| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed A Salem, Barbara Budzyńska, Joanna Kowalczyk, Nesrine S El Sayed, Suzan M Mansou. Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways. Toxicology and applied pharmacology. vol 429. 2021-09-14. PMID:34428446. |
furthermore, tad and bg boosted hippocampal levels of cgmp, pkg, wnt3a, and ampk and reduced expression of β-catenin and mtor by 74% and 51%, respectively. |
2021-09-14 |
2023-08-13 |
mouse |
| Yousheng Liu, Shan Jin, Yun-Tian Yang, Yinbao Bai, Hong Yong, Wuyuntu Ba. Cognitive dysfunction associated with activation of the mTOR signaling pathway after TSH suppression therapy in rats. Endocrine journal. vol 67. issue 10. 2021-09-07. PMID:32581146. |
these results indicated that tsh suppression therapy after total thyroidectomy in rats could impair cognitive function, which might be related to the activation of the mtor signaling pathway and the damage and necrosis of hippocampal neurons. |
2021-09-07 |
2023-08-13 |
rat |
| Yu Lei, Xiaoyuan Jin, Mingli Sun, Zhiyong J. miR-129-5p Ameliorates Ischemic Brain Injury by Binding to SIAH1 and Activating the mTOR Signaling Pathway. Journal of molecular neuroscience : MN. vol 71. issue 9. 2021-09-07. PMID:34355355. |
additionally, enforced mir-129-5p inhibited the apoptosis of ogd-induced cells and decreased the cerebral infarct area, neurological scores and apoptosis of hippocampal neuronal cells by downregulating siah1 and activating the mtor signaling pathway. |
2021-09-07 |
2023-08-13 |
mouse |
| Jesús David Urbano-Gámez, Juan José Casañas, Itziar Benito, María Luz Montesino. Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34034796. |
we have previously reported hippocampal mtor (mammalian target of rapamycin) hyperactivation, and related plasticity as well as memory deficits in ts1cje mice, a ds experimental model. |
2021-08-12 |
2023-08-13 |
mouse |
| Andressa Radiske, Maria Carolina Gonzalez, Diana A Nôga, Janine I Rossato, Lia R M Bevilaqua, Martín Cammarot. GluN2B and GluN2A-containing NMDAR are differentially involved in extinction memory destabilization and restabilization during reconsolidation. Scientific reports. vol 11. issue 1. 2021-08-09. PMID:33420399. |
hippocampal nmdars drive local protein synthesis via mtor signaling and may control active memory maintenance. |
2021-08-09 |
2023-08-13 |
rat |
| Rajas P Kale, Thanh Thanh L Nguyen, J Blair Price, Nathanael J Yates, Ken Walder, Michael Berk, Roy V Sillitoe, Abbas Z Kouzani, Susannah J Ty. Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats. Frontiers in human neuroscience. vol 15. 2021-08-06. PMID:34349629. |
we investigated the antidepressant-like effects of chronic nucleus accumbens (nac) dbs and its association with change in glycogen synthase kinase 3 (gsk3) and mammalian target of rapamycin (mtor) expression in the infralimbic cortex (il), and the dorsal (dhip) and ventral (vhip) subregions of the hippocampus of antidepressant resistant rats. |
2021-08-06 |
2023-08-13 |
rat |
| Kyoung Hoon Jeong, Kyung-Ok Cho, Mun-Yong Lee, Seong Yun Kim, Won-Joo Ki. Vascular endothelial growth factor receptor-3 regulates astroglial glutamate transporter-1 expression via mTOR activation in reactive astrocytes following pilocarpine-induced status epilepticus. Glia. vol 69. issue 2. 2021-07-28. PMID:32835451. |
therefore, we investigated whether vegfr-3 upregulation within reactive astrocytes is associated with the activation of mammalian target of rapamycin (mtor) signaling, which we confirmed by assaying for the phosphorylated form of s6 protein (ps6), and whether vegfr-3-mediated mtor activation induces astroglial glutamate transporter-1 (glt-1) expression in the hippocampus after pilocarpine-induced se. |
2021-07-28 |
2023-08-13 |
Not clear |
| Min Guo, Jianmeng Xu, Shiwei Wang, Baohua Don. Asiaticoside reduces autophagy and improves memory in a rat model of dementia through mTOR signaling pathway regulation. Molecular medicine reports. vol 24. issue 3. 2021-07-19. PMID:34278477. |
asiaticoside treatment also prevented suppression of mammalian target of rapamycin (mtor) phosphorylation in vd rat hippocampal tissues. |
2021-07-19 |
2023-08-13 |
rat |
| Ting Xu, Jiao Liu, Xin-Rui Li, Yinghua Yu, Xuan Luo, Xian Zheng, Yuan Cheng, Pei-Quan Yu, Yi Li. The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33860440. |
in the present study, we investigated whether mtor regulates the nf-κb signaling pathway to modulate inflammatory cytokines and synaptic plasticity in hippocampal neurons. |
2021-07-15 |
2023-08-13 |
mouse |
| Ting Xu, Jiao Liu, Xin-Rui Li, Yinghua Yu, Xuan Luo, Xian Zheng, Yuan Cheng, Pei-Quan Yu, Yi Li. The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33860440. |
the inhibition of mtor and nf-κb suppressed mtor/nf-κb signaling pathway, increased synaptic proteins, and improved ultrastructural synaptic plasticity in the hippocampus of diabetic mice. |
2021-07-15 |
