| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniele Lana, Francesca Cerbai, Jacopo Di Russo, Francesca Boscaro, Ambra Giannetti, Polina Petkova-Kirova, Anna Maria Pugliese, Maria Grazia Giovannin. Hippocampal long term memory: effect of the cholinergic system on local protein synthesis. Neurobiology of learning and memory. vol 106. 2014-08-11. PMID:24076274. |
we found that (1) mtor and p70s6k activation in the hippocampus were involved in long term memory formation; (2) rapa administration caused inhibition of mtor activation at 1 h and 4 h and of p70s6k activation at 4 h, and long term memory impairment at 24 h after acquisition; (3) scopolamine treatment caused short but not long term memory impairment with an early increase of mtor/p70s6k activation at 1 h followed by stabilization at longer times; (4) mecamylamine plus scopolamine treatment caused short term memory impairment at 1 h and 4 h and reduced the scopolamine-induced increase of mtor/p70s6k activation at 1 h and 4 h; (5) mecamylamine plus scopolamine treatment did not impair long term memory formation; (6) in vitro treatment with carbachol activated mtor and p70s6k and this effect was blocked by scopolamine and mecamylamine. |
2014-08-11 |
2023-08-12 |
rat |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology. vol 73. issue 7. 2014-08-06. PMID:24918639. |
mtor hyperactivation in down syndrome hippocampus appears early during development. |
2014-08-06 |
2023-08-13 |
human |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology. vol 73. issue 7. 2014-08-06. PMID:24918639. |
increased expression of phosphorylated s6, phosphorylated s6 kinase, phosphorylated eukaryotic initiation factor 4e binding protein 1, and phosphorylated mtor was observed in ds hippocampus compared with controls. |
2014-08-06 |
2023-08-13 |
human |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology. vol 73. issue 7. 2014-08-06. PMID:24918639. |
these findings suggest that a dysregulated mtor pathway may contribute to both early hippocampal developmental abnormalities and hippocampal functional impairment developing before neurodegeneration. |
2014-08-06 |
2023-08-13 |
human |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology. vol 73. issue 7. 2014-08-06. PMID:24918639. |
moreover, the expression patterns of mtor components in adult ds hippocampus support its association with alzheimer disease-related histopathologic changes. |
2014-08-06 |
2023-08-13 |
human |
| Antonella Caccamo, Vito De Pinto, Angela Messina, Caterina Branca, Salvatore Odd. Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 23. 2014-07-25. PMID:24899720. |
mechanistically, the reduction in mtor signaling led to an increase in autophagy induction and restored the hippocampal gene expression signature of the tg2576 mice to wild-type levels. |
2014-07-25 |
2023-08-13 |
mouse |
| Dan Lyu, Wenli Yu, Ning Tang, Ruirui Wang, Zhenyu Zhao, Fang Xie, Yongjin He, Hongyin Du, Jun Che. The mTOR signaling pathway regulates pain-related synaptic plasticity in rat entorhinal-hippocampal pathways. Molecular pain. vol 9. 2014-07-17. PMID:24313960. |
the protein kinase mtor is a critical regulator of protein synthesis-dependent synaptic plasticity in the hippocampus as well as synaptic plasticity associated with central and peripheral pain sensitization. |
2014-07-17 |
2023-08-12 |
rat |
| Yong-Xin Sun, Xunming Ji, Xiaoou Mao, Lin Xie, Jianping Jia, Veronica Galvan, David A Greenberg, Kunlin Ji. Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 38. issue 2. 2014-06-27. PMID:23979023. |
autopsy brain hippocampal tissues were obtained from controls and patients with ad and western blots were performed using antibodies against mtor signaling molecules and ragc, an upstream component of mtor complex 1 (mtorc1) signaling. |
2014-06-27 |
2023-08-12 |
human |
| Luli Akinfiresoye, Yousef Tizab. Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR. Psychopharmacology. vol 230. issue 2. 2014-06-23. PMID:23732839. |
antidepressant effects of ampa and ketamine combination: role of hippocampal bdnf, synapsin, and mtor. |
2014-06-23 |
2023-08-12 |
Not clear |
| Yan Bergeron, Laure Chagniel, Geneviève Bureau, Guy Massicotte, Michel Cy. mTOR signaling contributes to motor skill learning in mice. Frontiers in molecular neuroscience. vol 7. 2014-04-28. PMID:24772063. |
we first observed that the rotarod learning did not alter the levels of total mtor in the striatum, hippocampus, cerebellum, and anterior cortex of trained mice. |
