| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
in the present study, we show that impaired mitochondrial function can augment the nlrp3 inflammasome-driven proinflammatory cascade in microglia. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
primary mouse microglia treated with the common inflammogen lps increased nlrp3 and pro-il-1β expression. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
interestingly, exposure of lps-primed microglial cells to the mitochondrial complex-i inhibitory pesticides rotenone and tebufenpyrad specifically potentiated the nlrp3 induction, asc speck formation and pro-il-1β processing to il-1β in a dose-dependent manner, indicating that mitochondrial impairment heightened the nlrp3 inflammasome-mediated proinflammatory response in microglia. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
the neurotoxic pesticide-induced nlrp3 inflammasome activation was accompanied by bioenergetic defects and lysosomal dysfunction in microglia. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
furthermore, the pesticides enhanced mitochondrial ros generation in primary microglia, while amelioration of mitochondria-derived ros by the mitochondria-targeted antioxidant mito-apocynin completely abolished il-1β release, indicating mitochondrial ros drives potentiation of the nlrp3 inflammasome in microglia. |
2020-09-30 |
2023-08-13 |
mouse |
| Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29057315. |
collectively, our results demonstrate that mitochondrial impairment in microglia can amplify nlrp3 inflammasome signaling, which augments the dopaminergic neurodegenerative process. |
2020-09-30 |
2023-08-13 |
mouse |
| Zhi-Hang Lin, Si-Yuan Wang, Li-Li Chen, Jia-Yuan Zhuang, Qing-Feng Ke, Dan-Rui Xiao, Wen-Ping Li. Methylene Blue Mitigates Acute Neuroinflammation after Spinal Cord Injury through Inhibiting NLRP3 Inflammasome Activation in Microglia. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29311826. |
methylene blue mitigates acute neuroinflammation after spinal cord injury through inhibiting nlrp3 inflammasome activation in microglia. |
2020-09-30 |
2023-08-13 |
Not clear |
| Katharine M von Herrmann, Lucas A Salas, Eileen M Martinez, Alison L Young, Joseph M Howard, Mary S Feldman, Brock C Christensen, Owen M Wilkins, Stephen L Lee, William F Hickey, Matthew C Havrd. NPJ Parkinson's disease. vol 4. 2020-09-30. PMID:30131971. |
these cellular complexes are well characterized in the innate immune system and activity of the nlrp3 inflammasome has been reported in microglia. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiujing Feng, Yuan Zhao, Tianyuan Yang, Manyu Song, Chaoran Wang, Yujie Yao, Honggang Fa. Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31555091. |
glucocorticoid-driven nlrp3 inflammasome activation in hippocampal microglia mediates chronic stress-induced depressive-like behaviors. |
2020-09-30 |
2023-08-13 |
rat |
| Xiujing Feng, Yuan Zhao, Tianyuan Yang, Manyu Song, Chaoran Wang, Yujie Yao, Honggang Fa. Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31555091. |
recent studies show that the nod-like receptor protein 3 (nlrp3) inflammasome is expressed in microglia and may play a crucial role in depression. |
2020-09-30 |
2023-08-13 |
rat |
| Xiujing Feng, Yuan Zhao, Tianyuan Yang, Manyu Song, Chaoran Wang, Yujie Yao, Honggang Fa. Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31555091. |
however, the mechanism of nlrp3 inflammasome activation in hippocampal microglia and its role in depressive-like behaviors remain poorly understood. |
2020-09-30 |
2023-08-13 |
rat |
| Na Yue, Bing Li, Liu Yang, Qiu-Qin Han, Hui-Jie Huang, Ya-Lin Wang, Jing Wang, Rui Yu, Gen-Cheng Wu, Qiong Liu, Jin Y. Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression. Frontiers in molecular neuroscience. vol 11. 2020-09-29. PMID:29946236. |
