| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana S Falcão, Luís A R Carvalho, Gonçalo Lidónio, Ana R Vaz, Susana D Lucas, Rui Moreira, Dora Brite. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. ACS chemical neuroscience. vol 8. issue 1. 2017-10-30. PMID:27797173. |
vs also suppressed aβ-induced expression of inflammatory mediators in microglia, such as matrix metalloproteinase (mmp)-2 and mmp-9, as well as high-mobility group box protein-1 (hmgb1), nod-like receptor protein 3 (nlrp3)-inflammasome, and interleukin (il)-1β. |
2017-10-30 |
2023-08-13 |
mouse |
| Leslie Freeman, Haitao Guo, Clément N David, W June Brickey, Sushmita Jha, Jenny P-Y Tin. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. The Journal of experimental medicine. vol 214. issue 5. 2017-09-12. PMID:28404595. |
nlr members nlrc4 and nlrp3 mediate sterile inflammasome activation in microglia and astrocytes. |
2017-09-12 |
2023-08-13 |
Not clear |
| Leslie Freeman, Haitao Guo, Clément N David, W June Brickey, Sushmita Jha, Jenny P-Y Tin. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. The Journal of experimental medicine. vol 214. issue 5. 2017-09-12. PMID:28404595. |
in this study, we reveal that lysophosphatidylcholine (lpc), a molecule associated with neurodegeneration and demyelination, elicits nlrp3 and nlrc4 inflammasome activation in microglia and astrocytes, which are central players in neuroinflammation. |
2017-09-12 |
2023-08-13 |
Not clear |
| Holger Scholz, Claudia Ede. Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes. Journal of neuroimmunology. vol 310. 2017-08-22. PMID:28778433. |
lpc-induced caspase-1 activation in microglia was found to depend on lps prestimulation, inflammasome nlrp3 and adaptor molecule asc. |
2017-08-22 |
2023-08-13 |
Not clear |
| Ernest T Chivero, Ming-Lei Guo, Palsamy Periyasamy, Ke Liao, Shannon E Callen, Shilpa Buc. HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 13. 2017-08-18. PMID:28270571. |
we found a dose- and time-dependent induction of nlrp3 expression in microglia exposed to tat compared with control. |
2017-08-18 |
2023-08-13 |
Not clear |
| Sheng-Tao Yao, Fang Cao, Jia-Lin Chen, Wei Chen, Rui-Ming Fan, Gang Li, You-Chao Zeng, Song Jiao, Xiang-Ping Xia, Chong Han, Qi-Shan Ra. NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH. Journal of molecular neuroscience : MN. vol 61. issue 3. 2017-06-29. PMID:27933491. |
the nlrp3 inflammasome was activated after ich and was located in the microglial cell of the mouse brain, which exhibits a time-dependent manner. |
2017-06-29 |
2023-08-13 |
mouse |
| Xinchun Ye, Dandan Zuo, Lu Yu, Liang Zhang, Jiao Tang, Chengcheng Cui, Lei Bao, Kun Zan, Zuohui Zhang, Xinxin Yang, Hao Chen, Hai Tang, Jie Zu, Hongjuan Shi, Guiyun Cu. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochemical and biophysical research communications. vol 485. issue 2. 2017-06-13. PMID:28202418. |
ros/txnip pathway contributes to thrombin induced nlrp3 inflammasome activation and cell apoptosis in microglia. |
2017-06-13 |
2023-08-13 |
human |
| Christopher Nebel, Alexander Aslanidis, Khalid Rashid, Thomas Langman. Activated microglia trigger inflammasome activation and lysosomal destabilization in human RPE cells. Biochemical and biophysical research communications. vol 484. issue 3. 2017-06-06. PMID:28159556. |
in this study, we investigated whether reactive microglia trigger and sustain nlrp3 inflammasome activation in human retinal pigment epithelium (arpe-19) cells. |
2017-06-06 |
2023-08-13 |
human |
| Ya-Min Liu, Ji-Duo Shen, Li-Ping Xu, Han-Bing Li, Yu-Cheng Li, Li-Tao Y. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. International immunopharmacology. vol 45. 2017-06-01. PMID:28213267. |
considering that depression is an inflammatory related mental disease, our present study was aimed to investigate the role of ferulic acid in the regulation of microglia activation, pro-inflammatory cytokines, nuclear factor kappa b (nf-κb) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome in mice exposed to chronic unpredictable mild stress (cums). |
2017-06-01 |
2023-08-13 |
mouse |
| Ya-Min Liu, Ji-Duo Shen, Li-Ping Xu, Han-Bing Li, Yu-Cheng Li, Li-Tao Y. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. International immunopharmacology. vol 45. 2017-06-01. PMID:28213267. |
then, we found that cums significantly caused interleukin-1β (il-1β), interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α) up-regulation, microglia, nf-κb signaling and nlrp3 inflammasome activation in the prefrontal cortex. |
