| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael D Weber, Matthew G Frank, Kevin J Tracey, Linda R Watkins, Steven F Maie. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568124. |
intracerebral disulfide hmgb-1 mimicked the effect of the stressor, because microglia isolated from hmgb-1-treated rats expressed exaggerated nlrp3 and proinflammatory cytokine expression after lps treatment, whereas fully reduced hmgb-1 had no effect. |
2015-03-20 |
2023-08-13 |
rat |
| Michael D Weber, Matthew G Frank, Kevin J Tracey, Linda R Watkins, Steven F Maie. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568124. |
the present results suggest that the cns innate immune system can respond to an acute stressor as if it were cellular damage, thereby releasing the danger signal hmgb-1 in the brain to prime microglia by acting on the nlrp3 inflammasome, in preparation for a later immune challenge. |
2015-03-20 |
2023-08-13 |
rat |
| Matthew G Frank, Sarah A Hershman, Michael D Weber, Linda R Watkins, Steven F Maie. Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology. vol 40. 2014-10-09. PMID:24485491. |
chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces nlrp3 mrna in the hippocampus. |
2014-10-09 |
2023-08-12 |
rat |
| Meng-Shan Tan, Jin-Tai Yu, Teng Jiang, Xi-Chen Zhu, Lan Ta. The NLRP3 inflammasome in Alzheimer's disease. Molecular neurobiology. vol 48. issue 3. 2014-06-18. PMID:23686772. |
we review here the activation mechanisms of nlrp3 inflammasome in microglia and several downstream effects in the brain, demonstrating that toxic aβ peptide can light a fire in nlrp3 inflammasome and eventually induce ad pathology and tissue damage. |
2014-06-18 |
2023-08-12 |
mouse |
| Juan Pablo de Rivero Vaccari, W Dalton Dietrich, Robert W Kean. Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 3. 2014-04-28. PMID:24398940. |
in this review, we consider the different types of inflammasomes (nlrp1, nlrp2, nlrp3, and aim2) that have been described in cns cells, namely neurons, astrocytes, and microglia. |
2014-04-28 |
2023-08-12 |
Not clear |
| Mareike Schnaars, Hannes Beckert, Annett Hall. Assessing β-amyloid-induced NLRP3 inflammasome activation in primary microglia. Methods in molecular biology (Clifton, N.J.). vol 1040. 2014-02-07. PMID:23852592. |
assessing β-amyloid-induced nlrp3 inflammasome activation in primary microglia. |
2014-02-07 |
2023-08-12 |
Not clear |
| Mareike Schnaars, Hannes Beckert, Annett Hall. Assessing β-amyloid-induced NLRP3 inflammasome activation in primary microglia. Methods in molecular biology (Clifton, N.J.). vol 1040. 2014-02-07. PMID:23852592. |
stimulation of cultured primary microglia by synthetic fibrillar aβ causes the release of il-1β via activation of the nlrp3 inflammasome.here we provide protocols for the preparation of primary microglial cultures and synthetic oligomeric and fibrillar forms of aβ. |
2014-02-07 |
2023-08-12 |
Not clear |
| Tobias Goldmann, Tuan Leng Tay, Marco Prin. Love and death: microglia, NLRP3 and the Alzheimer's brain. Cell research. vol 23. issue 5. 2013-11-26. PMID:23399597. |
love and death: microglia, nlrp3 and the alzheimer's brain. |
2013-11-26 |
2023-08-12 |
Not clear |
| Iva Hafner-Bratkovič, Mojca Benčina, Katherine A Fitzgerald, Douglas Golenbock, Roman Jeral. NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity. Cellular and molecular life sciences : CMLS. vol 69. issue 24. 2013-02-18. PMID:22926439. |
microglia and macrophages release il-1β upon stimulation by prp fibrils, which depends on the nlrp3 inflammasome. |
2013-02-18 |
2023-08-12 |
mouse |
| Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T Golenboc. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. vol 493. issue 7434. 2013-02-13. PMID:23254930. |
indeed, amyloid-β activation of the nlrp3 inflammasome in microglia is fundamental for interleukin-1β maturation and subsequent inflammatory events. |
2013-02-13 |
2023-08-12 |
mouse |
| Richa Hanamsagar, Victor Torres, Tammy Kielia. Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia. Journal of neurochemistry. vol 119. issue 4. 2011-12-23. PMID:21913925. |
therefore, the functional role of the nlrp3 inflammasome and its adaptor protein apoptosis-associated speck-like protein (asc) in eliciting il-1β and il-18 release was examined in primary microglia. |
2011-12-23 |
2023-08-12 |
Not clear |
| Richa Hanamsagar, Victor Torres, Tammy Kielia. Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia. Journal of neurochemistry. vol 119. issue 4. 2011-12-23. PMID:21913925. |
interestingly, we found that il-1β, but not il-18 production, was significantly attenuated in both nlrp3 and asc knockout microglia following exposure to live s. aureus. |
2011-12-23 |
2023-08-12 |
Not clear |
| Richa Hanamsagar, Victor Torres, Tammy Kielia. Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia. Journal of neurochemistry. vol 119. issue 4. 2011-12-23. PMID:21913925. |
a cathepsin b inhibitor attenuated il-β release from nlrp3 and asc knockout microglia, demonstrating the existence of alternative inflammasome-independent mechanisms for il-1β processing. |
2011-12-23 |
2023-08-12 |
Not clear |