| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuoli Sun, Lina Jia, Dandan Shi, Yi He, Yanping Ren, Jian Yang, Xin M. Deep brain stimulation improved depressive-like behaviors and hippocampal synapse deficits by activating the BDNF/mTOR signaling pathway. Behavioural brain research. 2021-12-10. PMID:34890598. |
furthermore, dbs restored the reduced synaptic density in the hippocampus induced by cus and increased the expression or activity of bdnf, akt, and mtor in the hippocampus. |
2021-12-10 |
2023-08-13 |
rat |
| Faheem Hyder Pottoo, Mohammed Salahuddin, Firdos Alam Khan, Fadhel Alomar, Marwa Abdullah Al Dhamen, Abrar Fouad Alhashim, Hawra Hussain Alqattan, Mohamed S Gomaa, Mohammad N Alomar. Thymoquinone Potentiates the Effect of Phenytoin against Electroshock-Induced Convulsions in Rats by Reducing the Hyperactivation of m-TOR Pathway and Neuroinflammation: Evidence from In Vivo, In Vitro and Computational Studies. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832914. |
apart from observing convulsions, hippocampal mtor, il-1β, il-6 and tnf-α levels were measured. |
2021-11-30 |
2023-08-13 |
rat |
| Faheem Hyder Pottoo, Mohammed Salahuddin, Firdos Alam Khan, Marwa Abdullah Al Dhamen, Walaa Jafar Alsaeed, Mohamed S Gomaa, Chittibabu Vatte, Mohammad N Alomar. Combinatorial Regimen of Carbamazepine and Imipramine Exhibits Synergism against Grandmal Epilepsy in Rats: Inhibition of Pro-Inflammatory Cytokines and PI3K/Akt/mTOR Signaling Pathway. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832986. |
along with behavioral monitoring, the rat hippocampus was processed for quantification of mtor, il-1β, il-6 and tnf-α levels. |
2021-11-30 |
2023-08-13 |
rat |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
levels of oxidative stress and inflammation-related factors and mtor pathway-related proteins in se rats and hippocampal neurons were detected. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
tug1 knockout inactivated the mtor pathway via the mir-421/timp2 axis to relieve neuronal apoptosis, oxidative stress and inflammation in se rats and hippocampal neurons. |
2021-11-29 |
2023-08-13 |
human |
| Armin Yazdani, Belal Howidi, Meng Zhu Shi, Nicol Tugarinov, Zehra Khoja, Pia Wintermar. Sildenafil improves hippocampal brain injuries and restores neuronal development after neonatal hypoxia-ischemia in male rat pups. Scientific reports. vol 11. issue 1. 2021-11-18. PMID:34764335. |
western blots of the hippocampus were performed at p12, p17, and p30 to study the expression of neuronal markers and mtor pathway. |
2021-11-18 |
2023-08-13 |
rat |
| Jing Xu, Eunchai Kang, C David Mint. Anesthetics disrupt brain development via actions on the mTOR pathway. Communicative & integrative biology. vol 11. issue 2. 2021-11-17. PMID:30083288. |
intriguingly, our recently published work shows that anesthetics can chronically alter mtor signaling in the hippocampal dentate gyrus and that normalization of mtor signaling can prevent anesthesia-induced perturbation of structure and function. |
2021-11-17 |
2023-08-13 |
Not clear |
| Heba M Mansour, Hala M Fawzy, Aiman S El-Khatib, Mahmoud M Khatta. Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats. Neurochemistry international. vol 150. 2021-11-11. PMID:34481907. |
we postulated that inhibiting the mitochondrial pyruvate carrier-1 (mpc-1), which inhibits the activation of the mammalian target of rapamycin (mtor), may ameliorate the neurodegeneration of hippocampal neurons in the rat ad model. |
2021-11-11 |
2023-08-13 |
human |
| Katarzyna M Targowska-Duda, Barbara Budzynska, Agnieszka Michalak, Artur Wnorowski, Claus J Loland, Maciej Maj, Dina Manetti, Maria Novella Romanelli, Krzysztof Jozwiak, Grazyna Biala, Hugo R Aria. Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 52. 2021-11-01. PMID:34237657. |
to assess whether mtor and erk signaling pathways are involved in the activity of α7-pams, the phosphorylation status of key signaling nodes was determined in prefrontal cortex and hippocampus from mice chronically treated with pam-2. |
2021-11-01 |
2023-08-13 |
mouse |
| Chao Lu, Xiangfei Liu, Jia Li, Yunke Huang, Xi Huang, Guoliang Dai, Lei W. Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus. ACS chemical neuroscience. vol 12. issue 20. 2021-10-28. PMID:34601865. |
merazin hydrate produces rapid antidepressant effects depending on activating mtor signaling by upregulating downstream synaptic proteins in the hippocampus. |
