| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Yousef Rezaei, Hamidreza Pazoki-Toroud. Preconditioning with morphine protects hippocampal CA1 neurons from ischemia-reperfusion injury via activation of the mTOR pathway. Canadian journal of physiology and pharmacology. vol 96. issue 1. 2018-07-27. PMID:28881154. |
these results describe novel findings whereby chronic morphine preconditioning in hippocampal ca1 neurons is mediated by the mtor pathway, and through increased phosphorylation of mtor can alleviate oxidative stress and apoptosis, and eventually protect the hippocampus from i/r injury. |
2018-07-27 |
2023-08-13 |
Not clear |
| Victor R Santos, Raymund Y K Pun, Salwa R Arafa, Candi L LaSarge, Shane Rowley, Shadi Khademi, Tom Bouley, Katherine D Holland, Norberto Garcia-Cairasco, Steve C Danze. PTEN deletion increases hippocampal granule cell excitability in male and female mice. Neurobiology of disease. vol 108. 2018-07-23. PMID:28855130. |
deletion of the mtor pathway inhibitor pten from postnatally-generated hippocampal dentate granule cells causes epilepsy. |
2018-07-23 |
2023-08-13 |
mouse |
| Wenyu Liu, Jia'nan Guo, Jie Mu, Linyu Tian, Dong Zho. Rapamycin Protects Sepsis-Induced Cognitive Impairment in Mouse Hippocampus by Enhancing Autophagy. Cellular and molecular neurobiology. vol 37. issue 7. 2018-07-13. PMID:27904994. |
rapamycin did not affect total mtor targets, while phosphorylated mtor targets (p-mtor-ser2448, p-p70s6k-thr389, p-akt-s473) decreased (p < 0.05) and autophagy indicators (lc3-ii, atg5, atg7) were increased, and p62 was decreased in rapamycin-treated clp mice compared with the untreated (p < 0.05) in hippocampus. |
2018-07-13 |
2023-08-13 |
mouse |
| Dawei Xu, Yuyu Sun, Chengniu Wang, Hao Wang, Yingjie Wang, Wei Zhao, Guofeng Bao, Fei Wang, Zhiming Cui, Bo Jian. Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine. Neuropharmacology. vol 128. 2018-07-13. PMID:29030165. |
hippocampal mtor signaling is required for the antidepressant effects of paroxetine. |
2018-07-13 |
2023-08-13 |
Not clear |
| Dawei Xu, Yuyu Sun, Chengniu Wang, Hao Wang, Yingjie Wang, Wei Zhao, Guofeng Bao, Fei Wang, Zhiming Cui, Bo Jian. Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine. Neuropharmacology. vol 128. 2018-07-13. PMID:29030165. |
we first examined whether chronic paroxetine administration restores the effects of cums and csds on the mtor signaling cascade in the hippocampus and prefrontal cortex. |
2018-07-13 |
2023-08-13 |
Not clear |
| Dawei Xu, Yuyu Sun, Chengniu Wang, Hao Wang, Yingjie Wang, Wei Zhao, Guofeng Bao, Fei Wang, Zhiming Cui, Bo Jian. Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine. Neuropharmacology. vol 128. 2018-07-13. PMID:29030165. |
it was found that paroxetine treatment fully reversed the effects of cums and csds on the mtor signaling in the hippocampus, but not the prefrontal cortex. |
2018-07-13 |
2023-08-13 |
Not clear |
| Dawei Xu, Yuyu Sun, Chengniu Wang, Hao Wang, Yingjie Wang, Wei Zhao, Guofeng Bao, Fei Wang, Zhiming Cui, Bo Jian. Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine. Neuropharmacology. vol 128. 2018-07-13. PMID:29030165. |
moreover, gene silencing of hippocampal mtor by mtor-shrna also abolished the antidepressant effects of paroxetine. |
2018-07-13 |
2023-08-13 |
Not clear |
| Dawei Xu, Yuyu Sun, Chengniu Wang, Hao Wang, Yingjie Wang, Wei Zhao, Guofeng Bao, Fei Wang, Zhiming Cui, Bo Jian. Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine. Neuropharmacology. vol 128. 2018-07-13. PMID:29030165. |
taken together, hippocampal mtor signaling is necessary for the antidepressant effects of paroxetine. |
2018-07-13 |
2023-08-13 |
Not clear |
| Anneke Olde Engberink, Ruben Hernandez, Pierre de Graan, Donna L Gruo. Rapamycin-Sensitive Late-LTP is Enhanced in the Hippocampus of IL-6 Transgenic Mice. Neuroscience. vol 367. 2018-07-10. PMID:29104031. |
an inhibitor of mtor, rapamycin, reduced l-ltp in slices from both genotypes, and eliminated the difference in magnitude of l-ltp between il-6 and non-tg hippocampus. |
2018-07-10 |
2023-08-13 |
mouse |
| Bin Yu, Ming Ruan, Tao Liang, Shi-Wen Huang, Yun Yu, Hai-Bo Cheng, Xiang-Chun She. The Synergic Effect of Tetramethylpyrazine Phosphate and Borneol for Protecting Against Ischemia Injury in Cortex and Hippocampus Regions by Modulating Apoptosis and Autophagy. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28779236. |
moreover, bo increased neuron autophagy in the hippocampus by modulating mtor, whereas tmpp targeted both mtor and beclin1. |
2018-06-27 |
2023-08-13 |
rat |
| Corwin R Butler, Jeffery A Boychuk, Bret N Smit. Brain Injury-Induced Synaptic Reorganization in Hilar Inhibitory Neurons Is Differentially Suppressed by Rapamycin. eNeuro. vol 4. issue 5. 2018-06-14. PMID:29085896. |
