| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research. vol 45. issue 2. 2020-11-17. PMID:31865521. |
the present study investigated whether rapamycin can ameliorate surgery-induced cognitive deficits by inhibiting mtor and activating autophagy in the hippocampus. |
2020-11-17 |
2023-08-13 |
mouse |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research. vol 45. issue 2. 2020-11-17. PMID:31865521. |
hippocampal autophagy-related (atg)-5, phosphorylated mtor, and phosphorylated p70s6k were examined at each time point. |
2020-11-17 |
2023-08-13 |
mouse |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research. vol 45. issue 2. 2020-11-17. PMID:31865521. |
following partial hepatectomy, the levels of phosphorylated mtor, phosphorylated 70s6k, and phosphorylated tau were all increased in the hippocampus. |
2020-11-17 |
2023-08-13 |
mouse |
| Hanqing Wang, Yue Tong, Dong Xiao, Baomei Xi. Involvement of mTOR-related signaling in antidepressant effects of Sophoraflavanone G on chronically stressed mice. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-23. PMID:32246575. |
furthermore, the protein expressions of pi3k, akt, mtor, p70s6k, bdnf, and trkb in hippocampus were detected. |
2020-10-23 |
2023-08-13 |
mouse |
| Yingying Huang, Yingjun Liao, Huijun Zhang, Shuyun L. Lead exposure induces cell autophagy via blocking the Akt/mTOR signaling in rat astrocytes. The Journal of toxicological sciences. vol 45. issue 9. 2020-10-09. PMID:32879255. |
moreover, lead exposure induced autophagy in astrocytes, as evidenced by increased lc3ii and beclin 1 protein levels and decreased p62 expression in both the rat hippocampus and astrocytes, and it was confirmed that this autophagy was activated through blocking the downstream akt/target of the rapamycin (mtor) pathway in astrocytes. |
2020-10-09 |
2023-08-13 |
human |
| Rosanna Cabré, Mariona Jové, Alba Naudí, Victoria Ayala, Gerard Piñol-Ripoll, Maria P Gil-Villar, Mayelin Dominguez-Gonzalez, Èlia Obis, Rebeca Berdun, Natalia Mota-Martorell, Manuel Portero-Otin, Isidre Ferrer, Reinald Pamplon. Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex. Frontiers in molecular neuroscience. vol 9. 2020-10-01. PMID:28008307. |
these findings, along with the better antioxidant capacity and lower mtor signaling also seen in frontal cortex, suggest that this brain region is especially resistant to stress compared to the entorhinal cortex and hippocampus, which are more vulnerable regions. |
2020-10-01 |
2023-08-13 |
human |
| Jihong Xing, Jian L. Effects of mTOR on Neurological Deficits after Transient Global Ischemia. Translational neuroscience. vol 8. 2020-10-01. PMID:28729914. |
blocking mtor using rapamycin attenuated upregulation of pro-inflammatory cytokines (namely il-1β, il-6 and tnf-α), and caspase-3, indicating cell apoptosis and also promoting the levels of vascular endothelial growth factor (vegf) and its subtype receptor vegfr-2 in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Yang Yang, Zhiying Hu, Xiaoxue Du, Henry Davies, Xue Huo, Marong Fan. miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28790887. |
furthermore, cums was found to decrease levels of hippocampal mtor, pi3k, and akt. |
2020-10-01 |
2023-08-13 |
rat |
| Liying Yang, Yingying Zhang, Zhongrui Yan, Feng Tia. The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:28912846. |
compared with the sham operation group, the levels of mtor, p-mtor, akt and p-akt mrnas and hippocampal proteins were significantly lower in the cerebral ischemia group and cerebral ischemia-reperfusion group (p<0.05). |
2020-10-01 |
2023-08-13 |
rat |
| Jia-Nan Guo, Lin-Yu Tian, Wen-Yu Liu, Jie Mu, Dong Zho. Activation of the Akt/mTOR signaling pathway: A potential response to long-term neuronal loss in the hippocampus after sepsis. Neural regeneration research. vol 12. issue 11. 2020-10-01. PMID:29239329. |
we observed elevated phosphorylation of akt, mammalian target of rapamycin (mtor) and p70s6k on days 14 and 60, progressive neuronal loss in the cornu ammonis 1 region, and abnormal neuronal morphology in the hippocampus in the sepsis mouse model. |
2020-10-01 |
2023-08-13 |
mouse |
| Zhu-Jin Song, San-Juan Yang, Lan Han, Bin Wang, Guoqi Zh. Postnatal calpeptin treatment causes hippocampal neurodevelopmental defects in neonatal rats. Neural regeneration research. vol 14. issue 5. 2020-10-01. PMID:30688269. |
