| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung Woo Park, Jung Goo Lee, Mi Kyoung Seo, Chan Hong Lee, Hye Yeon Cho, Bong Ju Lee, Wongi Seol, Young Hoon Ki. Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons. The international journal of neuropsychopharmacology. vol 17. issue 11. 2015-05-26. PMID:24901414. |
differential effects of antidepressant drugs on mtor signalling in rat hippocampal neurons. |
2015-05-26 |
2023-08-13 |
rat |
| W Zhou, N Wang, C Yang, X-M Li, Z-Q Zhou, J-J Yan. Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24321772. |
ketamine-induced antidepressant effects are associated with ampa receptors-mediated upregulation of mtor and bdnf in rat hippocampus and prefrontal cortex. |
2015-05-15 |
2023-08-12 |
rat |
| W Zhou, N Wang, C Yang, X-M Li, Z-Q Zhou, J-J Yan. Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24321772. |
therefore, we pretreated rats with nbqx, an ampa receptor antagonist, or cx546, an ampa receptor agonist, and subsequently observed the immobility time during the forced swimming test (fst) and the hippocampal and prefrontal cortical levels of mtor and bdnf. |
2015-05-15 |
2023-08-12 |
rat |
| W Zhou, N Wang, C Yang, X-M Li, Z-Q Zhou, J-J Yan. Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24321772. |
the results showed ketamine decreased the immobility time of rats during the fst and increased the hippocampal and prefrontal cortical mtor and bdnf. |
2015-05-15 |
2023-08-12 |
rat |
| W Zhou, N Wang, C Yang, X-M Li, Z-Q Zhou, J-J Yan. Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24321772. |
our results suggest ketamine-induced antidepressant effects are associated with ampa receptors-mediated upregulation of mtor and bdnf in rat hippocampus and prefrontal cortex. |
2015-05-15 |
2023-08-12 |
rat |
| Bianca De Filippis, Valentina Chiodi, Walter Adriani, Enza Lacivita, Cinzia Mallozzi, Marcello Leopoldo, Maria Rosaria Domenici, Andrea Fuso, Giovanni Laviol. Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. Frontiers in behavioral neuroscience. vol 9. 2015-04-30. PMID:25926782. |
lp-211 also restores the activation of the ribosomal protein (rp) s6, the downstream target of mtor and s6 kinase, in the hippocampus of rtt female mice. |
2015-04-30 |
2023-08-13 |
mouse |
| Erica D Smith, G Aleph Prieto, Liqi Tong, Ilse Sears-Kraxberger, Jeffrey D Rice, Oswald Steward, Carl W Cotma. Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. The Journal of biological chemistry. vol 289. issue 30. 2015-02-11. PMID:24917666. |
activation of mtor is necessary for the many beneficial effects of brain-derived neurotrophic factor (bdnf), including dendritic translation and memory formation in the hippocampus. |
2015-02-11 |
2023-08-13 |
rat |
| Erica D Smith, G Aleph Prieto, Liqi Tong, Ilse Sears-Kraxberger, Jeffrey D Rice, Oswald Steward, Carl W Cotma. Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. The Journal of biological chemistry. vol 289. issue 30. 2015-02-11. PMID:24917666. |
we report that mtor activation is necessary for bdnf-dependent survival of primary rat hippocampal neurons, as either mtor inhibition by rapamycin or genetic manipulation of the downstream molecule p70s6k specifically blocked bdnf rescue. |
2015-02-11 |
2023-08-13 |
rat |
| Peng Zhong, Wei Wang, Bin Pan, Xiaojie Liu, Zhen Zhang, Jonathan Z Long, Han-ting Zhang, Benjamin F Cravatt, Qing-song Li. Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 7. 2014-12-29. PMID:24476943. |
cus induced depressive-like behaviors and decreased mammalian target of rapamycin (mtor) activation in the hippocampus, and these biochemical and behavioral abnormalities were ameliorated by chronic jzl184 treatments. |
2014-12-29 |
2023-08-12 |
mouse |
| Peng Zhong, Wei Wang, Bin Pan, Xiaojie Liu, Zhen Zhang, Jonathan Z Long, Han-ting Zhang, Benjamin F Cravatt, Qing-song Li. Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 7. 2014-12-29. PMID:24476943. |
genetic deletion of mtor with adeno-associated viral (aav) vector carrying the cre recombinase in the hippocampus of mtorf/f mice recapitulated depressive-like behaviors induced by cus and abrogated the antidepressant-like effects of chronic jzl184 treatments. |
2014-12-29 |
2023-08-12 |
mouse |
| Bin Zhu, Chun Yang, Liang-Cai Ding, Ning Li. 3-methyladenine, an autophagic inhibitor, attenuates therapeutic effects of sirolimus on scopolamine-induced cognitive dysfunction in a rat model. International journal of clinical and experimental medicine. vol 7. issue 10. 2014-11-24. PMID:25419365. |
after behavioral test, rats were sacrificed and prefrontal cortex and hippocampus were harvested for measuring amyloid-β (aβ), beclin-1 and mammalian target of rapamycin (mtor). |
2014-11-24 |
2023-08-13 |
rat |
| Bin Zhu, Chun Yang, Liang-Cai Ding, Ning Li. 3-methyladenine, an autophagic inhibitor, attenuates therapeutic effects of sirolimus on scopolamine-induced cognitive dysfunction in a rat model. International journal of clinical and experimental medicine. vol 7. issue 10. 2014-11-24. PMID:25419365. |
