| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiujing Feng, Yuan Zhao, Tianyuan Yang, Manyu Song, Chaoran Wang, Yujie Yao, Honggang Fa. Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31555091. |
glucocorticoid-driven nlrp3 inflammasome activation in hippocampal microglia mediates chronic stress-induced depressive-like behaviors. |
2020-09-30 |
2023-08-13 |
rat |
| Xiujing Feng, Yuan Zhao, Tianyuan Yang, Manyu Song, Chaoran Wang, Yujie Yao, Honggang Fa. Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31555091. |
recent studies show that the nod-like receptor protein 3 (nlrp3) inflammasome is expressed in microglia and may play a crucial role in depression. |
2020-09-30 |
2023-08-13 |
rat |
| Xiujing Feng, Yuan Zhao, Tianyuan Yang, Manyu Song, Chaoran Wang, Yujie Yao, Honggang Fa. Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31555091. |
however, the mechanism of nlrp3 inflammasome activation in hippocampal microglia and its role in depressive-like behaviors remain poorly understood. |
2020-09-30 |
2023-08-13 |
rat |
| Na Yue, Bing Li, Liu Yang, Qiu-Qin Han, Hui-Jie Huang, Ya-Lin Wang, Jing Wang, Rui Yu, Gen-Cheng Wu, Qiong Liu, Jin Y. Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression. Frontiers in molecular neuroscience. vol 11. 2020-09-29. PMID:29946236. |
the results showed that 10 week of chronic unpredictable stress (cus) caused behavioral deficits in rats and neuroinflammation in hippocampus, such as increased expression of nlrp3 inflammasome components, upregulated mrna level of il-1β and the protein level of il-1β mature form (p17) and activation of microglia. |
2020-09-29 |
2023-08-13 |
rat |
| Jianhai Long, Qian Wang, Huanhuan He, Xin Sui, Guodong Lin, Shuai Wang, Jun Yang, Pengsheng You, Yuan Luo, Yongan Wan. NLRP3 inflammasome activation is involved in trimethyltin-induced neuroinflammation. Brain research. vol 1718. 2020-09-29. PMID:31059678. |
tmt treatment activated the nlrp3 inflammasome in the microglial cell line bv2. |
2020-09-29 |
2023-08-13 |
human |
| Shiquan Wang, Jin Wang, Haidong Wei, Tingting Gu, Jiajia Wang, Zhixin Wu, Qianzi Yan. Genistein Attenuates Acute Cerebral Ischemic Damage by Inhibiting the NLRP3 Inflammasome in Reproductively Senescent Mice. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32625078. |
the expression of nlrp3 inflammasome-related proteins in microglia was downregulated by gen. |
2020-09-28 |
2023-08-13 |
mouse |
| Shiquan Wang, Jin Wang, Haidong Wei, Tingting Gu, Jiajia Wang, Zhixin Wu, Qianzi Yan. Genistein Attenuates Acute Cerebral Ischemic Damage by Inhibiting the NLRP3 Inflammasome in Reproductively Senescent Mice. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32625078. |
however, the overexpression of nlrp3 in microglia abrogated the gen-induced inhibition of inflammatory factor release and reversed the neuroprotective effect of gen. taken together, the results suggest that gen treatment could attenuate the acute injury induced by cerebral ischemia in reproductively senescent mice |
2020-09-28 |
2023-08-13 |
mouse |
| Yadi Guan, Fang Ha. Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases. Frontiers in integrative neuroscience. vol 14. 2020-09-28. PMID:32792920. |
however, in the case of als, not only microglia but also astrocytes express increased nlrp3 levels and contribute to activation of the nlrp3 pathway. |
2020-09-28 |
2023-08-13 |
human |
| Lulu Xie, Zhimin Gu, Haizhao Liu, Beitian Jia, Yiyang Wang, Min Cao, Ruiwen Song, Zhaiyi Zhang, Yuhong Bia. The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32922291. |
pcr and western blot were used to monitor the differences of nlrp3, caspase-1, asc activation in the levels of genes and proteins in the pfc of rats and microglia. |
2020-09-28 |
2023-08-13 |
rat |
| Lulu Xie, Zhimin Gu, Haizhao Liu, Beitian Jia, Yiyang Wang, Min Cao, Ruiwen Song, Zhaiyi Zhang, Yuhong Bia. The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32922291. |
in addition, hesperidin decreased the expression levels of il-1β, il-6, tnf-α, nlrp3, caspase-1, and asc in the pfc and microglia. |
2020-09-28 |
2023-08-13 |
rat |
| Lili Si, Haifeng Wang, Leyuan Wan. Suppression of miR-193a alleviates neuroinflammation and improves neurological function recovery after traumatic brain injury (TBI) in mice. Biochemical and biophysical research communications. vol 523. issue 2. 2020-09-15. PMID:31924304. |
of note, cci-induced activation of microglia was repressed by mir-193a inhibition, along with significantly reduced expression of neuroinflammatory markers, which were associated with the blockage of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome. |
