eman Kamel M Khalfallah, Hala Magdy Anwe. Berberine chloride loaded nano-PEGylated liposomes attenuates imidacloprid-induced neurotoxicity by inhibiting NLRP3/Caspase-1/GSDMD-mediated pyroptosis. BioFactors (Oxford, England). 2024-07-29. PMID:39074847. |
oral administration of imi resulted in apparent cerebellar histopathological alterations, oxidative stress, predominance of m1 microglia phenotype, significantly upregulated nlrp3, caspase-1, gsdmd, il-18 and aβ deposits and significantly decreased neprilysin expression. |
2024-07-29 |
2024-08-02 |
rat |
| Alaa H Shehata, Aliaa F Anter, Sara Mohamed Naguib Abdel Hafez, Ahmed Rn Ibrahim, Eman S Kamel, Al-Shaimaa F Ahme. Pioglitazone ameliorates sepsis-associated encephalopathy through SIRT1 signaling pathway. International immunopharmacology. vol 139. 2024-07-27. PMID:39067401. |
pio also promoted cerebral sirt1 expression and reduced cerebral activation of microglia, oxidative stress, hmgb, inos, nlrp3 and caspase-3 along with an obvious improvement in behavioral deficits and cerebral pathological damage induced by lps. |
2024-07-27 |
2024-08-02 |
mouse |
| Yousef Mohamadi, Maryam Borhani-Haghigh. Retraction notice to "TGN020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and NLRP3 inflammasome in a cuprizone mouse model" [J. Chem. Neuroanat. 132 (2023) 102306]. Journal of chemical neuroanatomy. 2024-07-25. PMID:39054199. |
retraction notice to "tgn020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and nlrp3 inflammasome in a cuprizone mouse model" [j. chem. |
2024-07-25 |
2024-07-28 |
mouse |
| Brice Ayissi Owona, Arnaud Mary, Angelique N Messi, Kishore Aravind Ravichandran, Josephine Ngo Mbing, Emmanuel Pegnyemb, Paul F Moundipa, Michael T Henek. Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation. Molecular neurobiology. 2024-07-16. PMID:39012444. |
neuroinflammation is a common hallmark of alzheimer's disease (ad), with nlrp3 inflammasome proven to be activated in microglia of ad patients' brains. |
2024-07-16 |
2024-07-18 |
human |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
activation of the nlrp3 inflammasome, situated within microglia, can be triggered by diverse danger signals, leading to cell pyroptosis, apoptosis, and tauopathy. |
2024-07-14 |
2024-07-18 |
Not clear |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
in this review, we focus on elucidating the inhibitory regulatory mechanism of the nlrp3 inflammasome in microglia, which ultimately manifests as suppression of the inflammatory response. |
2024-07-14 |
2024-07-18 |
Not clear |
| Wenjing Ning, Shi Lv, Qian Wang, Yuzhen X. The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage. Neural regeneration research. 2024-07-12. PMID:38993136. |
currently, microglia in subarachnoid hemorrhage are targeted with tlr inhibitors, nuclear factor-κb and stat3 pathway inhibitors, glycine/tyrosine kinases, nlrp3 signaling pathway inhibitors, gasdermin d inhibitors, vincristine receptor α receptor agonists, ferroptosis inhibitors, genetic modification techniques, stem cell therapies, and traditional chinese medicine. |
2024-07-12 |
2024-07-14 |
Not clear |
| Daniel C Shippy, Abigail H Evered, Tyler K Ullan. Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease. Immunological reviews. 2024-07-11. PMID:38989642. |
nlrp3 inflammasome activation in microglia, the primary immune effector cells of the brain, results in caspase-1 activation and secretion of il-1β and il-18. |
2024-07-11 |
2024-07-13 |
Not clear |
| Hilal Cihankaya, Verian Bader, Konstanze F Winklhofer, Matthias Vorgerd, Johann Matschke, Sarah Stahlke, Carsten Theiss, Veronika Matschk. Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS. Cells. vol 13. issue 12. 2024-06-26. PMID:38920626. |
