| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashley M Fortress, Lu Fan, Patrick T Orr, Zaorui Zhao, Karyn M Fric. Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 3. 2013-08-06. PMID:23422279. |
collectively, these data demonstrate for the first time that activation of the dorsal hippocampal mtor signaling pathway is necessary for e(2) to enhance object recognition memory consolidation and that e(2)-induced mtor activation is dependent on upstream activation of erk and pi3k signaling. |
2013-08-06 |
2023-08-12 |
Not clear |
| Chun Yang, Yi-Min Hu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jian-Jun Yan. Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test. Upsala journal of medical sciences. vol 118. issue 1. 2013-08-05. PMID:22970723. |
acute administration of ketamine in rats increases hippocampal bdnf and mtor levels during forced swimming test. |
2013-08-05 |
2023-08-12 |
rat |
| Chun Yang, Yi-Min Hu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jian-Jun Yan. Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test. Upsala journal of medical sciences. vol 118. issue 1. 2013-08-05. PMID:22970723. |
this study aims to investigate the effects of acute administration of different doses of ketamine on the immobility time of rats in the forced swimming test (fst) and to determine levels of hippocampal brain-derived neurotrophic factor (bdnf) and mammalian target of rapamycin (mtor). |
2013-08-05 |
2023-08-12 |
rat |
| Helen S Bateup, Caroline A Johnson, Cassandra L Denefrio, Jessica L Saulnier, Karl Kornacker, Bernardo L Sabatin. Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron. vol 78. issue 3. 2013-07-09. PMID:23664616. |
in tsc1 ko neurons, weakened inhibition caused by deregulated mtor alters the balance of excitatory and inhibitory synaptic transmission, leading to hippocampal hyperexcitability. |
2013-07-09 |
2023-08-12 |
mouse |
| Anna R Malik, Malgorzata Urbanska, Agata Gozdz, Lukasz J Swiech, Andrzej Nagalski, Malgorzata Perycz, Magdalena Blazejczyk, Jacek Jaworsk. Cyr61, a matricellular protein, is needed for dendritic arborization of hippocampal neurons. The Journal of biological chemistry. vol 288. issue 12. 2013-05-15. PMID:23362279. |
in this work, we performed a screen for modifiers of dendritic growth in hippocampal neurons, the expression of which is potentially regulated by mtor. |
2013-05-15 |
2023-08-12 |
Not clear |
| Victor Briz, Yu-Tien Hsu, Yi Li, Erin Lee, Xiaoning Bi, Michel Baudr. Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467348. |
in rat hippocampal slices, cortical synaptoneurosomes, and cultured neurons, bdnf-induced mtor pathway activation and protein translation were blocked by calpain inhibition. |
2013-04-26 |
2023-08-12 |
rat |
| Stephanie J B Fretham, Erik S Carlson, Michael K Georgief. Neuronal-specific iron deficiency dysregulates mammalian target of rapamycin signaling during hippocampal development in nonanemic genetic mouse models. The Journal of nutrition. vol 143. issue 3. 2013-04-09. PMID:23303869. |
here, the specific role of iron in regulation of mammalian target of rapamycin (mtor) signaling (a kinase pathway that integrates metabolic supply and demand to regulate cell growth and morphology) was examined using 2 hippocampal, pyramidal cell-specific, nonanemic, genetic mouse models of id: a camkiiα cre-loxp permanent knockout of divalent metal transporter-1 (dmt-1 cko) and a camkiiα-tta-driven reversible, overexpression of nonfunctional, dominant negative transferrin receptor-1 (dn tfr-1). |
2013-04-09 |
2023-08-12 |
mouse |
| Israeli Ran, Christos G Gkogkas, Cristina Vasuta, Maylis Tartas, Arkady Khoutorsky, Isabel Laplante, Armen Parsyan, Tatiana Nevarko, Nahum Sonenberg, Jean-Claude Lacaill. Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 5. 2013-04-02. PMID:23365227. |
the eukaryotic initiation factor 4e-binding protein-2 (4e-bp2) is a repressor of cap-dependent mrna translation and a major downstream effector of the mammalian target of rapamycin (mtor) implicated in hippocampal long-term synaptic plasticity and memory. |
2013-04-02 |
2023-08-12 |
mouse |
| Long-Ze Sha, Xiao-Liang Xing, Dan Zhang, Yuan Yao, Wan-Chen Dou, Li-Ri Jin, Li-Wen Wu, Qi X. Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy. PloS one. vol 7. issue 6. 2013-03-26. PMID:22761730. |
here, we used an animal model of tle and sclerotic hippocampus from patients with refractory tle to determine whether cell-type specific activation of mtor signaling occurs during each stage of epileptogenesis. |
2013-03-26 |
2023-08-12 |
mouse |
| Long-Ze Sha, Xiao-Liang Xing, Dan Zhang, Yuan Yao, Wan-Chen Dou, Li-Ri Jin, Li-Wen Wu, Qi X. Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy. PloS one. vol 7. issue 6. 2013-03-26. PMID:22761730. |