2023-08-13 |
mouse |
| Gislaine Olescowicz, Tuane B Sampaio, Cristine de Paula Nascimento-Castro, Patricia S Brocardo, Joana Gil-Mohapel, Ana Lúcia S Rodrigue. Protective Effects of Agmatine Against Corticosterone-Induced Impairment on Hippocampal mTOR Signaling and Cell Death. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32399718. |
protective effects of agmatine against corticosterone-induced impairment on hippocampal mtor signaling and cell death. |
2021-06-14 |
2023-08-13 |
mouse |
| Gislaine Olescowicz, Tuane B Sampaio, Cristine de Paula Nascimento-Castro, Patricia S Brocardo, Joana Gil-Mohapel, Ana Lúcia S Rodrigue. Protective Effects of Agmatine Against Corticosterone-Induced Impairment on Hippocampal mTOR Signaling and Cell Death. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32399718. |
treatment on the levels of phosphorylated mtor (p-mtor), neuronal death, and overall volume in the hippocampal dentate gyrus (dg) of mice exposed to chronic corticosterone (20 mg/kg, p.o.) |
2021-06-14 |
2023-08-13 |
mouse |
| Erica L Littlejohn, Anthony J DeSana, Hannah C Williams, Rudy T Chapman, Binoy Joseph, Jelena A Juras, Kathryn E Saatma. IGF1-Stimulated Posttraumatic Hippocampal Remodeling Is Not Dependent on mTOR. Frontiers in cell and developmental biology. vol 9. 2021-06-08. PMID:34095131. |
igf1-stimulated posttraumatic hippocampal remodeling is not dependent on mtor. |
2021-06-08 |
2023-08-13 |
mouse |
| Erica L Littlejohn, Anthony J DeSana, Hannah C Williams, Rudy T Chapman, Binoy Joseph, Jelena A Juras, Kathryn E Saatma. IGF1-Stimulated Posttraumatic Hippocampal Remodeling Is Not Dependent on mTOR. Frontiers in cell and developmental biology. vol 9. 2021-06-08. PMID:34095131. |
to determine whether mtor activation is necessary for igf1-mediated stimulation of posttraumatic hippocampal neurogenesis, wildtype and igf1 transgenic mice received the mtor inhibitor rapamycin daily beginning at 3 days after tbi, following pulse labeling with bromodeoxyuridine. |
2021-06-08 |
2023-08-13 |
mouse |
| Erica L Littlejohn, Anthony J DeSana, Hannah C Williams, Rudy T Chapman, Binoy Joseph, Jelena A Juras, Kathryn E Saatma. IGF1-Stimulated Posttraumatic Hippocampal Remodeling Is Not Dependent on mTOR. Frontiers in cell and developmental biology. vol 9. 2021-06-08. PMID:34095131. |
because beneficial effects of igf1 on hippocampal neurogenesis were maintained or even enhanced with delayed inhibition of mtor, combination therapy approaches may hold promise for tbi. |
2021-06-08 |
2023-08-13 |
mouse |
| Nashwa Amin, Shiyi Xie, Xiaoning Tan, Yili Chen, Qiannan Ren, Benson O A Botchway, Shaohua Hu, Yongchun Ma, Zhiying Hu, Marong Fan. Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32243998. |
the protein levels of phosphatidylinositol 3 kinase (pi3k)/ protein kinase b (akt)/mechanistic target of rapamycin (mtor)/phosphorylated extracellular signal-regulated kinase1/2 (p-erk 1/2)/brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) of hippocampus and cortex are assessed by western blot. |
2021-06-04 |
2023-08-13 |
mouse |
| Jehoon Lee, Raine Lunde-Young, Vishal Naik, Josue Ramirez, Marcus Orzabal, Jayanth Ramados. Chronic Binge Alcohol Exposure During Pregnancy Alters mTOR System in Rat Fetal Hippocampus. Alcoholism, clinical and experimental research. vol 44. issue 6. 2021-06-02. PMID:32333810. |
chronic binge alcohol exposure during pregnancy alters mtor system in rat fetal hippocampus. |
2021-06-02 |
2023-08-13 |
rat |
| Jehoon Lee, Raine Lunde-Young, Vishal Naik, Josue Ramirez, Marcus Orzabal, Jayanth Ramados. Chronic Binge Alcohol Exposure During Pregnancy Alters mTOR System in Rat Fetal Hippocampus. Alcoholism, clinical and experimental research. vol 44. issue 6. 2021-06-02. PMID:32333810. |
based on our previous quantitative mass spectrometry proteomic studies, we hypothesized that gestational chronic binge alcohol exposure alters mtor signaling and downstream pathways in the fetal hippocampus. |
2021-06-02 |
2023-08-13 |
rat |
| Cuiting Wang, Feng Niu, Ningna Ren, Xiaokun Wang, Hequan Zhong, Jie Zhu, Bing L. Hyperbaric Oxygen Improves Cerebral Ischemia/Reperfusion Injury in Rats Probably via Inhibition of Autophagy Triggered by the Downregulation of Hypoxia-Inducing Factor-1 Alpha. BioMed research international. vol 2021. 2021-05-26. PMID:33816617. |
as shown by western blot analysis, hbo significantly reduced autophagy by regulating autophagy-related proteins (mtor, p-mtor, atg13, lc3b ii and lc3b ii) in the hippocampus 72 hours after i/r, which was accompanied by inhibiting the expression of hypoxia inducible factor-1 |
2021-05-26 |
2023-08-13 |
rat |
| Sara Palumbo, Clare Paterson, Feng Yang, Veronica L Hood, Amanda J La. PKBβ/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:33328589. |
pkbβ/akt2 deficiency impacts brain mtor signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. |
2021-05-14 |
2023-08-13 |
mouse |