| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juyeon Park, Jimmy Zhang, Jianhua Qiu, Xiaoxia Zhu, Alexei Degterev, Eng H Lo, Michael J Whale. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 2. 2012-03-21. PMID:21934697. |
following cci, phospho-akt-473 (p-akt) and -s6 ribosomal protein (p-s6rp), a downstream substrate of mtor, were increased in cortical and hippocampal brain homogenates (p<0.05 versus sham). |
2012-03-21 |
2023-08-12 |
mouse |
| Juyeon Park, Jimmy Zhang, Jianhua Qiu, Xiaoxia Zhu, Alexei Degterev, Eng H Lo, Michael J Whale. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 2. 2012-03-21. PMID:21934697. |
importantly, administration of akt and mtor inhibitors together (but not of either alone) improved postinjury motor (p=0.02) and cognitive deficits (hidden platform trials, p=0.001; probe trials, p<0.05), decreased propidium iodide-positive cells in ca1 and ca3 (p<0.005), and unexpectedly increased p-gsk3β in hippocampus. |
2012-03-21 |
2023-08-12 |
mouse |
| Tao Ma, Nikos Tzavaras, Panayiotis Tsokas, Emmanuel M Landau, Robert D Blitze. Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 48. 2012-02-09. PMID:22131415. |
we report that mtor is tonically suppressed in rat hippocampus under resting conditions, a consequence of the basal activity of glycogen synthetase kinase 3 (gsk3). |
2012-02-09 |
2023-08-12 |
rat |
| Shibu M Poulose, Donna F Bielinski, Kirsty Carrihill-Knoll, Bernard M Rabin, Barbara Shukitt-Hal. Exposure to 16O-particle radiation causes aging-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy. Radiation research. vol 176. issue 6. 2012-01-26. PMID:21962006. |
compared to nonirradiated controls, exposure to (16)o particles significantly inhibited autophagy function in the hippocampus as measured by accumulation of ubiquitin inclusion bodies such as p62/sqstm1, autophagosome marker microtubule-associated protein 1 beta light chain 3 (map1b-lc3), beclin1 and proteins such as mammalian target of rapamycin (mtor). |
2012-01-26 |
2023-08-12 |
rat |
| Lakshmi Raman, Xiangmei Kong, Jennifer A Gilley, Steven G Kerni. Chronic hypoxia impairs murine hippocampal development and depletes the postnatal progenitor pool by attenuating mammalian target of rapamycin signaling. Pediatric research. vol 70. issue 2. 2011-11-15. PMID:21532529. |
systemic inhibition of the mtor pathway using rapamycin also caused impairment of hippocampal neurogenesis that mimics exposure to ch. |
2011-11-15 |
2023-08-12 |
mouse |
| Lakshmi Raman, Xiangmei Kong, Jennifer A Gilley, Steven G Kerni. Chronic hypoxia impairs murine hippocampal development and depletes the postnatal progenitor pool by attenuating mammalian target of rapamycin signaling. Pediatric research. vol 70. issue 2. 2011-11-15. PMID:21532529. |
our findings demonstrate that ch results in long-term impairment of hippocampal neurogenesis and is mediated, in part, by attenuation of the mtor pathway. |
2011-11-15 |
2023-08-12 |
mouse |
| Sharon S McDaniel, Nicholas R Rensing, Liu Lin Thio, Kelvin A Yamada, Michael Won. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia. vol 52. issue 3. 2011-05-09. PMID:21371020. |
the expression of ps6 and pakt, markers of mtor pathway activation, was reduced in hippocampus and liver of rats fed kd. |
2011-05-09 |
2023-08-12 |
rat |
| Sihua Qi, Makoto Mizuno, Kazuyoshi Yonezawa, Hiroyuki Nawa, Nobuyuki Take. Activation of mammalian target of rapamycin signaling in spatial learning. Neuroscience research. vol 68. issue 2. 2010-12-21. PMID:20599569. |
here, we show that mammalian target of rapamycin (mtor), a key serine/threonine protein kinase in translational control, is activated in hippocampus of the learning rat as revealed by in vitro kinase assay, western blotting and immunohistochemistry. |
2010-12-21 |
2023-08-12 |
rat |
| Sihua Qi, Makoto Mizuno, Kazuyoshi Yonezawa, Hiroyuki Nawa, Nobuyuki Take. Activation of mammalian target of rapamycin signaling in spatial learning. Neuroscience research. vol 68. issue 2. 2010-12-21. PMID:20599569. |
the substrates of mtor, eukaryotic initiation factor 4e-binding protein (4ebp) and p70s6 kinase (p70s6k) are phosphorylated, and total protein synthesis is enhanced, in the learning hippocampus. |
2010-12-21 |
2023-08-12 |
rat |
| Julie Deguil, François Chavant, Claire Lafay-Chebassier, Marie-Christine Pérault-Pochat, Bernard Fauconneau, Stéphanie Pai. Neuroprotective effect of PACAP on translational control alteration and cognitive decline in MPTP parkinsonian mice. Neurotoxicity research. vol 17. issue 2. 2010-03-02. PMID:19626386. |
in the present study, the results indicated that a subchronic mptp intoxication in mice decreased the dopaminergic neuron number, produced an activation of pkr way and an inhibition of mtor way of tc especially in striatum and frontal cortex associated with a great activation of pkr in hippocampus. |
2010-03-02 |
2023-08-12 |
mouse |
| Ali Sharma, Charles A Hoeffer, Yukihiro Takayasu, Takahiro Miyawaki, Sean M McBride, Eric Klann, R Suzanne Zuki. Dysregulation of mTOR signaling in fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 2. 2010-02-01. PMID:20071534. |
