| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Narvaiz, Katherine J Blandin, D Gregory Sullens, Paige D Womble, Jacob B Pilcher, Grace O'Neill, Taylor A Wiley, Eliesse M Kwok, Srikhar V Chilukuri, Joaquin N Lug. NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density. Epilepsy research. vol 206. 2024-08-30. PMID:39213710. |
as a model of hyperactive mtor induced epilepsy, neuronal subset specific phosphatase and tensin homolog (ns-pten) knockout (ko) mice exhibit hyperactive mtor signaling in the hippocampus, seizures that progress with age, and enhanced hippocampal microglia/macrophage activation. |
2024-08-30 |
2024-09-04 |
mouse |
| J Krummeich, L Nardi, C Caliendo, D Aschauer, V Engelhardt, A Arlt, J Maier, F Bicker, M D Kwiatkowski, K Rolski, K Vincze, R Schneider, S Rumpel, S Gerber, M J Schmeisser, S Schweige. Premature cognitive decline in a mouse model of tuberous sclerosis. Aging cell. 2024-08-28. PMID:39192595. |
while we did not detect any morphological changes of hippocampal projections and synaptic contacts, molecular markers of neurodegeneration were increased and the mtor signaling cascade was downregulated in hippocampal synaptosomes. |
2024-08-28 |
2024-08-30 |
mouse |
| Zhen-Yan Li, Xian Yang, Ji-Kai Wang, Xiao-Xin Yan, Fei Liu, Yu-Chun Zu. MFGE8 promotes adult hippocampal neurogenesis in rats following experimental subarachnoid hemorrhage via modifying the integrin β3/Akt signaling pathway. Cell death discovery. vol 10. issue 1. 2024-08-11. PMID:39128910. |
rhmgfe8 treatment elevated the levels of phosphatidylinositol 3-kinase (pi3k), p-akt, mammalian target of rapamycin (mtor), cyclind1, hpca and dcx in hippocampal lysates, but not that of integrin β3 and akt, at 24 hr after sah. |
2024-08-11 |
2024-08-14 |
human |
| Zhangjie Wu, Ying Yin, Ruiyi Liu, Xianhui Li, Yan Sun, Suk-Yu Yau, Lei Wu, Yan Liu, Miroslav Adzic, Hailou Zhang, Gang Che. A refined formula derived from Jiawei-Xiaoyao Pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling. Journal of ethnopharmacology. 2024-08-02. PMID:39094756. |
furthermore, rapamycin, a selective inhibitor of mtor, blunted the rapid antidepressant-like effects and hippocampal bdnf signaling upregulation by gma conclusion: gma may serve as a refined formula from jwx, capable of inducing rapid antidepressant-like effects. |
2024-08-02 |
2024-08-06 |
mouse |
| Long Tao, Xiao-Xiao Li, Xin-Ru Tu, Rui Liu, Jia-Wen Xu, Yi-Li Lv, Yu-You Ya. Hippocampal Crhr1 conditional gene knockout ameliorated the depression-like behavior and pathological damage in male offspring mice caused by chronic stress during pregnancy. Behavioural brain research. 2024-07-05. PMID:38969017. |
conditional gene knockout of hippocampal crhr1 in mice reduced csdp-induced depression-like behavior, hippocampal neuronal dendrite damage and apoptosis in male offspring, and counteracted the csdp-induced decreased expression of p-akt and mtor activity in male offspring hippocampus. |
2024-07-05 |
2024-07-08 |
mouse |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
fxs induces abnormal hippocampal autophagy and mtor overactivation. |
2024-06-08 |
2024-06-11 |
mouse |
| Huang Xiaoyan, Yang Zhaoxi, Zhang Lingli, Chen Jinyuan, Qin We. Taurine Improved Autism-Like Behaviours and Defective Neurogenesis of the Hippocampus in BTBR Mice through the PTEN/mTOR/AKT Signalling Pathway. Folia biologica. vol 70. issue 1. 2024-06-03. PMID:38830122. |
