| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yidan Zhang, Yuan Zhao, Jian Zhang, Guofeng Yan. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32929691. |
however, nlrp3 or caspase-1 deletion in app/ps1 mice promotes microglia to transform to an anti-inflammatory m2 phenotype, with decreased secretion of caspase-1 and il-1β. |
2021-06-02 |
2023-08-13 |
mouse |
| Juliana Helena Dos Santos de Toledo, Thais Fernanda de Campos Fraga-Silva, Patrícia Aparecida Borim, Larissa Ragozo Cardoso de Oliveira, Evelyn da Silva Oliveira, Larissa Lucena Périco, Clélia Akiko Hiruma-Lima, Adriana Aparecida Lopes de Souza, Carlos Alberto Ferreira de Oliveira, Pedro de Magalhães Padilha, Marcos Felipe Pinatto-Botelho, Alcindo Aparecido Dos Santos, Alexandrina Sartori, Sofia Fernanda Gonçalves Zorzella-Pezavent. Organic Selenium Reaches the Central Nervous System and Downmodulates Local Inflammation: A Complementary Therapy for Multiple Sclerosis? Frontiers in immunology. vol 11. 2021-05-31. PMID:33193354. |
in addition of a tolerogenic profile in dendritic cells from the mesenteric lymph nodes, lad-βse also downregulated cell amount, activation status of macrophages and microglia, nlrp3 (nod-like receptors) inflammasome activation and other pro-inflammatory parameters in the cns. |
2021-05-31 |
2023-08-13 |
mouse |
| Sahabuddin Ahmed, Mohit Kwatra, Samir Ranjan Panda, U S N Murty, V G M Naid. Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:32971182. |
andrographolide suppresses nlrp3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of parkinson disease. |
2021-05-27 |
2023-08-13 |
Not clear |
| Yue Qin, Jingru Qiu, Ping Wang, Jia Liu, Yong Zhao, Fan Jiang, Haiyan Lo. Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson's disease. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33039664. |
impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating nlrp3 inflammasome activation in experimental models of parkinson's disease. |
2021-05-27 |
2023-08-13 |
Not clear |
| Limin Lang, Bin Xu, Jianbin Yuan, Shize Li, Shuai Lian, Yan Chen, Jingru Guo, Huanmin Yan. GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33166810. |
gaba-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the nlrp3 inflammasome and nf-κb signaling pathways. |
2021-05-25 |
2023-08-13 |
mouse |
| Limin Lang, Bin Xu, Jianbin Yuan, Shize Li, Shuai Lian, Yan Chen, Jingru Guo, Huanmin Yan. GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33166810. |
we demonstrated that chronic cold stress induced the activation of microglia, the emergence of neuroinflammation, and the impairment of neurons in the hippocampus, which might be the result of gaba-mediated activation of nod-like receptor protein 3 (nlrp3) inflammasome and the nuclear factor kappa b (nf-κb) signaling pathway. |
2021-05-25 |
2023-08-13 |
mouse |
| Christopher Hoyle, Elena Redondo-Castro, James Cook, Te-Chen Tzeng, Stuart M Allan, David Brough, Eloise Lemarchan. Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture. Immunology. vol 161. issue 1. 2021-05-24. PMID:32445196. |
most mechanistic studies on nlrp3 activation use two-dimensional pure microglial cell culture systems. |
2021-05-24 |
2023-08-13 |
Not clear |
| Christopher Hoyle, Elena Redondo-Castro, James Cook, Te-Chen Tzeng, Stuart M Allan, David Brough, Eloise Lemarchan. Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture. Immunology. vol 161. issue 1. 2021-05-24. PMID:32445196. |
nigericin-induced nlrp3 inflammasome activation was dynamically visualized in microglia through asc speck formation. |
2021-05-24 |
2023-08-13 |
Not clear |
| Xiangyuan Cao, Yida Wang, Liang Ga. CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33405023. |
the proliferation, inflammatory cytokine expressions, nod-like receptor protein 3 (nlrp3) level, cell pyroptosis, and viability and lactate dehydrogenase (ldh) activity in ogd/r-treated microglia were detected after chrfam7a overexpression. |
2021-05-24 |
2023-08-13 |
Not clear |
| Xiangyuan Cao, Yida Wang, Liang Ga. CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33405023. |
in ogd/r-treated microglia, chrfam7a overexpression promoted cell proliferation and viability, reduced inflammation and ldh activity, and inhibited nlrp3 inflammasome activation and cell pyroptosis. |
