| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Ehninger, Sangyeul Han, Carrie Shilyansky, Yu Zhou, Weidong Li, David J Kwiatkowski, Vijaya Ramesh, Alcino J Silv. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nature medicine. vol 14. issue 8. 2008-08-21. PMID:18568033. |
we show that hyperactive hippocampal mammalian target of rapamycin (mtor) signaling led to abnormal long-term potentiation in the ca1 region of the hippocampus and consequently to deficits in hippocampal-dependent learning. |
2008-08-21 |
2023-08-12 |
mouse |
| Usha Narayanan, Vijayalaxmi Nalavadi, Mika Nakamoto, George Thomas, Stephanie Ceman, Gary J Bassell, Stephen T Warre. S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18474609. |
here we identify ribosomal protein s6 kinase (s6k1) as a major fmrp kinase in the mouse hippocampus, finding that activity-dependent phosphorylation of fmrp by s6k1 requires signaling inputs from mammalian target of rapamycin (mtor), erk1/2, and pp2a. |
2008-08-19 |
2023-08-12 |
mouse |
| Li Sui, Jing Wang, Bao-Ming L. Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats. Neurochemical research. vol 33. issue 6. 2008-07-24. PMID:18097751. |
in this study, we administrated 3,5,3'-triiodo-l: -thyronine (t3) into rat dorsal hippocampus and determined the phosphorylation of akt and its downstream targets, mammalian target of rapamycin (mtor), p70s6 kinase (p70s6k) and the eukaryotic initiation factor 4e-binding protein 1 (4e-bp1) signaling molecules. |
2008-07-24 |
2023-08-12 |
rat |
| Fred J Helmstetter, Ryan G Parsons, Georgette M Gaffor. Macromolecular synthesis, distributed synaptic plasticity, and fear conditioning. Neurobiology of learning and memory. vol 89. issue 3. 2008-06-16. PMID:17977027. |
finally, a series of recent experiments from our laboratory studying the role of a specific signaling pathway (mtor) which regulates translational processes and memory formation in the amygdala and hippocampus during fear conditioning are reviewed. |
2008-06-16 |
2023-08-12 |
rat |
| Jociane C Myskiw, Janine I Rossato, Lia R M Bevilaqua, Jorge H Medina, Iván Izquierdo, Martín Cammarot. On the participation of mTOR in recognition memory. Neurobiology of learning and memory. vol 89. issue 3. 2008-06-16. PMID:18039584. |
here, we report that inhibition of hippocampal mtor, a protein kinase involved in the initiation of mrna translation, immediately or 180min but not 540min after training impairs consolidation of long-term object recognition memory without affecting short-term memory retention or exploratory behavior. |
2008-06-16 |
2023-08-12 |
Not clear |
| Jociane C Myskiw, Janine I Rossato, Lia R M Bevilaqua, Jorge H Medina, Iván Izquierdo, Martín Cammarot. On the participation of mTOR in recognition memory. Neurobiology of learning and memory. vol 89. issue 3. 2008-06-16. PMID:18039584. |
our results indicate that mtor activity is required in the dorsal hippocampus for consolidation of object recognition memory and suggest that inhibition of this kinase after memory retrieval in the presence of a particular set of cues hinders persistence of the original recognition memory trace. |
2008-06-16 |
2023-08-12 |
Not clear |
| Milena Damjanac, Agnès Rioux Bilan, Marc Paccalin, Raymond Pontcharraud, Bernard Fauconneau, Jacques Hugon, Guylène Pag. Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease. Neurobiology of disease. vol 29. issue 2. 2008-04-04. PMID:18023354. |
here, we analysed upstream and downstream factors of mtor in brain of app(sl)/ps1 ki mice displaying a massive neuronal loss in hippocampus. |
2008-04-04 |
2023-08-12 |
mouse |
| Yves Jossin, André M Goffine. Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. Molecular and cellular biology. vol 27. issue 20. 2008-02-15. PMID:17698586. |
on the other hand, mtor, but not gsk3beta, mediates the effects of reelin on the growth and branching of dendrites of hippocampal neurons. |
2008-02-15 |
2023-08-12 |
Not clear |
| Stephan Rüegg, Marianna Baybis, Hal Juul, Marc Dichter, Peter B Crin. Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons. Epilepsy research. vol 77. issue 2-3. 2008-02-14. PMID:17983731. |
we assayed the effects of rapamycin, an immunomodulatory agent known to inhibit the activity of the mammalian target of rapamycin (mtor) cascade, on candidate gene expression and single unit firing properties in cultured rat hippocampal neurons as a strategy to define the effects of rapamycin on neuronal gene transcription and excitability. |
2008-02-14 |
2023-08-12 |
rat |
| Erik G Puffenberger, Kevin A Strauss, Keri E Ramsey, David W Craig, Dietrich A Stephan, Donna L Robinson, Christine L Hendrickson, Steven Gottlieb, David A Ramsay, Victoria M Siu, Gregory G Heuer, Peter B Crino, D Holmes Morto. Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17522105. |