following traumatic brain injury (tbi), treatment with rapamycin suppresses mammalian (mechanistic) target of rapamycin (mtor) activity and specific components of hippocampal synaptic reorganization associated with altered cortical excitability and seizure susceptibility. |
2018-06-14 |
2023-08-13 |
Not clear |
| Qinji Zhou, Jianyang Dong, Ting Xu, Xiang Ca. Synaptic potentiation mediated by L-type voltage-dependent calcium channels mediates the antidepressive effects of lateral habenula stimulation. Neuroscience. vol 362. 2018-06-04. PMID:28844005. |
additionally, mtor phosphorylation significantly increased and field population excitatory postsynaptic potentials increased in the hippocampus. |
2018-06-04 |
2023-08-13 |
rat |
| Helena M Abelaira, Gislaine Z Réus, Zuleide M Ignácio, Maria Augusta B Dos Santos, Airam B de Moura, Danyela Matos, Júlia P Demo, Júlia B I da Silva, Lucineia G Danielski, Fabricia Petronilho, André F Carvalho, João Queved. Ketamine Exhibits Different Neuroanatomical Profile After Mammalian Target of Rapamycin Inhibition in the Prefrontal Cortex: the Role of Inflammation and Oxidative Stress. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27590136. |
in the present study, we examined the behavioral and biochemical effects of ketamine in the prefrontal cortex (pfc), hippocampus, amygdala, and nucleus accumbens after inhibition of mtor signaling in the pfc. |
2018-05-18 |
2023-08-13 |
rat |
| Diana J Wallin, Tara G Zamora, Michelle Alexander, Kathleen M Ennis, Phu V Tran, Michael K Georgief. Neonatal mouse hippocampus: phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of rapamycin signaling. Pediatric research. vol 82. issue 3. 2018-05-16. PMID:28399115. |
the mammalian target of rapamycin (mtor) pathway senses the status of critical metabolites (e.g., oxygen, iron), thereby regulating hippocampal growth and function. |
2018-05-16 |
2023-08-13 |
mouse |
| Diana J Wallin, Tara G Zamora, Michelle Alexander, Kathleen M Ennis, Phu V Tran, Michael K Georgief. Neonatal mouse hippocampus: phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of rapamycin signaling. Pediatric research. vol 82. issue 3. 2018-05-16. PMID:28399115. |
hippocampal phosphorylated to total protein ratios of four key mtor pathway proteins were measured by western blotting at p14 and compared with non-phlebotomized, non-anemic control mice. |
2018-05-16 |
2023-08-13 |
mouse |
| Changchun Hei, Ping Liu, Xiao Yang, Jianguo Niu, P Andy L. Inhibition of mTOR signaling Confers Protection against Cerebral Ischemic Injury in Acute Hyperglycemic Rats. International journal of biological sciences. vol 13. issue 7. 2018-05-04. PMID:28808420. |
the results showed that hyperglycemia significantly increased neuronal death in the cortex and hippocampus and the exacerbation effect of hyperglycemia was associated with further activation of mtor under control and/or ischemic conditions. |
2018-05-04 |
2023-08-13 |
rat |
| Jing Wu, Shan-Lei Zhou, Lin-Hua Pi, Xia-Jie Shi, Ling-Ran Ma, Zi Chen, Min-Li Qu, Xin Li, Sheng-Dan Nie, Duan-Fang Liao, Jin-Jing Pei, Shan Wan. High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction. Oncotarget. vol 8. issue 25. 2018-04-25. PMID:28489581. |
we found: 1) that a chronic hgc directly decreases cav-1 expression, increases tau phosphorylation and activates mtor/s6k signalling in the brain neurons of diabetic rats, 2) that overexpression of cav-1 attenuates tau hyperphosphorylation induced by chronic hgc in primary hippocampal neurons, whereas down-regulation of cav-1 using cav-1 sirna dramatically worsens tau hyperphosphorylation via mtor/s6k signalling pathway, and 3) that the down-regulation of cav-1 induced by hgc is independent of mtor signalling. |
2018-04-25 |
2023-08-13 |
rat |
| Yuan Liu, Rong Wang, Zhiwei Zhao, Wen Dong, Xu Zhang, Xi Chen, Lina M. Short-term caloric restriction exerts neuroprotective effects following mild traumatic brain injury by promoting autophagy and inhibiting astrocyte activation. Behavioural brain research. vol 331. 2018-04-03. PMID:28495608. |
in the hippocampus, the expression of gfap and mtor was increased in the mtbi+he group and decreased in the mtbi+cr group. |
2018-04-03 |
2023-08-13 |
mouse |
| Xue-Feng Ding, Xiang Gao, Xin-Chun Ding, Ming Fan, Jinhui Che. Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment. Scientific reports. vol 6. 2018-03-26. PMID:27173138. |
using a unique genetic approach to conditionally and selectively knockout notch 1 in the postnatally born immature neurons in the hippocampus decreases mtor signaling, compromises their dendrite morphogenesis, and impairs spatial learning and memory. |
2018-03-26 |
2023-08-13 |
mouse |
| Xue-Feng Ding, Xiang Gao, Xin-Chun Ding, Ming Fan, Jinhui Che. Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment. Scientific reports. vol 6. 2018-03-26. PMID:27173138. |
conditional overexpression of nicd in the postnatally born immature neurons in the hippocampus increases mtor signaling and promotes dendrite arborization. |
2018-03-26 |
2023-08-13 |
mouse |