| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas H Varvel, Claudia Espinosa-Garcia, Sarah Hunter-Chang, Di Chen, Ariel Biegel, Allison Hsieh, Lisa Blackmer-Raynolds, Thota Ganesh, Raymond Dingledin. Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 5. 2021-04-28. PMID:33293358. |
the induction of hippocampal il-6 after pilocarpine se was nearly abolished in ep2 conditional ko mice. |
2021-04-28 |
2023-08-13 |
mouse |
| Hyunha Kim, Ji Seon Seo, Seo-Yeon Lee, Ki-Tae Ha, Byung Tae Choi, Yong-Il Shin, Young Ju Yun, Hwa Kyoung Shi. AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32201254. |
aim2 knockout (ko) and ac-yvad-cmk-induced caspase-1 inhibition in mice significantly improved cognitive function and reversed brain volume in the hippocampus relative to those in stroke mice. |
2021-04-27 |
2023-08-13 |
mouse |
| Claudia Fuchs, Laura Gennaccaro, Elisa Ren, Giuseppe Galvani, Stefania Trazzi, Giorgio Medici, Manuela Loi, Erin Conway, Orrin Devinsky, Roberto Rimondini, Elisabetta Cian. Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder. Neuropharmacology. vol 167. 2021-04-23. PMID:31469994. |
here we show a dysregulation of hippocampal and cortical serotonergic (5-ht) receptor expression in heterozygous cdkl5 knockout (ko) female mice, suggesting that impaired 5-ht neurotransmission contributes to cdd. |
2021-04-23 |
2023-08-13 |
mouse |
| Mary Jasmin Ang, Juhwan Kim, Sueun Lee, Sung-Ho Kim, Jong-Choon Kim, Tae-Il Jeon, Seung-Soon Im, Changjong Moo. Transcriptome Profiling Reveals Novel Candidate Genes Related to Hippocampal Dysfunction in SREBP-1c Knockout Mice. International journal of molecular sciences. vol 21. issue 11. 2021-03-25. PMID:32531902. |
to investigate whether there are novel molecular mechanisms involved in the neurological aberrations caused by srebp-1c deficiency, we analyzed the transcriptomes of the hippocampus of srebp-1c knockout (ko) mice and wild-type mice. |
2021-03-25 |
2023-08-13 |
mouse |
| Mary Jasmin Ang, Juhwan Kim, Sueun Lee, Sung-Ho Kim, Jong-Choon Kim, Tae-Il Jeon, Seung-Soon Im, Changjong Moo. Transcriptome Profiling Reveals Novel Candidate Genes Related to Hippocampal Dysfunction in SREBP-1c Knockout Mice. International journal of molecular sciences. vol 21. issue 11. 2021-03-25. PMID:32531902. |
we found seven differentially expressed genes (three up-regulated and four down-regulated genes) in the hippocampus of srebp-1c ko mice. |
2021-03-25 |
2023-08-13 |
mouse |
| Mary Jasmin Ang, Juhwan Kim, Sueun Lee, Sung-Ho Kim, Jong-Choon Kim, Tae-Il Jeon, Seung-Soon Im, Changjong Moo. Transcriptome Profiling Reveals Novel Candidate Genes Related to Hippocampal Dysfunction in SREBP-1c Knockout Mice. International journal of molecular sciences. vol 21. issue 11. 2021-03-25. PMID:32531902. |
the protein levels of glp2r and ndn were considerably decreased, but the level of erbb4 was significantly increased in the hippocampus of srebp-1c ko mice. |
2021-03-25 |
2023-08-13 |
mouse |
| Laura F McNair, Jens V Andersen, Jakob D Nissen, Yan Sun, Kathryn D Fischer, Nathaniel W Hodgson, Muzi Du, Chiye J Aoki, Helle S Waagepetersen, Paul A Rosenberg, Blanca I Aldan. Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus. Neurochemical research. vol 45. issue 6. 2021-03-22. PMID:32144526. |
here we determined whether neuronal glt-1 plays a similar role in the hippocampus and striatum, using conditional glt-1 knockout mice in which glt-1 was inactivated in neurons by expression of synapsin-cre (synglt-1 ko). |
2021-03-22 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Lindsay A Tomac, Ilyasah D A Muhammad, Matthew S Binder, Joseph H Taube, Joaquin N Lug. Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology & behavior. vol 215. 2021-03-04. PMID:31838149. |
in response to lps, fmr1 ko mice had elevated hippocampal il-1β and il-6 mrna levels 4 h post-treatment compared to wt mice, with no differences detected in any cytokines at baseline or between genotypes 24 h post-lps administration. |
2021-03-04 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Lindsay A Tomac, Ilyasah D A Muhammad, Matthew S Binder, Joseph H Taube, Joaquin N Lug. Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology & behavior. vol 215. 2021-03-04. PMID:31838149. |
fmr1 ko mice also had upregulated hippocampal bdnf gene expression 4 h post-treatment compared to wt mice, which was not dependent on lps administration. |
2021-03-04 |
2023-08-13 |
mouse |
| Manuela Loi, Stefania Trazzi, Claudia Fuchs, Giuseppe Galvani, Giorgio Medici, Laura Gennaccaro, Marianna Tassinari, Elisabetta Cian. Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons. Molecular neurobiology. vol 57. issue 5. 2021-02-03. PMID:32002787. |
importantly, increased kainic acid-induced cell death of hippocampal neurons of cdkl5 ko mice correlated with an increased γh2ax immunostaining. |
2021-02-03 |
2023-08-13 |
mouse |
| Ronald R Seese, Aliza A Le, Kathleen Wang, Conor D Cox, Gary Lynch, Christine M Gal. A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability. Neurobiology of disease. vol 134. 2021-01-13. PMID:31494285. |
relatedly, hippocampal long-term potentiation (ltp) is impaired in the fmr1 knockout (ko) mouse model of fxs. |
