| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arindam Ghosh Mazumder, Vikram Patial, Damanpreet Sing. Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy. Brain, behavior, and immunity. vol 75. 2020-01-23. PMID:30243822. |
furthermore, the hippocampal mrna level of il-1β, il-2, pi3k, akt, hif-1α, raptor, mtor, rps6kb1 and rps6 was found to be decreased in mmf treated animals. |
2020-01-23 |
2023-08-13 |
rat |
| Arindam Ghosh Mazumder, Vikram Patial, Damanpreet Sing. Mycophenolate mofetil contributes to downregulation of the hippocampal interleukin type 2 and 1β mediated PI3K/AKT/mTOR pathway hyperactivation and attenuates neurobehavioral comorbidities in a rat model of temporal lobe epilepsy. Brain, behavior, and immunity. vol 75. 2020-01-23. PMID:30243822. |
mtor, s6, ps6 and gfap protein expression was decreased, whereas neun was increased in the rat hippocampus of the treated animals. |
2020-01-23 |
2023-08-13 |
rat |
| Dong Xiao, Li Liu, Yuanjie Li, Jie Ruan, Hanqing Wan. Licorisoflavan A Exerts Antidepressant-Like Effect in Mice: Involvement of BDNF-TrkB Pathway and AMPA Receptors. Neurochemical research. vol 44. issue 9. 2020-01-20. PMID:31278631. |
in chronical-stimulated mice, the licorisoflavan a treatment effectively attenuated the expressions of brain-derived neurotrophic factor (bdnf), tyrosine kinase b (trkb), the phosphorylations of camp response element binding protein (creb), extracellular signal-regulated kinase (erk)-1/2, eukaryotic elongation factor 2 (eef2), mammalian target of rapamycin (mtor), initiation factor 4e-binding protein 1 (4e-bp-1), and p70 ribosomal protein s6 kinase (p70s6k) in hippocampus of cms-induced mice. |
2020-01-20 |
2023-08-13 |
mouse |
| Peng Gao, Feng Wang, Junming Huo, Ding Wan, Jing Zhang, Jianguo Niu, Ji Wu, Baoli Yu, Tao Su. ALG13 Deficiency Associated with Increased Seizure Susceptibility and Severity. Neuroscience. vol 409. 2020-01-09. PMID:30872163. |
this study also preliminarily explored the possible mechanisms of alg13-involved epilepsy by showing hyperactive mtor signaling pathways in the cortex and hippocampus of alg13 ko mice. |
2020-01-09 |
2023-08-13 |
mouse |
| Niannian Huang, Chun Yang, Dongyu Hua, Shan Li, Gaofeng Zhan, Ning Yang, Ailin Luo, Hui X. Alterations in the BDNF-mTOR Signaling Pathway in the Spinal Cord Contribute to Hyperalgesia in a Rodent Model of Chronic Restraint Stress. Neuroscience. vol 409. 2020-01-09. PMID:30940563. |
crs significantly altered bdnf and mtor phosphorylation in the anterior cingulate cortex and spinal cord but not in the hippocampus. |
2020-01-09 |
2023-08-13 |
Not clear |
| Gina Hadley, Daniel J Beard, Zoi Alexopoulou, Brad A Sutherland, Alastair M Bucha. Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia. Neuroscience letters. vol 706. 2019-12-27. PMID:31100427. |
hamartin, a component of the tuberous sclerosis complex (tsc) that actively inhibits the mammalian target of rapamycin (mtor), may mediate the endogenous resistance of cornu ammonis 3 (ca3) hippocampal neurons following global cerebral ischemia. |
2019-12-27 |
2023-08-13 |
Not clear |
| Maoxing Li, Yuting Zhu, Jing Li, Liping Chen, Wendi Tao, Xiaoling Li, Yan Qi. Effect and mechanism of verbascoside on hypoxic memory injury in plateau. Phytotherapy research : PTR. vol 33. issue 10. 2019-12-26. PMID:31364205. |
the mrna expression of mtor, p70s6k, and 4e-bp1 in the hippocampus tissue was determined by pcr. |
2019-12-26 |
2023-08-13 |
rat |
| Xia Guo, Yao Liu, Yaning Zhao, Rong Fan, Yali Bai, Xiangfei Guo, Jianmin Li, Changxiang Che. Role of the PI3K‑mTOR autophagy pathway in nerve damage in rats with intermittent hypoxia‑aggravated whole brain ischemia. Molecular medicine reports. vol 20. issue 2. 2019-12-11. PMID:31173224. |
immunohistochemical and reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) analyses were performed to detect the expression levels of pi3‑k, mtor and beclin‑1 in the hippocampal brain tissues of the rats. |
2019-12-11 |
2023-08-13 |
rat |
| Yuki Matsushita, Yasunari Sakai, Mitsunori Shimmura, Hiroshi Shigeto, Miki Nishio, Satoshi Akamine, Masafumi Sanefuji, Yoshito Ishizaki, Hiroyuki Torisu, Yusaku Nakabeppu, Akira Suzuki, Hidetoshi Takada, Toshiro Har. Corrigendum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. Scientific reports. vol 6. 2019-11-20. PMID:27282259. |
corrigendum: hyperactive mtor signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. |
2019-11-20 |
2023-08-13 |
mouse |
| . Correction: Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway. PLoS biology. vol 16. issue 3. 2019-11-20. PMID:29596419. |
correction: early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mtor pathway. |
2019-11-20 |
2023-08-13 |
Not clear |
| Withdrawn CNS & neurological disorders drug targets. 2019-11-20. PMID:30864513. |
