| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenyang Han, Qiaohong Hu, Anqi Yu, Qingcai Jiao, Yi Yan. Mafenide derivatives inhibit neuroinflammation in Alzheimer's disease by regulating pyroptosis. Journal of cellular and molecular medicine. vol 25. issue 22. 2021-11-18. PMID:34632701. |
as a result, the administration of sulfa-4 and sulfa-22 could significantly inhibit the activation of microglia, decrease the expression of inflammatory factors in the central nervous system and simultaneously suppress the production of p30-gsdmd as well as the expression of upstream nlrp3 inflammasome and caspase-1 protein. |
2021-11-18 |
2023-08-13 |
Not clear |
| Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wan. Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease. Frontiers in immunology. vol 12. 2021-11-17. PMID:34691027. |
findings demonstrate an elevated level of nlrp3 inflammasome in activated microglia in the substantia nigra of pd patients. |
2021-11-17 |
2023-08-13 |
Not clear |
| Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wan. Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease. Frontiers in immunology. vol 12. 2021-11-17. PMID:34691027. |
abnormal protein aggregation of α-synuclein (α-syn), a pathologically relevant protein of pd, were reported to activate the nlrp3 inflammasome of microglia through interaction with toll-like receptors (tlrs). |
2021-11-17 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
α-synuclein evokes nlrp3 inflammasome-mediated il-1β secretion from primary human microglia. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
the main driver of il-1β secretion from microglia is the nlrp3 inflammasome. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
α-syn is known to activate the microglial nlrp3 inflammasome in murine models, but its relationship to this inflammasome in human microglia has not been established. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
in this study, il-1β secretion from primary mouse microglia induced by α-syn fibrils was dependent on nlrp3 inflammasome assembly and caspase-1 activity, as previously reported. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
this work presents similarities between primary human and mouse microglia in the mechanisms of activation of the nlrp3 inflammasome by α-syn, but also highlights evidence to suggest that there may be a difference in the requirement for caspase-1 activity in il-1β output. |
2021-11-16 |
2023-08-13 |
mouse |
| Adrianne F Pike, Tatiana Varanita, Maaike A C Herrebout, Bonnie C Plug, Jeroen Kole, René J P Musters, Charlotte E Teunissen, Jeroen J M Hoozemans, Luigi Bubacco, Robert Veerhui. α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia. Glia. vol 69. issue 6. 2021-11-16. PMID:33506583. |
the data represent a novel characterization of pd-related nlrp3 inflammasome activation in primary human microglia and further implicate this mechanism in the pathology underlying pd. |
2021-11-16 |
2023-08-13 |
mouse |
| Lin Yuan, Yurong Zhu, Shuang Huang, Lin Lin, Xugan Jiang, Shengxia Che. NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells. Journal of microbiology (Seoul, Korea). vol 59. issue 8. 2021-11-16. PMID:34061343. |
nf-κb/ros and erk pathways regulate nlrp3 inflammasome activation in listeria monocytogenes infected bv2 microglia cells. |
2021-11-16 |
2023-08-13 |
Not clear |
| Dong Yuan, ShuangXian Guan, Zhen Wang, HongLiang Ni, DongLiang Ding, WenBo Xu, GuoMin L. HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34166779. |
hif-1α aggravated traumatic brain injury by nlrp3 inflammasome-mediated pyroptosis and activation of microglia. |
2021-11-10 |
2023-08-13 |
mouse |
| Dong Yuan, ShuangXian Guan, Zhen Wang, HongLiang Ni, DongLiang Ding, WenBo Xu, GuoMin L. HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34166779. |
in addition, hif-1α accumulated nlrp3 inflammasome-mediated pyroptosis and activation of microglia. |
2021-11-10 |
2023-08-13 |
mouse |
| Dong Yuan, ShuangXian Guan, Zhen Wang, HongLiang Ni, DongLiang Ding, WenBo Xu, GuoMin L. HIF-1α aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34166779. |
hif-1α was implicated in tbi-induced brain injury, aggravated nlrp3 inflammasome -mediated pyroptosis, and the activation of microglia, which provided a potential target for treating tbi. |
2021-11-10 |
