| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya Gao, Shuyue Li, Yidan Zhang, Jian Zhang, Yuan Zhao, Cui Chang, Xuan Gao, Guofeng Yan. Cattle Encephalon Glycoside and Ignotin Attenuates Aβ1-42-Mediated Neurotoxicity by Preventing NLRP3 Inflammasome Activation and Modulating Microglial Polarization via TLR4/NF-κB Signaling Pathway. Neurotoxicity research. 2022-10-10. PMID:36214996. |
however, it is not clear whether cegi can inhibit nlrp3 inflammasome activation and regulate the polarization of microglia in ad and whether its effects rely on tlr4/nf-κb signaling pathway. |
2022-10-10 |
2023-08-14 |
mouse |
| Ya Gao, Shuyue Li, Yidan Zhang, Jian Zhang, Yuan Zhao, Cui Chang, Xuan Gao, Guofeng Yan. Cattle Encephalon Glycoside and Ignotin Attenuates Aβ1-42-Mediated Neurotoxicity by Preventing NLRP3 Inflammasome Activation and Modulating Microglial Polarization via TLR4/NF-κB Signaling Pathway. Neurotoxicity research. 2022-10-10. PMID:36214996. |
furthermore, the roles of cegi in inhibiting nlrp3 inflammasome activation, modulating microglia m1/m2 polarization, and increasing aβ degrading enzyme expression were further validated in vivo using app/ps1 mice. |
2022-10-10 |
2023-08-14 |
mouse |
| Ya Gao, Shuyue Li, Yidan Zhang, Jian Zhang, Yuan Zhao, Cui Chang, Xuan Gao, Guofeng Yan. Cattle Encephalon Glycoside and Ignotin Attenuates Aβ1-42-Mediated Neurotoxicity by Preventing NLRP3 Inflammasome Activation and Modulating Microglial Polarization via TLR4/NF-κB Signaling Pathway. Neurotoxicity research. 2022-10-10. PMID:36214996. |
in conclusion, cegi promotes aβ degradation and protects microglia against aβ1-42-induced neurotoxicity by preventing nlrp3 inflammasome activation and regulating m1/m2 polarization via tlr4/nf-κb pathways. |
2022-10-10 |
2023-08-14 |
mouse |
| Janeli Viil, Kelli Somelar-Duracz, Külli Jaako, Kaili Anier, Alexander Zharkovsk. Characterization of IMG Microglial Cell Line as a Valuable In Vitro Tool for NLRP3 Inflammasome Studies. Cellular and molecular neurobiology. 2022-09-27. PMID:36163404. |
characterization of img microglial cell line as a valuable in vitro tool for nlrp3 inflammasome studies. |
2022-09-27 |
2023-08-14 |
mouse |
| Janeli Viil, Kelli Somelar-Duracz, Külli Jaako, Kaili Anier, Alexander Zharkovsk. Characterization of IMG Microglial Cell Line as a Valuable In Vitro Tool for NLRP3 Inflammasome Studies. Cellular and molecular neurobiology. 2022-09-27. PMID:36163404. |
here, we investigated whether the mouse microglial cell line img is suitable to study nlrp3 inflammasome by incubating cells with different concentrations of nlrp3 inflammasome priming and activating agents lipopolysaccharide (lps) and atp, respectively, and applying short (4 h) or long (24 h) lps incubation times. |
2022-09-27 |
2023-08-14 |
mouse |
| Xiu Chen, Juan-Ling He, Xue-Ting Liu, Na Zhao, Fan Geng, Meng-Meng Zhu, Gong-Ping Liu, Qing-Guo Re. DI-3-n-butylphthalide mitigates stress-induced cognitive deficits in mice through inhibition of NLRP3-Mediated neuroinflammation. Neurobiology of stress. vol 20. 2022-09-26. PMID:36160816. |
activated microglia and nlrp3 inflammasome were found after 8-week chronic stress. |
2022-09-26 |
2023-08-14 |
mouse |
| Jung Lo, Ching-Chih Liu, Yueh-Shan Li, Po-Yen Lee, Po-Len Liu, Pei-Chang Wu, Tzu-Chieh Lin, Chi-Shuo Chen, Chien-Chih Chiu, Yu-Hung Lai, Yo-Chen Chang, Hsin-En Wu, Yuan-Ru Chen, Yu-Kai Huang, Shu-Pin Huang, Shu-Chi Wang, Chia-Yang L. Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation. Journal of inflammation research. vol 15. 2022-09-22. PMID:36131784. |