there was abundant anti-phospho-ribosomal s6 labelling of large cells within the frontal cortex, basal ganglia, hippocampus and spinal cord, consistent with constitutive activation of the mammalian target of rapamycin (mtor) signalling pathway in brain. |
2007-07-24 |
2023-08-12 |
Not clear |
| Panayiotis Tsokas, Tao Ma, Ravi Iyengar, Emmanuel M Landau, Robert D Blitze. Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of rapamycin pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 22. 2007-06-13. PMID:17537959. |
we studied the interaction between the mtor and erk pathways in hippocampal ltp induced at ca3-ca1 synapses by high-frequency synaptic stimulation (hfs). |
2007-06-13 |
2023-08-12 |
Not clear |
| Shaoyi Chen, Coleen M Atkins, Chunli L Liu, Ofelia F Alonso, W Dalton Dietrich, Bingren R H. Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 27. issue 5. 2007-05-22. PMID:16955078. |
using western blot analysis, we found that mtor, p70s6k, rps6, and 4e-bp1 phosphorylation levels were significantly increased in the ipsilateral parietal cortex and hippocampus from 30 mins to 24 h after tbi, whereas total protein levels were unchanged. |
2007-05-22 |
2023-08-12 |
rat |
| Pedro Bekinschtein, Cynthia Katche, Leandro N Slipczuk, Lionel Müller Igaz, Martín Cammarota, Iván Izquierdo, Jorge H Medin. mTOR signaling in the hippocampus is necessary for memory formation. Neurobiology of learning and memory. vol 87. issue 2. 2007-03-21. PMID:17005423. |
mtor signaling in the hippocampus is necessary for memory formation. |
2007-03-21 |
2023-08-12 |
rat |
| Kimberly F Raab-Graham, Patrick C G Haddick, Yuh Nung Jan, Lily Yeh Ja. Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science (New York, N.Y.). vol 314. issue 5796. 2006-10-18. PMID:17023663. |
we found that the mtor inhibitor, rapamycin, increased the kv1.1 voltage-gated potassium channel protein in hippocampal neurons and promoted kv1.1 surface expression on dendrites without altering its axonal expression. |
2006-10-18 |
2023-08-12 |
Not clear |
| Guylène Page, Fuad A L Khidir, Stéphanie Pain, Laurence Barrier, Bernard Fauconneau, Olivier Guillard, Alain Piriou, Jacques Hugo. Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes. Neurochemistry international. vol 49. issue 4. 2006-10-02. PMID:16549223. |
group i metabotropic glutamate receptors activate the p70s6 kinase via both mammalian target of rapamycin (mtor) and extracellular signal-regulated kinase (erk 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes. |
2006-10-02 |
2023-08-12 |
rat |
| Guylène Page, Fuad A L Khidir, Stéphanie Pain, Laurence Barrier, Bernard Fauconneau, Olivier Guillard, Alain Piriou, Jacques Hugo. Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes. Neurochemistry international. vol 49. issue 4. 2006-10-02. PMID:16549223. |
the mtor activation is dose-dependent and requires the stimulation of mglur1 subtype receptors as for the p70s6k activation observed in striatum and hippocampus. |
2006-10-02 |
2023-08-12 |
rat |
| Ruomu Gong, Chang Sin Park, Nima Rezaei Abbassi, Shao-Jun Tan. Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. The Journal of biological chemistry. vol 281. issue 27. 2006-09-18. PMID:16651266. |
roles of glutamate receptors and the mammalian target of rapamycin (mtor) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. |
2006-09-18 |
2023-08-12 |
Not clear |
| Ruomu Gong, Chang Sin Park, Nima Rezaei Abbassi, Shao-Jun Tan. Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. The Journal of biological chemistry. vol 281. issue 27. 2006-09-18. PMID:16651266. |
we first characterized the involvement of various subtypes of glutamate receptors and the mtor kinase in regulating dendritic synthesis of a green fluorescent protein (gfp) reporter controlled by alphacamkii 5' and 3' untranslated regions in cultured hippocampal neurons. |
2006-09-18 |
2023-08-12 |
Not clear |
| Ruomu Gong, Chang Sin Park, Nima Rezaei Abbassi, Shao-Jun Tan. Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. The Journal of biological chemistry. vol 281. issue 27. 2006-09-18. PMID:16651266. |
in addition, we also found that inhibition of the mtor kinase blocked dendritic synthesis of the endogenous alphacamkii and map2 proteins induced by tetanic stimulations in hippocampal slices. |
2006-09-18 |
2023-08-12 |
Not clear |
| Ruomu Gong, Chang Sin Park, Nima Rezaei Abbassi, Shao-Jun Tan. Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. The Journal of biological chemistry. vol 281. issue 27. 2006-09-18. PMID:16651266. |
these results identify critical roles of nmda receptors and the mtor signaling pathway for control of synaptic activity-induced dendritic protein synthesis in hippocampal neurons. |
2006-09-18 |
2023-08-12 |
Not clear |