| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Xu, Bowen Zheng, Yanmei Ma, Xiaopeng Zhang, Jianhua Cheng, Jing Yang, Peng Li, Jianzhong Zhang, Li Jing, Fang X. PI3K-AKT-mTOR signaling pathway regulates autophagy of hippocampal neurons in diabetic rats with chronic unpredictable mild stress. Behavioural brain research. 2023-06-30. PMID:37390967. |
the present study investigated the histopathology, autophagy of hippocampal neurons, and the pi3k-akt- mtor signaling pathway in type 2 diabetes with depression（t2dd） rats. |
2023-06-30 |
2023-08-14 |
rat |
| Chang Woo Chae, Jee Hyeon Yoon, Jae Ryong Lim, Ji Yong Park, Ji Hyeon Cho, Young Hyun Jung, Gee Euhn Choi, Hyun Jik Lee, Ho Jae Ha. TRIM16-mediated lysophagy suppresses high-gluocse-accumulated neuronal Aβ. Autophagy. 2023-06-26. PMID:37357416. |
among lysophagy-related factors, the expression of trim16 (tripartite motif containing 16) was reduced in high-glucose-treated neuronal cells and the diabetic hippocampus through mtor (mechanistic target of rapamycin kinase) complex 1 (mtorc1)-mediated inhibition of tfeb (transcription factor eb) activity. |
2023-06-26 |
2023-08-14 |
mouse |
| Yuanming Lu, Wanshi Wang, Yanping Ma, Zilian Fan, Lan Xiong, Junhao Zhao, Yongwen He, Chao Li, Anjie Wang, Nanping Xiao, Tianxun Wan. miR-10a induces inflammatory responses in epileptic hippocampal neurons of rats via PI3K/Akt/mTOR signaling pathway. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270844. |
the hippocampal neurons were transfected with mir-10a mimics, and transcript levels of mir-10a, pi3k, akt and mtor were detected by quantitative reverse transcription-pcr, and pi3k, mtor, akt, tnf-α, il-1β, il-6 protein expression levels were detected by western blot. |
2023-06-04 |
2023-08-14 |
rat |
| Yuanming Lu, Wanshi Wang, Yanping Ma, Zilian Fan, Lan Xiong, Junhao Zhao, Yongwen He, Chao Li, Anjie Wang, Nanping Xiao, Tianxun Wan. miR-10a induces inflammatory responses in epileptic hippocampal neurons of rats via PI3K/Akt/mTOR signaling pathway. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270844. |
in the epileptic hippocampal neurons model, the expression levels of mir-10a were significantly increased, with decreasing levels of pi3k, akt and mtor, and increasing levels of tnf-α, il-1β and il-6. |
2023-06-04 |
2023-08-14 |
rat |
| Katarzyna Stachowicz, Patrycja Pańczyszyn-Trzewik, Magdalena Sowa-Kućma, Paulina Miszta. Changes in working memory induced by lipopolysaccharide administration in mice are associated with metabotropic glutamate receptors 5 and contrast with changes induced by cyclooxygenase-2: Involvement of postsynaptic density protein 95 and down syndrome cell adhesion molecule. Neuropeptides. vol 100. 2023-05-14. PMID:37182274. |
here, the effects of treatment with an antagonist of mglur5 (mtep) and ns398 (cyclooxygenase-2, cox-2 inhibitor) on psd95, mtor, and dscam in the hippocampus (hc) of c57b1/6 j mice using western blots in the context of learning were examined. |
2023-05-14 |
2023-08-14 |
mouse |
| Bingjie Liu, Yuxin Du, Chang Xu, Qingzhen Liu, Lidong Zhan. Antidepressant effects of repeated s-ketamine administration as NMDAR Antagonist: Involvement of CaMKIIα and mTOR signaling in the hippocampus of CUMS mice. Brain research. 2023-05-05. PMID:37146745. |
antidepressant effects of repeated s-ketamine administration as nmdar antagonist: involvement of camkiiα and mtor signaling in the hippocampus of cums mice. |
2023-05-05 |
2023-08-14 |
mouse |
| Bingjie Liu, Yuxin Du, Chang Xu, Qingzhen Liu, Lidong Zhan. Antidepressant effects of repeated s-ketamine administration as NMDAR Antagonist: Involvement of CaMKIIα and mTOR signaling in the hippocampus of CUMS mice. Brain research. 2023-05-05. PMID:37146745. |