our results showed that taurine improved the autism-like behaviour, increased the proliferation of hippocampal cells, promoted pten expression, and reduced phosphorylation of mtor and akt in hippocampal tissue of the btbr mice. |
2024-06-03 |
2024-06-06 |
mouse |
| Jiuseng Zeng, Li Chen, Xi Peng, Fei Luan, Jingwen Hu, Zhiqiang Xie, Hongxiao Xie, Rong Liu, Haizhen Lv, Nan Zen. The anti-depression effect and potential mechanism of the petroleum ether fraction of CDB: Integrated network pharmacology and metabolomics. Heliyon. vol 10. issue 7. 2024-04-08. PMID:38586416. |
pefc significantly reversed abnormalities of hippocampus metabolites in cums mice, mainly affecting the synthesis and metabolism of glycine, serine, and threonine, impacting catecholamine transfer and cholinergic synapses and regulating the activity of the mtor signaling pathway. |
2024-04-08 |
2024-04-10 |
mouse |
| Liesbeth François, Alessia Romagnolo, Mark J Luinenburg, Jasper J Anink, Patrice Godard, Marek Rajman, Jonathan van Eyll, Angelika Mühlebner, Andrew Skelton, James D Mills, Stefanie Dedeurwaerdere, Eleonora Aronic. Identification of gene regulatory networks affected across drug-resistant epilepsies. Nature communications. vol 15. issue 1. 2024-03-12. PMID:38467626. |
this study included the most common drug-resistant epilepsies (dres), such as temporal lobe epilepsy with hippocampal sclerosis (tle-hs), and mtor pathway-related malformations of cortical development (mtoropathies). |
2024-03-12 |
2024-03-14 |
Not clear |
| Xing Ye, Jun-Yi Lin, Ling-Xia Chen, Xue-Chun Wu, Kai-Jun Ma, Bei-Xu Li, You-Xin Fan. SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus. Heliyon. vol 10. issue 1. 2024-01-11. PMID:38205297. |
moreover, we found that srebp1 is regulated by the mtor signaling pathway, and inhibiting mtor signaling contributed to the amelioration of se-induced hippocampal neuron pyroptosis, accompanied by a reduction in srebp1 expression. |
2024-01-11 |
2024-01-13 |
rat |
| Yasaman Yadollahi-Farsani, Vahid Reisi Vanani, Zahra Lorigooini, Anahita Farahzad, Hossein Amini-Khoe. Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice. IBRO neuroscience reports. vol 16. 2023-12-25. PMID:38145174. |
the gene expression of the pi3k, akt and mtor assessed in the hippocampus by qrt-pcr. |
2023-12-25 |
2023-12-27 |
mouse |
| Yasaman Yadollahi-Farsani, Vahid Reisi Vanani, Zahra Lorigooini, Anahita Farahzad, Hossein Amini-Khoe. Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice. IBRO neuroscience reports. vol 16. 2023-12-25. PMID:38145174. |
also, anethole increased the gene expression of pi3k, akt and mtor in the hippocampus of ms mice. |
2023-12-25 |
2023-12-27 |
mouse |
| Jingyun Zhang, Xiaoyi Sun, Xueqing Jia, Binggui Sun, Shijun Xu, Weiping Zhang, Zuyun Li. Integrative multi-omics analysis reveals the critical role of the PBXIP1 gene in Alzheimer's disease. Aging cell. 2023-11-20. PMID:37984333. |
moreover, pbxip1 may be related to ad through its role in astrocytes and hippocampal neurons, and the mtor pathway. |
2023-11-20 |
2023-11-29 |
Not clear |
| Sandra Ledesma-Corvi, M Julia García-Fuste. Electroconvulsive seizures regulate various stages of hippocampal cell genesis and mBDNF at different times after treatment in adolescent and adult rats of both sexes. Frontiers in molecular neuroscience. vol 16. 2023-11-15. PMID:37965039. |
several hippocampal markers of neuroplasticity, commonly regulated by most antidepressants, such as those of neurogenesis (cell proliferation, neurogenic differentiation, long-term cell survival) or mbdnf and associated signaling (e.g., mtor and erk1/2) were evaluated at different time-points after treatment (1-, 8-, 15- and up to 30-days post-treatment). |