2021-05-24 |
2023-08-13 |
Not clear |
| Xiao Fan, Wei Ma, Yingyu Zhang, Li Zhan. P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952148. |
p2x7 receptor (p2x7r) of microglia mediates neuroinflammation by regulating (nod)-like receptor protein 3 (nlrp3) inflammasome-dependent inflammation after spinal cord injury. |
2021-05-20 |
2023-08-13 |
rat |
| Xiao Fan, Wei Ma, Yingyu Zhang, Li Zhan. P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952148. |
the aim of this study was to explore the mechanism by which the p2x7 receptor of microglia regulates neuroinflammation after spinal cord injury in nlrp3 inflammasome-dependent inflammation. |
2021-05-20 |
2023-08-13 |
rat |
| Xiao Fan, Wei Ma, Yingyu Zhang, Li Zhan. P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952148. |
(iii) p2x7r of microglia participates in spinal cord-mediated neuroinflammation via regulating nlrp3 inflammasome-dependent inflammation. |
2021-05-20 |
2023-08-13 |
rat |
| Xiao Fan, Wei Ma, Yingyu Zhang, Li Zhan. P2X7 Receptor (P2X7R) of Microglia Mediates Neuroinflammation by Regulating (NOD)-Like Receptor Protein 3 (NLRP3) Inflammasome-Dependent Inflammation After Spinal Cord Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32952148. |
conclusions p2x7r of microglia in spinal cord mediates neuroinflammation by regulating nlrp3 inflammasome-dependent inflammation after spinal cord injury. |
2021-05-20 |
2023-08-13 |
rat |
| Roya Aryanpour, Kazem Zibara, Parichehr Pasbakhsh, Seyyed Behnamodin Jame'ei, Zeinab Namjoo, Amir Ghanbari, Reza Mahmoudi, Showan Amani, Iraj Ragerdi Kashan. 17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome. Neuroscience. vol 463. 2021-05-19. PMID:33794337. |
17β-estradiol reduces demyelination in cuprizone-fed mice by promoting m2 microglia polarity and regulating nlrp3 inflammasome. |
2021-05-19 |
2023-08-13 |
mouse |
| Roya Aryanpour, Kazem Zibara, Parichehr Pasbakhsh, Seyyed Behnamodin Jame'ei, Zeinab Namjoo, Amir Ghanbari, Reza Mahmoudi, Showan Amani, Iraj Ragerdi Kashan. 17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome. Neuroscience. vol 463. 2021-05-19. PMID:33794337. |
in summary, this study demonstrated for the first time that exogenous 17β-estradiol therapy robustly leads to the reduction of m1 phenotype, stimulation of polarized m2 microglia, and repression of nlrp3 inflammasome in the corpus callosum of cpz demyelination model of ms. |
2021-05-19 |
2023-08-13 |
mouse |
| Ya-Jie Ji, Hui-Lin Wang, Bian-Li Yin, Xiang-Yang Re. Down-regulation of DJ-1 Augments Neuroinflammation via Nrf2/Trx1/NLRP3 Axis in MPTP-induced Parkinson's Disease Mouse Model. Neuroscience. vol 442. 2021-05-14. PMID:32526245. |
dj-1 and nrf2 knockdown promoted inflammation and cell apoptosis in bv2 microglia, while nlrp3 knockdown had opposite effects. |
2021-05-14 |
2023-08-13 |
mouse |
| Xiao-Fei He, Jing-Hui Xu, Ge Li, Ming-Yue Li, Li-Li Li, Zhong Pei, Li-Ying Zhang, Xi-Quan H. NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer's disease. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33051464. |
in addition, we injected mcc950 to inhibit nlrp3 activation and used an inducible cre recombinase to delete the nlrp3 gene in microglia. |
2021-05-13 |
2023-08-13 |
mouse |
| Yang Jiao, Jianjian Wang, Huixue Zhang, Yuze Cao, Yang Qu, Siyu Huang, Xiaotong Kong, Chang Song, Jie Li, Qian Li, Heping Ma, Xiaoyu Lu, Lihua Wan. Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke. Journal of cellular and molecular medicine. vol 24. issue 21. 2021-05-04. PMID:32990414. |
in vivo and vitro data revealed that rhtrx-1 reduced necroptosis, mitochondrial membrane potential damage, reactive oxygen species accumulation and nlr family, pyrin domain-containing 3 protein (nlrp3) inflammasome activation and regulated the microglial m1/m2 phenotypic changes by inhibiting ripk1 expression in ischaemic microglia. |
2021-05-04 |
2023-08-13 |
human |
| Yang Liu, Yue Dai, Qing Li, Chen Chen, Hao Chen, Yuanjian Song, Fang Hua, Zuohui Zhan. Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia. Neuroscience letters. vol 736. 2021-04-30. PMID:32726591. |
beta-amyloid activates nlrp3 inflammasome via tlr4 in mouse microglia. |
2021-04-30 |
2023-08-13 |
mouse |