compared with saline group, scopolamine administered significantly decreased the cognitive performance of rats during the morris water maze test and changed aβ, beclin-1 and mtor levels in rat prefrontal cortex and hippocampus (p<0.05); in addition, rats in sirolimus plus scopolamine group significantly reversed scopolamine-induced effects (p<0.05). |
2014-11-24 |
2023-08-13 |
rat |
| Fengying Yang, Xiaolei Chu, Miaomiao Yin, Xiaolei Liu, Hairui Yuan, Yanmei Niu, Li F. mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits. Behavioural brain research. vol 264. 2014-11-05. PMID:24525424. |
however, whether cr can ameliorate age-related cognition deficits by inhibiting mtor and activate autophagy in hippocampus needs to be further investigated. |
2014-11-05 |
2023-08-12 |
mouse |
| Fengying Yang, Xiaolei Chu, Miaomiao Yin, Xiaolei Liu, Hairui Yuan, Yanmei Niu, Li F. mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits. Behavioural brain research. vol 264. 2014-11-05. PMID:24525424. |
here we showed a decline of autophagic degradation in mice hippocampus in correlation with age-dependent cognitive dysfunction, whereas the activity of mtor and its upstream brain-derived neurotrophic factor (bdnf)/phosphatidylinositide 3-kinase (pi3k)/protein kinase b (akt) signaling was decreased with aging. |
2014-11-05 |
2023-08-12 |
mouse |
| Fengying Yang, Xiaolei Chu, Miaomiao Yin, Xiaolei Liu, Hairui Yuan, Yanmei Niu, Li F. mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits. Behavioural brain research. vol 264. 2014-11-05. PMID:24525424. |
in addition, facilitating the mtor pathway successfully declines and sustains autophagic degradation with aging in hippocampus by cr treatment and is involved in cr by ameliorating age-related cognitive deficits. |
2014-11-05 |
2023-08-12 |
mouse |
| Xiaoxia Zhu, Juyeon Park, Julianne Golinski, Jianhua Qiu, Jugta Khuman, Christopher C H Lee, Eng H Lo, Alexei Degterev, Michael J Whale. Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 9. 2014-10-31. PMID:24938400. |
in a mouse closed head injury (chi) concussion traumatic brain injury (tbi) model, phosphorylation of akt (p-akt), mtor (p-mtor), and s6rp (p-s6rp) was increased by 24 hours in cortical and hippocampal brain homogenates (p<0.05 versus sham for each), and p-s6rp was robustly induced in iba-1+ microglia and glial fibrillary acidic protein-positive (gfap+) astrocytes. |
2014-10-31 |
2023-08-13 |
mouse |
| Im-Joon Shin, Sung Un Son, Hyunwoo Park, Yoorim Kim, Sung Hyun Park, Kelley Swanberg, Joo-Yeon Shin, Sang-Kyu Ha, Yoonju Cho, Soo-Yong Bang, Jae-Hwan Lew, Seung-Hun Cho, Sungho Maen. Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract. PloS one. vol 9. issue 2. 2014-10-13. PMID:24520403. |
also similarly to ketamine, radix polygalae appeared to acutely decrease phosphorylation of glur1 serine-845 in the hippocampus while leaving the phosphorylation of hippocampal mtor serine 2448 unchanged. |
2014-10-13 |
2023-08-12 |
mouse |
| Yael Kusne, Emily L Goldberg, Sara S Parker, Sophie M Hapak, Irina Y Maskaykina, Wade M Chew, Kirsten H Limesand, Heddwen L Brooks, Theodore J Price, Nader Sanai, Janko Nikolich-Zugich, Sourav Ghos. Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. Age (Dordrecht, Netherlands). vol 36. issue 1. 2014-09-29. PMID:23949159. |
here we report the effects of chronic and systemic administration of the two mtor inhibitors, rapamycin and metformin, on adult neural stem cells of the subventricular region and the dendate gyrus of the mouse hippocampus. |
2014-09-29 |
2023-08-12 |
mouse |
| Daniele Lana, Francesca Cerbai, Jacopo Di Russo, Francesca Boscaro, Ambra Giannetti, Polina Petkova-Kirova, Anna Maria Pugliese, Maria Grazia Giovannin. Hippocampal long term memory: effect of the cholinergic system on local protein synthesis. Neurobiology of learning and memory. vol 106. 2014-08-11. PMID:24076274. |
we performed in vivo behavioral experiments using the step down inhibitory avoidance test (ia) in adult wistar rats to evaluate memory formation under different conditions, and immunohistochemistry on hippocampal slices to evaluate the level and the time-course of mtor and p70s6k activation. |
2014-08-11 |
2023-08-12 |
rat |
| Daniele Lana, Francesca Cerbai, Jacopo Di Russo, Francesca Boscaro, Ambra Giannetti, Polina Petkova-Kirova, Anna Maria Pugliese, Maria Grazia Giovannin. Hippocampal long term memory: effect of the cholinergic system on local protein synthesis. Neurobiology of learning and memory. vol 106. 2014-08-11. PMID:24076274. |
to confirm our results we performed in vitro experiments on live hippocampal slices: we evaluated whether stimulation of the cholinergic system with the cholinergic receptor agonist carbachol (cch) activated the mtor pathway and whether the administration of the above-mentioned antagonists together with cch could revert this activation. |
2014-08-11 |
2023-08-12 |
rat |