additionally, we showed the upregulation of protein levels and the colocalization of nlrp3, c-casp1, and gsdmd in neurons, as well as in microglia and astrocytes. |
2024-06-26 |
2024-06-29 |
mouse |
| FangFang Qian, RenHong He, XiaoHui Du, Yi Wei, Zhou Zhou, JianZhong Fan, YouHua H. Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury. Neurochemical research. 2024-06-23. PMID:38909329. |
rtms also reduced the levels of pyroptosis within microglia and pyroptosis-related proteins (nlrp3, caspase-1, gsdmd, il-1β and il-18). |
2024-06-23 |
2024-06-25 |
rat |
| Jing-Hao Liang, Heng Yu, Chuan-Peng Xia, Yue-Hui Zheng, Zhe Zhang, Yu Chen, Mazhar Ali Raza, Long Wu, Hede Ya. Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908197. |
in the in vivo study, we adopted the rat chronic constriction injury model, and the results showed that gb(4 mg/kg) treatment effectively reduced pain sensation in rats and decreased the expressions of iba-1 (a microglia marker), nlrp3 inflammasome, and inflammatory factors, such as interleukin (il)-1β, in the spinal cord 7 days post-surgery. |
2024-06-22 |
2024-06-25 |
rat |
| Jing-Hao Liang, Heng Yu, Chuan-Peng Xia, Yue-Hui Zheng, Zhe Zhang, Yu Chen, Mazhar Ali Raza, Long Wu, Hede Ya. Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908197. |
moreover, it lowered the expression of inflammation-related proteins, such as caspase-1, il-1β, and nlrp3 in microglia. |
2024-06-22 |
2024-06-25 |
rat |
| Ryan Gober, Julian Dallmeier, David Davis, Daniel Brzostowicki, Juan Pablo de Rivero Vaccari, Brianna Cyr, Ayled Barreda, Xiaoyan Sun, Sakir Humayun Gultekin, Susanna Garamszegi, William Scott, Regina Vontel. Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia. Journal of neuropathology and experimental neurology. 2024-06-21. PMID:38904417. |
to assess changes in the cell populations that express key inflammasome proteins, we performed ihc analyses of apoptosis-associated speck-like protein containing a card (asc), nod-like receptor protein 3 (nlrp3), and interleukin (il)-18 to determine if these proteins are expressed in microglia, astrocytes, oligodendrocytes, or neurons. |
2024-06-21 |
2024-06-23 |
Not clear |
| Ryan Gober, Julian Dallmeier, David Davis, Daniel Brzostowicki, Juan Pablo de Rivero Vaccari, Brianna Cyr, Ayled Barreda, Xiaoyan Sun, Sakir Humayun Gultekin, Susanna Garamszegi, William Scott, Regina Vontel. Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia. Journal of neuropathology and experimental neurology. 2024-06-21. PMID:38904417. |
increased numbers of microglia were present in the sfc of scz brains and exhibited higher inflammasome protein expression of asc, nlrp3, and il-18 compared to nps. |
2024-06-21 |
2024-06-23 |
Not clear |
| Jia-Rui Zhang, Shi-Yu Shen, Meng-Ying Zhai, Zu-Qi Shen, Wei Li, Ling-Feng Liang, Shu-Yuan Yin, Qiu-Qin Han, Bing Li, Yu-Qiu Zhang, Jin Y. Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress. Nature communications. vol 15. issue 1. 2024-06-18. PMID:38890305. |
extracellular atp (eatp) signaling through the p2x7 receptor pathway is widely believed to trigger nlrp3 inflammasome assembly in microglia, potentially contributing to depression. |
2024-06-18 |
2024-06-21 |
mouse |
| Abudurousuli Adili, Aerken Dilihumaer, Huhu Zhu, Huifang Tan. Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2024-06-11. PMID:38860393. |
pde4 inhibitors play a role in depression; autism spectrum and huntington's disease by inhibiting the advanced glycation end product receptor (rage), tlr4 and nlrp3 pathways in the hippocampus, reducing the activation of microglia and the production of interleukin-1β, down-regulating hmgb1/rage signaling pathway and inhibiting inflammatory factors and increase the nociception threshold. |
2024-06-11 |
2024-06-14 |
Not clear |