| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaolong Yao, Shengbo Wang, Yingchun Chen, Liuqing Sheng, Huanhuan Li, Huichao You, Jianfeng Ye, Qing Zhang, Jun L. Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34405489. |
the results showed that sh inhibited tlr4 and nlrp3 inflammasome activation in the microglia cell. |
2021-09-29 |
2023-08-13 |
mouse |
| Lei Niu, Shi Shi Luo, Yang Xu, Zhen Wang, Dan Luo, Hui Yang, Wei Li, Jie He, Xiao Lin Zhong, Zheng Hai Liu, Jia Yu Zeng, Wen Yu Cao, Wei Wa. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice. Neurobiology of learning and memory. vol 175. 2021-09-27. PMID:32882398. |
minocycline also prevented expression of the hippocampal nlrp3 inflammasome, indicating that microglia might be the primary contributor to si-induced hippocampal nlrp3 inflammasome activation. |
2021-09-27 |
2023-08-13 |
mouse |
| Kemal Ugur Tufekci, Ilkcan Ercan, Kamer Burak Isci, Melis Olcum, Bora Tastan, Ceren Perihan Gonul, Kursad Genc, Sermin Gen. Sulforaphane inhibits NLRP3 inflammasome activation in microglia through Nrf2-mediated miRNA alteration. Immunology letters. vol 233. 2021-09-27. PMID:33711331. |
sulforaphane inhibits nlrp3 inflammasome activation in microglia through nrf2-mediated mirna alteration. |
2021-09-27 |
2023-08-13 |
Not clear |
| Kemal Ugur Tufekci, Ilkcan Ercan, Kamer Burak Isci, Melis Olcum, Bora Tastan, Ceren Perihan Gonul, Kursad Genc, Sermin Gen. Sulforaphane inhibits NLRP3 inflammasome activation in microglia through Nrf2-mediated miRNA alteration. Immunology letters. vol 233. 2021-09-27. PMID:33711331. |
our data indicate that sfn suppresses nlrp3 inflammasome via the inhibition of nf-κb nuclear translocation and nrf2 mediated mirnas expression modulation in murine microglia. |
2021-09-27 |
2023-08-13 |
Not clear |
| Yangqi Xu, Lei Zhao, Hongyan Qiu, Ting Qian, Shaoming Sang, Chunjiu Zhon. The impact of thiamine deficiency and benfotiamine treatment on Nod-like receptor protein-3 inflammasome in microglia. Neuroreport. vol 32. issue 12. 2021-09-20. PMID:34232130. |
in this study, we found that nlrp3 inflammasomes were significantly activated in the microglia of thiamine deficiency mice model. |
2021-09-20 |
2023-08-13 |
mouse |
| Eliana Cristina de Brito Toscano, Natalia Pessoa Rocha, Beatriz Noele Azevedo Lopes, Claudia Kimie Suemoto, Antonio Lucio Teixeir. Neuroinflammation in Alzheimer's disease: focus on NLRP1 and NLRP3 inflammasomes. Current protein & peptide science. 2021-09-17. PMID:34530705. |
experimental models of ad have suggested that aβ accumulation induces, through microglia, activation of the nlrp3 inflammasome. |
2021-09-17 |
2023-08-13 |
human |
| Xu Wu, Linjing Gong, Liang Xie, Wenyu Gu, Xinyuan Wang, Zilong Liu, Shanqun L. NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea. Frontiers in immunology. vol 12. 2021-09-15. PMID:33717152. |
in addition, nlrp3 knockout mice displayed the mitigated microglia activation that elicited by cih, concomitantly with elimination of damaged mitochondria and reduction of oxidative stress levels (malondialdehyde and superoxide dismutase). |
2021-09-15 |
2023-08-13 |
mouse |
| Jindan He, Taotao Liu, Yue Li, Xinning Mi, Dengyang Han, Ning Yang, Lei Chen, Yitong Li, Jingshu Hong, Chongshen Kuang, Yi Yuan, Yiyun Cao, Yongzheng Han, Chengmei Shi, Zhengqian Li, Xiangyang Gu. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. International immunopharmacology. vol 99. 2021-09-08. PMID:34298396. |
