| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Tian Zhu, Xin Ji Liu, Kai Yong Liu, Qiang Zhang, Lin Sheng Yang, Rong Wei, Jing Jing Zhang, Fang Biao Ta. Persistently Upregulated Hippocampal mTOR Signals Mediated by Fecal SCFAs Impair Memory in Male Pups with SMM Exposure in Utero. Biomedical and environmental sciences : BES. vol 32. issue 5. 2019-08-08. PMID:31217051. |
persistently upregulated hippocampal mtor signals mediated by fecal scfas impair memory in male pups with smm exposure in utero. |
2019-08-08 |
2023-08-13 |
Not clear |
| Yu-Tien Hsu, Jie Li, Dick Wu, Thomas C Südhof, Lu Che. Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 14. 2019-05-16. PMID:30782829. |
treatment of mice with the mtor inhibitor rapamycin during an ee experience not only restored normal ampa-receptor expression levels but also reversed the increases in runaway hebbian plasticity and learning after hippocampal rarα deletion. |
2019-05-16 |
2023-08-13 |
mouse |
| Muaz Belviranlı, Nilsel Okuda. Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. Neuromolecular medicine. vol 20. issue 3. 2019-05-14. PMID:29971668. |
hippocampal bdnf, fndc5, pgc-1α, mtor, arc, cf-os, erk, sirt, and foxo expressions were lower, but nf-κb expressions were higher in the aged control rats than in the young control, young exercised, and aged exercised rats (p < 0.05). |
2019-05-14 |
2023-08-13 |
rat |
| Salwa R Arafa, Candi L LaSarge, Raymund Y K Pun, Shadi Khademi, Steve C Danze. Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth. Experimental neurology. vol 311. 2019-04-10. PMID:30268766. |
loss of the mtor pathway negative regulator pten from hippocampal dentate granule cells leads to neuronal hypertrophy, increased dendritic branching and aberrant basal dendrite formation in animal models. |
2019-04-10 |
2023-08-13 |
mouse |
| Jie Gao, Bingrui Xiong, Bo Zhang, Shan Li, Niannian Huang, Gaofeng Zhan, Riyue Jiang, Ling Yang, Yeshun Wu, Liying Miao, Bin Zhu, Chun Yang, Ailin Lu. Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30086367. |
the present study aimed to investigate the therapeutic effects of sulforaphane (sfn) on lipopolysaccharide (lps)-induced spatial learning and memory dysfunction, and tried to elucidate its relationship with the role of hippocampal brain-derived neurotrophic factor (bdnf)-mammalian target of rapamycin (mtor) signaling pathway. |
2019-03-29 |
2023-08-13 |
mouse |
| Jie Gao, Bingrui Xiong, Bo Zhang, Shan Li, Niannian Huang, Gaofeng Zhan, Riyue Jiang, Ling Yang, Yeshun Wu, Liying Miao, Bin Zhu, Chun Yang, Ailin Lu. Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30086367. |
in addition, hippocampal levels of inflammatory cytokines, synaptic proteins, bdnf-tropomyosin receptor kinase b (trkb) and mtor signaling pathways were altered in the processes of lps-induced cognitive dysfunction and sfn's therapeutic effects. |
2019-03-29 |
2023-08-13 |
mouse |
| Jie Gao, Bingrui Xiong, Bo Zhang, Shan Li, Niannian Huang, Gaofeng Zhan, Riyue Jiang, Ling Yang, Yeshun Wu, Liying Miao, Bin Zhu, Chun Yang, Ailin Lu. Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30086367. |
furthermore, we found that ana-12 (a trkb inhibitor) or rapamycin (a mtor inhibitor) could block the beneficial effects of sfn on lps-induced cognitive dysfunction, and that hippocampal levels of synaptic proteins, bdnf-trkb and mtor signaling pathways were also notably changed. |
2019-03-29 |
2023-08-13 |
mouse |
| Yang Xing, Dan Zo. Ethanol-induced cognitive dysfunction is associated with alterations in the mammalian target of rapamycin signalling pathway in the hippocampus of male mice. Neuroreport. vol 29. issue 14. 2019-02-27. PMID:30063559. |
the expression of p-mtor, p-akt, mtor and akt proteins was tested by western blotting and immunohistochemical staining methods in the hippocampal formation in each group, and haematoxylin-eosin stain was used to identify morphological changes in the hippocampal region. |
2019-02-27 |
2023-08-13 |
mouse |
| Claudia Brandt, Petra Hillmann, Andreas Noack, Kerstin Römermann, Leon A Öhler, Denise Rageot, Florent Beaufils, Anna Melone, Alexander M Sele, Matthias P Wymann, Doriano Fabbro, Wolfgang Lösche. The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy. Neuropharmacology. vol 140. 2019-02-20. PMID:30081001. |
furthermore, they significantly decreased phosphorylation of s6 ribosomal protein in the hippocampus of normal and epileptic mice, demonstrating effective mtor inhibition. |
2019-02-20 |
2023-08-13 |
mouse |
| Samantha L Hodges, Conner D Reynolds, Gregory D Smith, Taylor S Jefferson, Suzanne O Nolan, Joaquin N Lug. Molecular interplay between hyperactive mammalian target of rapamycin signaling and Alzheimer's disease neuropathology in the NS-Pten knockout mouse model. Neuroreport. vol 29. issue 13. 2019-02-18. PMID:29965873. |
in the present study, we examine how neuron subset-specific deletion of pten (ns-pten) in mice, which presents with hyperactive mammalian target of rapamycin (mtor) activity, affects the hippocampal protein levels of key neuropathological hallmarks of ad. |