2017-06-01 |
2023-08-13 |
mouse |
| Leoni Lammerding, Alexander Slowik, Sonja Johann, Cordian Beyer, Adib Zendede. Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain. Neuroendocrinology. vol 103. issue 5. 2017-05-16. PMID:26337121. |
within the limits of antibody availability, immunofluorescence labeling demonstrated that microglia and neurons are major sources of the locally activated inflammasomes nod-like receptor protein-3 (nlrp3) and associated speck-like protein (asc), respectively. |
2017-05-16 |
2023-08-13 |
rat |
| Philippe Leff-Gelman, Ismael Mancilla-Herrera, Mónica Flores-Ramos, Carlos Cruz-Fuentes, Juan Pablo Reyes-Grajeda, María Del Pilar García-Cuétara, Marielle Danitza Bugnot-Pérez, David Ellioth Pulido-Ascenci. The Immune System and the Role of Inflammation in Perinatal Depression. Neuroscience bulletin. vol 32. issue 4. 2017-02-24. PMID:27432060. |
thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during pregnancy, proposing that the same stress-related mechanisms involved in the activation of the nlrp3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. |
2017-02-24 |
2023-08-13 |
Not clear |
| Yang Cai, Hong Kong, Yin-Bing Pan, Lai Jiang, Xiu-Xiu Pan, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Li. Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia. Journal of neuroinflammation. vol 13. issue 1. 2017-02-14. PMID:26931361. |
procyanidins alleviates morphine tolerance by inhibiting activation of nlrp3 inflammasome in microglia. |
2017-02-14 |
2023-08-13 |
Not clear |
| Yang Cai, Hong Kong, Yin-Bing Pan, Lai Jiang, Xiu-Xiu Pan, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Li. Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia. Journal of neuroinflammation. vol 13. issue 1. 2017-02-14. PMID:26931361. |
our present study investigated the effects and possible mechanism of a natural product procyanidins in improving morphine tolerance via its specific inhibition on nod-like receptor protein3 (nlrp3) inflammasome in microglia. |
2017-02-14 |
2023-08-13 |
Not clear |
| Ji-Yun Kim, James C Paton, David E Briles, Dong-Kwon Rhee, Suhkneung Py. Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia. Oncotarget. vol 6. issue 42. 2016-11-07. PMID:26683708. |
thus, the present data demonstrate that s. pneumoniae induces pyroptosis in murine microglia and that nlrp3 inflammasome is critical for caspase-1 activation during the process. |
2016-11-07 |
2023-08-13 |
mouse |
| Yanran Liang, Xiuna Jing, Zhifen Zeng, Wei Bi, Ying Chen, Xia Wu, Lianhong Yang, Jun Liu, Songhua Xiao, Shuqiong Liu, Danyu Lin, Enxiang Ta. Rifampicin attenuates rotenone-induced inflammation via suppressing NLRP3 inflammasome activation in microglia. Brain research. vol 1622. 2016-06-02. PMID:26086368. |
rifampicin attenuates rotenone-induced inflammation via suppressing nlrp3 inflammasome activation in microglia. |
2016-06-02 |
2023-08-13 |
Not clear |
| Audrey Gustin, Mélanie Kirchmeyer, Eric Koncina, Paul Felten, Sophie Losciuto, Tony Heurtaux, Aubry Tardivel, Paul Heuschling, Catherine Doster. NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes. PloS one. vol 10. issue 6. 2016-05-10. PMID:26091541. |
nlrp3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes. |
2016-05-10 |
2023-08-13 |
mouse |
| Audrey Gustin, Mélanie Kirchmeyer, Eric Koncina, Paul Felten, Sophie Losciuto, Tony Heurtaux, Aubry Tardivel, Paul Heuschling, Catherine Doster. NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes. PloS one. vol 10. issue 6. 2016-05-10. PMID:26091541. |
amyloid-β peptides were able to activate the nlrp3 inflammasome in microglia and il-1β secretion occurred in a p2x7 receptor-independent manner. |
2016-05-10 |
2023-08-13 |
mouse |
| Matthew G Frank, Michael D Weber, Linda R Watkins, Steven F Maie. Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming. Brain, behavior, and immunity. vol 48. 2016-04-13. PMID:25816800. |
a model of neuroinflammatory priming is developed wherein glucocorticoids induce synthesis and release of hmgb1 from microglia, which signals through tlr2/tlr4, thereby priming the nlrp3 inflammasome. |
2016-04-13 |
2023-08-13 |
Not clear |
| Weihua Zhao, David R Beers, Shaughn Bell, Jinghong Wang, Shixiang Wen, Robert H Baloh, Stanley H Appe. TDP-43 activates microglia through NF-κB and NLRP3 inflammasome. Experimental neurology. vol 273. 2016-02-18. PMID:26222336. |
tdp-43 activates microglia through nf-κb and nlrp3 inflammasome. |
2016-02-18 |
2023-08-13 |
Not clear |