in the tle mouse model, we found that hyperactivation of the mtor pathway is present in distinct hippocampal subfields at three different stages after kainate-induced seizures, and occurs in neurons of the granular and pyramidal cell layers, in reactive astrocytes, and in dispersed granule cells, respectively. |
2013-03-26 |
2023-08-12 |
mouse |
| Long-Ze Sha, Xiao-Liang Xing, Dan Zhang, Yuan Yao, Wan-Chen Dou, Li-Ri Jin, Li-Wen Wu, Qi X. Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy. PloS one. vol 7. issue 6. 2013-03-26. PMID:22761730. |
in agreement with the findings in tle mice, upregulated mtor was observed in the sclerotic hippocampus of tle patients. |
2013-03-26 |
2023-08-12 |
mouse |
| Long-Ze Sha, Xiao-Liang Xing, Dan Zhang, Yuan Yao, Wan-Chen Dou, Li-Ri Jin, Li-Wen Wu, Qi X. Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy. PloS one. vol 7. issue 6. 2013-03-26. PMID:22761730. |
all sclerotic hippocampus (n = 13) exhibited widespread reactive astrocytes with overactivated mtor, some of which invaded the dispersed granular layer. |
2013-03-26 |
2023-08-12 |
mouse |
| Long-Ze Sha, Xiao-Liang Xing, Dan Zhang, Yuan Yao, Wan-Chen Dou, Li-Ri Jin, Li-Wen Wu, Qi X. Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy. PloS one. vol 7. issue 6. 2013-03-26. PMID:22761730. |
moreover, two sclerotic hippocampus exhibited mtor activation in some of the granule cells, which was accompanied by cell body hypertrophy. |
2013-03-26 |
2023-08-12 |
mouse |
| Long-Ze Sha, Xiao-Liang Xing, Dan Zhang, Yuan Yao, Wan-Chen Dou, Li-Ri Jin, Li-Wen Wu, Qi X. Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy. PloS one. vol 7. issue 6. 2013-03-26. PMID:22761730. |
taken together, our results indicate that mtor activation is most prominent in reactive astrocytes in both an animal model of tle and the sclerotic hippocampus from patients with drug resistant tle. |
2013-03-26 |
2023-08-12 |
mouse |
| Agata Chandran, Abiye H Iyo, Courtney S Jernigan, Beata Legutko, Mark C Austin, Beata Karolewic. Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 40. 2013-03-26. PMID:22889863. |
in the present study, we examined the effect of cus on the expression of phosphorylated mtor and its downstream signaling components in the frontal cortex, hippocampus, amygdala, and dorsal raphe. |
2013-03-26 |
2023-08-12 |
human |
| Christopher G Vecsey, Lucia Peixoto, Jennifer H K Choi, Mathieu Wimmer, Devan Jaganath, Pepe J Hernandez, Jennifer Blackwell, Karuna Meda, Alan J Park, Sridhar Hannenhalli, Ted Abe. Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus. Physiological genomics. vol 44. issue 20. 2013-03-17. PMID:22930738. |
our findings represent the first genome-wide analysis of the effects of sleep deprivation on the mouse hippocampus, and they suggest that the detrimental effects of sleep deprivation may be mediated by reductions in protein synthesis via downregulation of mtor. |
2013-03-17 |
2023-08-12 |
mouse |
| Malgorzata Urbanska, Agata Gozdz, Lukasz J Swiech, Jacek Jaworsk. Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons. The Journal of biological chemistry. vol 287. issue 36. 2012-11-19. PMID:22810227. |
we provide evidence that both mtor complexes are crucial for the proper dendritic arbor morphology of hippocampal neurons. |
2012-11-19 |
2023-08-12 |
Not clear |
| J Annelies E Polman, Richard G Hunter, Niels Speksnijder, Jessica M E van den Oever, Oksana B Korobko, Bruce S McEwen, E Ronald de Kloet, Nicole A Datso. Glucocorticoids modulate the mTOR pathway in the hippocampus: differential effects depending on stress history. Endocrinology. vol 153. issue 9. 2012-10-29. PMID:22778218. |
glucocorticoids modulate the mtor pathway in the hippocampus: differential effects depending on stress history. |
2012-10-29 |
2023-08-12 |
rat |
| J Annelies E Polman, Richard G Hunter, Niels Speksnijder, Jessica M E van den Oever, Oksana B Korobko, Bruce S McEwen, E Ronald de Kloet, Nicole A Datso. Glucocorticoids modulate the mTOR pathway in the hippocampus: differential effects depending on stress history. Endocrinology. vol 153. issue 9. 2012-10-29. PMID:22778218. |
we demonstrate that regulators of the mtor pathway, dna damage-induced transcript (ddit)4 and fk506-binding protein 51 are transcriptionally up-regulated by an acute gc challenge in the dentate gyrus (dg) subregion of the rat hippocampus, most likely via a gc-response element-driven mechanism. |
2012-10-29 |
2023-08-12 |
rat |
| J Annelies E Polman, Richard G Hunter, Niels Speksnijder, Jessica M E van den Oever, Oksana B Korobko, Bruce S McEwen, E Ronald de Kloet, Nicole A Datso. Glucocorticoids modulate the mTOR pathway in the hippocampus: differential effects depending on stress history. Endocrinology. vol 153. issue 9. 2012-10-29. PMID:22778218. |
basal hippocampal mtor protein levels were higher in animals exposed to chronic stress than in controls. |
2012-10-29 |
2023-08-12 |
rat |