in the study, in vitro and in vivo models of dncr were used to examine the potential effects of the mitogen‑activated protein kinase signaling pathway on nod-like receptor protein 3 (nlrp3) inflammasome-mediated microglia pyroptosis and cognitive deficits following surgery. |
2021-09-08 |
2023-08-13 |
mouse |
| Jindan He, Taotao Liu, Yue Li, Xinning Mi, Dengyang Han, Ning Yang, Lei Chen, Yitong Li, Jingshu Hong, Chongshen Kuang, Yi Yuan, Yiyun Cao, Yongzheng Han, Chengmei Shi, Zhengqian Li, Xiangyang Gu. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. International immunopharmacology. vol 99. 2021-09-08. PMID:34298396. |
in vivo, we observed surgery-induced upregulation of phosphorylated (p)-c-jun n-terminal kinases (jnk) in microglia and subsequently nlrp3 inflammasome activation, pyroptosis, and inflammatory cytokines release in mice hippocampus. |
2021-09-08 |
2023-08-13 |
mouse |
| Jindan He, Taotao Liu, Yue Li, Xinning Mi, Dengyang Han, Ning Yang, Lei Chen, Yitong Li, Jingshu Hong, Chongshen Kuang, Yi Yuan, Yiyun Cao, Yongzheng Han, Chengmei Shi, Zhengqian Li, Xiangyang Gu. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. International immunopharmacology. vol 99. 2021-09-08. PMID:34298396. |
interestingly, jnk inhibitor sp600125 significantly attenuated surgery-induced cognitive impairments through inhibiting pyroptosis, inflammatory responses, and reducing immunoreactivity of nlrp3 and gasdermin d n terminus (gsdmd-n) in hippocampal microglia. |
2021-09-08 |
2023-08-13 |
mouse |
| Jindan He, Taotao Liu, Yue Li, Xinning Mi, Dengyang Han, Ning Yang, Lei Chen, Yitong Li, Jingshu Hong, Chongshen Kuang, Yi Yuan, Yiyun Cao, Yongzheng Han, Chengmei Shi, Zhengqian Li, Xiangyang Gu. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. International immunopharmacology. vol 99. 2021-09-08. PMID:34298396. |
furthermore, treatment with nlrp3 specific inhibitor, mcc950, attenuated microglia pyroptosis induced by lps, but did not rescue lps-induced increased expression of p-jnk. |
2021-09-08 |
2023-08-13 |
mouse |
| Jindan He, Taotao Liu, Yue Li, Xinning Mi, Dengyang Han, Ning Yang, Lei Chen, Yitong Li, Jingshu Hong, Chongshen Kuang, Yi Yuan, Yiyun Cao, Yongzheng Han, Chengmei Shi, Zhengqian Li, Xiangyang Gu. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. International immunopharmacology. vol 99. 2021-09-08. PMID:34298396. |
these results indicate that the jnk pathway is largely upstream of the nlrp3 inflammasome, which exerts a crucial regulatory impact on microglia pyroptosis and inflammatory responses, thus providing a promising avenue to prevent dncr. |
2021-09-08 |
2023-08-13 |
mouse |
| Jun Ho Lee, Hong Jun Kim, Jong Uk Kim, Tae Han Yook, Kyeong Han Kim, Joo Young Lee, Gabsik Yan. A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer's and Parkinson's Disease. International journal of molecular sciences. vol 22. issue 3. 2021-09-03. PMID:33525754. |
many studies have demonstrated that the release of nlrp3 inflammasome-mediated proinflammatory cytokines by the excessive activation of microglia is associated with the pathogenesis of ad and pd and suggested that the nlrp3 inflammasome plays an important role in ad and pd development. |
2021-09-03 |
2023-08-13 |
Not clear |
| Jun Ho Lee, Hong Jun Kim, Jong Uk Kim, Tae Han Yook, Kyeong Han Kim, Joo Young Lee, Gabsik Yan. A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer's and Parkinson's Disease. International journal of molecular sciences. vol 22. issue 3. 2021-09-03. PMID:33525754. |