punicalagin attenuates lps-induced inflammation and ros production in microglia by inhibiting the mapk/nf-κb signaling pathway and nlrp3 inflammasome activation. |
2022-09-22 |
2023-08-14 |
Not clear |
| Jung Lo, Ching-Chih Liu, Yueh-Shan Li, Po-Yen Lee, Po-Len Liu, Pei-Chang Wu, Tzu-Chieh Lin, Chi-Shuo Chen, Chien-Chih Chiu, Yu-Hung Lai, Yo-Chen Chang, Hsin-En Wu, Yuan-Ru Chen, Yu-Kai Huang, Shu-Pin Huang, Shu-Chi Wang, Chia-Yang L. Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation. Journal of inflammation research. vol 15. 2022-09-22. PMID:36131784. |
this study aimed to investigate the effects of punicalagin on lps-induced inflammatory responses, nlrp3 inflammasome activation, and the production of ros using murine microglia bv2 cells. |
2022-09-22 |
2023-08-14 |
Not clear |
| Yulin Huang, Jing Hao, Xuli Yang, Li Xu, Yue Liu, Yu'e Sun, Xiaoping Gu, Wei Zhang, Zhengliang M. Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal Cord. Neurochemical research. 2022-09-14. PMID:36104611. |
pretreatment of the ros inhibitor phenyl-n-tert-butylnitrone alleviates sleep deprivation-induced hyperalgesia by suppressing microglia activation and nlrp3 inflammasome activity in the spinal dorsal cord. |
2022-09-14 |
2023-08-14 |
mouse |
| Zhou Hong, Jiaqi Cheng, Yong Ye, Xiaoqing Chen, Feng Zhan. MicroRNA-451 attenuates the inflammatory response of activated microglia by downregulating NLRP3. World neurosurgery. 2022-09-10. PMID:36087911. |
microrna-451 attenuates the inflammatory response of activated microglia by downregulating nlrp3. |
2022-09-10 |
2023-08-14 |
Not clear |
| Liping Zhou, Xingzhe Wang, Xueyao Wang, Jing An, Xin Zheng, Deqiang Han, Zhiguo Che. Neuroprotective effects of human umbilical cord mesenchymal stromal cells in PD mice via centrally and peripherally suppressing NLRP3 inflammasome-mediated inflammatory responses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076517. |
subsequently, the striatal content of dopamine (da) and its metabolites, tyrosine hydroxylase (th)-positive neurons and activated microglia, circulating inflammatory cytokines, gene expression of cytokines, and nod-like receptor protein 3 (nlrp3) inflammasome molecules were measured using high-performance liquid chromatography, flow cytometry, immunohistochemistry, immunofluorescent staining, and real-time polymerase chain reaction assays, respectively. |
2022-09-09 |
2023-08-14 |
mouse |
| Linglong Xiao, Mengqi Wang, Yifeng Shi, Yangyang Xu, Yuan Gao, Wei Zhang, Yang Wu, Hao Deng, Wei Pan, Wei Wang, Haitao Su. Secondary White Matter Injury Mediated by Neuroinflammation After Intracerebral Hemorrhage and Promising Therapeutic Strategies of Targeting the NLRP3 Inflammasome. Current neuropharmacology. 2022-08-31. PMID:36043798. |
moreover, nlrp3 inflammasome is activated in microglia and astrocytes and exerts a vital role in microglia and astrocytes-mediated neuroinflammation. |
2022-08-31 |
2023-08-14 |
Not clear |
| Linglong Xiao, Mengqi Wang, Yifeng Shi, Yangyang Xu, Yuan Gao, Wei Zhang, Yang Wu, Hao Deng, Wei Pan, Wei Wang, Haitao Su. Secondary White Matter Injury Mediated by Neuroinflammation After Intracerebral Hemorrhage and Promising Therapeutic Strategies of Targeting the NLRP3 Inflammasome. Current neuropharmacology. 2022-08-31. PMID:36043798. |
we speculate that nlrp3 inflammasome activation is closely related to the polarization of microglia and astrocytes and that nlrp3 inflammasome activation may exacerbate wmi by polarizing microglia and astrocytes to the pro-inflammatory phenotype after ich, while nlrp3 inflammasome inhibition may attenuate wmi by polarizing microglia and astrocytes to the anti-inflammatory phenotype following ich. |
