| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Heng Hsiung, Wan-Ling Huang, Li-Yu Kan, Li-Hsien Chen, Sherry Shu-Jung H. The facilitating effect of MK-801 on inhibitory avoidance memory via mTOR signaling in the mouse hippocampus. Behavioural brain research. vol 389. 2021-05-06. PMID:32348869. |
the facilitating effect of mk-801 on inhibitory avoidance memory via mtor signaling in the mouse hippocampus. |
2021-05-06 |
2023-08-13 |
mouse |
| Ming-Heng Hsiung, Wan-Ling Huang, Li-Yu Kan, Li-Hsien Chen, Sherry Shu-Jung H. The facilitating effect of MK-801 on inhibitory avoidance memory via mTOR signaling in the mouse hippocampus. Behavioural brain research. vol 389. 2021-05-06. PMID:32348869. |
we next showed that mk-801 induced a fast-onset increase in the extent of mammalian target of rapamycin (mtor) phosphorylation in the hippocampus. |
2021-05-06 |
2023-08-13 |
mouse |
| Ming-Heng Hsiung, Wan-Ling Huang, Li-Yu Kan, Li-Hsien Chen, Sherry Shu-Jung H. The facilitating effect of MK-801 on inhibitory avoidance memory via mTOR signaling in the mouse hippocampus. Behavioural brain research. vol 389. 2021-05-06. PMID:32348869. |
these results indicate that hippocampal mtor signaling mediates the facilitating effect of mk-801 on memory consolidation of the inhibitory avoidance task. |
2021-05-06 |
2023-08-13 |
mouse |
| Sunan Gao, Siyu Zhang, Hongmei Zhou, Xiaoyan Tao, Yunjian Ni, Daqing Pei, Shuai Kang, Weiwei Yan, Jian L. Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice. Frontiers in aging neuroscience. vol 13. 2021-05-04. PMID:33935683. |
this study aimed to explore whether rapamycin can ameliorate anesthesia/surgery-induced cognitive deficits by inhibiting mtor, activating autophagy and rising synaptic plasticity-related proteins in the hippocampus. |
2021-05-04 |
2023-08-13 |
mouse |
| Sunan Gao, Siyu Zhang, Hongmei Zhou, Xiaoyan Tao, Yunjian Ni, Daqing Pei, Shuai Kang, Weiwei Yan, Jian L. Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice. Frontiers in aging neuroscience. vol 13. 2021-05-04. PMID:33935683. |
in conclusion, anesthesia/surgery induced mtor hyperactivation and autophagy impairments, and then reduced the levels of syn and psd-95 in the hippocampus. |
2021-05-04 |
2023-08-13 |
mouse |
| Magdalena Gąssowska-Dobrowolska, Agnieszka Kolasa-Wołosiuk, Magdalena Cieślik, Agnieszka Dominiak, Kristina Friedland, Agata Adamczy. Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33809910. |
our results indicated that maternal exposure to vpa induces: (1) decrease the level of α/β-tubulin along with tau accumulation in the hippocampus and cerebral cortex; (2) excessive tau phosphorylation and activation of tau-kinases: cdk5, erk1/2, and p70s6k in the cerebral cortex; (3) up-regulation of mtor kinase-dependent signalling in the hippocampus and cerebral cortex of adolescent rat offspring. |
2021-04-30 |
2023-08-13 |
rat |
| Jen-Yin Goh, Saoirse E O'Sullivan, Sinead E Shortall, Nicole Zordan, Anna M Piccinini, Harry G Potter, Kevin C F Fone, Madeleine V Kin. Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat 'dual-hit' model for neurodevelopmental disorders. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32485291. |
thus isolation reared rats exhibited locomotor hyperactivity, impaired associative memory and reversal learning, elevated hippocampal and frontal cortical cytokine levels, and increased mammalian target of rapamycin (mtor) activation in the frontal cortex - which were not evident in isolates previously exposed to gestational pic. |
2021-04-27 |
2023-08-13 |
rat |