in both diseases, various stimuli, such as aβ and α-synuclein, accelerate the formation of the nlrp3 inflammasome in microglia and induce pyroptosis through the expression of interleukin (il)-1β, caspase-1, etc., where neuroinflammation contributes to gradual progression and deterioration. |
2021-09-03 |
2023-08-13 |
Not clear |
| Hui-Qi Wang, Kai-Yi Song, Jin-Zhou Feng, Si-Yuan Huang, Xiu-Ming Guo, Lei Zhang, Gang Zhang, Ying-Chao Huo, Rong-Rong Zhang, Yue Ma, Qing-Zhe Hu, Xin-Yue Qi. Caffeine Inhibits Activation of the NLRP3 Inflammasome via Autophagy to Attenuate Microglia-Mediated Neuroinflammation in Experimental Autoimmune Encephalomyelitis. Journal of molecular neuroscience : MN. 2021-09-03. PMID:34478049. |
furthermore, the proinflammatory response induced by the nlr family pyrin domain containing 3 (nlrp3) inflammasome can be amplified in microglia after nlrp3 inflammasome activation. |
2021-09-03 |
2023-08-13 |
mouse |
| Hui-Qi Wang, Kai-Yi Song, Jin-Zhou Feng, Si-Yuan Huang, Xiu-Ming Guo, Lei Zhang, Gang Zhang, Ying-Chao Huo, Rong-Rong Zhang, Yue Ma, Qing-Zhe Hu, Xin-Yue Qi. Caffeine Inhibits Activation of the NLRP3 Inflammasome via Autophagy to Attenuate Microglia-Mediated Neuroinflammation in Experimental Autoimmune Encephalomyelitis. Journal of molecular neuroscience : MN. 2021-09-03. PMID:34478049. |
taken together, these data suggest that caffeine exerts a newly discovered effect on eae by reducing nlrp3 inflammasome activation via the induction of autophagy in microglia. |
2021-09-03 |
2023-08-13 |
mouse |
| Weixiang Chen, Chao Guo, Suna Huang, Zhengcai Jia, Jie Wang, Jun Zhong, Hongfei Ge, Jichao Yuan, Tunan Chen, Xin Liu, Rong Hu, Yi Yin, Hua Fen. MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH. Pharmacological research. vol 161. 2021-09-01. PMID:32791262. |
mitoq attenuates brain damage by polarizing microglia towards the m2 phenotype through inhibition of the nlrp3 inflammasome after ich. |
2021-09-01 |
2023-08-13 |
Not clear |
| Dan-Dan Tian, Min Wang, An Liu, Mei-Rong Gao, Chen Qiu, Wen Yu, Wen-Ju Wang, Kun Zhang, Le Yang, Yan-Yan Jia, Chang-Bin Yang, Yu-Mei W. Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:33025508. |
nod-like receptor protein 3 (nlrp3)-associated neuroinflammation mediated by activated microglia is involved in the pathogenesis of depression. |
2021-09-01 |
2023-08-13 |
mouse |
| Dan-Dan Tian, Min Wang, An Liu, Mei-Rong Gao, Chen Qiu, Wen Yu, Wen-Ju Wang, Kun Zhang, Le Yang, Yan-Yan Jia, Chang-Bin Yang, Yu-Mei W. Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:33025508. |
we further demonstrated that pf administration inhibited the enhanced expression of gsdmd which mainly distributed in microglia, along with the proteins involved in pyroptosis signaling transduction including caspase (casp)-11, casp-1, nlrp3, and interleukin (il)-1β in the hippocampus of mice treated with reserpine. |
2021-09-01 |
2023-08-13 |
mouse |
| Dan-Dan Tian, Min Wang, An Liu, Mei-Rong Gao, Chen Qiu, Wen Yu, Wen-Ju Wang, Kun Zhang, Le Yang, Yan-Yan Jia, Chang-Bin Yang, Yu-Mei W. Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:33025508. |
and also, pf prevented lipopolysaccharide (lps) and adenosine triphosphate (atp)-induced pyroptosis in murine n9 microglia in vitro, evidenced by inhibiting the expression of casp-11, nlrp3, casp-1 cleavage, as well as il-1β. |
2021-09-01 |
2023-08-13 |
mouse |