2020-09-15 |
2023-08-13 |
mouse |
| César J Carranza-Aguilar, Araceli Hernández-Mendoza, Carlos Mejias-Aponte, Kenner C Rice, Marisela Morales, Claudia González-Espinosa, Silvia L Cru. Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors. Cellular and molecular neurobiology. 2020-09-14. PMID:32926257. |
two hours after the last (19th) administration, we analyzed nlrp3 oligomerization, caspase-1 activation and gasdermin d-n (gsdmd-n) expression in microglia (cd11b positive cells), astrocytes (gfap-positive cells) and neurons (neun-positive cells). |
2020-09-14 |
2023-08-13 |
rat |
| César J Carranza-Aguilar, Araceli Hernández-Mendoza, Carlos Mejias-Aponte, Kenner C Rice, Marisela Morales, Claudia González-Espinosa, Silvia L Cru. Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors. Cellular and molecular neurobiology. 2020-09-14. PMID:32926257. |
the opioid receptor antagonist (-)-naloxone, but not the tlr4 receptor antagonist (+)-naloxone, prevented microglia activation and nlrp3 oligomerization. |
2020-09-14 |
2023-08-13 |
rat |
| Xiaobo Li, Yanshu Zhang, Bin Li, Hongbao Yang, Jian Cui, Xiaoyan Li, Xinwei Zhang, Hao Sun, Qingtao Meng, Shenshen Wu, Shuang Li, Jianbo Wang, Michael Aschner, Rui Che. Activation of NLRP3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice. Environment international. vol 136. 2020-09-10. PMID:31999974. |
activation of nlrp3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice. |
2020-09-10 |
2023-08-13 |
mouse |
| Veni Bharti, Hua Tan, Hong Zhou, Jun-Feng Wan. Txnip mediates glucocorticoid-activated NLRP3 inflammatory signaling in mouse microglia. Neurochemistry international. vol 131. 2020-09-03. PMID:31586460. |
txnip mediates glucocorticoid-activated nlrp3 inflammatory signaling in mouse microglia. |
2020-09-03 |
2023-08-13 |
mouse |
| Veni Bharti, Hua Tan, Hong Zhou, Jun-Feng Wan. Txnip mediates glucocorticoid-activated NLRP3 inflammatory signaling in mouse microglia. Neurochemistry international. vol 131. 2020-09-03. PMID:31586460. |
the purpose of this study is to investigate the effect of chronic stress hormone treatment on txnip and nlrp3 inflammasome signaling in cultured microglia cells. |
2020-09-03 |
2023-08-13 |
mouse |
| Jialing Peng, Hongxuan Wang, Zhe Gong, Xiangpen Li, Lei He, Qingyu Shen, Jingrui Pan, Ying Pen. Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity. Molecular immunology. vol 123. 2020-08-18. PMID:32438202. |
it raises questions how exactly nlrp3 inflammasom was activated in microglia and neuron and whether idebenone reverses the process in i/r. |
2020-08-18 |
2023-08-13 |
Not clear |
| Silvia L Cruz, Monserrat Armenta-Reséndiz, César J Carranza-Aguilar, Emilio J Galvá. Minocycline prevents neuronal hyperexcitability and neuroinflammation in medial prefrontal cortex, as well as memory impairment caused by repeated toluene inhalation in adolescent rats. Toxicology and applied pharmacology. vol 395. 2020-08-17. PMID:32234516. |
these effects are accompanied by significant decreased expression of astrocytes and activated microglia in the mpfc, reduced nlrp3 inflammasome activation and mrna expression levels of the pro-inflammatory cytokine interleukin 1β (il-1β), as well as increased mrna expression of the anti-inflammatory cytokine transforming growth factor β (tgf-β). |
2020-08-17 |
2023-08-13 |
rat |
| Xiaojuan Han, Sifan Sun, Yiming Sun, Qiqi Song, Jialei Zhu, Nanshan Song, Miaomiao Chen, Ting Sun, Meiling Xia, Jianhua Ding, Ming Lu, Honghong Yao, Gang H. Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease. Autophagy. vol 15. issue 11. 2020-08-05. PMID:30966861. |
mechanically, ka promoted macroautophagy/autophagy in microglia, leading to reduced nlrp3 protein expression, which in turn deactivated the nlrp3 inflammasome. |
2020-08-05 |
2023-08-13 |
mouse |
| Mariusz Z Ratajczak, Aaron Mack, Kamila Bujko, Alison Domingues, Daniel Pedziwiatr, Magda Kucia, Janina Ratajczak, Henning Ulrich, Jolanta Kucharska-Mazur, Jerzy Samochowie. ATP-Nlrp3 Inflammasome-Complement Cascade Axis in Sterile Brain Inflammation in Psychiatric Patients and its Impact on Stem Cell Trafficking. Stem cell reviews and reports. vol 15. issue 4. 2020-07-23. PMID:31020518. |
in this review we will present a concept that aberrant purinergic signaling and increases in extracellular level of adenosine triphosphate (atp) in the brain parenchyma may lead to activation of nlrp3 inflammasome in microglia cells and as a consequence microglia released danger associated molecular pattern (damp) proteins activate complement cascade (comc) in mannan binding lectin (mbl) - dependent manner. |
2020-07-23 |
2023-08-13 |
Not clear |