| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pan Su, Liming Liu, Yuhang Gong, Shuaijun Peng, Xiangli Yan, Ming Bai, Erping Xu, Yucheng L. Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling. International immunopharmacology. vol 143. issue Pt 3. 2024-11-04. PMID:39492132. |
the pathogenesis of depression is largely influenced by dyshomeostasis of neuroinflammation regulated by microglia m1/m2 polarization, and nlrp3 inflammasome acts critical roles in shifting microglia polarization. |
2024-11-04 |
2024-11-06 |
Not clear |
| Wei Shen, Xuzhong Zhang, Min Tang, Wei Chen, Ying Wang, Haoquan Zho. Targeting of ubiquitination and degradation of KLF15 by E3 ubiquitin ligase KBTBD7 regulates LPS-induced septic brain injury in microglia. Experimental cell research. 2024-11-03. PMID:39489209. |
in addition, clp was found to evoke microglia activation, increase inflammation, induce the activation of nlrp3 inflammasome and nf-κb signaling pathway, and upregulate kbtbd7 expression. |
2024-11-03 |
2024-11-06 |
rat |
| Yijia Lin, Lizhen Cheng, Yixin Chen, Wei Li, Qihao Guo, Ya Mia. TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy. American journal of physiology. Cell physiology. 2024-10-22. PMID:39437446. |
our findings have unraveled the pathogenesis of a previously underappreciated disease, implying that the activation of nlrp3 inflammasome and impairment of autophagy in microglia are significant etiological factors in the de. |
2024-10-22 |
2024-10-25 |
mouse |
| Qiuhong Jiang, Ge Li, Huacheng Wang, Weineng Chen, Fengyin Liang, Haifan Kong, Tara S R Chen, Lishan Lin, Hua Hong, Zhong Pe. SARS-CoV-2 spike S1 protein induces microglial NLRP3-dependent neuroinflammation and cognitive impairment in mice. Experimental neurology. 2024-10-20. PMID:39428044. |
we stimulated bv2 cells with s1 protein in vitro and injected the hippocampi of wild-type (wt) mice, nlrp3 knockout (ko), and microglia nlrp3 ko mice in vivo with s1 protein to induce cognitive impairment. |
2024-10-20 |
2024-10-23 |
mouse |
| Qiuhong Jiang, Ge Li, Huacheng Wang, Weineng Chen, Fengyin Liang, Haifan Kong, Tara S R Chen, Lishan Lin, Hua Hong, Zhong Pe. SARS-CoV-2 spike S1 protein induces microglial NLRP3-dependent neuroinflammation and cognitive impairment in mice. Experimental neurology. 2024-10-20. PMID:39428044. |
we found that s1 protein injection led to cognitive impairment, neuronal loss, and neuroinflammation by activating nlrp3 inflammation, and this was reduced by global nlrp3 ko and microglia nlrp3 ko. |
2024-10-20 |
2024-10-23 |
mouse |
| Zhixin Zhang, Miao Li, Xiang Li, Zhiyang Feng, Gan Luo, Ying Wang, Xiaoyan Ga. Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-10-16. PMID:39407211. |
the nlr family pyrin domain containing 3 (nlrp3) inflammasome in microglia is intimately linked to the pathogenesis of alzheimer's disease (ad). |
2024-10-16 |
2024-10-18 |
mouse |
| Zhixin Zhang, Miao Li, Xiang Li, Zhiyang Feng, Gan Luo, Ying Wang, Xiaoyan Ga. Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-10-16. PMID:39407211. |
here, we found that under the pathological conditions of ad, the activation of nlrp3 inflammasome in microglia is accompanied by increased glutamine metabolism. |
2024-10-16 |
2024-10-18 |
mouse |
| Zhixin Zhang, Miao Li, Xiang Li, Zhiyang Feng, Gan Luo, Ying Wang, Xiaoyan Ga. Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-10-16. PMID:39407211. |
suppression of glutaminase, the rate limiting enzyme in glutamine metabolism, attenuated the nlrp3 inflammasome activation both in the microglia of ad mice and cultured inflammatory microglia. |
2024-10-16 |
2024-10-18 |
mouse |
| Zhixin Zhang, Miao Li, Xiang Li, Zhiyang Feng, Gan Luo, Ying Wang, Xiaoyan Ga. Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-10-16. PMID:39407211. |
mechanistically, inhibiting glutaminase blocked the anaplerotic flux of glutamine to the tricarboxylic acid cycle and amino acid synthesis, down-regulated mtorc1 signaling by phosphorylating ampk, which stimulated mitophagy and limited the accumulation of intracellular reactive oxygen species, ultimately prevented the activation of nlrp3 inflammasomes in activated microglia during ad. |
2024-10-16 |
2024-10-18 |
mouse |
| Zhixin Zhang, Miao Li, Xiang Li, Zhiyang Feng, Gan Luo, Ying Wang, Xiaoyan Ga. Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-10-16. PMID:39407211. |
taken together, our findings suggest that glutamine metabolism regulates the activation of nlrp3 inflammasome through mitophagy in microglia, thus providing a potential therapeutic target for ad treatment. |
2024-10-16 |
2024-10-18 |
mouse |
| Honghu Song, Rizhao Pang, Zhixuan Chen, Linjie Wang, Xiaomin Hu, Jingzhi Feng, Wenchun Wang, Jiancheng Liu, Anren Zhan. Every-other-day fasting inhibits pyroptosis while regulating bile acid metabolism and activating TGR5 signaling in spinal cord injury. Frontiers in molecular neuroscience. vol 17. 2024-09-27. PMID:39328272. |
