| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melina Rafiee, Rahim Nosrati, Parvin Babae. Protective effect of miR-34c antagomir against STZ-induced memory impairment by targeting mTOR and PSD-95 in the hippocampus of rats. Neuroscience letters. 2022-09-24. PMID:36152745. |
protective effect of mir-34c antagomir against stz-induced memory impairment by targeting mtor and psd-95 in the hippocampus of rats. |
2022-09-24 |
2023-08-14 |
rat |
| Melina Rafiee, Rahim Nosrati, Parvin Babae. Protective effect of miR-34c antagomir against STZ-induced memory impairment by targeting mTOR and PSD-95 in the hippocampus of rats. Neuroscience letters. 2022-09-24. PMID:36152745. |
finally, psd-95 and mtor levels were measured by quantitative real-time pcr (qpcr) and western blotting on hippocampal samples. |
2022-09-24 |
2023-08-14 |
rat |
| Melina Rafiee, Rahim Nosrati, Parvin Babae. Protective effect of miR-34c antagomir against STZ-induced memory impairment by targeting mTOR and PSD-95 in the hippocampus of rats. Neuroscience letters. 2022-09-24. PMID:36152745. |
results showed that mir-34c antagomir markedly ameliorated spatial learning and memory deficits induced by stz, and significantly enhanced psd-95 and mtor levels in the hippocampus. |
2022-09-24 |
2023-08-14 |
rat |
| Nada El-Megiri, Yasser M Mostafa, Amal Ahmed, Eman T Mehanna, Mona F El-Azab, Fatma Alshehri, Hadil Alahdal, Norhan M El-Saye. Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice. Pharmaceuticals (Basel, Switzerland). vol 15. issue 9. 2022-09-23. PMID:36145334. |
at the end of the experiment, animals were sacrificed under deep anesthesia and the hippocampus was isolated for analysis of glucose transporters by rt-pcr, nerve growth factor (ngf) by elisa and mtor by western blotting, in addition to histopathological investigation. |
2022-09-23 |
2023-08-14 |
mouse |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
neuronal subset-specific phosphatase and tensin homolog (pten) knockout (ko) mice display hyperactive mammalian target of rapamycin (mtor) signaling in the hippocampus, cerebellum, and cortex followed by seizures that increase in severity with age. |
2022-07-01 |
2023-08-14 |
mouse |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
we show that hyperactive mtor signaling is associated with an altered spatiotemporal pattern of microglia/macrophage activation in the brain and induces an enhanced neuroimmune response in the hippocampus. |
2022-07-01 |
2023-08-14 |
mouse |
| Changchun Hei, Yujia Zhou, Chenyang Zhang, Furong Gao, Meiling Cao, Shilin Yuan, Yixin Qin, P Andy Li, Xiao Yan. Rapamycin ameliorates brain damage and maintains mitochondrial dynamic balance in diabetic rats subjected to middle cerebral artery occlusion. Metabolic brain disease. 2022-06-07. PMID:35670992. |
the protein of hippocampus was extracted and western blotting were performed to detect the levels of mtor, mitochondrial dynamin related proteins (drp1, p-drp1, opa1), sirt3, and nix/bnip3l. |
2022-06-07 |
2023-08-14 |
rat |
| Sonia Sanchez-Bezanilla, Daniel J Beard, Rebecca J Hood, N David Åberg, Patricia Crock, Frederick R Walker, Michael Nilsson, Jörgen Isgaard, Lin Kooi On. Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice. Neural plasticity. vol 2022. 2022-04-25. PMID:35465399. |
we aimed to explore the mechanisms of gh treatment by investigating how gh modulates pathways known to induce neuroplasticity, focusing on association between brain-derived neurotrophic factor (bdnf) and mammalian target of rapamycin (mtor) in the peri-infarct area, hippocampus, and thalamus. |
2022-04-25 |
2023-08-13 |
mouse |
| Charlotte Schömig, Laura Oberholz, Gregor Fink, Jenny Voggel, Maria Wohlfarth, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüske. Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35276811. |
hippocampal mtor dysregulation and morphological changes in male rats after fetal growth restriction. |
2022-03-12 |
2023-08-13 |
rat |
| Charlotte Schömig, Laura Oberholz, Gregor Fink, Jenny Voggel, Maria Wohlfarth, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüske. Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35276811. |
to determine possible underlying mechanisms, we examined hippocampal cellular composition and mtor signaling of male rat fgr offspring during main brain growth and development (postnatal days (pnd) 1 and 12). |
2022-03-12 |
2023-08-13 |
rat |
| Charlotte Schömig, Laura Oberholz, Gregor Fink, Jenny Voggel, Maria Wohlfarth, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüske. Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35276811. |
our findings suggest that hippocampal cellular proliferation and mtor signaling are dysregulated in different ways depending on the cause of fgr. |
2022-03-12 |
2023-08-13 |
rat |
| Gülin Özdamar Ünal, Kuyaş Hekimler Öztürk, Gamze Erkılınç, Feyza Dönmez, Duygu Kumbul Doğuç, Özlem Özmen, Mekin Sezi. Maternal prenatal stress and depression-like behavior associated with hippocampal and cortical neuroinflammation in the offspring: An experimental study. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-03-09. PMID:35261075. |
