| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Corwin R Butler, Jeffery A Boychuk, Bret N Smit. Effects of Rapamycin Treatment on Neurogenesis and Synaptic Reorganization in the Dentate Gyrus after Controlled Cortical Impact Injury in Mice. Frontiers in systems neuroscience. vol 9. 2015-12-07. PMID:26640431. |
in this study, the role of mtor in modifying functional hippocampal circuit reorganization after focal tbi induced by controlled cortical impact (cci) was investigated. |
2015-12-07 |
2023-08-13 |
mouse |
| Candi L LaSarge, Victor R Santos, Steve C Danze. PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure. Neurobiology of disease. vol 75. 2015-11-20. PMID:25600212. |
in mice, deletion of pten from hippocampal dentate granule cells leads to mtor hyperactivation and promotes the rapid onset of spontaneous seizures. |
2015-11-20 |
2023-08-13 |
mouse |
| Janne Koskimäki, Nobuaki Matsui, Juzoh Umemori, Tomi Rantamäki, Eero Castré. Nimodipine activates TrkB neurotrophin receptors and induces neuroplastic and neuroprotective signaling events in the mouse hippocampus and prefrontal cortex. Cellular and molecular neurobiology. vol 35. issue 2. 2015-11-17. PMID:25204460. |
adult male mice were acutely treated with vehicle or nimodipine (10 mg/kg, s.c., 1.5 h) after which the phosphorylation states of trkb, cyclic-amp response element binding protein (creb), protein kinase b (akt), extracellular regulated kinase (erk), mammalian target of rapamycin (mtor) and p70s6 kinase (p70s6k) from prefrontal cortex and hippocampus were assessed. |
2015-11-17 |
2023-08-13 |
mouse |
| Janne Koskimäki, Nobuaki Matsui, Juzoh Umemori, Tomi Rantamäki, Eero Castré. Nimodipine activates TrkB neurotrophin receptors and induces neuroplastic and neuroprotective signaling events in the mouse hippocampus and prefrontal cortex. Cellular and molecular neurobiology. vol 35. issue 2. 2015-11-17. PMID:25204460. |
nimodipine-induced trkb phosphorylation was associated with increased phosphorylation levels of akt and creb in the prefrontal cortex and the hippocampus whereas phosphorylation of erk, mtor and p70s6k remained unaltered. |
2015-11-17 |
2023-08-13 |
mouse |
| Swati Agarwal, Shashi Kant Tiwari, Brashket Seth, Anuradha Yadav, Anshuman Singh, Anubha Mudawal, Lalit Kumar Singh Chauhan, Shailendra Kumar Gupta, Vinay Choubey, Anurag Tripathi, Amit Kumar, Ratan Singh Ray, Shubha Shukla, Devendra Parmar, Rajnish Kumar Chaturved. Activation of Autophagic Flux against Xenoestrogen Bisphenol-A-induced Hippocampal Neurodegeneration via AMP kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Pathways. The Journal of biological chemistry. vol 290. issue 34. 2015-11-17. PMID:26139607. |
activation of autophagic flux against xenoestrogen bisphenol-a-induced hippocampal neurodegeneration via amp kinase (ampk)/mammalian target of rapamycin (mtor) pathways. |
2015-11-17 |
2023-08-13 |
human |
| Emilio Russo, Paolo Follesa, Rita Citraro, Caterina Camastra, Annalidia Donato, Daniela Isola, Andrew Constanti, Giovambattista De Sarro, Giuseppe Donat. The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 11. 2015-11-10. PMID:24889758. |
the mtor signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model. |
2015-11-10 |
2023-08-13 |
rat |
| Emilio Russo, Paolo Follesa, Rita Citraro, Caterina Camastra, Annalidia Donato, Daniela Isola, Andrew Constanti, Giovambattista De Sarro, Giuseppe Donat. The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 11. 2015-11-10. PMID:24889758. |
here, we have addressed this issue by analyzing immunohistochemically: (1) the brain levels of total and phosphorylated mtor in young (before seizures) and adult wag/rij rats; (2) the proliferation of hippocampal neuronal stem/progenitor cells assessed by brdu analysis at different ages. |
2015-11-10 |
2023-08-13 |
rat |
| Emilio Russo, Paolo Follesa, Rita Citraro, Caterina Camastra, Annalidia Donato, Daniela Isola, Andrew Constanti, Giovambattista De Sarro, Giuseppe Donat. The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 11. 2015-11-10. PMID:24889758. |
our results support a role for persistent mtor activation and consequent change in hippocampal progenitor cell proliferation during the epileptogenic process leading to the development of absence seizures in wag/rij rats. |
2015-11-10 |
2023-08-13 |
rat |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24682776. |
in the present study, we found that phosphorylated mtor at ser2448, phosphorylated p70s6k at thr421/ser424 and phosphorylated tau at ser396 were significantly increased in the hippocampus of streptozotocin (stz)-induced diabetic mice when compared with control mice. |
2015-10-16 |
2023-08-12 |
mouse |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24682776. |
these findings indicate that mtor/p70s6k signaling pathway is hyperactive in the hippocampus of stz-induced diabetic mice and inhibiting mtor signaling with rapamycin prevents the dm-related cognitive deficits partly through attenuating the hyperphosphorylation of tau protein. |
2015-10-16 |
2023-08-12 |