here we show that mtor phosphorylation and activity are elevated in hippocampus of juvenile fmr1 knock-out mice by four functional readouts: (1) association of mtor with regulatory associated protein of mtor; (2) mtor kinase activity; (3) phosphorylation of mtor downstream targets s6 kinase and 4e-binding protein; and (4) formation of eukaryotic initiation factor complex 4f, a critical first step in cap-dependent translation. |
2010-02-01 |
2023-08-12 |
mouse |
| Emma Puighermanal, Giovanni Marsicano, Arnau Busquets-Garcia, Beat Lutz, Rafael Maldonado, Andrés Ozait. Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nature neuroscience. vol 12. issue 9. 2009-09-23. PMID:19648913. |
cannabinoid modulation of hippocampal long-term memory is mediated by mtor signaling. |
2009-09-23 |
2023-08-12 |
mouse |
| Emma Puighermanal, Giovanni Marsicano, Arnau Busquets-Garcia, Beat Lutz, Rafael Maldonado, Andrés Ozait. Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nature neuroscience. vol 12. issue 9. 2009-09-23. PMID:19648913. |
we found that cb1 cannabinoid receptor (cb1r) activation transiently modulated the mammalian target of rapamycin (mtor)/p70s6k pathway and the protein synthesis machinery in the mouse hippocampus, which correlated with the amnesic properties of delta9-tetrahydrocannabinol (thc). |
2009-09-23 |
2023-08-12 |
mouse |
| Ling-Hui Zeng, Nicholas R Rensing, Michael Won. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474323. |
an initial rise in p-s6 expression started approximately 1 h after seizure onset, peaked at 3-6 h, and returned to baseline by 24 h in both hippocampus and neocortex, reflecting widespread stimulation of mtor signaling by acute seizure activity. |
2009-06-23 |
2023-08-12 |
mouse |
| Li Sui, Jing Wang, Bao-Ming L. Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex. Learning & memory (Cold Spring Harbor, N.Y.). vol 15. issue 10. 2009-02-10. PMID:18832563. |
phosphatidylinositol 3-kinase (pi3k) and its downstream targets, including akt (also known as protein kinase b, pkb), mammalian target of rapamycin (mtor), the 70-kda ribosomal s6 kinase (p70s6k), and the eukaryotic initiation factor 4e (eif4e)-binding protein 1 (4e-bp1), may play important roles in long-term synaptic plasticity and memory in many brain regions, such as the hippocampus and the amygdala. |
2009-02-10 |
2023-08-12 |
rat |
| Julie Deguil, Marie-Christine Perault-Pochat, François Chavant, Claire Lafay-Chebassier, Bernard Fauconneau, Stéphanie Pai. Activation of the protein p7OS6K via ERK phosphorylation by cholinergic muscarinic receptors stimulation in human neuroblastoma cells and in mice brain. Toxicology letters. vol 182. issue 1-3. 2009-01-09. PMID:18809477. |
our results showed that muscarinic receptor activation significantly increased the expression of phosphorylated p70s6k, eif4e and erk without modification of mtor activity in neuroblastoma cells and in cerebral cortex and hippocampus of mice, suggesting a stimulation of protein synthesis. |
2009-01-09 |
2023-08-12 |
mouse |
| Ru-Xin Li, Xin-Zhu Yu, Min Fu, Min Zong, Ru-Lin Liu, Zuo-Ping Xi. Frequency modulation of synchronized Ca(2+) spikes in cultured hippocampal networks through mTOR. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18586400. |
frequency modulation of synchronized ca(2+) spikes in cultured hippocampal networks through mtor. |
2008-11-05 |
2023-08-12 |
Not clear |
| Delphine Gobert, Lisa Topolnik, Mounia Azzi, Linda Huang, Frédérique Badeaux, Luc Desgroseillers, Wayne S Sossin, Jean-Claude Lacaill. Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18466337. |
our findings indicate that forskolin induces l-ltp in hippocampal neurons and up-regulates 5' top mrnas translation via mtor, suggesting that up-regulation of the translational machinery is a candidate mechanism for the stabilization of ltp. |
2008-09-15 |
2023-08-12 |
rat |
| Na Chen, Bruce Onisko, Joseph L Napol. The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation. The Journal of biological chemistry. vol 283. issue 30. 2008-09-08. PMID:18495661. |
all-trans-retinoic acid stimulates dendritic growth in hippocampal neurons within minutes by activating mitogen-activated protein kinase and mtor and increasing dendritic translation of calcium calmodulin-dependent protein kinase ii alpha and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole propionate receptor subunit glur1. |
2008-09-08 |
2023-08-12 |
Not clear |
| Claire M Williams, Manal Abd El Mohsen, David Vauzour, Catarina Rendeiro, Laurie T Butler, Judi A Ellis, Matthew Whiteman, Jeremy P E Spence. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free radical biology & medicine. vol 45. issue 3. 2008-08-26. PMID:18457678. |
furthermore, age and blueberry supplementation were linked to changes in the activation state of akt, mtor, and the levels of arc/arg3.1 in the hippocampus, suggesting that pathways involved in de novo protein synthesis may be involved. |
2008-08-26 |
2023-08-12 |
Not clear |