nlrp3 (nod-, lrr- and pyrin domain-containing protein 3) pathway gene expressions in the hippocampus and immunohistochemical caspase 3 (cas-3), mammalian target of rapamycin (mtor), and transient receptor potential melastatin (trpm) staining in the temporal and prefrontal cortices were evaluated. |
2022-03-09 |
2023-08-13 |
rat |
| Gülin Özdamar Ünal, Kuyaş Hekimler Öztürk, Gamze Erkılınç, Feyza Dönmez, Duygu Kumbul Doğuç, Özlem Özmen, Mekin Sezi. Maternal prenatal stress and depression-like behavior associated with hippocampal and cortical neuroinflammation in the offspring: An experimental study. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-03-09. PMID:35261075. |
compared to controls, exposure to prenatal stress was associated with increased depression and anxiety-like behavior, hippocampal nlrp3 inflammasome activation (p=0.022 and p=0.035 for female and male pups, respectively), neuronal degeneration and increased cas-3, mtor, and trpm immunostaining in the prefrontal and temporal cortices of both female and male offspring (p<0.05 for all comparisons except p<0.01 for cas-3 in the male cortex and female temporal cortex). |
2022-03-09 |
2023-08-13 |
rat |
| Yu-Lu Chen, Lei Tong, Yao Chen, Chang-Hai Fu, Jun-Bo Peng, Li-Li J. MiR-153 downregulation alleviates PTSD-like behaviors and reduces cell apoptosis by upregulating the Sigma-1 receptor in the hippocampus of rats exposed to single-prolonged stress. Experimental neurology. 2022-03-08. PMID:35259352. |
in addition, we showed that the mtor signaling pathway might be involved in the regulation of σ-1r in the hippocampus of rats exposed to sps. |
2022-03-08 |
2023-08-13 |
rat |
| Yu-Lu Chen, Lei Tong, Yao Chen, Chang-Hai Fu, Jun-Bo Peng, Li-Li J. MiR-153 downregulation alleviates PTSD-like behaviors and reduces cell apoptosis by upregulating the Sigma-1 receptor in the hippocampus of rats exposed to single-prolonged stress. Experimental neurology. 2022-03-08. PMID:35259352. |
the results of this study indicated that mir-153 might alleviate ptsd-like behaviors by regulating cell morphology and reducing cell apoptosis in the hippocampus of rats exposed to sps by targeting σ-1r, which might be related to the mtor signaling pathway. |
2022-03-08 |
2023-08-13 |
rat |
| Bingyi Liu, Ning Zhang, Junrong Yang, Wei Sun, Ruiyan Zhang, Xuexing Zheng, Zhengping Wang, Hans-Christian Siebert, Jun Ha. Preparation, Characterization, Evaluation of Neuroprotective Effect, and Related Mechanisms of Phosphatidylserine Emulsion in 5- and 12-Week Old Mice. Journal of agricultural and food chemistry. 2022-02-02. PMID:35107277. |
western-blotting analysis displayed that the 2% (w/w) ps emulsion treated group upregulated bdnf, trkb, psd95, mtor, mbp, and erbb4 expression in the hippocampus of 5- and 12-week old mice. |
2022-02-02 |
2023-08-13 |
mouse |
| Juan Wang, Feng Gao, Shuai Cui, Shaojie Yang, Fang Gao, Xuncui Wang, Guoqi Zh. Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD. Pharmacological research. 2022-01-13. PMID:35026406. |
from the perspective of synaptic function, the sps&s model displayed reduced expression of bdnf, p-trkb, postsynaptic density protein 95 (psd95), ampa receptor subunit glur1 (glua1), nmda receptor subunit n2a/n2b ratio, calpain-1, phosphorylated protein kinase b (akt) and phosphorylated mammalian target of rapamycin (mtor) and conversely, higher phosphatase and tension homolog (pten) expression in the hippocampus. |
2022-01-13 |
2023-08-13 |
mouse |
| Ester Francija, Iva Lukic, Zorica Petrovic, Zeljka Brkic, Milos Mitic, Jelena Radulovic, Miroslav Adzi. GluN2A-ERK-mTOR pathway confers a vulnerability to LPS-induced depressive-like behaviour. Behavioural brain research. vol 417. 2021-12-11. PMID:34637854. |
specifically, in glun2a knockout mice, we estimated the activity of the mtor pathway in the hippocampus and prefrontal cortex (pfc) by measuring synaptic levels of upstream regulators (p-akt, p-erk, and p-gsk3β) and downstream effectors (p-mtor, and p-p70s6k) of mtor activity. |
2021-12-11 |
2023-08-13 |
mouse |
| Ester Francija, Iva Lukic, Zorica Petrovic, Zeljka Brkic, Milos Mitic, Jelena Radulovic, Miroslav Adzi. GluN2A-ERK-mTOR pathway confers a vulnerability to LPS-induced depressive-like behaviour. Behavioural brain research. vol 417. 2021-12-11. PMID:34637854. |
contrary to downregulated mtor signaling and decreased synaptic markers in lps-treated wild-type animals, the resilience of glun2a ko mice to depressive-like behaviour was paralleled with sustained mtor signaling activity synaptic stability in hippocampus and pfc. |
2021-12-11 |
2023-08-13 |
mouse |
| Elisa Colombo, Guilherme Horta, Mona K Roesler, Natascha Ihbe, Stuti Chhabra, Konstantin Radyushkin, Giovanni Di Liberto, Mario Kreutzfeldt, Sven Schumann, Jakob von Engelhardt, Doron Merkler, Christian Behl, Thomas Mittmann, Albrecht M Clement, Ari Waisman, Michael J Schmeisse. The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 47. 2021-12-11. PMID:34782467. |
the k63 deubiquitinase cyld modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mtor signaling. |
2021-12-11 |
2023-08-13 |
mouse |