2023-08-13 |
mouse |
| Ana Belen Lopez-Rodriguez, Edel Hennessy, Carol L Murray, Arshed Nazmi, Hugh J Delaney, Dáire Healy, Steven G Fagan, Michael Rooney, Erika Stewart, Anouchka Lewis, Niamh de Barra, Philip Scarry, Louise Riggs-Miller, Delphine Boche, Mark O Cunningham, Colm Cunningha. Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 10. 2021-11-09. PMID:34080771. |
the nlrp3 inflammasome was assembled surrounding amyloid beta, and microglia were primed, facilitating exaggerated interleukin-1β (il-1β) responses to subsequent lps stimulation. |
2021-11-09 |
2023-08-13 |
mouse |
| Su Yang, Xingxing Zhang, Hengli Zhang, Xiangxiang Lin, Xijun Chen, Ying Zhang, Xiao Lin, Lijie Huang, Qichuan Zhug. Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway. Molecular medicine reports. vol 24. issue 3. 2021-11-09. PMID:34296312. |
the present study examined the molecular mechanism of di on nlr family pyrin domain‑containing 3 (nlrp3) inflammasome assembly and nlrp3 inflammasome‑dependent pyroptosis in microglia. |
2021-11-09 |
2023-08-13 |
Not clear |
| Rong Rong, Rongliang Yang, Haibo Li, Mengling You, Zhuotao Liang, Zhou Zeng, Rongrong Zhou, Xiaobo Xia, Dan J. The roles of mitochondrial dynamics and NLRP3 inflammasomes in the pathogenesis of retinal light damage. Annals of the New York Academy of Sciences. 2021-11-06. PMID:34741555. |
further experiments revealed that dynamin-related protein 1 (drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the nlrp3 inflammasome. |
2021-11-06 |
2023-08-13 |
mouse |
| Yun-Ying Feng, Hui Che. [Nucleotide-binding Oligomerization Domain-like Receptor Family Pyrin Domain Containing 3 Inflammasome in Alzheimer's Disease]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 5. 2021-11-04. PMID:34728041. |
alzheimer's disease(ad)is a chronic neurodegenerative disease whose cause remains unclear.the β-amyloid plaques in the brain are one of the major pathological features of ad.however,the drugs targeting extracellular β-amyloid plaques have failed to cure the disease.innate immunity and neuroinflammation play a role in the pathogenesis and progression of ad.as the macrophages existing in the central nervous system,microglia are related with extracellular β-amyloid deposition,intracellular neurofibrillary tangle formation,and neuron injury.accumulating evidence demonstrates that the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3(nlrp3)inflammasome in microglia plays a role in ad,suggesting new therapeutic target for ad in this signaling pathway.this article reviewed the studies about the activation and regulation of nlrp3 inflammasome in the pathogenesis and progression of ad as well as the development of ad therapies targeting this pathway,aiming to provide reference for further studies in this field. |
2021-11-04 |
2023-08-13 |
Not clear |
| Folashade A Ogunrinade, Stephanie T Guetchueng, Folashade O Katola, Mutalib A Aderogba, Idowu S Akande, Satyajit D Sarker, Olumayokun A Olajid. Zanthoxylum zanthoxyloides inhibits lipopolysaccharide- and synthetic hemozoin-induced neuroinflammation in BV-2 microglia: roles of NF-κB transcription factor and NLRP3 inflammasome activation. The Journal of pharmacy and pharmacology. vol 73. issue 1. 2021-11-02. PMID:33791805. |
zanthoxylum zanthoxyloides inhibits lipopolysaccharide- and synthetic hemozoin-induced neuroinflammation in bv-2 microglia: roles of nf-κb transcription factor and nlrp3 inflammasome activation. |
2021-11-02 |
2023-08-13 |
Not clear |
| Olumayokun A Olajide, Victoria U Iwuanyanwu, Oyinkansola D Adegbola, Alaa A Al-Hindaw. SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia. Molecular neurobiology. 2021-10-30. PMID:34709564. |
exposure of s1 to bv-2 microglia also increased the protein levels of nlrp3 inflammasome and enhanced caspase-1 activity. |
2021-10-30 |
2023-08-13 |
Not clear |
| Ming-Lei Guo, Ernest T Chivero, Shannon E Callen, Shilpa Buc. NLRP3 Inflammasome Is Involved in Cocaine-Mediated Potentiation on Behavioral Changes in CX3CR1-Deficient Mice. Journal of personalized medicine. vol 11. issue 10. 2021-10-26. PMID:34683104. |
taken together, our findings demonstrated that the functional status of microglia could have an impact on cocaine-mediated reward effects, and nlrp3 inflammasome activity was associated with this phenomenon. |
2021-10-26 |
2023-08-13 |
mouse |