2023-11-15 |
2023-11-20 |
rat |
| Eduardo J Fusse, Franciele F Scarante, Maria A Vicente, Mariana M Marrubia, Flávia Turcato, Davi S Scomparin, Melissa A Ribeiro, Maria J Figueiredo, Tamires A V Brigante, Francisco S Guimarães, Alline C Campo. Anxiogenic doses of rapamycin prevent URB597-induced anti-stress effects in socially defeated mice. Neuroscience letters. vol 818. 2023-11-01. PMID:37852528. |
the mtor protein regulates various neuroplastic processes in the brain disrupted by stress, including adult hippocampal neurogenesis. |
2023-11-01 |
2023-11-08 |
mouse |
| Eduardo J Fusse, Franciele F Scarante, Maria A Vicente, Mariana M Marrubia, Flávia Turcato, Davi S Scomparin, Melissa A Ribeiro, Maria J Figueiredo, Tamires A V Brigante, Francisco S Guimarães, Alline C Campo. Anxiogenic doses of rapamycin prevent URB597-induced anti-stress effects in socially defeated mice. Neuroscience letters. vol 818. 2023-11-01. PMID:37852528. |
sds exposure altered the hippocampal expression of the mtor scaffold protein raptor. |
2023-11-01 |
2023-11-08 |
mouse |
| Shuixin Lv, Yusi Zhang, Yingbin Lin, Wenting Fang, Yu Wang, Zihang Li, Anlan Lin, Xiaoman Dai, Qinyong Ye, Jing Zhang, Xiaochun Che. ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl-CoA level. Aging cell. 2023-08-18. PMID:37594184. |
using humanized apoe4- and apoe3- target replacement mice, we found the accumulation of senescent neurons and the activation of mtor and endosome-lysosome-autophagy (ela) system in the hippocampus of aged apoe4 mice. |
2023-08-18 |
2023-09-07 |
mouse |
| Shuixin Lv, Yusi Zhang, Yingbin Lin, Wenting Fang, Yu Wang, Zihang Li, Anlan Lin, Xiaoman Dai, Qinyong Ye, Jing Zhang, Xiaochun Che. ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl-CoA level. Aging cell. 2023-08-18. PMID:37594184. |
further analyses revealed that apoe4 aggravated the profile change of hippocampal transcription and metabolism in an age-dependent manner, accompanying with an disruption of metabolism, which is presented with the downregulating activity of citrate synthase, the level of atp and, most importantly, the level of acetyl coenzyme a (ac-coa); gta supplement, an ac-coa substrate, reversed the senescent characteristics, decreased the activation of mtor and ela system, and enhanced the synaptic structure and increasing level of pre-/post-synaptic plasticity-related protein, leading to cognitive improvement in aged apoe4 mice. |
2023-08-18 |
2023-09-07 |
mouse |
| Jehoon Lee, Marcus R Orzabal, Vishal D Naik, Jayanth Ramados. Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat fetal hippocampus. Frontiers in neuroscience. vol 17. 2023-07-15. PMID:37449268. |
impact of e-cigarette vaping aerosol exposure in pregnancy on mtor signaling in rat fetal hippocampus. |
2023-07-15 |
2023-08-14 |
rat |
| Jehoon Lee, Marcus R Orzabal, Vishal D Naik, Jayanth Ramados. Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat fetal hippocampus. Frontiers in neuroscience. vol 17. 2023-07-15. PMID:37449268. |
implementing a state-of-the-art engineered vaping system, comprising an atomizer similar to those sold in vape shops, we aimed to utilize a translational e-cig inhalation delivery method to provide crucial information on the impact of prenatal e-cig aerosols on the developing brain hippocampal mtor system in a rat model system. |
2023-07-15 |
2023-08-14 |
rat |