2014-04-28 |
2023-08-13 |
mouse |
| Yan Bergeron, Laure Chagniel, Geneviève Bureau, Guy Massicotte, Michel Cy. mTOR signaling contributes to motor skill learning in mice. Frontiers in molecular neuroscience. vol 7. 2014-04-28. PMID:24772063. |
however, it increased the levels of phosphorylated mtor in the striatum and hippocampus exclusively during the first session of training; no change was observed at the second and third sessions. |
2014-04-28 |
2023-08-13 |
mouse |
| Georgette M Gafford, Ryan G Parsons, Fred J Helmstette. Memory accuracy predicts hippocampal mTOR pathway activation following retrieval of contextual fear memory. Hippocampus. vol 23. issue 9. 2014-04-09. PMID:23640842. |
memory accuracy predicts hippocampal mtor pathway activation following retrieval of contextual fear memory. |
2014-04-09 |
2023-08-12 |
Not clear |
| Georgette M Gafford, Ryan G Parsons, Fred J Helmstette. Memory accuracy predicts hippocampal mTOR pathway activation following retrieval of contextual fear memory. Hippocampus. vol 23. issue 9. 2014-04-09. PMID:23640842. |
we tested whether p70s6 kinase (p70s6k), a key component of the mtor signaling pathway, is activated following retrieval of context fear memory in the dorsal hippocampus (dh) and anterior cingulate cortex (acc) at 1, 10, or 36 days after context fear conditioning. |
2014-04-09 |
2023-08-12 |
Not clear |
| Yanzhen Zhu, Yanjun Zeng, Xuan Wang, Xiaobao Y. Effect of electroacupuncture on the expression of mTOR and eIF4E in hippocampus of rats with vascular dementia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 7. 2014-03-17. PMID:23053837. |
effect of electroacupuncture on the expression of mtor and eif4e in hippocampus of rats with vascular dementia. |
2014-03-17 |
2023-08-12 |
rat |
| Yanzhen Zhu, Yanjun Zeng, Xuan Wang, Xiaobao Y. Effect of electroacupuncture on the expression of mTOR and eIF4E in hippocampus of rats with vascular dementia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 7. 2014-03-17. PMID:23053837. |
western blot assay was performed to detect the expression of mammalian target of rapamycin (mtor) and eukaryotic translation initiation factor 4e (eif4e) in hippocampus of rats. |
2014-03-17 |
2023-08-12 |
rat |
| Yanzhen Zhu, Yanjun Zeng, Xuan Wang, Xiaobao Y. Effect of electroacupuncture on the expression of mTOR and eIF4E in hippocampus of rats with vascular dementia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 7. 2014-03-17. PMID:23053837. |
electroacupuncture improves learning and memory ability by up-regulating expression of mtor and eif4e in the hippocampus of vascular dementia rats. |
2014-03-17 |
2023-08-12 |
rat |
| Zheng Huan Fang, Chan Hong Lee, Mi Kyoung Seo, Hyeyeon Cho, Jung Goo Lee, Bong Ju Lee, Sung Woo Park, Young Hoon Ki. Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats. Neuroscience research. vol 76. issue 4. 2014-03-13. PMID:23665137. |
immobilization stress significantly decreased bdnf expression and phosphorylation of trk receptor, akt, gsk-3β, mtor, and p70s6k in the hippocampus of rats; furthermore, synaptophysin, psd-95, neuroligin 1, and β-neurexin were decreased. |
2014-03-13 |
2023-08-12 |
rat |
| Victor Briz, Michel Baudr. Estrogen Regulates Protein Synthesis and Actin Polymerization in Hippocampal Neurons through Different Molecular Mechanisms. Frontiers in endocrinology. vol 5. 2014-03-10. PMID:24611062. |
reorganization of the actin cytoskeleton and stimulation of mammalian target of rapamycin (mtor)-mediated protein synthesis are two major events required for the consolidation of hippocampal long-term potentiation and memory. |
2014-03-10 |
2023-08-12 |
rat |
| Victor Briz, Michel Baudr. Estrogen Regulates Protein Synthesis and Actin Polymerization in Hippocampal Neurons through Different Molecular Mechanisms. Frontiers in endocrinology. vol 5. 2014-03-10. PMID:24611062. |
here, we used acute rat hippocampal slices to analyze the mechanisms underlying rapid changes in mtor activity and actin polymerization elicited by estradiol. |
2014-03-10 |
2023-08-12 |
rat |
| Matthew C Weston, Hongmei Chen, John W Swan. Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures. Frontiers in molecular neuroscience. vol 7. 2014-02-27. PMID:24574959. |
loss of mtor repressors tsc1 or pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures. |
2014-02-27 |
2023-08-12 |
mouse |