the protein expressions of glun1, glun2a, glun2b, glur1, camkiiα, phosphorylated camkiiα (p-camkiiα), bdnf, trkb, phosphorylated trkb (p-trkb), mtor, and phosphorylated mtor (p-mtor) as well as modification of synaptic ultrastructure was identified in hippocampal tissues. |
2023-05-05 |
2023-08-14 |
mouse |
| Bo Zhang, Hang Li, Yan Wang, Yang Li, Zhongsheng Zhou, Xuejia Hou, Xiaowen Zhang, Te Li. Mechanism of autophagy mediated by IGF-1 signaling pathway in the neurotoxicity of lead in pubertal rats. Ecotoxicology and environmental safety. vol 251. 2023-01-18. PMID:36652739. |
we found that lead exposure caused significant damage to rat nervous systems, that is, compared with the control group, the lead treatment group had more autophagosomes in their hippocampal neurons; lower serum and hippocampal igf-1 levels; lower hippocampal igf-1, igf-1r, pi3k, akt, and mtor gene expression; and upregulated hippocampal autophagy-associated proteins levels. |
2023-01-18 |
2023-08-14 |
rat |
| Mengxin Shen, Dan Lv, Xinya Liu, Chuang Wan. ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice. Translational psychiatry. vol 12. issue 1. 2022-12-22. PMID:36550125. |
produced antidepressant-like actions dependent on the increase in extracellular regulated protein kinase (erk)/mammalian target of rapamycin (mtor) signaling and downstream substrates p70s6 kinase (p70s6k) and the eukaryotic initiation factor 4e-binding protein 1 (4e-bp1), which may induce the expression of vgf and bdnf in the hippocampus and prefrontal cortex of mice. |
2022-12-22 |
2023-08-14 |
mouse |
| Ekram Mohammadi, Farnaz Nikbakht, Mahmoud Barati, Mehrdad Roghani, Somayeh Vazifekhah, Ali Mohammad Khanizadeh, Zahra Heidar. Protective effect of N-acetyl cysteine on the mitochondrial dynamic imbalance in temporal lobe epilepsy: Possible role of mTOR. Neuropeptides. vol 96. 2022-10-21. PMID:36270032. |
the total mtor and drp1 levels in the hippocampus were evaluated by western blotting. |
2022-10-21 |
2023-08-14 |
rat |
| Meiwen Guo, Shuang Chen, Jitong Lao, Jiantang Liang, Hao Chen, Jingyi Tong, Yonghao Huang, Dandan Jia, Qifu L. 3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model. Neurochemical research. 2022-10-15. PMID:36243819. |
immunohistochemistry, western blot and q-pcr were employed to detect the expression of autophagy-related proteins and mtor in the hippocampus and cortex. less seizures, increased hippocampal neurons and reduced astrocytes of hippocampus were observed in the 3bdo-treated epileptic mice than in the ptz-kindled epileptic mice. |
2022-10-15 |
2023-08-14 |
mouse |
| Meiwen Guo, Shuang Chen, Jitong Lao, Jiantang Liang, Hao Chen, Jingyi Tong, Yonghao Huang, Dandan Jia, Qifu L. 3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model. Neurochemical research. 2022-10-15. PMID:36243819. |
immunohistochemistry and immunofluorescence also showed 3bdo inhibited the lc3 expression and increased the mtor expression in the hippocampus of epileptic mice. |
2022-10-15 |
2023-08-14 |
mouse |
| Meiwen Guo, Shuang Chen, Jitong Lao, Jiantang Liang, Hao Chen, Jingyi Tong, Yonghao Huang, Dandan Jia, Qifu L. 3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model. Neurochemical research. 2022-10-15. PMID:36243819. |
in addition, the autophagy activator en6 reversed the decrease in the 3bdo-induced autophagy and aggravated the seizures and cognitive dysfunction in the epileptic mice. 3bdo regulates autophagy by activating the mtor signaling pathway in ptz-kindled epileptic mice model, thereby alleviating hippocampus neuronal loss and astrocytes proliferation, reducing seizures and effectively improving cognitive function. |
