| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helena M Abelaira, Gislaine Z Réus, Zuleide M Ignácio, Maria Augusta B Dos Santos, Airam B de Moura, Danyela Matos, Júlia P Demo, Júlia B I da Silva, Monique Michels, Mariane Abatti, Beatriz Sonai, Felipe Dal Pizzol, André F Carvalho, João Queved. Effects of ketamine administration on mTOR and reticulum stress signaling pathways in the brain after the infusion of rapamycin into prefrontal cortex. Journal of psychiatric research. vol 87. 2017-09-19. PMID:28017918. |
we evaluate the effects of ketamine administration on the mtor signaling pathway and proteins of upr in the prefrontal cortex (pfc), hippocampus, amygdala and nucleus accumbens, after the inhibiton of mtor signaling in the pfc. |
2017-09-19 |
2023-08-13 |
rat |
| Marion Rame, Dorian Caudal, Esther Schenker, Per Svenningsson, Michael Spedding, Thérèse M Jay, Bill P Godsi. Clozapine counteracts a ketamine-induced depression of hippocampal-prefrontal neuroplasticity and alters signaling pathway phosphorylation. PloS one. vol 12. issue 5. 2017-09-15. PMID:28472198. |
to address which signaling molecules might mediate such effects, we also examined phosphorylation and total protein levels of gsk3β, glua1, trkb, erk, and mtor in prefrontal and hippocampal sub-regions. |
2017-09-15 |
2023-08-13 |
rat |
| Fabiana Kalyne Ludka, Leandra Celso Constantino, Tharine Dal-Cim, Luisa Bandeira Binder, Andréa Zomkowski, Ana Lúcia S Rodrigues, Carla Inês Tasc. Involvement of PI3K/Akt/GSK-3β and mTOR in the antidepressant-like effect of atorvastatin in mice. Journal of psychiatric research. vol 82. 2017-09-08. PMID:27468164. |
these behavioral findings were supported by neurochemical observations, as atorvastatin treatment increased the immunocontent of the phosphorylated isoforms of akt, gsk-3β and mtor in the hippocampus of mice. |
2017-09-08 |
2023-08-13 |
mouse |
| Alexandre Aparecido de Almeida, Sérgio Gomes da Silva, Glauber Menezes Lopim, Diego Vannucci Campos, Jansen Fernandes, Francisco Romero Cabral, Ricardo Mario Arid. Resistance Exercise Reduces Seizure Occurrence, Attenuates Memory Deficits and Restores BDNF Signaling in Rats with Chronic Epilepsy. Neurochemical research. vol 42. issue 4. 2017-08-04. PMID:28078614. |
using western blotting, multiplex and enzyme-linked immunosorbent assays, we determined the effects of a 4-week resistance exercise program on igf-1 and bdnf levels and erk, creb, mtor activation in the hippocampus of rats with epilepsy. |
2017-08-04 |
2023-08-13 |
human |
| Xiangfei Guo, Yaning Zhao, Jianmin Li, Wenqian Liu, Changxiang Che. [Activation of autophagy pathway in hippocampus and deterioration of learning and memory ability by intermittent hypoxia in rats after cerebral ischemia]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 9. 2017-06-27. PMID:27609578. |
the morphological changes of nerve cells in the hippocampus of rat brain were detected by he staining; the levels of mammalian target of rapamycin (mtor) and beclin 1 mrna in the hippocampus were determined by quantitative real-time pcr; the distribution of mtor and beclin 1 in the hippocampus was observed by immunohistochemistry; the learning and memory ability of rats was assessed by the morris water maze test. |
2017-06-27 |
2023-08-13 |
rat |
| Xiangfei Guo, Yaning Zhao, Jianmin Li, Wenqian Liu, Changxiang Che. [Activation of autophagy pathway in hippocampus and deterioration of learning and memory ability by intermittent hypoxia in rats after cerebral ischemia]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 9. 2017-06-27. PMID:27609578. |
results compared with the so group, the never cell morphology was damaged, the number of survival neurons in the hippocampus was reduced, the expressions of mtor and beclin 1 in the hippocampus were strengthened, and the learning and memory ability declined in the i/r group. |
2017-06-27 |
2023-08-13 |
rat |
| Xiangfei Guo, Yaning Zhao, Jianmin Li, Wenqian Liu, Changxiang Che. [Activation of autophagy pathway in hippocampus and deterioration of learning and memory ability by intermittent hypoxia in rats after cerebral ischemia]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 9. 2017-06-27. PMID:27609578. |
compared with the i/r group, the never cell morphology was damaged seriously, the number of survival neurons in the hippocampus decreased, the expressions of mtor and beclin 1 in the hippocampus increased, and the learning and memory ability dropped in the intermittent hypoxia groups. |
2017-06-27 |
2023-08-13 |
rat |
| Jiming Wu, Le Gao, Lei Shang, Guihua Wang, Nana Wei, Tiantian Chu, Suping Chen, Yujun Zhang, Jian Huang, Jinhui Wang, Ruichao Li. Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats. Fitoterapia. vol 119. 2017-06-15. PMID:28373010. |
iljin reduce hippocampal excitotoxic cell loss and upregulate mtor signaling in rats. |
2017-06-15 |
2023-08-13 |
rat |
| Corwin R Butler, Jeffery A Boychuk, Bret N Smit. Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice. Experimental neurology. vol 280. 2017-04-28. PMID:27018320. |
