| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pramod K Dash, Sara A Orsi, Anthony N Moor. Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 31. 2006-09-05. PMID:16885218. |
to test our hypothesis, we directly administered rapamycin (an inhibitor of mtor), glucose, 5-aminoimidazole-4-carboxamide-1beta-4-ribonucleoside (aicar; an activator of amp kinase), or glucose plus rapamycin into the dorsal hippocampus after we trained rats in the morris water maze task. |
2006-09-05 |
2023-08-12 |
rat |
| Jacek Jaworski, Samantha Spangler, Daniel P Seeburg, Casper C Hoogenraad, Morgan Shen. Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 49. 2006-03-23. PMID:16339025. |
here, we show that the phosphoinositide-3' kinase (pi3k)-akt-mammalian target of rapamycin (mtor) signaling pathway promotes the growth and branching of dendrites in cultured hippocampal neurons. |
2006-03-23 |
2023-08-12 |
Not clear |
| Lingfei Hou, Eric Klan. Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 28. 2004-12-13. PMID:15254091. |
we found that brief incubations of mouse hippocampal slices with dhpg resulted in increased phosphorylation of akt and mtor in hippocampal area ca1. |
2004-12-13 |
2023-08-12 |
mouse |
| Maurizio Cammalleri, Robert Lütjens, Fulvia Berton, Alvin R King, Cindy Simpson, Walter Francesconi, Pietro Paolo Sann. Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 24. 2004-02-02. PMID:14623952. |
second, we observed that thr-389-phosphorylated p70 s6 kinase (p70s6k), the main active phosphoform of the mtor effector p70s6k, was induced in an n-methyl-d-aspartate and phosphatidylinositol 3-kinase-dependent manner throughout the dendrites but not in the cell bodies of ca1 neurons in hippocampal slices after l-ltp induction. |
2004-02-02 |
2023-08-12 |
aplysia |
| Shao Jun Tang, Gerald Reis, Hyejin Kang, Anne-Claude Gingras, Nahum Sonenberg, Erin M Schuma. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 1. 2002-04-15. PMID:11756682. |
several components of this translational signaling pathway, including mtor, eukaryotic initiation factor-4e-binding proteins 1 and 2, and eukaryotic initiation factor-4e, are present in the rat hippocampus as shown by western blot analysis, and these proteins are detected in the cell bodies and dendrites in the hippocampal slices by immunostaining studies. |
2002-04-15 |
2023-08-12 |
rat |