previous studies have focused on the impact of hyperactivation of the mtor pathway in hippocampus and cortex and behaviors among those structures, but little is known about the relationship of pten and mtor signaling in the development and function of the cerebellum. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xu-Feng Xu, Xu Jing, Hui-Xian Ma, Rong-Rong Yuan, Qing Dong, Jun-Lu Dong, Xiao-Fei Han, Zhe-Yu Chen, Xiang-Zhi Li, Yue Wan. miR-181a Participates in Contextual Fear Memory Formation Via Activating mTOR Signaling Pathway. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 9. 2019-11-13. PMID:28968688. |
upregulated mir-181a can downregulate the prkaa1 and redd1 protein levels and promote mtor activity to facilitate hippocampal fear memory consolidation. |
2019-11-13 |
2023-08-13 |
Not clear |
| Xu-Feng Xu, Xu Jing, Hui-Xian Ma, Rong-Rong Yuan, Qing Dong, Jun-Lu Dong, Xiao-Fei Han, Zhe-Yu Chen, Xiang-Zhi Li, Yue Wan. miR-181a Participates in Contextual Fear Memory Formation Via Activating mTOR Signaling Pathway. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 9. 2019-11-13. PMID:28968688. |
these results indicate that mir-181a is involved in hippocampal contextual fear memory by activating the mtor signaling pathway. |
2019-11-13 |
2023-08-13 |
Not clear |
| Yusuke Umegaki, Antonio Martínez Brotons, Yui Nakanishi, Zhongyue Luo, Hanlu Zhang, Azad Bonni, Yoshiho Ikeuch. Palladin Is a Neuron-Specific Translational Target of mTOR Signaling That Regulates Axon Morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 21. 2019-10-22. PMID:29712777. |
among proteins whose translation was significantly affected by mtor inhibition selectively in neurons, we identified the cytoskeletal regulator protein palladin, which is localized within the cell body and axons in hippocampal neurons. |
2019-10-22 |
2023-08-13 |
mouse |
| Ju-Young Oh, Yu-Kang Kim, Seung-Nam Kim, Bombi Lee, Jae-Hwan Jang, Sunoh Kwon, Hi-Joon Par. Acupuncture modulates stress response by the mTOR signaling pathway in a rat post-traumatic stress disorder model. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:30089868. |
in addition, we investigated whether the effects were mediated by increased mtor activity and its downstream signaling components, which contribute to protein synthesis required for synaptic plasticity in the hippocampus. |
2019-10-16 |
2023-08-13 |
rat |
| Ju-Young Oh, Yu-Kang Kim, Seung-Nam Kim, Bombi Lee, Jae-Hwan Jang, Sunoh Kwon, Hi-Joon Par. Acupuncture modulates stress response by the mTOR signaling pathway in a rat post-traumatic stress disorder model. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:30089868. |
acupuncture regulated protein translation in the mtor signaling pathway and enhanced the activation of synaptic proteins, psd95, syn1, and glur1 in the hippocampus. |
2019-10-16 |
2023-08-13 |
rat |
| Ju-Young Oh, Yu-Kang Kim, Seung-Nam Kim, Bombi Lee, Jae-Hwan Jang, Sunoh Kwon, Hi-Joon Par. Acupuncture modulates stress response by the mTOR signaling pathway in a rat post-traumatic stress disorder model. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:30089868. |
these results suggest that acupuncture exerts antidepressant and anxiolytic effects on ptsd-related symptoms by increasing protein synthesis required for synaptic plasticity via the mtor pathway in the hippocampus. |
2019-10-16 |
2023-08-13 |
rat |
| Kimberly P Keil, Galen W Miller, Hao Chen, Sunjay Sethi, Martin R Schmuck, Kiran Dhakal, Ji Won Kim, Pamela J Lei. PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Archives of toxicology. vol 92. issue 10. 2019-10-10. PMID:30132043. |
pcb 95 (1 nm) activated mtor in hippocampal cultures as evidenced by increased phosphorylation of mtor at ser2448. |
2019-10-10 |
2023-08-13 |
human |
| Lena H Nguyen, Anne E Anderso. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific reports. vol 8. issue 1. 2019-09-11. PMID:29476105. |
here, we investigated whether constitutive mtor hyperactivation in the hippocampus is associated with altered voltage-gated ion channel expression in the neuronal subset-specific pten knockout (ns-pten ko) mouse model of cd with epilepsy. |
2019-09-11 |
2023-08-13 |
mouse |
| Jawad Fares, Zeina Bou Diab, Sanaa Nabha, Youssef Fare. Neurogenesis in the adult hippocampus: history, regulation, and prospective roles. The International journal of neuroscience. vol 129. issue 6. 2019-08-12. PMID:30433866. |
abbreviations ahn adult hippocampal neurogenesis akt protein kinase b bmp bone morphogenic protein brdu bromodeoxyuridine cns central nervous system dg dentate gyrus disc1 disrupted-in-schizophrenia 1 fgf-2 fibroblast growth factor 2 gaba gamma-aminobutyric acid mbd1 methyl-cpg-binding domain protein 1 mecp2 methyl-cpg-binding protein 2 mtor mammalian target of rapamycin nscs neural stem cells ob olfactory bulb; p21: cyclin-dependent kinase inhibitor 1 rbpj recombination signal binding protein for immunoglobulin kappa j region rms rostral migratory stream sgz subgranular zone shh sonic hedgehog sox2 sry (sex determining region y)-box 2 svz subventricular zone wnt3 wingless-type mouse mammary tumor virus. |
2019-08-12 |
2023-08-13 |
mouse |