in this study, we assessed the effect of mtor inhibition on hippocampal hilar inhibitory interneuron loss and synaptic and tonic gabaergic inhibition of dentate gyrus granule cells (dgcs) after controlled cortical impact (cci) to determine if mtor activation after tbi modulates gabaar function. |
2017-04-28 |
2023-08-13 |
mouse |
| Yuki Matsushita, Yasunari Sakai, Mitsunori Shimmura, Hiroshi Shigeto, Miki Nishio, Satoshi Akamine, Masafumi Sanefuji, Yoshito Ishizaki, Hiroyuki Torisu, Yusaku Nakabeppu, Akira Suzuki, Hidetoshi Takada, Toshiro Har. Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. Scientific reports. vol 6. 2017-03-13. PMID:26961412. |
hyperactive mtor signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. |
2017-03-13 |
2023-08-13 |
mouse |
| Yuki Matsushita, Yasunari Sakai, Mitsunori Shimmura, Hiroshi Shigeto, Miki Nishio, Satoshi Akamine, Masafumi Sanefuji, Yoshito Ishizaki, Hiroyuki Torisu, Yusaku Nakabeppu, Akira Suzuki, Hidetoshi Takada, Toshiro Har. Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. Scientific reports. vol 6. 2017-03-13. PMID:26961412. |
these data indicate that the mtor pathway regulates hippocampal excitability in the postnatal brain. |
2017-03-13 |
2023-08-13 |
mouse |
| Xiaoming Zhang, Youfa Zhou, Mingmin Xu, Gang Che. Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats. PloS one. vol 11. issue 4. 2017-02-21. PMID:27111854. |
rapamycin treatment led to the rapid accumulation of autophagic bodies and autophagy lysosomes, decreased p62 protein levels, and increased the ratio of microtubule-associated protein light chain 3 ii (lc3-ii) to lc3-i in hippocampal neurons through the mtor signaling pathway. |
2017-02-21 |
2023-08-13 |
rat |
| Hee-Soo Choi, Ji Hyeon Ahn, Joon Ha Park, Moo-Ho Won, Choong-Hyun Le. Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging. Molecular medicine reports. vol 13. issue 3. 2016-12-23. PMID:26846432. |
age-dependent changes in the protein expression levels of redd1 and mtor in the gerbil hippocampus during normal aging. |
2016-12-23 |
2023-08-13 |
Not clear |
| Hee-Soo Choi, Ji Hyeon Ahn, Joon Ha Park, Moo-Ho Won, Choong-Hyun Le. Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging. Molecular medicine reports. vol 13. issue 3. 2016-12-23. PMID:26846432. |
in the present study, age‑related changes in the protein expression levels of mtor and redd1 were investigated using immunohistochemistry and western blot in the gerbil hippocampus at postnatal month (pm) 3, 6, 12 and 24. |
2016-12-23 |
2023-08-13 |
Not clear |
| Song liu, Tong Li, Hansen Liu, Xueer Wang, Shishi Bo, Yunkai Xie, Xuemei Bai, Lin Wu, Zhen Wang, Dexiang Li. Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex. Behavioural brain research. vol 302. 2016-12-13. PMID:26801825. |
resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mtor pathway in the rat hippocampus and prefrontal cortex. |
2016-12-13 |
2023-08-13 |
rat |
| Song liu, Tong Li, Hansen Liu, Xueer Wang, Shishi Bo, Yunkai Xie, Xuemei Bai, Lin Wu, Zhen Wang, Dexiang Li. Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex. Behavioural brain research. vol 302. 2016-12-13. PMID:26801825. |
additionally, cums exposure significantly decreased phosphorylation of akt and mtor in the hippocampus and pfc, while resveratrol treatment normalized these parameters. |
2016-12-13 |
2023-08-13 |
rat |
| Song liu, Tong Li, Hansen Liu, Xueer Wang, Shishi Bo, Yunkai Xie, Xuemei Bai, Lin Wu, Zhen Wang, Dexiang Li. Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex. Behavioural brain research. vol 302. 2016-12-13. PMID:26801825. |
in conclusion, our study showed that resveratrol exerted antidepressant-like effects in cums rats, which was mediated in part by its antioxidant action, up-regulation of phosphor-akt and mtor levels in the hippocampus and pfc. |
2016-12-13 |
2023-08-13 |
rat |
| Sha Sha, Jin Xu, Zi-Hong Lu, Juan Hong, Wei-Jun Qu, Jian-Wei Zhou, Ling Che. Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation. Molecular neurobiology. vol 53. issue 1. 2016-10-10. PMID:25432888. |
the levels of hippocampal fak, akt, and mtor phosphorylation in jwa-nko mice were higher than those in control mice. |
2016-10-10 |
2023-08-13 |
mouse |
| Xiao-Long Liu, Liu Luo, Rong-Hao Mu, Bin-Bin Liu, Di Geng, Qing Liu, Li-Tao Y. Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice. Scientific reports. vol 5. 2016-09-13. PMID:26522512. |
in the present study, we examined whether fluoxetine, a type of commonly used antidepressant agent, alters mtor signaling following chronic administration in different brain regions, including the frontal cortex, hippocampus, amygdala and hypothalamus. |
2016-09-13 |
2023-08-13 |
mouse |
| Xiao-Long Liu, Liu Luo, Rong-Hao Mu, Bin-Bin Liu, Di Geng, Qing Liu, Li-Tao Y. Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice. Scientific reports. vol 5. 2016-09-13. PMID:26522512. |
the results indicated that chronic fluoxetine treatment attenuated the chronic, unpredictable, mild stress (cums)-induced mtor phosphorylation reduction in the hippocampus and amygdala of mice but not in the frontal cortex or the hypothalamus. |
2016-09-13 |
2023-08-13 |
mouse |