| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Long Liu, Liu Luo, Rong-Hao Mu, Bin-Bin Liu, Di Geng, Qing Liu, Li-Tao Y. Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice. Scientific reports. vol 5. 2016-09-13. PMID:26522512. |
in conclusion, our findings suggest that chronic treatment with fluoxetine can induce synaptic protein expression by activating the mtor signaling pathway in a region-dependent manner and mainly in the hippocampus. |
2016-09-13 |
2023-08-13 |
mouse |
| Eunchai Kang, Ju Young Kim, Cindy Y Liu, Bo Xiao, Po Yu Chen, Kimberly M Christian, Paul F Worley, Hongjun Song, Guo-Li Min. Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus. Neurogenesis (Austin, Tex.). vol 2. issue 1. 2016-09-08. PMID:27606328. |
our genetic and functional studies demonstrate that rheb1 acts as a key mediator of disc1-dependent regulation of mtor signaling and neuronal development during adult hippocampal neurogenesis. |
2016-09-08 |
2023-08-13 |
Not clear |
| Hui Xiong, Frédéric Cassé, Yang Zhou, Ming Zhou, Zhi-Qi Xiong, Marian Joëls, Stéphane Martin, Harm J Kruger. mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory. Learning & memory (Cold Spring Harbor, N.Y.). vol 22. issue 12. 2016-08-23. PMID:26572647. |
mtor is essential for corticosteroid effects on hippocampal ampa receptor function and fear memory. |
2016-08-23 |
2023-08-13 |
Not clear |
| Jennifer J Tuscher, Victoria Luine, Maya Frankfurt, Karyn M Fric. Estradiol-Mediated Spine Changes in the Dorsal Hippocampus and Medial Prefrontal Cortex of Ovariectomized Female Mice Depend on ERK and mTOR Activation in the Dorsal Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 5. 2016-06-22. PMID:26843632. |
estradiol-mediated spine changes in the dorsal hippocampus and medial prefrontal cortex of ovariectomized female mice depend on erk and mtor activation in the dorsal hippocampus. |
2016-06-22 |
2023-08-13 |
mouse |
| Jin-Ju Jeong, Kyung-Ah Kim, Young-Tae Ahn, Jae-Hun Sim, Jae-Yeon Woo, Chul-Sung Huh, Dong-Hyun Ki. Probiotic Mixture KF Attenuates Age-Dependent Memory Deficit and Lipidemia in Fischer 344 Rats. Journal of microbiology and biotechnology. vol 25. issue 9. 2016-06-13. PMID:25975611. |
orally administered kf suppressed the expression of p16, p53, and cyclooxygenase-2, the phosphorylation of akt and mtor, and the activation of nf-κb in the hippocampus of the brain. |
2016-06-13 |
2023-08-13 |
rat |
| Zhenya Lu, Furong Liu, Linglin Chen, Huadan Zhang, Yuemin Ding, Jianxiang Liu, Michael Wong, Ling-Hui Zen. Effect of Chronic Administration of Low Dose Rapamycin on Development and Immunity in Young Rats. PloS one. vol 10. issue 8. 2016-05-06. PMID:26248290. |
we found that the expression of the marker proteins of mtor pathway was changed during development in brain hippocampus and neocortex. |
2016-05-06 |
2023-08-13 |
rat |
| Jing Han, Dong-Sheng Wang, Shui-Bing Liu, Ming-Gao Zha. Cytisine, a Partial Agonist of α4β2 Nicotinic Acetylcholine Receptors, Reduced Unpredictable Chronic Mild Stress-Induced Depression-Like Behaviors. Biomolecules & therapeutics. vol 24. issue 3. 2016-05-02. PMID:27098858. |
cyt significantly reversed the decreases of 5-ht1a, bdnf, and mtor levels in the hippocampus and amygdala. |
2016-05-02 |
2023-08-13 |
mouse |
| Jennifer Romine, Xiang Gao, Xiao-Ming Xu, Kwok Fai So, Jinhui Che. The proliferation of amplifying neural progenitor cells is impaired in the aging brain and restored by the mTOR pathway activation. Neurobiology of aging. vol 36. issue 4. 2016-03-17. PMID:25655438. |
stimulating the mtor signaling revitalizes the nscs, restores their proliferation, and enhances neurogenesis in the hippocampus of the aged brain. |
2016-03-17 |
2023-08-13 |
mouse |
| Md Mahiuddin Ahmed, A Ranjitha Dhanasekaran, Aaron Block, Suhong Tong, Alberto C S Costa, Melissa Stasko, Katheleen J Gardine. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome. PloS one. vol 10. issue 3. 2016-02-09. PMID:25793384. |
here, we extend this analysis to ts65dn mice, measuring levels of 85 proteins/protein modifications, including components of map kinase and mtor pathways, and subunits of nmda receptors, in cortex and hippocampus of ts65dn mice after failed learning in cfc and after learning was rescued by memantine. |
2016-02-09 |
2023-08-13 |
mouse |
| Yunqing Ma, Dongke Wu, Wei Zhang, Jiankun Liu, Siping Chen, Binghong Hu. Investigation of PI3K/PKB/mTOR/S6K1 signaling pathway in relationship of type 2 diabetes and Alzheimer's disease. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770471. |
based on the high-sugar high-fat diet, the single intraperitoneal injection of streptozotocin was performed to induce the t2dm rat model; the immunohistochemistry and rt-pcr technique were then performed to detect the expression levels of mtor, pi3k, pkb, s6k1 and phosphorylated tau protein in the hippocampal tissues of each group. |
2016-01-15 |
2023-08-13 |
rat |