2022-08-31 |
2023-08-14 |
Not clear |
| Linglong Xiao, Mengqi Wang, Yifeng Shi, Yangyang Xu, Yuan Gao, Wei Zhang, Yang Wu, Hao Deng, Wei Pan, Wei Wang, Haitao Su. Secondary White Matter Injury Mediated by Neuroinflammation After Intracerebral Hemorrhage and Promising Therapeutic Strategies of Targeting the NLRP3 Inflammasome. Current neuropharmacology. 2022-08-31. PMID:36043798. |
therefore, nlrp3 inflammasome may act as leveraged regulatory fulcrums for microglia and astrocytes polarization to modulate wmi and wm repair after ich. |
2022-08-31 |
2023-08-14 |
Not clear |
| Hao Jiang, Ying Zhang, Juan Yue, Yuchen Shi, Bo Xiao, Wenbiao Xiao, Zhaohui Lu. Non-coding RNAs: The Neuroinflammatory Regulators in Neurodegenerative Diseases. Frontiers in neurology. vol 13. 2022-08-29. PMID:36034298. |
in this study, we summarize four main mechanisms of lncrnas and mirnas involved in neuroinflammation in neurodegenerative diseases, including the imbalance between proinflammatory and neuroprotective cells in microglia and astrocytes, nlrp3 inflammasome, oxidative stress, and mitochondrial dysfunction, and inflammatory mediators. |
2022-08-29 |
2023-08-14 |
Not clear |
| Mengdi Liu, Haoran Zheng, Ze Liu, Yiyan Guo, Shuhong Wang, Yaohui Tang, Hengli Tian, Zhijun Zhang, Guoyuan Yan. Dl-3-n-Butylphthalide Reduced Neuroinflammation by Inhibiting Inflammasome in Microglia in Mice after Middle Cerebral Artery Occlusion. Life (Basel, Switzerland). vol 12. issue 8. 2022-08-26. PMID:36013423. |
brain infarct volume, neurological deficits, nlrp3, microglia, and neuronal death were examined in sacrificed mice to explore the correction between nbp effects and nlrp3 expression. |
2022-08-26 |
2023-08-14 |
mouse |
| Zhi-Qiang Cui, Xiao-Ying Hu, Tuo Yang, Jing-Wei Guan, Ying Gu, Hui-Yuan Li, Hui-Yu Zhang, Qing-Huan Xiao, Xiao-Hong Su. TMEM16F may be a new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018189. |
we performed a morris water maze test to evaluate the spatial memory ability of animals and detected markers for the microglia m1/m2 phenotype and nlrp3 inflammasome. |
2022-08-26 |
2023-08-14 |
mouse |
| Zhi-Qiang Cui, Xiao-Ying Hu, Tuo Yang, Jing-Wei Guan, Ying Gu, Hui-Yuan Li, Hui-Yu Zhang, Qing-Huan Xiao, Xiao-Hong Su. TMEM16F may be a new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018189. |
after tmem16f knockdown in mice, spatial memory ability was improved, microglia polarization to the m2 phenotype was promoted, nlrp3 inflammasome activation was inhibited, cell apoptosis and aβ plaque deposition in brain tissue were reduced, and brain injury was alleviated. |
2022-08-26 |
2023-08-14 |
mouse |
| Linh Thi Nhat Nguyen, Huu Dat Nguyen, Yun Joong Kim, Tinh Thi Nguyen, Thuy Thi Lai, Yoon Kyoung Lee, Hyeo-Il Ma, Young Eun Ki. Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations. Journal of Parkinson's disease. 2022-08-21. PMID:35988226. |
afterward, activated nlrp3 triggers local microglia and astrocytes to release additional il-1β. |
2022-08-21 |
2023-08-14 |
Not clear |
| Yihua He, Yuan Chang, Yuqin Peng, Juan Zhu, Kewei Liu, Jiancong Chen, Yongming Wu, Zhong Ji, Zhenzhou Lin, Shengnan Wang, Sohan Gupta, Nailiang Zang, Suyue Pan, Kaibin Huan. Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation In Microglia. Molecular neurobiology. 2022-08-16. PMID:35972671. |
glibenclamide directly prevents neuroinflammation by targeting sur1-trpm4-mediated nlrp3 inflammasome activation in microglia. |
2022-08-16 |
2023-08-14 |
rat |