| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matylda Macias, Magdalena Blazejczyk, Paulina Kazmierska, Bartosz Caban, Agnieszka Skalecka, Bartosz Tarkowski, Anna Rodo, Jan Konopacki, Jacek Jaworsk. Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. PloS one. vol 8. issue 5. 2014-01-10. PMID:23724051. |
we showed that mtor signaling was activated by kainic acid (ka)-induced status epilepticus through several brain areas, including the hippocampus and cortex as well as revealed two waves of mtor activation: an early wave (2 h) that occurs in neurons and a late wave that predominantly occurs in astrocytes. |
2014-01-10 |
2023-08-12 |
rat |
| Fuencisla Pilar-Cuéllar, Rebeca Vidal, Alvaro Díaz, Elena Castro, Severiano dos Anjos, Jesús Pascual-Brazo, Raquel Linge, Veronica Vargas, Helena Blanco, Beatriz Martínez-Villayandre, Ángel Pazos, Elsa M Valdizá. Neural plasticity and proliferation in the generation of antidepressant effects: hippocampal implication. Neural plasticity. vol 2013. 2013-12-30. PMID:23862076. |
we will especially focus on the hippocampal cellularity and plasticity modulation by serotonin, trophic factors as brain-derived neurotrophic factor (bdnf), and vascular endothelial growth factor (vegf) through intracellular signalling pathways-camp, wnt/ β -catenin, and mtor. |
2013-12-30 |
2023-08-12 |
Not clear |
| Nicole Carrier, Mohamed Kabba. Sex differences in the antidepressant-like effects of ketamine. Neuropharmacology. vol 70. 2013-11-26. PMID:23337256. |
in preclinical studies, the mammalian target of rapamycin (mtor) in the medial prefrontal cortex and the eukaryotic elongation factor (eef2) in the hippocampus have been proposed as critical mediators of ketamine's rapid antidepressant actions. |
2013-11-26 |
2023-08-12 |
human |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. |
mtor and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and alzheimer's disease. |
2013-11-04 |
2023-08-12 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. |
mtor activity and tau protein hyperphosphorylation in the hippocampus were analyzed by immunohistochemical staining and rt-pcr. |
2013-11-04 |
2023-08-12 |
rat |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. |
t2dm may excessively activate mtor in the hippocampal tissue by impairing insulin signaling, thereby increasing the extent of tau hyperphosphorylation and promoting the occurrence of ad. |
2013-11-04 |
2023-08-12 |
rat |
| Fatemeh Zare Mehrjerdi, Nahid Aboutaleb, Rouhollah Habibey, Marjan Ajami, Mansoureh Soleimani, Maedeh Arabian, Somayeh Niknazar, Sayed Hossein Davoodi, Hamidreza Pazoki-Toroud. Increased phosphorylation of mTOR is involved in remote ischemic preconditioning of hippocampus in mice. Brain research. vol 1526. 2013-10-23. PMID:23806777. |
increased phosphorylation of mtor is involved in remote ischemic preconditioning of hippocampus in mice. |
2013-10-23 |
2023-08-12 |
mouse |
| Fatemeh Zare Mehrjerdi, Nahid Aboutaleb, Rouhollah Habibey, Marjan Ajami, Mansoureh Soleimani, Maedeh Arabian, Somayeh Niknazar, Sayed Hossein Davoodi, Hamidreza Pazoki-Toroud. Increased phosphorylation of mTOR is involved in remote ischemic preconditioning of hippocampus in mice. Brain research. vol 1526. 2013-10-23. PMID:23806777. |
present study evaluated the role of mtor in remote ischemic preconditioning (ripc) of hippocampus. |
2013-10-23 |
2023-08-12 |
mouse |
| Fatemeh Zare Mehrjerdi, Nahid Aboutaleb, Rouhollah Habibey, Marjan Ajami, Mansoureh Soleimani, Maedeh Arabian, Somayeh Niknazar, Sayed Hossein Davoodi, Hamidreza Pazoki-Toroud. Increased phosphorylation of mTOR is involved in remote ischemic preconditioning of hippocampus in mice. Brain research. vol 1526. 2013-10-23. PMID:23806777. |
rapamycin abolished all protective effects of ripc (p<0.05 vs. ripc+ir) suggesting a role for mtor in ripc induced hippocampal protection. |
2013-10-23 |
2023-08-12 |
mouse |
| Pingfu Feng, Chunfa Huan. Phospholipase D-mTOR signaling is compromised in a rat model of depression. Journal of psychiatric research. vol 47. issue 5. 2013-09-10. PMID:23421961. |
using neonatal clomipramine (cl)-treated rats as a model to elucidate the association of phospholipase d (pld) and mammalian target of rapamycin (mtor) signaling with depressive pathology, we found that the hippocampus of cl-treated rats showed significantly down-regulation of pld1 expression and attenuation of pld activity which leads to the less formation of phosphatidic acid (pa), an activator of mtor, and free choline, a potential biomarker for depression. |