the results showed that 10 week of chronic unpredictable stress (cus) caused behavioral deficits in rats and neuroinflammation in hippocampus, such as increased expression of nlrp3 inflammasome components, upregulated mrna level of il-1β and the protein level of il-1β mature form (p17) and activation of microglia. |
2020-09-29 |
2023-08-13 |
rat |
| Jianhai Long, Qian Wang, Huanhuan He, Xin Sui, Guodong Lin, Shuai Wang, Jun Yang, Pengsheng You, Yuan Luo, Yongan Wan. NLRP3 inflammasome activation is involved in trimethyltin-induced neuroinflammation. Brain research. vol 1718. 2020-09-29. PMID:31059678. |
tmt treatment activated the nlrp3 inflammasome in the microglial cell line bv2. |
2020-09-29 |
2023-08-13 |
human |
| Shiquan Wang, Jin Wang, Haidong Wei, Tingting Gu, Jiajia Wang, Zhixin Wu, Qianzi Yan. Genistein Attenuates Acute Cerebral Ischemic Damage by Inhibiting the NLRP3 Inflammasome in Reproductively Senescent Mice. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32625078. |
the expression of nlrp3 inflammasome-related proteins in microglia was downregulated by gen. |
2020-09-28 |
2023-08-13 |
mouse |
| Shiquan Wang, Jin Wang, Haidong Wei, Tingting Gu, Jiajia Wang, Zhixin Wu, Qianzi Yan. Genistein Attenuates Acute Cerebral Ischemic Damage by Inhibiting the NLRP3 Inflammasome in Reproductively Senescent Mice. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32625078. |
however, the overexpression of nlrp3 in microglia abrogated the gen-induced inhibition of inflammatory factor release and reversed the neuroprotective effect of gen. taken together, the results suggest that gen treatment could attenuate the acute injury induced by cerebral ischemia in reproductively senescent mice |
2020-09-28 |
2023-08-13 |
mouse |
| Yadi Guan, Fang Ha. Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases. Frontiers in integrative neuroscience. vol 14. 2020-09-28. PMID:32792920. |
however, in the case of als, not only microglia but also astrocytes express increased nlrp3 levels and contribute to activation of the nlrp3 pathway. |
2020-09-28 |
2023-08-13 |
human |
| Lulu Xie, Zhimin Gu, Haizhao Liu, Beitian Jia, Yiyang Wang, Min Cao, Ruiwen Song, Zhaiyi Zhang, Yuhong Bia. The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32922291. |
pcr and western blot were used to monitor the differences of nlrp3, caspase-1, asc activation in the levels of genes and proteins in the pfc of rats and microglia. |
2020-09-28 |
2023-08-13 |
rat |
| Lulu Xie, Zhimin Gu, Haizhao Liu, Beitian Jia, Yiyang Wang, Min Cao, Ruiwen Song, Zhaiyi Zhang, Yuhong Bia. The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32922291. |
in addition, hesperidin decreased the expression levels of il-1β, il-6, tnf-α, nlrp3, caspase-1, and asc in the pfc and microglia. |
2020-09-28 |
2023-08-13 |
rat |
| Lili Si, Haifeng Wang, Leyuan Wan. Suppression of miR-193a alleviates neuroinflammation and improves neurological function recovery after traumatic brain injury (TBI) in mice. Biochemical and biophysical research communications. vol 523. issue 2. 2020-09-15. PMID:31924304. |
of note, cci-induced activation of microglia was repressed by mir-193a inhibition, along with significantly reduced expression of neuroinflammatory markers, which were associated with the blockage of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome. |
2020-09-15 |
2023-08-13 |
mouse |
| César J Carranza-Aguilar, Araceli Hernández-Mendoza, Carlos Mejias-Aponte, Kenner C Rice, Marisela Morales, Claudia González-Espinosa, Silvia L Cru. Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors. Cellular and molecular neurobiology. 2020-09-14. PMID:32926257. |
two hours after the last (19th) administration, we analyzed nlrp3 oligomerization, caspase-1 activation and gasdermin d-n (gsdmd-n) expression in microglia (cd11b positive cells), astrocytes (gfap-positive cells) and neurons (neun-positive cells). |
2020-09-14 |
2023-08-13 |
rat |