| Kui Chen, Liang Zhu, Lin Guo, Yuan-Bo Pan, Dong-Fu Fen. Maf1 regulates dendritic morphogenesis and influences learning and memory. Cell death & disease. vol 11. issue 7. 2021-03-25. PMID:32732865. |
maf1, a general transcriptional regulator and mtor downstream effector, is highly expressed in the hippocampus and cortex, but the function of maf1 in neurons is not well elucidated. |
2021-03-25 |
2023-08-13 |
mouse |
| Karina Pereira Gomes, Pedro Paulo Pereira Braga, Claudio Quintino de Lima, Poliana Peres Ghazale, Gustavo Rodrigues Pedrino, Elizabeth Pereira Mendes, Aline Priscila Pansani, Carlos Henrique Xavier, Carlos Henrique Castro, Diego Basile Colugnat. Antiepileptic effects of long-term intracerebroventricular infusion of angiotensin-(1-7) in an animal model of temporal lobe epilepsy. Clinical science (London, England : 1979). vol 134. issue 17. 2021-03-23. PMID:32803259. |
moreover, ang-(1-7) positively regulated the hippocampal levels of antioxidant protein catalase and antiapoptotic protein b-cell lymphoma 2 (bcl-2), as well as mammalian target of rapamycin (mtor) phosphorylation, which were reduced by tle. |
2021-03-23 |
2023-08-13 |
rat |
| Swati Agarwal, Shashi Kant Tiwari, Brashket Seth, Anuradha Yadav, Anshuman Singh, Anubha Mudawal, Lalit Kumar Singh Chauhan, Shailendra Kumar Gupta, Vinay Choubey, Anurag Tripathi, Amit Kumar, Ratan Singh Ray, Shubha Shukla, Devendra Parmar, Rajnish Kumar Chaturved. Withdrawal: Activation of autophagic flux against xenoestrogen bisphenol-A-Induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of rapamycin (mTOR) pathways. The Journal of biological chemistry. vol 295. issue 9. 2021-03-17. PMID:32111724. |
withdrawal: activation of autophagic flux against xenoestrogen bisphenol-a-induced hippocampal neurodegeneration via amp kinase (ampk)/mammalian target of rapamycin (mtor) pathways. |
2021-03-17 |
2023-08-13 |
Not clear |
| Jianyi Zhuo, Baoyi Chen, Chaoyue Sun, Tao Jiang, Zhiwei Chen, Yanlu Liu, Juan Nie, Hongmei Yang, Jingna Zheng, Xiaoping Lai, Ziren Su, Chuwen Li, Yucui L. Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-02-16. PMID:32244196. |
in addition, pa markedly attenuated cums-induced mtor, p70s6k, and 4e-bp-1 phosphorylation reduction in the hippocampus. |
2021-02-16 |
2023-08-13 |
rat |
| Jianyi Zhuo, Baoyi Chen, Chaoyue Sun, Tao Jiang, Zhiwei Chen, Yanlu Liu, Juan Nie, Hongmei Yang, Jingna Zheng, Xiaoping Lai, Ziren Su, Chuwen Li, Yucui L. Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-02-16. PMID:32244196. |
these results suggest that pa exerted antidepressant-like effect in cums rats through inhibiting autophagy, repairing synapse, and restoring autophagic flux in the hippocampus by activating the mtor signaling pathway. |
2021-02-16 |
2023-08-13 |
rat |
| Candice E Van Skike, Ai-Ling Lin, Raquel Roberts Burbank, Jonathan J Halloran, Stephen F Hernandez, James Cuvillier, Vanessa Y Soto, Stacy A Hussong, Jordan B Jahrling, Martin A Javors, Matthew J Hart, Kathleen E Fischer, Steven N Austad, Veronica Galva. mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging. Aging cell. vol 19. issue 1. 2021-01-13. PMID:31693798. |
additionally, morphometric and biochemical analyses of hippocampus and cortex revealed that mtor drives age-related declines in synaptic and vascular density during aging. |
2021-01-13 |
2023-08-13 |
mouse |
| Anfeng Wang, Xiaojuan Zou, Jiajia Wu, Qingyu Ma, Naijun Yuan, Fengmin Ding, Xiaojuan Li, Jiaxu Che. Early-Life Stress Alters Synaptic Plasticity and mTOR Signaling: Correlation With Anxiety-Like and Cognition-Related Behavior. Frontiers in genetics. vol 11. 2021-01-01. PMID:33381149. |
