| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
mptp-driven nlrp3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. |
2020-04-07 |
2023-08-13 |
mouse |
| Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
in primary microglia and mixed glial cell cultures, mptp/atp treatment promotes the robust assembly and activation of the nlrp3 inflammasome via producing mitochondrial reactive oxygen species. |
2020-04-07 |
2023-08-13 |
mouse |
| Xiaoling Zhang, Wenmin Huang, Qianhang Shao, Yuan Yang, Zhengxin Xu, Jing Chen, Xiaoyan Zhang, Xiaoqun G. Drp1, a potential therapeutic target for Parkinson's disease, is involved in olfactory bulb pathological alteration in the Rotenone-induced rat model. Toxicology letters. vol 325. 2020-03-30. PMID:32088201. |
additionally, increased nf-κb nuclear translocation and nlrp3 inflammasome components expressions caused by rotenone injection were observed accompanied by the activation of microglia and astrocytes in the olfactory bulb. |
2020-03-30 |
2023-08-13 |
rat |
| Zhenyi Xue, Zimu Zhang, Hongkun Liu, Wen Li, Xiangdong Guo, Zhihui Zhang, Ying Liu, Long Jia, Yan Li, Yinghui Ren, Hongwei Yang, Lijuan Zhang, Qi Zhang, Yurong Da, Junwei Hao, Zhi Yao, Rongxin Zhan. lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. Cell death and differentiation. vol 26. issue 1. 2020-03-11. PMID:29666475. |
elucidation of the link between lincrna-cox2 and the inflammasome-autophagy crosstalk in macrophage and microglia reveals a role for lncrnas in activation of nlrp3 inflammasome and autophagy, and provides new opportunities for therapeutic intervention in neuroinflammation-dependent diseases. |
2020-03-11 |
2023-08-13 |
Not clear |
| Ravikanth Velagapudi, Ayokulehin M Kosoko, Olumayokun A Olajid. Induction of Neuroinflammation and Neurotoxicity by Synthetic Hemozoin. Cellular and molecular neurobiology. vol 39. issue 8. 2020-01-20. PMID:31332667. |
treatment of bv-2 microglia with shz increased protein levels of nlrp3 with accompanying increase in caspase-1 activity. |
2020-01-20 |
2023-08-13 |
Not clear |
| Yujie Luo, Cesar Reis, Sheng Che. NLRP3 Inflammasome in the Pathophysiology of Hemorrhagic Stroke: A Review. Current neuropharmacology. vol 17. issue 7. 2020-01-06. PMID:30592254. |
the nod-like receptor family, pyrin domain containing 3 (nlrp3) inflammasome is predominantly released by microglia and is believed as the main contributor of neuroinflammation. |
2020-01-06 |
2023-08-13 |
Not clear |
| Judith Houtman, Kiara Freitag, Niclas Gimber, Jan Schmoranzer, Frank L Heppner, Marina Jendrac. Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3. The EMBO journal. vol 38. issue 4. 2020-01-06. PMID:30617086. |
beclin1-driven autophagy modulates the inflammatory response of microglia via nlrp3. |
2020-01-06 |
2023-08-13 |
Not clear |
| Deidiane Elisa Ribeiro, Aline Lulho Roncalho, Talita Glaser, Henning Ulrich, Gregers Wegener, Sâmia Joc. P2X7 Receptor Signaling in Stress and Depression. International journal of molecular sciences. vol 20. issue 11. 2019-11-19. PMID:31174279. |
moreover, p2x7r stimulation in microglia modulates the innate immune response by activating the nlr family pyrin domain containing 3 (nlrp3) inflammasome, consistent with the neuroimmune hypothesis of mdd. |
2019-11-19 |
2023-08-13 |
Not clear |
| Cira Dansokho, Michael Thomas Henek. Neuroinflammatory responses in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 5. 2019-11-04. PMID:29273951. |
this review discusses recent knowledge on microglia responses toward amyloid and tau pathology in ad, focusing on the role of toll-like receptors and nod-like receptor protein 3 (nlrp3) inflammasome activation in microglial cells. |
2019-11-04 |
2023-08-13 |
mouse |
| Xiaolong Yao, Qian Jiang, Wei Ding, Pengjie Yue, Junwen Wang, Kai Zhao, Huaqiu Zhan. Interleukin 4 inhibits high mobility group box-1 protein-mediated NLRP3 inflammasome formation by activating peroxisome proliferator-activated receptor-γ in astrocytes. Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-28. PMID:30606476. |
high mobility group box-1 protein (hmgb-1) is one of the most important damps and has been previously shown to promote the formation of the nod-like receptor with pyrin domain containing-3 (nlrp3) inflammasome in microglia. |
2019-10-28 |
2023-08-13 |
Not clear |
| Ji Peng, Peng Zhang, Han Zheng, Yun-Qin Ren, Hong Ya. Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3. Chinese journal of traumatology = Zhonghua chuang shang za zhi. vol 22. issue 3. 2019-10-18. PMID:31056470. |
dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting nlrp3. |
2019-10-18 |
2023-08-13 |
Not clear |
