| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhaohua Xiao, Jing Peng, Liwen Wu, Ahmed Arafat, Fei Yi. The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy. Neurological research. vol 39. issue 7. 2018-03-26. PMID:28372486. |
phosphatidylinositol 3-kinase (pi3k)/akt/ mammalian target of rapamycin (mtor) signaling pathway may play a critical role in regulating syn expression and electrophysiology of hippocampal neurons. |
2018-03-26 |
2023-08-13 |
rat |
| Manimaran Ramani, Thomas van Groen, Inga Kadish, Namasivayam Ambalavanan, Lori L McMaho. Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult mice. Neurobiology of learning and memory. vol 141. 2018-03-26. PMID:28458035. |
in conclusion, vara attenuated neonatal hyperoxia-induced neurobehavioral impairment and associated reductions in hippocampal volume in adult mice, possibly by increasing mtor signaling and synaptic density. |
2018-03-26 |
2023-08-13 |
mouse |
| Robbert Havekes, Ted Abe. The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function. Current opinion in neurobiology. vol 44. 2018-03-01. PMID:28242433. |
in this review, we highlight recent studies showing that sleep deprivation impairs hippocampal camp and mtor signaling, and ultimately causes spine loss in ca1 neurons in a cofilin-dependent fashion. |
2018-03-01 |
2023-08-13 |
Not clear |
| D Lana, J Di Russo, T Mello, G L Wenk, M G Giovannin. Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory. Neurobiology of learning and memory. vol 137. 2018-02-26. PMID:27838442. |
the present study was aimed at establishing whether the mtor pathway and its downstream effector p70s6k in ca3 pyramidal neurons are under the modulation of the cholinergic input to trigger the formation of long term memories, similar to what we demonstrated in ca1 hippocampus. |
2018-02-26 |
2023-08-13 |
rat |
| Xuemei Chen, Shuai Wang, Ying Zhou, Yanfei Han, Shengtian Li, Qing Xu, Longyong Xu, Ziqi Zhu, Youming Deng, Lu Yu, Lulu Song, Adele Pin Chen, Juan Song, Eiki Takahashi, Guang He, Lin He, Weidong Li, Charlie Degui Che. Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway. Nature communications. vol 9. issue 1. 2018-02-26. PMID:29317619. |
we also show that mtor signaling pathway is hyperactive in hippocampus in phf8 knockout mouse. |
2018-02-26 |
2023-08-13 |
mouse |
| Xueqin Wang, Longze Sha, Nannan Sun, Yan Shen, Qi X. Deletion of mTOR in Reactive Astrocytes Suppresses Chronic Seizures in a Mouse Model of Temporal Lobe Epilepsy. Molecular neurobiology. vol 54. issue 1. 2018-02-09. PMID:26732600. |
down-regulation of mtor significantly ameliorated astrogliosis in the sclerotic hippocampus but did not rescue mossy fiber sprouting. |
2018-02-09 |
2023-08-13 |
mouse |
| Candi L LaSarge, Raymund Y K Pun, Michael B Muntifering, Steve C Danze. Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells. Neurobiology of disease. vol 96. 2018-02-09. PMID:27597527. |
recently, we demonstrated that introducing morphologically abnormal granule cells into an otherwise normal mouse brain - by selectively deleting the mtor pathway inhibitor pten from postnatally-generated granule cells - produced hippocampal and cortical seizures. |
2018-02-09 |
2023-08-13 |
mouse |
| Fabrízio Dos Santos Cardoso, Erivelton Fernandes França, Fernando Tadeu Serra, Angélica Begatti Victorino, Alexandre Aparecido de Almeida, Jansen Fernandes, Francisco Romero Cabral, Daniel Paulino Venancio, Ricardo Mario Arida, Sérgio Gomes da Silv. Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats. Hippocampus. vol 27. issue 8. 2018-02-02. PMID:28569408. |
to do this, we evaluated the hippocampal activation of intracellular signaling proteins linked to cell growth, proliferation, and survival, such as akt, mtor, p70s6k, erk, creb, and p38. |
2018-02-02 |
2023-08-13 |
rat |
| Fabrízio Dos Santos Cardoso, Erivelton Fernandes França, Fernando Tadeu Serra, Angélica Begatti Victorino, Alexandre Aparecido de Almeida, Jansen Fernandes, Francisco Romero Cabral, Daniel Paulino Venancio, Ricardo Mario Arida, Sérgio Gomes da Silv. Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats. Hippocampus. vol 27. issue 8. 2018-02-02. PMID:28569408. |
the hippocampal activation and expression of akt, mtor, p70s6k, and creb were not statistically different between the groups. |
2018-02-02 |
2023-08-13 |
rat |
| Kirsty Sawicka, Alexander Pyronneau, Miranda Chao, Michael V L Bennett, R Suzanne Zuki. Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 41. 2018-01-30. PMID:27663742. |
erk (extracellular signal-regulated kinase) and mtor (mechanistic target of rapamycin) signaling regulate protein synthesis by activating downstream targets critical to translation initiation and elongation and are known to contribute to hippocampal defects in fragile x. |