| Yunqing Ma, Dongke Wu, Wei Zhang, Jiankun Liu, Siping Chen, Binghong Hu. Investigation of PI3K/PKB/mTOR/S6K1 signaling pathway in relationship of type 2 diabetes and Alzheimer's disease. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770471. |
the related metabolic indicators of the t2dm group and the t2dm + ad group were significantly higher than the normal control group and the ad group (p<0.01); the morris water maze test of the ad group and the learning and memory of the t2dm + ad group were than significantly decreased than the t2dm group (p<0.01); the t2dm + ad group exhibited significantly increased expression levels of mtor, s6k1 and tau protein in the hippocampal tissues than the ad group and the t2dm group (p<0.05), and while the expression levels of pi3k and pkb were decreased (p<0.05). |
2016-01-15 |
2023-08-13 |
rat |
| Ashley M Fortress, John D Heisler, Karyn M Fric. The mTOR and canonical Wnt signaling pathways mediate the mnemonic effects of progesterone in the dorsal hippocampus. Hippocampus. vol 25. issue 5. 2016-01-13. PMID:25483228. |
the mtor and canonical wnt signaling pathways mediate the mnemonic effects of progesterone in the dorsal hippocampus. |
2016-01-13 |
2023-08-13 |
mouse |
| Ashley M Fortress, John D Heisler, Karyn M Fric. The mTOR and canonical Wnt signaling pathways mediate the mnemonic effects of progesterone in the dorsal hippocampus. Hippocampus. vol 25. issue 5. 2016-01-13. PMID:25483228. |
we previously showed that intrahippocampal infusion of p4 in ovariectomized female mice enhances object recognition (or) memory consolidation in a manner dependent on activation of dorsal hippocampal erk and mtor signaling. |
2016-01-13 |
2023-08-13 |
mouse |
| Rachel Lennox, Rachael R Lennox, R Charlotte Moffett, Charlotte Moffett, David W Porter, Nigel Irwin, Victor A Gault, Peter R Flat. Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice. Molecular medicine reports. vol 12. issue 1. 2015-12-30. PMID:25760229. |
the chronic consumption of a high-fat diet decreased the hippocampal gene expression levels of mammalian target of rapamycin (mtor), neurotrophic tyrosine kinase receptor type 2 (ntrk2) and synaptophysin. |
2015-12-30 |
2023-08-13 |
mouse |
| Rachel Lennox, Rachael R Lennox, R Charlotte Moffett, Charlotte Moffett, David W Porter, Nigel Irwin, Victor A Gault, Peter R Flat. Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice. Molecular medicine reports. vol 12. issue 1. 2015-12-30. PMID:25760229. |
notably, the gipr ko mice fed a high-fat diet exhibited no reduction in the hippocampal expression of synaptophysin expression, however, the gipr ko mice fed a standard rodent maintenance diet exhibited reduced hippocampal expression of mtor compared with the wt controls. |
2015-12-30 |
2023-08-13 |
mouse |
| Rachel Lennox, Rachael R Lennox, R Charlotte Moffett, Charlotte Moffett, David W Porter, Nigel Irwin, Victor A Gault, Peter R Flat. Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice. Molecular medicine reports. vol 12. issue 1. 2015-12-30. PMID:25760229. |
these data highlighted the importance of intact gipr signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity, including mtor and ntrk2, appear to be key in this regard. |
2015-12-30 |
2023-08-13 |
mouse |
| Ayako Shima, Naoki Nitta, Fumio Suzuki, Anne-Marie Laharie, Kazuhiko Nozaki, Antoine Depauli. Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy. The European journal of neuroscience. vol 41. issue 7. 2015-12-29. PMID:25605420. |
here, we addressed whether mtor activation promotes mtle epileptogenesis via increasing neuronal excitability and/or bdnf expression or rather mediates neuroplasticity associated with hippocampal sclerosis. |
2015-12-29 |
2023-08-13 |
mouse |
| Maria Grazia Giovannini, Daniele Lana, Giancarlo Pepe. The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory. Neurobiology of learning and memory. vol 119. 2015-12-08. PMID:25595880. |
the integrated role of ach, erk and mtor in the mechanisms of hippocampal inhibitory avoidance memory. |
2015-12-08 |
2023-08-13 |
Not clear |
| Maria Grazia Giovannini, Daniele Lana, Giancarlo Pepe. The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory. Neurobiology of learning and memory. vol 119. 2015-12-08. PMID:25595880. |
the purpose of this review is to summarize the present knowledge on the interplay among the cholinergic system, extracellular signal-regulated kinase (erk) and mammalian target of rapamycin (mtor) pathways in the development of short and long term memories during the acquisition and recall of the step-down inhibitory avoidance in the hippocampus. |
2015-12-08 |
2023-08-13 |
Not clear |
| Maria Grazia Giovannini, Daniele Lana, Giancarlo Pepe. The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory. Neurobiology of learning and memory. vol 119. 2015-12-08. PMID:25595880. |
it seems therefore that the complex interplay among the cholinergic system, erk and mtor is crucial in the development of new inhibitory avoidance memories in the hippocampus. |
2015-12-08 |
2023-08-13 |
Not clear |