2019-02-18 |
2023-08-13 |
mouse |
| Patrizia Ratano, Carla Petrella, Fabrizio Forti, Pamela Petrocchi Passeri, Maria Morena, Maura Palmery, Viviana Trezza, Cinzia Severini, Patrizia Campolong. Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation. Neuropharmacology. vol 138. 2019-02-13. PMID:29842858. |
moreover, we found that increased 2-ag signaling prevented the activation of the mammalian target of rapamycin (mtor) signaling pathway in the hippocampus through a cb2-dependent mechanism. |
2019-02-13 |
2023-08-13 |
rat |
| Dolors Puigoriol-Illamola, Christian Griñán-Ferré, Foteini Vasilopoulou, Rosana Leiva, Santiago Vázquez, Mercè Pallà. 11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29611102. |
likewise, we found changes in hippocampal autophagy markers such as beclin1, lc3b, ampkα, and mtor, indicating a progression in the autophagy process. |
2019-01-18 |
2023-08-13 |
mouse |
| Fei-Fei Liu, Shuang Zhao, Peng Liu, Shu-Ping Hu. Influence of mTOR signaling pathway on ketamine-induced injuries in the hippocampal neurons of rats. Neurological research. vol 41. issue 1. 2018-12-31. PMID:30373500. |
influence of mtor signaling pathway on ketamine-induced injuries in the hippocampal neurons of rats. |
2018-12-31 |
2023-08-13 |
rat |
| Alicja Koscielny, Anna R Malik, Ewa Liszewska, Justyna Zmorzynska, Aleksandra Tempes, Bartosz Tarkowski, Jacek Jaworsk. Adaptor Complex 2 Controls Dendrite Morphology via mTOR-Dependent Expression of GluA2. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28190237. |
we found that the knockdown of ap2b1 (β2-adaptin), an ap2 subunit, reduced the number of dendrites in developing rat hippocampal neurons and decreased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor subunit glua2 levels by inhibiting mechanistic/mammalian target of rapamycin (mtor). |
2018-12-21 |
2023-08-13 |
rat |
| T M Khlebodarova, V V Kogai, E A Trifonova, V A Likhoshva. Dynamic landscape of the local translation at activated synapses. Molecular psychiatry. vol 23. issue 1. 2018-12-17. PMID:29203851. |
the results suggest that autistic disorders associated with mtor pathway hyperactivation may be due to impaired proteome stability associated with the formation of complex dynamic regimes of psd protein synthesis in response to stimulation of mglur receptors on the postsynaptic membrane of excitatory synapses on pyramidal hippocampal cells. |
2018-12-17 |
2023-08-13 |
Not clear |
| María Del Carmen Rubio Osornio, Verónica Custodio Ramírez, Daniela Calderón Gámez, Carlos Paz Tres, Karla G Carvajal Aguilera, Bryan V Phillips Farfá. Metformin Plus Caloric Restriction Show Anti-epileptic Effects Mediated by mTOR Pathway Inhibition. Cellular and molecular neurobiology. vol 38. issue 7. 2018-11-05. PMID:30132243. |
the effects of metformin, alone or combined with cr, on the electrical kindling epilepsy model and the mtor cascade in the hippocampus and the neocortex were studied. |
2018-11-05 |
2023-08-13 |
Not clear |
| Katie L Davis-Anderson, Hendrik Wesseling, Lara M Siebert, Emilie R Lunde-Young, Vishal D Naik, Hanno Steen, Jayanth Ramados. Fetal regional brain protein signature in FASD rat model. Reproductive toxicology (Elmsford, N.Y.). vol 76. 2018-10-31. PMID:29408587. |
ingenuity analysis identified proteins involved in protein homeostasis, oxidative stress, mitochondrial dysfunction, and mtor as major pathways in the cortex and hippocampus significantly (p < .05) affected by alcohol. |
2018-10-31 |
2023-08-13 |
rat |
| Kun Han, Ning Jia, Yi Zhong, Xiuli Shan. S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse. Journal of cellular biochemistry. vol 119. issue 4. 2018-10-25. PMID:29058763. |
our results demonstrated that hng could improve the learning ability and memory in app/ps1 transgenic mice, possibly through decreasing irs-1 ser636 phosphorylation and mtor protein expression in the hippocampus, thus improving insulin resistance in the brain. |
2018-10-25 |
2023-08-13 |
mouse |
| Bing Chun Yan, Dan Jiang, Jie Wang, Yuanyuan Zhang, Xiaolu Zhu, Pei Xu, Xing Yu, Moo-Ho Won, Pei Qing S. Both decreased Akt expression and mTOR phosphorylation are related to decreased neuronal differentiation in the hippocampal alveus of aged mice. Aging clinical and experimental research. vol 30. issue 7. 2018-09-26. PMID:29027613. |
both decreased akt expression and mtor phosphorylation are related to decreased neuronal differentiation in the hippocampal alveus of aged mice. |
2018-09-26 |
2023-08-13 |
mouse |
| Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Yousef Rezaei, Hamidreza Pazoki-Toroud. Preconditioning with morphine protects hippocampal CA1 neurons from ischemia-reperfusion injury via activation of the mTOR pathway. Canadian journal of physiology and pharmacology. vol 96. issue 1. 2018-07-27. PMID:28881154. |
in this study, we examined the role of mammalian target of rapamycin (mtor) to identify the neuroprotective effects of chronic morphine preconditioning on the hippocampus following ischemia-reperfusion (i/r) injury. |
2018-07-27 |
2023-08-13 |
Not clear |