2018-01-30 |
2023-08-13 |
mouse |
| Kirsty Sawicka, Alexander Pyronneau, Miranda Chao, Michael V L Bennett, R Suzanne Zuki. Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 41. 2018-01-30. PMID:27663742. |
in contrast to the hippocampus, erk (but not mtor) signaling is elevated in the neocortex of fragile x mice. |
2018-01-30 |
2023-08-13 |
mouse |
| Bing Han, Lulu Yu, Yuan Geng, Li Shen, Hualong Wang, Yanyong Wang, Jinhua Wang, Mingwei Wan. Chronic Stress Aggravates Cognitive Impairment and Suppresses Insulin Associated Signaling Pathway in APP/PS1 Mice. Journal of Alzheimer's disease : JAD. vol 53. issue 4. 2018-01-29. PMID:27392857. |
the phosphorylation of insulin receptor, insulin receptor substrate 1 and associated signaling pathways (akt, mtor, p70s6k, erk1/2, and pten) were decreased in hippocampus in app/ps1 mice compared to control mice, while no changes were found in gsk3 and tsc2 phosphorylation. |
2018-01-29 |
2023-08-13 |
mouse |
| Jee-Yeon Hwang, Michael Gertner, Fabrizio Pontarelli, Brenda Court-Vazquez, Michael Vander Laan Bennett, Dimitry Ofengeim, Ruth Suzanne Zuki. Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die. Cell death and differentiation. vol 24. issue 2. 2018-01-18. PMID:27935582. |
global ischemia induces lysosomal-mediated degradation of mtor and activation of autophagy in hippocampal neurons destined to die. |
2018-01-18 |
2023-08-13 |
Not clear |
| Jee-Yeon Hwang, Michael Gertner, Fabrizio Pontarelli, Brenda Court-Vazquez, Michael Vander Laan Bennett, Dimitry Ofengeim, Ruth Suzanne Zuki. Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die. Cell death and differentiation. vol 24. issue 2. 2018-01-18. PMID:27935582. |
our findings identify a novel and previously unappreciated mechanism by which mtor self-regulates its own levels in hippocampal neurons in a clinically relevant model of ischemic stroke. |
2018-01-18 |
2023-08-13 |
Not clear |
| Mi Kyoung Seo, Cheol Min Choi, Roger S McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park, Jung Goo Le. Effects of escitalopram and paroxetine on mTORC1 signaling in the rat hippocampus under chronic restraint stress. BMC neuroscience. vol 18. issue 1. 2018-01-10. PMID:28446154. |
therefore, the present study evaluated whether antidepressant drugs would exert differential effects on mtor signaling in the rat hippocampus under conditions of chronic restraint stress. |
2018-01-10 |
2023-08-13 |
rat |
| Nopporn Thangthaeng, Shibu M Poulose, Stacey M Gomes, Marshall G Miller, Donna F Bielinski, Barbara Shukitt-Hal. Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats. Age (Dordrecht, Netherlands). vol 38. issue 5-6. 2017-12-18. PMID:27578256. |
following behavioral testing, the hippocampus was collected for western/densitometric analysis of inflammatory (gfap, nox-2, and cox-2) and autophagy (phosphorylated mtor, beclin 1, and p62/sqstm) markers. |
2017-12-18 |
2023-08-13 |
rat |
| Caterina Palleria, Antonio Leo, Francesco Andreozzi, Rita Citraro, Michelangelo Iannone, Rosangela Spiga, Giorgio Sesti, Andrew Constanti, Giovambattista De Sarro, Franco Arturi, Emilio Russ. Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects. Behavioural brain research. vol 321. 2017-11-29. PMID:28062257. |
furthermore, lir effects on hippocampal neurodegeneration and mtor pathway (akt, ampk, erk and p70s6k) were assessed. |
2017-11-29 |
2023-08-13 |
rat |
| Caterina Palleria, Antonio Leo, Francesco Andreozzi, Rita Citraro, Michelangelo Iannone, Rosangela Spiga, Giorgio Sesti, Andrew Constanti, Giovambattista De Sarro, Franco Arturi, Emilio Russ. Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects. Behavioural brain research. vol 321. 2017-11-29. PMID:28062257. |
finally, lir protected from diabetes-dependent hippocampal neurodegeneration likely through an effect on mtor pathway. |
2017-11-29 |
2023-08-13 |
rat |
| Ke Zhang, Vitor Nagai Yamaki, Zhisheng Wei, Yu Zheng, Xiang Ca. Differential regulation of GluA1 expression by ketamine and memantine. Behavioural brain research. vol 316. 2017-11-24. PMID:27599619. |
incubating acutely prepared hippocampal slices with ketamine but not memantine enhanced mtor phosphorylation in a time course parallel to the time course of glua1 elevation. |
2017-11-24 |
2023-08-13 |
Not clear |
| Eunchai Kang, Danye Jiang, Yun Kyoung Ryu, Sanghee Lim, Minhye Kwak, Christy D Gray, Michael Xu, Jun H Choi, Sue Junn, Jieun Kim, Jing Xu, Michele Schaefer, Roger A Johns, Hongjun Song, Guo-Li Ming, C David Mint. Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway. PLoS biology. vol 15. issue 7. 2017-10-03. PMID:28683067. |
early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mtor pathway. |
2017-10-03 |
2023-08-13 |
mouse |