| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangyuan Cao, Yida Wang, Liang Ga. CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33405023. |
the proliferation, inflammatory cytokine expressions, nod-like receptor protein 3 (nlrp3) level, cell pyroptosis, and viability and lactate dehydrogenase (ldh) activity in ogd/r-treated microglia were detected after chrfam7a overexpression. |
2021-05-24 |
2023-08-13 |
Not clear |
| Xiangyuan Cao, Yida Wang, Liang Ga. CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33405023. |
in ogd/r-treated microglia, chrfam7a overexpression promoted cell proliferation and viability, reduced inflammation and ldh activity, and inhibited nlrp3 inflammasome activation and cell pyroptosis. |
2021-05-24 |
2023-08-13 |
Not clear |
| Xiao Fan, Wei Ma, Yingyu Zhang, Li Zhan. P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952148. |
p2x7 receptor (p2x7r) of microglia mediates neuroinflammation by regulating (nod)-like receptor protein 3 (nlrp3) inflammasome-dependent inflammation after spinal cord injury. |
2021-05-20 |
2023-08-13 |
rat |
| Xiao Fan, Wei Ma, Yingyu Zhang, Li Zhan. P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952148. |
the aim of this study was to explore the mechanism by which the p2x7 receptor of microglia regulates neuroinflammation after spinal cord injury in nlrp3 inflammasome-dependent inflammation. |
2021-05-20 |
2023-08-13 |
rat |
| Xiao Fan, Wei Ma, Yingyu Zhang, Li Zhan. P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952148. |
(iii) p2x7r of microglia participates in spinal cord-mediated neuroinflammation via regulating nlrp3 inflammasome-dependent inflammation. |
2021-05-20 |
2023-08-13 |
rat |
| Xiao Fan, Wei Ma, Yingyu Zhang, Li Zhan. P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952148. |
conclusions p2x7r of microglia in spinal cord mediates neuroinflammation by regulating nlrp3 inflammasome-dependent inflammation after spinal cord injury. |
2021-05-20 |
2023-08-13 |
rat |
| Roya Aryanpour, Kazem Zibara, Parichehr Pasbakhsh, Seyyed Behnamodin Jame'ei, Zeinab Namjoo, Amir Ghanbari, Reza Mahmoudi, Showan Amani, Iraj Ragerdi Kashan. 17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome. Neuroscience. vol 463. 2021-05-19. PMID:33794337. |
17β-estradiol reduces demyelination in cuprizone-fed mice by promoting m2 microglia polarity and regulating nlrp3 inflammasome. |
2021-05-19 |
2023-08-13 |
mouse |
| Roya Aryanpour, Kazem Zibara, Parichehr Pasbakhsh, Seyyed Behnamodin Jame'ei, Zeinab Namjoo, Amir Ghanbari, Reza Mahmoudi, Showan Amani, Iraj Ragerdi Kashan. 17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome. Neuroscience. vol 463. 2021-05-19. PMID:33794337. |
in summary, this study demonstrated for the first time that exogenous 17β-estradiol therapy robustly leads to the reduction of m1 phenotype, stimulation of polarized m2 microglia, and repression of nlrp3 inflammasome in the corpus callosum of cpz demyelination model of ms. |
2021-05-19 |
2023-08-13 |
mouse |
| Ya-Jie Ji, Hui-Lin Wang, Bian-Li Yin, Xiang-Yang Re. Down-regulation of DJ-1 Augments Neuroinflammation via Nrf2/Trx1/NLRP3 Axis in MPTP-induced Parkinson's Disease Mouse Model. Neuroscience. vol 442. 2021-05-14. PMID:32526245. |
dj-1 and nrf2 knockdown promoted inflammation and cell apoptosis in bv2 microglia, while nlrp3 knockdown had opposite effects. |
2021-05-14 |
2023-08-13 |
mouse |
| Xiao-Fei He, Jing-Hui Xu, Ge Li, Ming-Yue Li, Li-Li Li, Zhong Pei, Li-Ying Zhang, Xi-Quan H. NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer's disease. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33051464. |
in addition, we injected mcc950 to inhibit nlrp3 activation and used an inducible cre recombinase to delete the nlrp3 gene in microglia. |
2021-05-13 |
2023-08-13 |
mouse |
| Yang Jiao, Jianjian Wang, Huixue Zhang, Yuze Cao, Yang Qu, Siyu Huang, Xiaotong Kong, Chang Song, Jie Li, Qian Li, Heping Ma, Xiaoyu Lu, Lihua Wan. Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke. Journal of cellular and molecular medicine. vol 24. issue 21. 2021-05-04. PMID:32990414. |