ultimately, it was confirmed that eodf influences the activation of microglia and nlrp3 inflammasomes associated with the tgr5 signaling, along with the expression of downstream pyroptosis pathway related proteins and inflammatory cytokines, as evidenced by the activation of the nlrp3/caspase-1/gsdmd pyroptosis pathway in sci rats. |
2024-09-27 |
2024-09-29 |
rat |
| Savannah Biby, Prasenjit Mondal, Yiming Xu, Ashley Gomm, Baljit Kaur, Jannatun N Namme, Changning Wang, Rudolph E Tanzi, Shijun Zhang, Can Zhan. Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome. ACS chemical neuroscience. 2024-09-19. PMID:39297418. |
in addition, studies using the mouse microglia bv2 cell model demonstrated that ym-i-26 is not cytotoxic, improved the phagocytotic functions of bv2 cells toward beta-amyloid, and suppressed the production of cytokines of il-1β and il-10 upon the activation of the nlrp3 inflammasome. |
2024-09-19 |
2024-09-26 |
mouse |
| Dilek Saker, Leman Sencar, Gulfidan Coskun, Tugce Sapmaz Ercakalli, Dervis Mansuri Yilmaz, Sait Pola. Galantamine and Wedelolactone Combined Treatment Suppresses LPS-Induced NLRP3 İnflammasome Activation in Microglial Cells. Immunopharmacology and immunotoxicology. 2024-09-16. PMID:39279139. |
we aimed to investigate the mechanisms underlying the pharmacological effects of galantamine and wedelolactone by evaluating the response of the nuclear factor kappa b (nf-κb) signaling pathway and nlrp3 inflammasome in lipopolysaccharide (lps)-activated n9 microglia. |
2024-09-16 |
2024-09-18 |
Not clear |
| Yanan Guo, Jiayi Liu, Xingyue Du, Mian Qi, Tongping She, Ke Xue, Xinhe Wu, Lihua Xu, Bin Peng, Yunfeng Zhang, Yufeng Liu, Zhenglin Jiang, Xia Li, Yuan Yua. ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice. Scientific reports. vol 14. issue 1. 2024-09-13. PMID:39271781. |
in this study, we confirmed that hbo treatments beginning within 1 h post reperfusion significantly alleviated the haemorrhage and neurological deficits in hyperglycemic transient middle cerebral arterial occlusion (tmcao) mice, partly due to the inhibition of the nlrp3 inflammasome-mediated pro-inflammatory response in microglia. |
2024-09-13 |
2024-09-16 |
mouse |
| Yanan Guo, Jiayi Liu, Xingyue Du, Mian Qi, Tongping She, Ke Xue, Xinhe Wu, Lihua Xu, Bin Peng, Yunfeng Zhang, Yufeng Liu, Zhenglin Jiang, Xia Li, Yuan Yua. ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice. Scientific reports. vol 14. issue 1. 2024-09-13. PMID:39271781. |
notably, reactive oxygen species (ros) mediate the anti-inflammatory and protective effect of early hbo treatment, as edaravone and n-acetyl-l-cysteine (nac), two commonly used antioxidants, reversed the suppressive effect of hbo treatment on nlrp3 inflammasome-mediated inflammation in microglia. |
2024-09-13 |
2024-09-16 |
mouse |
| Jing Yao, Yuan Li, Xi Liu, Wenping Liang, Yu Li, Liyong Wu, Zhe Wang, Weihong Son. FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression. Neural regeneration research. vol 20. issue 7. 2024-09-10. PMID:39254567. |
because nlrp3 is primarily found in brain microglia, and tau is predominantly located in neurons, it has been suggested that nlrp3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory cytokines. |
2024-09-10 |
2024-09-13 |
mouse |
| Junyun Wu, Reng Ren, Tao Chen, Li-Da Su, Tianchi Tan. Neuroimmune and Neuroinflammation Response for Traumatic Brain Injury. Brain research bulletin. 2024-09-06. PMID:39241894. |
keywords included "traumatic brain injury," "neuroimmune response," "neuroinflammation," "astrocytes," "microglia," and "nlrp3." |
2024-09-06 |
2024-09-10 |
Not clear |
| Tong-Qi Ge, Pei-Pei Guan, Pu Wan. Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer's disease. Neuroscience and biobehavioral reviews. 2024-09-01. PMID:39218048. |
the overloading of nlrp3 inflammasomes activate microglia, leading to the formation of inflammatory environment. |
2024-09-01 |
2024-09-04 |
Not clear |
| Yaqi Liu, Xiying Fu, Jiangjin Sun, Ranji Cui, Wei Yan. AdipoRon exerts an antidepressant effect by inhibiting NLRP3 inflammasome activation in microglia via promoting mitophagy. International immunopharmacology. vol 141. 2024-08-30. PMID:39213872. |
adiporon exerts an antidepressant effect by inhibiting nlrp3 inflammasome activation in microglia via promoting mitophagy. |
2024-08-30 |
2024-09-04 |
Not clear |
| Yaqi Liu, Xiying Fu, Jiangjin Sun, Ranji Cui, Wei Yan. AdipoRon exerts an antidepressant effect by inhibiting NLRP3 inflammasome activation in microglia via promoting mitophagy. International immunopharmacology. vol 141. 2024-08-30. PMID:39213872. |
overall, these findings indicate that adiporon alleviates depression by inhibiting nlrp3 inflammasome activation in microglia via improving mitophagy. |
2024-08-30 |
2024-09-04 |
Not clear |