2021-01-13 |
2023-08-13 |
mouse |
| Amanda Q Nguyen, Samantha Sutley, Jordan Koeppen, Karen Mina, Simone Woodruff, Sandy Hanna, Alekya Vengala, Peter W Hickmott, Andre Obenaus, Iryna M Ethel. Astrocytic Ephrin-B1 Controls Excitatory-Inhibitory Balance in Developing Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 36. 2021-01-01. PMID:32801156. |
lower numbers of parvalbumin-expressing cells and a reduction in the inhibitory vgat/gephyrin-positive synaptic sites on ca1 neurons in the stratum pyramidale and stratum oriens layers of ko hippocampus may contribute to reduced inhibition and higher excitation. |
2021-01-01 |
2023-08-13 |
mouse |
| Tue G Banke, Andres Barri. Transient Enhanced GluA2 Expression in Young Hippocampal Neurons of a Fragile X Mouse Model. Frontiers in synaptic neuroscience. vol 12. 2020-12-22. PMID:33343326. |
here, we have investigated the development of ampar-mediated synaptic transmission in the hippocampus of the fmr1 knock-out (ko) mouse, a widely used model of fragile x syndrome (fxs). |
2020-12-22 |
2023-08-13 |
mouse |
| Brendan B McAllister, Nicoline Bihelek, Richelle Mychasiuk, Richard H Dyc. Brain-derived Neurotrophic Factor and TrkB Levels in Mice that Lack Vesicular Zinc: Effects of Age and Sex. Neuroscience. vol 425. 2020-12-15. PMID:31785352. |
and in females, but not males, znt3 ko mice exhibited great hippocampal bdnf mrna expression than wild type mice. |
2020-12-15 |
2023-08-13 |
mouse |
| Matthew R Taylor, E Anne Martin, Brooke Sinnen, Rajdeep Trilokekar, Emmanuelle Ranza, Stylianos E Antonarakis, Megan E William. Kirrel3-Mediated Synapse Formation Is Attenuated by Disease-Associated Missense Variants. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 28. 2020-11-26. PMID:32503885. |
previously, we studied kirrel3 loss of function using ko mice and showed that kirrel3 is a synaptic adhesion molecule necessary to form one specific type of hippocampal synapse |
2020-11-26 |
2023-08-13 |
mouse |
| b' Marta Rolland, Rebecca Powell, Muriel Jacquier-Sarlin, Sylvie Boisseau, Robin Reynaud-Dulaurier, Jose Martinez-Hernandez, Louise Andr\\xc3\\xa9, Eve Borel, Alain Buisson, Fabien Lant\\xc3\\xa. Effect of A\\xce\\xb2 Oligomers on Neuronal APP Triggers a Vicious Cycle Leading to the Propagation of Synaptic Plasticity Alterations to Healthy Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 27. 2020-11-23. PMID:32444385.' |
we used complementary techniques ranging from electrophysiological recordings and molecular biology to confocal microscopy in primary cortical cultures, and from acute hippocampal and cortical slices from male wild-type and amyloid precursor protein (app) knock-out (ko) mice to assess the effects of aβos on glutamatergic transmission, synaptic plasticity, and dendritic spine structure. |
2020-11-23 |
2023-08-13 |
mouse |
| Peter Baumann, Sonja C Schriever, Stephanie Kullmann, Annemarie Zimprich, Annette Feuchtinger, Oana Amarie, Andreas Peter, Axel Walch, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Matthias H Tschöp, Martin Heni, Sabine M Hölter, Paul T Pfluge. Dusp8 affects hippocampal size and behavior in mice and humans. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31862894. |
consistent with a decreased hippocampus size in dusp8 ko mice, we found reduced volumes of the hippocampal subregions subiculum and ca4 in humans carrying the dusp8 allelic variant snp rs2334499:c > t. |
2020-11-09 |
2023-08-13 |
mouse |
| Peter Baumann, Sonja C Schriever, Stephanie Kullmann, Annemarie Zimprich, Annette Feuchtinger, Oana Amarie, Andreas Peter, Axel Walch, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Matthias H Tschöp, Martin Heni, Sabine M Hölter, Paul T Pfluge. Dusp8 affects hippocampal size and behavior in mice and humans. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31862894. |
overall, aberrations in morphology and behavior in dusp8 ko mice and a decrease in hippocampal volume of snp rs2334499:c > t carriers point to a novel, translationally relevant role of dusp8 in hippocampus function that warrants further studies on the role of dusp8 within the limbic network. |
2020-11-09 |
2023-08-13 |
mouse |
| Jonas Feuge, Franziska Scharkowski, Kristin Michaelsen-Preusse, Martin Kort. FMRP Modulates Activity-Dependent Spine Plasticity by Binding Cofilin1 mRNA and Regulating Localization and Local Translation. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 12. 2020-11-04. PMID:30953439. |
here, we provide evidence that structural and functional plasticity are severely impaired after nmdar-dependent ltp in the hippocampus of fmr1 ko mice. |
2020-11-04 |
2023-08-13 |
mouse |
| Sara M Hancock, Stuart D Portbury, Adam P Gunn, Blaine R Roberts, Ashley I Bush, Paul A Adlar. Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome. International journal of molecular sciences. vol 21. issue 3. 2020-11-04. PMID:32012946. |
to do this, we utilised size exclusion chromatography-inductively coupled plasma mass spectrometry (sec-icp-ms) and examined hippocampal homogenates from znt3 ko and age-matched wild-type mice at 3, 6 and 18 months of age. |
2020-11-04 |
2023-08-13 |
mouse |