in vivo and vitro data revealed that rhtrx-1 reduced necroptosis, mitochondrial membrane potential damage, reactive oxygen species accumulation and nlr family, pyrin domain-containing 3 protein (nlrp3) inflammasome activation and regulated the microglial m1/m2 phenotypic changes by inhibiting ripk1 expression in ischaemic microglia. |
2021-05-04 |
2023-08-13 |
human |
| Yang Liu, Yue Dai, Qing Li, Chen Chen, Hao Chen, Yuanjian Song, Fang Hua, Zuohui Zhan. Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia. Neuroscience letters. vol 736. 2021-04-30. PMID:32726591. |
beta-amyloid activates nlrp3 inflammasome via tlr4 in mouse microglia. |
2021-04-30 |
2023-08-13 |
mouse |
| Lorena Olivares-González, Sheyla Velasco, José María Millán, Regina Rodrig. Intravitreal administration of adalimumab delays retinal degeneration in rd10 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 10. 2021-04-30. PMID:32816354. |
adalimumab prevented from retinal degeneration without affecting caspase -dependent mechanisms but decreasing parp activation, microglia activation as well as nlrp3 inflammasome. |
2021-04-30 |
2023-08-13 |
mouse |
| Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Ha. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:32032696. |
consequently, the intestinal expression of nlrp3 was down-regulated, the cognitive ability of mice was improved, the activation of microglia in central hippocampus was suppressed and the expression of neuroinflammatory factors was also down-regulated. |
2021-04-28 |
2023-08-13 |
mouse |
| Michael J Butler, Rachel M Cole, Nicholas P Deems, Martha A Belury, Ruth M Barriento. Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32544595. |
our results indicate that hfd increased gene expression of microglial markers of activation indicative of microglial priming, including cd11b, mhcii, cx3cr1, and nlrp3, as well as the pro-inflammatory marker il-1β in both hippocampus and amygdala-derived microglia. |
2021-04-27 |
2023-08-13 |
rat |
| Ning Zhang, Chunhong Liu, Ruiyan Zhang, Li Jin, Xiaohan Yin, Xuexing Zheng, Hans-Christian Siebert, Yubao Li, Zhengping Wang, Gabriele Loers, Athanasios K Petridi. Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet. Food & function. vol 11. issue 6. 2021-04-26. PMID:32539054. |
in conclusion, these data demonstrate that kd decreased the reactive astrocytes and activated the microglia in the corpus callosum, and that kd inhibited the hadc3 and nlrp3 inflammasome signaling pathway in cpz-treated mice. |
2021-04-26 |
2023-08-13 |
mouse |
| Xiaoqi Chu, Chun Wang, Zheng Wu, Liting Fan, Chunmei Tao, Jiaqi Lin, Shuang Chen, Yongzhong Lin, Yusong G. JNK/c-Jun-driven NLRP3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy. Experimental eye research. vol 202. 2021-04-16. PMID:33141050. |
jnk/c-jun-driven nlrp3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy. |
2021-04-16 |
2023-08-13 |
Not clear |
| Xiaoqi Chu, Chun Wang, Zheng Wu, Liting Fan, Chunmei Tao, Jiaqi Lin, Shuang Chen, Yongzhong Lin, Yusong G. JNK/c-Jun-driven NLRP3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy. Experimental eye research. vol 202. 2021-04-16. PMID:33141050. |
the present study concentrated on jnk/c-jun-driven nlrp3 inflammasome activation in microglia during the degeneration of retinal ganglion cells (rgcs) in iton. |
2021-04-16 |
2023-08-13 |
Not clear |
| Baohua Hou, Yahui Zhang, Peiyu Liang, Yuan He, Biwen Peng, Wanhong Liu, Song Han, Jun Yin, Xiaohua H. Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32415059. |
activation of the nlrp3 inflammasome in microglia is fundamental for subsequent inflammatory events. |
2021-04-07 |
2023-08-13 |
mouse |
| Jibrin Danladi, Hemmen Sabi. Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia. International journal of molecular sciences. vol 22. issue 2. 2021-04-02. PMID:33445791. |
hypothermia stimulates microglia to secret cold-inducible rna-binding protein (cirp), which triggers nf-κb, controlling multiple inflammatory pathways, including nod-like receptor family pyrin domain containing 3 (nlrp3) inflammasomes and cyclooxygenase-2 (cox-2) signaling. |
2021-04-02 |
2023-08-13 |
human |