2021-10-28 |
2023-08-13 |
Not clear |
| Chao Lu, Xiangfei Liu, Jia Li, Yunke Huang, Xi Huang, Guoliang Dai, Lei W. Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus. ACS chemical neuroscience. vol 12. issue 20. 2021-10-28. PMID:34601865. |
moreover, the phosphorylated expression of mtor, reduced by lh or cms, was upregulated after a single administration of mh, and the expressions of bdnf and synaptic proteins in the hippocampus were also reversed 2 h later, similar to ketamine. |
2021-10-28 |
2023-08-13 |
Not clear |
| Long-Chun Li, Xiao-Ye Li, Xiao-Hua D. [Acupuncture improves cognitive function of vascular dementia rats by regulating PI3K/Akt/mTOR pathway]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 10. 2021-10-27. PMID:34698459. |
to explore the mechanism of acupuncture in improving cognitive ability by regulating hippocampal phosphatidylinositol-3 kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) pathway in vascular dementia (vd) rats. |
2021-10-27 |
2023-08-13 |
rat |
| Andressa Radiske, Maria Carolina Gonzalez, Diana A Nôga, Janine I Rossato, Lia R M Bevilaqua, Martín Cammarot. mTOR inhibition impairs extinction memory reconsolidation. Learning & memory (Cold Spring Harbor, N.Y.). vol 28. issue 1. 2021-10-25. PMID:33323495. |
importantly, coadministration of recombinant bdnf impedes the behavioral effect of hippocampal mtor inhibition. |
2021-10-25 |
2023-08-13 |
Not clear |
| Sree Lalitha Bojja, Bikash Medhi, Shashi Anand, Alka Bhatia, Rupa Joshi, Ranjana W Min. Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation. Inflammopharmacology. vol 29. issue 1. 2021-10-19. PMID:33386490. |
metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mtor modulation. |
2021-10-19 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
interestingly, both glur2 and mammalian target of rapamycin (mtor) receptor blocker aggravated mitophagy-induced hippocampal neuron apoptosis and abnormal expression of apoptotic protein. |
2021-10-15 |
2023-08-13 |
rat |
| Chu-Qin Zhang, Song Yi, Bo-Bei Chen, Pan-Pan Cui, Yan Wang, Yan-Zhong L. mTOR/NF-κB signaling pathway protects hippocampal neurons from injury induced by intermittent hypoxia in rats. The International journal of neuroscience. vol 131. issue 10. 2021-10-01. PMID:32378972. |
to expound the roles of mtor and nf-kb signaling pathway in intermittent hypoxia (ih)-induced damage of hippocampal neurons. |
2021-10-01 |
2023-08-13 |
rat |
| Candi L LaSarge, Raymund Y K Pun, Zhiqing Gu, Matthew R Riccetti, Devi V Namboodiri, Durgesh Tiwari, Christina Gross, Steve C Danze. mTOR-driven neural circuit changes initiate an epileptogenic cascade. Progress in neurobiology. vol 200. 2021-09-24. PMID:33309800. |
to better understand how this variability affects disease phenotype, we developed a mouse model in which the mtor pathway inhibitor pten can be deleted from 0 to 40 % of hippocampal granule cells. |
2021-09-24 |
2023-08-13 |
mouse |
| Alberto Javier Ramo. Brain angiotensin system: a new promise in the management of epilepsy? Clinical science (London, England : 1979). vol 135. issue 6. 2021-09-21. PMID:33729497. |
interestingly, but surprisingly, gomes and colleagues showed that masr expression and mtor activity were reduced in the hippocampus of the epileptic ang-(1-7) treated animals. |
2021-09-21 |
2023-08-13 |
Not clear |
| Jack C de la Torr. Deciphering Alzheimer's Disease Pathogenic Pathway: Role of Chronic Brain Hypoperfusion on p-Tau and mTOR. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459641. |
new biomolecular findings reveal the interplay of cbh in increasing tau phosphorylation (p-tau) in the hippocampus and cortex of ad mice, damaging fast axonal transport, increasing signaling of mammalian target of rapamycin (mtor), impairing learning-memory function, and promoting the formation of neurofibrillary tangles, a neuropathologic hallmark of ad. |
2021-09-15 |
2023-08-13 |
mouse |
| Malgorzata Lopatynska-Mazurek, Anna Pankowska, Ewa Gibula-Tarlowska, Radoslaw Pietura, Jolanta H Kotlinsk. Rapamycin Improves Recognition Memory and Normalizes Amino-Acids and Amines Levels in the Hippocampal Dentate Gyrus in Adult Rats Exposed to Ethanol during the Neonatal Period. Biomolecules. vol 11. issue 3. 2021-09-15. PMID:33673489. |
research suggests that ethanol exposure during pregnancy alters the mtor signaling pathway in the fetal hippocampus. |
2021-09-15 |
2023-08-13 |
human |