mouse |
| J-J Jeong, J-Y Woo, K-A Kim, M J Han, D-H Ki. Lactobacillus pentosus var. plantarum C29 ameliorates age-dependent memory impairment in Fischer 344 rats. Letters in applied microbiology. vol 60. issue 4. 2015-10-01. PMID:25598393. |
treatment of aged rats with c29 suppressed the expression of p16, cyclooxygenase-2, and inducible nitric oxide synthase, as well as the activation of akt, mtor, and nf-κb in the hippocampus. |
2015-10-01 |
2023-08-13 |
rat |
| Martine Dubois, Vadim Le Joncour, Marie-Christine Tonon, Youssef Anouar, François Proust, Fabrice Morin, Pierrick Gandolfo, Florence Joly, Pascal Hilber, Hélène Caste. Evaluation of the impact of the cancer therapy everolimus on the central nervous system in mice. PloS one. vol 9. issue 12. 2015-09-16. PMID:25436776. |
we evaluated the impact of everolimus, an anticancer agent targeting the mtor pathway, on cognitive functions, cerebral metabolism, and hippocampal cell proliferation/vascular density in mice. |
2015-09-16 |
2023-08-13 |
mouse |
| M A Orlovsky, V E Dosenko, F Spiga, G G Skibo, S L Lightma. Hippocampus remodeling by chronic stress accompanied by GR, proteasome and caspase-3 overexpression. Brain research. vol 1593. 2015-08-04. PMID:25285893. |
the aim of these studies was to investigate mrna expression of mineralocorticoid and glucocorticoid receptors (mr, gr), proteasome subunits β5 (constitutive subunit) and β1i (inducible immunoproteasome subunit), mtor (mammalian target of rapamycin), bcl-2; as well as caspase-3 immunoreactivity (confocal microscopy) in adult wistar rat hippocampus following 10-day restraint stress (plastic restrainers, 6h daily). |
2015-08-04 |
2023-08-13 |
rat |
| M A Orlovsky, V E Dosenko, F Spiga, G G Skibo, S L Lightma. Hippocampus remodeling by chronic stress accompanied by GR, proteasome and caspase-3 overexpression. Brain research. vol 1593. 2015-08-04. PMID:25285893. |
the study demonstrates that hippocampal remodeling induced by chronic restraint stress is associated with gr, immunoproteasome, mtor, caspase-3 and bcl-2 overexpression in hippocampus. |
2015-08-04 |
2023-08-13 |
rat |
| Rachael Lennox, Peter R Flatt, Victor A Gaul. Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice. Peptides. vol 61. 2015-07-29. PMID:25195184. |
lixisenatide improved recognition memory during a novel object recognition task and this was associated with up-regulation of hippocampal expression of neurotrophic tyrosine kinase receptor type 2 (ntrk2) and mammalian target of rapamycin (mtor) genes involved in modulating synaptic plasticity and long-term potentiation. |
2015-07-29 |
2023-08-13 |
mouse |
| Giuseppe Gangarossa, Laura Ceolin, Alexia Paucard, Mireille Lerner-Natoli, Julie Perroy, Laurent Fagni, Emmanuel Valjen. Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits. Hippocampus. vol 24. issue 12. 2015-07-22. PMID:25044816. |
these seizure episodes parallel the hyperactivation of the mtor signaling in the hippocampus, leading to disrupted long-term potentiation (ltp) in the dentate gyrus (dg) and altered recognition memories. |
2015-07-22 |
2023-08-13 |
mouse |
| Giuseppe Gangarossa, Laura Ceolin, Alexia Paucard, Mireille Lerner-Natoli, Julie Perroy, Laurent Fagni, Emmanuel Valjen. Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits. Hippocampus. vol 24. issue 12. 2015-07-22. PMID:25044816. |
our results show that repeated stimulation of d1r is sufficient to induce generalized seizures leading to the overactivation of mtor signaling, disrupted hippocampal plasticity, and impaired long-term recognition memories. |
2015-07-22 |
2023-08-13 |
mouse |
| Rachael Lennox, David W Porter, Peter R Flatt, Christian Holscher, Nigel Irwin, Victor A Gaul. Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice. Neuropharmacology. vol 86. 2015-07-14. PMID:24998752. |
expression of fundamental hippocampal genes including mtor, vegf, ntrk2 and sirt1 was also increased significantly (p < 0.001) by all treatments. |
2015-07-14 |
2023-08-13 |
mouse |
| Julie Davies, Elena Zachariades, Karly-Rai Rogers-Broadway, Emmanouil Karteri. Elucidating the role of DEPTOR in Alzheimer's disease. International journal of molecular medicine. vol 34. issue 5. 2015-06-17. PMID:25119265. |
it has also been implicated in alzheimer's disease (ad) with neuronal cells and hippocampal slices of ad transgenic mice experiencing dysregulated mtor and synaptic plasticity in response to treatment with the toxic amyloid β (aβ(1-42)) peptide, which has been implicated in ad. |
2015-06-17 |
2023-08-13 |
mouse |
| Libin Zhou, Zihong Lu, Lin Li, Lei Chen, Jianhua Qi, Ling Che. Pro-neurogenesis and anti-dementia properties of tetradecyl 2,3-dihydroxybenzoate through TrkA receptor-mediated signalling pathways. The international journal of neuropsychopharmacology. vol 17. issue 11. 2015-05-26. PMID:24787365. |
the abg001 administration (0.5 mg/kg) enhanced the phosphorylation of tyrosine kinase a (trka) receptor, which induced increases in the levels of erk, akt and mtor phosphorylation in hippocampus. |
2015-05-26 |
2023-08-13 |
mouse |