| Ji Peng, Peng Zhang, Han Zheng, Yun-Qin Ren, Hong Ya. Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3. Chinese journal of traumatology = Zhonghua chuang shang za zhi. vol 22. issue 3. 2019-10-18. PMID:31056470. |
to investigate whether dexmedetomidine (dex) can reduce the production of inflammatory factor il-1β by inhibiting the activation of nlrp3 inflammasome in hippocampal microglia, thereby alleviating the inflammatory response of the central nervous system induced by surgical injury. |
2019-10-18 |
2023-08-13 |
Not clear |
| Jie Feng, Jing-Xue Wang, Ye-Hong Du, Ying Liu, Wei Zhang, Jing-Fei Chen, Yuan-Jie Liu, Min Zheng, Ke-Jian Wang, Gui-Qiong H. Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice. CNS neuroscience & therapeutics. vol 24. issue 12. 2019-10-14. PMID:29869390. |
in addition, chronic activation of nlrp3 inflammasomes triggered by amyloid β peptide (aβ) in microglia contributes to persistent neuroinflammation. |
2019-10-14 |
2023-08-13 |
mouse |
| Richard Gordon, Eduardo A Albornoz, Daniel C Christie, Monica R Langley, Vinod Kumar, Susanna Mantovani, Avril A B Robertson, Mark S Butler, Dominic B Rowe, Luke A O'Neill, Anumantha G Kanthasamy, Kate Schroder, Matthew A Cooper, Trent M Woodruf. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science translational medicine. vol 10. issue 465. 2019-10-11. PMID:30381407. |
nlrp3 activation by fibrillar α-synuclein in mouse microglia resulted in a delayed but robust activation of the nlrp3 inflammasome leading to extracellular interleukin-1β and asc release in the absence of pyroptosis. |
2019-10-11 |
2023-08-13 |
mouse |
| Fangzhou Li, Takashi Ayaki, Takakuni Maki, Nobukatsu Sawamoto, Ryosuke Takahash. NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy. Journal of neuropathology and experimental neurology. vol 77. issue 11. 2019-10-07. PMID:30295793. |
we demonstrated that the density of microglia expressing nlrp3 inflammasome-related proteins was increased in the putamina of msa cases and was significantly related to the deposition of phosphorylated α-synuclein-positive glial cytoplasmic inclusions, tyrosine hydroxylase-positive fiber loss, and gliosis of glial fibrillary acidic protein-positive astrocytes. |
2019-10-07 |
2023-08-13 |
Not clear |
| Enquan Xu, Jianuo Liu, Han Liu, Xiaobei Wang, Huangui Xion. Inflammasome Activation by Methamphetamine Potentiates Lipopolysaccharide Stimulation of IL-1β Production in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 2. 2019-10-02. PMID:29492824. |
it is our hypothesis that meth activates nlrp3 inflammasome in microglia and promotes the processing and release of interleukin (il)-1β, resulting in neurotoxic activity. |
2019-10-02 |
2023-08-13 |
human |
| Sherif Rashad, Kuniyasu Niizuma, Mika Sato-Maeda, Miki Fujimura, Ahmed Mansour, Hidenori Endo, Shuntaro Ikawa, Teiji Tominag. Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis. Brain research. vol 1699. 2019-09-30. PMID:29981290. |
our data showed the intense activation of immune cells, particularly the microglia, along with the increase in macrophage activity and nlrp3 inflammasome activation that is indicated by nlrp3, il-1β, and il-18 gene and caspase-1 upregulation and cleavage as well as pyroptotic cell death. |
2019-09-30 |
2023-08-13 |
Not clear |
| Cun-Jin Zhang, Meiling Jiang, Hao Zhou, Weiwei Liu, Chenhui Wang, Zizhen Kang, Bing Han, Quanri Zhang, Xing Chen, Jianxin Xiao, Amanda Fisher, William J Kaiser, Masanori A Murayama, Yoichiro Iwakura, Ji Gao, Julie Carman, Ashok Dongre, George Dubyak, Derek W Abbott, Fu-Dong Shi, Richard M Ransohoff, Xiaoxia L. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. The Journal of clinical investigation. vol 128. issue 12. 2019-09-16. PMID:30372424. |
this study reports a mechanistic insight into noncanonical nlrp3 inflammasome activation in microglia for the effector stage of eae. |
2019-09-16 |
2023-08-13 |
Not clear |
| Xin Xu, Dongpei Yin, Honglei Ren, Weiwei Gao, Fei Li, Dongdong Sun, Yingang Wu, Shuai Zhou, Li Lyu, Mengchen Yang, Jianhua Xiong, Lulu Han, Rongcai Jiang, Jianning Zhan. Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859317. |
we found that nlrp3 inflammasome expression was significantly increased in the peri-contusional cortex and that microglia were the primary source of this expression. |
2019-09-06 |
2023-08-13 |
mouse |
| Runxiao Lv, Lili Du, Xueyong Liu, Fenghua Zhou, Zhiqiang Zhang, Lixin Zhan. Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway. International immunopharmacology. vol 70. 2019-08-27. PMID:30785088. |
above all, our data indicated that polydatin possessed neuroprotective effects in sci rats, possibly by suppressing inos expression and nlrp3 inflammasome activation in microglia. |
2019-08-27 |
2023-08-13 |
rat |