2022-10-15 |
2023-08-14 |
mouse |
| Braulio Munoz, Brandon M Fritz, Fuqin Yin, Brady K Atwoo. HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum. The Journal of physiology. 2022-10-01. PMID:36181477. |
dorsal striatal cannabinoid long-term depression requires mtor signaling, similar to hippocampal cannabinoid long-term depression, but dorsal striatal mu opioid long-term depression does not require mtor signaling. |
2022-10-01 |
2023-08-14 |
Not clear |
| Jessica Rosa, Jociane de Carvalho Myskiw, Natalia Gindri Fiorenza, Cristiane Regina Guerino Furini, Gerson Guilherme Sapiras, Ivan Izquierd. Hippocampal cholinergic receptors and the mTOR participation in fear-motivated inhibitory avoidance extinction memory. Behavioural brain research. 2022-09-30. PMID:36179804. |
hippocampal cholinergic receptors and the mtor participation in fear-motivated inhibitory avoidance extinction memory. |
2022-09-30 |
2023-08-14 |
rat |
| Jessica Rosa, Jociane de Carvalho Myskiw, Natalia Gindri Fiorenza, Cristiane Regina Guerino Furini, Gerson Guilherme Sapiras, Ivan Izquierd. Hippocampal cholinergic receptors and the mTOR participation in fear-motivated inhibitory avoidance extinction memory. Behavioural brain research. 2022-09-30. PMID:36179804. |
evidence has demonstrated the hippocampal cholinergic system and the mammalian target of rapamycin (mtor) participation during the memory formation of aversive events. |
2022-09-30 |
2023-08-14 |
rat |
| Jessica Rosa, Jociane de Carvalho Myskiw, Natalia Gindri Fiorenza, Cristiane Regina Guerino Furini, Gerson Guilherme Sapiras, Ivan Izquierd. Hippocampal cholinergic receptors and the mTOR participation in fear-motivated inhibitory avoidance extinction memory. Behavioural brain research. 2022-09-30. PMID:36179804. |
the post-extinction session administration of the nicotinic and muscarinic cholinergic receptor antagonists, mecamylamine and scopolamine, respectively, both at doses of 2µg/µl/side, and rapamycin, an mtor inhibitor (0.02µg/µl/side), into the ca1 region of the dorsal hippocampus, impaired the ia extinction memory. |
2022-09-30 |
2023-08-14 |
rat |
| Jessica Rosa, Jociane de Carvalho Myskiw, Natalia Gindri Fiorenza, Cristiane Regina Guerino Furini, Gerson Guilherme Sapiras, Ivan Izquierd. Hippocampal cholinergic receptors and the mTOR participation in fear-motivated inhibitory avoidance extinction memory. Behavioural brain research. 2022-09-30. PMID:36179804. |
these results have demonstrated the participation of the cholinergic receptors and mtor in the hippocampus for ia extinction, and that the cholinergic agonists had a dose-dependent effect on the ia extinction memory. |
2022-09-30 |
2023-08-14 |
rat |
| Jessica Rosa, Jociane de Carvalho Myskiw, Natalia Gindri Fiorenza, Cristiane Regina Guerino Furini, Gerson Guilherme Sapiras, Ivan Izquierd. Hippocampal cholinergic receptors and the mTOR participation in fear-motivated inhibitory avoidance extinction memory. Behavioural brain research. 2022-09-30. PMID:36179804. |
this study provides insights related to the behavioural aspects and the neurobiological properties underlying the early stage of fear-motivated ia extinction memory consolidation and suggests that there is hippocampal muscarinic receptor participation independent of mtor in this memory process. |
2022-09-30 |
2023-08-14 |
rat |
| Che-Wei Sung, Wei-Tang Chang, Ming-Huan Chan, Tsung-Han Kuo, Hwei-Hsien Che. L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-27. PMID:36166962. |
the phosphorylation levels of mtor and glur1 in the hippocampus were also increased after l-4fpg treatment. |
2022-09-27 |
2023-08-14 |
mouse |