2013-09-10 |
2023-08-12 |
rat |
| Pingfu Feng, Chunfa Huan. Phospholipase D-mTOR signaling is compromised in a rat model of depression. Journal of psychiatric research. vol 47. issue 5. 2013-09-10. PMID:23421961. |
with lower pa levels which could affect mtor signaling, we further observed that the phosphorylation of p70s6 kinase, one of the downstream effectors of mtor, was also significantly decreased in the hippocampus of cl-treated rats compared to the controls. |
2013-09-10 |
2023-08-12 |
rat |
| Lakshmi Raman, Xiangmei Kong, Steven G Kerni. Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice. Neuroscience letters. vol 541. 2013-09-03. PMID:23395832. |
pharmacological inhibition of the mtor pathway impairs hippocampal development in mice. |
2013-09-03 |
2023-08-12 |
mouse |
| Lakshmi Raman, Xiangmei Kong, Steven G Kerni. Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice. Neuroscience letters. vol 541. 2013-09-03. PMID:23395832. |
using a transgenic mouse that expresses green fluorescent protein (gfp) within this progenitor population we have previously shown that exposure to chronic hypoxia significantly decreases the progenitor stem cell pool in the dentate gyrus of the hippocampus that is in part mediated by inhibition of the mammalian target of rapamycin (mtor) pathway. |
2013-09-03 |
2023-08-12 |
mouse |
| Yevgeny Berdichevsky, Alexandra M Dryer, Yero Saponjian, Mark M Mahoney, Corrin A Pimentel, Corrina A Lucini, Marija Usenovic, Kevin J Stale. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 21. 2013-08-09. PMID:23699517. |
the rat hippocampal organotypic culture model of post-traumatic epilepsy was used to study the effects of long-term (four weeks) inhibition of signaling pathways that interact with mtor. |
2013-08-09 |
2023-08-12 |
rat |
| Yevgeny Berdichevsky, Alexandra M Dryer, Yero Saponjian, Mark M Mahoney, Corrin A Pimentel, Corrina A Lucini, Marija Usenovic, Kevin J Stale. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 21. 2013-08-09. PMID:23699517. |
the conclusions of the study are as follows: (1) the organotypic hippocampal culture model of post-traumatic epilepsy comprises a rapid assay of anti-epileptogenic and neuroprotective activities and, in this model (2) mtor activation depends on pi3k-akt signaling, and (3) transient inhibition of mtor has sustained effects on epilepsy. |
2013-08-09 |
2023-08-12 |
rat |
| Ashley M Fortress, Lu Fan, Patrick T Orr, Zaorui Zhao, Karyn M Fric. Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 3. 2013-08-06. PMID:23422279. |
estradiol-induced object recognition memory consolidation is dependent on activation of mtor signaling in the dorsal hippocampus. |
2013-08-06 |
2023-08-12 |
Not clear |
| Ashley M Fortress, Lu Fan, Patrick T Orr, Zaorui Zhao, Karyn M Fric. Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 3. 2013-08-06. PMID:23422279. |
the mammalian target of rapamycin (mtor) signaling pathway is an important regulator of protein synthesis and is essential for various forms of hippocampal memory. |
2013-08-06 |
2023-08-12 |
Not clear |
| Ashley M Fortress, Lu Fan, Patrick T Orr, Zaorui Zhao, Karyn M Fric. Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 3. 2013-08-06. PMID:23422279. |
here, we asked whether the enhancement of object recognition memory consolidation produced by dorsal hippocampal infusion of 17β-estradiol (e(2)) is dependent on mtor signaling in the dorsal hippocampus, and whether e(2)-induced mtor signaling is dependent on dorsal hippocampal phosphatidylinositol 3-kinase (pi3k) and extracellular signal-regulated kinase (erk) activation. |
2013-08-06 |
2023-08-12 |
Not clear |
| Ashley M Fortress, Lu Fan, Patrick T Orr, Zaorui Zhao, Karyn M Fric. Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 3. 2013-08-06. PMID:23422279. |
we first demonstrated that the enhancement of object recognition induced by e(2) was blocked by dorsal hippocampal inhibition of erk, pi3k, or mtor activation. |
2013-08-06 |
2023-08-12 |
Not clear |
| Ashley M Fortress, Lu Fan, Patrick T Orr, Zaorui Zhao, Karyn M Fric. Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 3. 2013-08-06. PMID:23422279. |
next, we found that icv infusion of e(2) increased phosphorylation of the downstream mtor targets s6k (thr-421) and 4e-bp1 in the dorsal hippocampus 5 min after infusion, and that this phosphorylation was blocked by dorsal hippocampal infusion of inhibitors of erk, pi3k, and mtor. |
2013-08-06 |
2023-08-12 |
Not clear |