psd95 and synaptophysin mrna and protein expression levels were decreased in the hippocampus, and phosphorylated mtor and phosphorylated s6 were significantly decreased in maternally separated mice vs. those not exposed to ms. our data demonstrate that ms impairs synaptic plasticity and inhibits mtor signaling, specifically via s6. |
2021-01-01 |
2023-08-13 |
mouse |
| Anfeng Wang, Xiaojuan Zou, Jiajia Wu, Qingyu Ma, Naijun Yuan, Fengmin Ding, Xiaojuan Li, Jiaxu Che. Early-Life Stress Alters Synaptic Plasticity and mTOR Signaling: Correlation With Anxiety-Like and Cognition-Related Behavior. Frontiers in genetics. vol 11. 2021-01-01. PMID:33381149. |
therefore, we speculate that els decreased synaptic plasticity via the inhibition of the mtor pathway in the hippocampus, which may underlie vulnerability to stress and mental disorders in adulthood. |
2021-01-01 |
2023-08-13 |
mouse |
| Walaa Fakih, Ali Mroueh, Houssein Salah, Ali H Eid, Makram Obeid, Firas Kobeissy, Hala Darwish, Ahmed F El-Yazb. Dysfunctional cerebrovascular tone contributes to cognitive impairment in a non-obese rat model of prediabetic challenge: Role of suppression of autophagy and modulation by anti-diabetic drugs. Biochemical pharmacology. vol 178. 2020-12-07. PMID:32439335. |
in parallel, the phosphorylation of akt and mtor increased in the prediabetic rat hippocampus alongside increased expression of p62 and lc3 puncta indicating a possible repression of autophagic flux. |
2020-12-07 |
2023-08-13 |
rat |
| Runfang Xie, Jiming Xie, Yi Ye, Xueyan Wang, Fan Chen, Lin Yang, Youyi Yan, Linchuan Lia. mTOR Expression in Hippocampus and Prefrontal Cortex Is Downregulated in a Rat Model of Schizophrenia Induced by Chronic Administration of Ketamine. Journal of molecular neuroscience : MN. vol 70. issue 2. 2020-11-19. PMID:31897968. |
mtor expression in hippocampus and prefrontal cortex is downregulated in a rat model of schizophrenia induced by chronic administration of ketamine. |
2020-11-19 |
2023-08-13 |
rat |
| Runfang Xie, Jiming Xie, Yi Ye, Xueyan Wang, Fan Chen, Lin Yang, Youyi Yan, Linchuan Lia. mTOR Expression in Hippocampus and Prefrontal Cortex Is Downregulated in a Rat Model of Schizophrenia Induced by Chronic Administration of Ketamine. Journal of molecular neuroscience : MN. vol 70. issue 2. 2020-11-19. PMID:31897968. |
this study aimed to explore whether the administration of ketamine in rats causes changes in mtor (mechanistic/mammalian target of rapamycin) expression in the hippocampus and prefrontal cortex. |
2020-11-19 |
2023-08-13 |
rat |
| Runfang Xie, Jiming Xie, Yi Ye, Xueyan Wang, Fan Chen, Lin Yang, Youyi Yan, Linchuan Lia. mTOR Expression in Hippocampus and Prefrontal Cortex Is Downregulated in a Rat Model of Schizophrenia Induced by Chronic Administration of Ketamine. Journal of molecular neuroscience : MN. vol 70. issue 2. 2020-11-19. PMID:31897968. |
immunohistochemistry was used to detect mtor protein expression in the hippocampus and prefrontal cortex from rats at 13 h after the last treatment. |
2020-11-19 |
2023-08-13 |
rat |
| Runfang Xie, Jiming Xie, Yi Ye, Xueyan Wang, Fan Chen, Lin Yang, Youyi Yan, Linchuan Lia. mTOR Expression in Hippocampus and Prefrontal Cortex Is Downregulated in a Rat Model of Schizophrenia Induced by Chronic Administration of Ketamine. Journal of molecular neuroscience : MN. vol 70. issue 2. 2020-11-19. PMID:31897968. |
using immunohistochemistry, the expression of the mtor protein was localized exclusively in the ca3 region of the hippocampus and in the cg1 region of the prefrontal cortexes. |
2020-11-19 |
2023-08-13 |
rat |