western blot assay was performed to analyze the protein levels of akt, erk, p-akt, p-erk1/2, erk1/2, scop, pten, mtor, p-mtor, creb and p-creb in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Zhu-Jin Song, San-Juan Yang, Lan Han, Bin Wang, Guoqi Zh. Postnatal calpeptin treatment causes hippocampal neurodevelopmental defects in neonatal rats. Neural regeneration research. vol 14. issue 5. 2020-10-01. PMID:30688269. |
scop expression was increased, and the phosphorylation levels of akt, mtor and creb were reduced in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Yanyong Wang, Qinying Ma, Xiaowei Ma, Zhongxia Zhang, Na Liu, Mingwei Wan. Role of mammalian target of rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse-prone 8 model. Experimental and therapeutic medicine. vol 14. issue 2. 2020-09-30. PMID:28810557. |
in the present study, mtor signaling in the hippocampus of samp8 newborn mice and in the control-strain samr1 mice was investigated. |
2020-09-30 |
2023-08-13 |
mouse |
| Eun J Na, Hye Yeon Nam, Jiyoung Park, Myung Ah Chung, Hyun Ae Woo, Hwa-Jung Ki. PI3K-mTOR-S6K Signaling Mediates Neuronal Viability via Collapsin Response Mediator Protein-2 Expression. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28966575. |
these changes corresponded to inhibition of neuronal viability and proliferation in cultured hippocampal ht-22 cells under both basal serum-free and serum- or insulin-induced mtor pathway-activated conditions. |
2020-09-30 |
2023-08-13 |
rat |
| Eun J Na, Hye Yeon Nam, Jiyoung Park, Myung Ah Chung, Hyun Ae Woo, Hwa-Jung Ki. PI3K-mTOR-S6K Signaling Mediates Neuronal Viability via Collapsin Response Mediator Protein-2 Expression. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28966575. |
crmp-2 expression tended to be increased by mtor activation, indicated by an increase in p-s6/s6 level, in pentylentetrazole (ptz)-induced epileptic rat hippocampal tissues was also significantly reduced by mtor inhibition. |
2020-09-30 |
2023-08-13 |
rat |
| Maedeh Arabian, Nahid Aboutaleb, Marjan Ajami, Rouhollah Habibe. Interaction of mTOR and iNOS pathways in protection against Ischemia/Reperfusion injury. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 2. 2020-09-30. PMID:31531061. |
in the present study, we investigated the interaction between the expressions of the mtor and inducible nitric oxide synthase (inos) and their possible protective effects on hippocampal neurons against i/r injury in morphine-dependent mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Bin Xu, Limin Lang, Shize Li, Jianbin Yuan, Jianfa Wang, Huanmin Yang, Shuai Lia. Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure. Animals : an open access journal from MDPI. vol 9. issue 9. 2020-09-30. PMID:31540011. |
autophagy was shown in mouse hippocampus tissues following cold exposure, including mitochondrial damage, autophagy, and 5' amp-activated protein kinase (ampk)/mammalian target of rapamycin (mtor) pathway activation after cort treatment. |
2020-09-30 |
2023-08-13 |
mouse |
| Richard Justin Garling, Lora Talley Watts, Shane Sprague, Murat Digicayliogl. Progesterone modulates mTOR in the hippocampus of mice after traumatic brain injury. Neural regeneration research. vol 13. issue 3. 2020-09-29. PMID:29623927. |
progesterone modulates mtor in the hippocampus of mice after traumatic brain injury. |
2020-09-29 |
2023-08-13 |
mouse |
| Richard Justin Garling, Lora Talley Watts, Shane Sprague, Murat Digicayliogl. Progesterone modulates mTOR in the hippocampus of mice after traumatic brain injury. Neural regeneration research. vol 13. issue 3. 2020-09-29. PMID:29623927. |
our study shows progesterone is a significant modulator of mtor levels in the hippocampus of mice following traumatic brain injury. |
2020-09-29 |
2023-08-13 |
mouse |
| Shaun S Sanders, Francesca I De Simone, Gareth M Thoma. mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTOR. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31001086. |
mtorc1 signaling is palmitoylation-dependent in hippocampal neurons and non-neuronal cells and involves dynamic palmitoylation of lamtor1 and mtor. |
2020-09-29 |
2023-08-13 |
Not clear |