| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bingjin Li, Jingjing Piao, Xinmiao Piao, Zihui Geng, Ziqian Cheng, Xiaohan Zou, Huiyi Jian. Effect of Kruppel-like factor 4 on PTZ-induced acute seizure mice. Journal of cellular and molecular medicine. vol 28. issue 17. 2024-09-05. PMID:39234952. |
moreover, c-fos expression induced by ptz was reduced by hippocampal conditional ko of klf4. |
2024-09-05 |
2024-09-08 |
mouse |
| David A Narvaiz, Katherine J Blandin, D Gregory Sullens, Paige D Womble, Jacob B Pilcher, Grace O'Neill, Taylor A Wiley, Eliesse M Kwok, Srikhar V Chilukuri, Joaquin N Lug. NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density. Epilepsy research. vol 206. 2024-08-30. PMID:39213710. |
as a model of hyperactive mtor induced epilepsy, neuronal subset specific phosphatase and tensin homolog (ns-pten) knockout (ko) mice exhibit hyperactive mtor signaling in the hippocampus, seizures that progress with age, and enhanced hippocampal microglia/macrophage activation. |
2024-08-30 |
2024-09-04 |
mouse |
| David A Narvaiz, Katherine J Blandin, D Gregory Sullens, Paige D Womble, Jacob B Pilcher, Grace O'Neill, Taylor A Wiley, Eliesse M Kwok, Srikhar V Chilukuri, Joaquin N Lug. NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density. Epilepsy research. vol 206. 2024-08-30. PMID:39213710. |
however, it is unknown where microglia/macrophages are most active within the hippocampus of ns-pten ko mice. |
2024-08-30 |
2024-09-04 |
mouse |
| David A Narvaiz, Katherine J Blandin, D Gregory Sullens, Paige D Womble, Jacob B Pilcher, Grace O'Neill, Taylor A Wiley, Eliesse M Kwok, Srikhar V Chilukuri, Joaquin N Lug. NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density. Epilepsy research. vol 206. 2024-08-30. PMID:39213710. |
ns-pten ko mice exhibited an overall increase in the number of iba1 positive microglia/macrophages in each subregion and in the entire hippocampus. |
2024-08-30 |
2024-09-04 |
mouse |
| David A Narvaiz, Katherine J Blandin, D Gregory Sullens, Paige D Womble, Jacob B Pilcher, Grace O'Neill, Taylor A Wiley, Eliesse M Kwok, Srikhar V Chilukuri, Joaquin N Lug. NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density. Epilepsy research. vol 206. 2024-08-30. PMID:39213710. |
after accounting for differences in size, the whole hippocampus of ns-pten ko mice still exhibited an increased density of iba1 positive microglia/macrophages. |
2024-08-30 |
2024-09-04 |
mouse |
| David A Narvaiz, Katherine J Blandin, D Gregory Sullens, Paige D Womble, Jacob B Pilcher, Grace O'Neill, Taylor A Wiley, Eliesse M Kwok, Srikhar V Chilukuri, Joaquin N Lug. NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density. Epilepsy research. vol 206. 2024-08-30. PMID:39213710. |
these data suggest enhanced microglia/macrophage activity may occur in the ns-pten ko mice in a hippocampal subregion and sex-dependent manner. |
2024-08-30 |
2024-09-04 |
mouse |
| S Li, J Wang, J V Andersen, B I Aldana, B Zhang, E V Prochownik, P A Rosenber. Misprogramming of glucose metabolism impairs recovery of hippocampal slices from neuronal GLT-1 knockout mice and contributes to excitotoxic injury through mitochondrial superoxide production. Journal of neurochemistry. 2024-08-28. PMID:39193789. |
we have previously reported a failure of recovery of synaptic function in the ca1 region of acute hippocampal slices from mice with a conditional neuronal knockout (ko) of glt-1 (eaat2, slc1a2) driven by synapsin-cre (synglt-1 ko). |
2024-08-28 |
2024-08-30 |
mouse |
| Nicole Bon Campomayor, Hee Jin Kim, Hyun Jun Lee, Leandro Val Sayson, Darlene Mae D Ortiz, Eunbi Cho, Dong Hyun Kim, Se Jin Jeon, Bung-Nyun Kim, Jae Hoon Cheong, Mikyung Ki. Impact and Interrelationships of Striatal Proteins, EPHB2, OPRM1, and PER2 on Mild Cognitive Impairment. Molecular neurobiology. 2024-07-13. PMID:39002057. |
however, there were no significant group differences in hippocampal long-term potentiation (ltp) between per2 ko and wt mice, whereas striatal ltp in per2 ko mice was lower compared to wt mice. |
2024-07-13 |
2024-07-16 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
here we show that pyramidal cells (pcs) in the dorsal ca1 region of the hippocampus elicited a larger action potential (ap) number in response to suprathreshold stimulation in juvenile fmr1 knockout (ko) than wild-type (wt) mice. |
2024-07-08 |
2024-07-12 |
mouse |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
to explore the mechanism by which fmrp deficiency inhibits autophagy, we examined the akt/mtor signaling pathway in the hippocampus of fmr1 ko mice, found that fmrp deficiency caused overactivation of the akt/mtor pathway. |
2024-06-08 |
2024-06-11 |
mouse |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
importantly, arc protein was upregulated in the hippocampus of tau knockout (tau ko) mice and dendrites of tau ko primary hippocampal neurons. |
2024-03-29 |
2024-04-01 |
mouse |
| George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. |
therefore, we employed a multi-level approach to study the behavioral profile and the glutamatergic and gabaergic neurotransmission status in pathophysiology-associated brain structures of fmr1 ko rats, including the recordings of evoked and spontaneous field potentials from hippocampal slices, paralleled with next-generation rna sequencing (rna-seq). |
2024-02-20 |
2024-02-23 |
mouse |
| George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. |
these results are coupled to affected excitability and local inhibitory processes in the hippocampus, along with a specific transcriptional profile, highlighting dysregulated hippocampal network activity in ko rats. |
2024-02-20 |
2024-02-23 |
mouse |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
septotemporal variation of information processing in the hippocampus of fmr1 ko rat. |
2024-02-18 |
2024-02-21 |
rat |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
method we used a fmr1 knock-out (ko) rat model of fxs and recordings of evoked field potentials from the ca1 field of transverse slices from both the dorsal and the ventral hippocampus of adult rats. |
2024-02-18 |
2024-02-21 |
rat |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
results following application of a frequency stimulation protocol consisting of a ten-pulse train and recordings of fepsp, we found that the dorsal but not ventral ko hippocampus shows altered short-term synaptic plasticity. |
2024-02-18 |
2024-02-21 |
rat |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
furthermore, applying the frequency stimulation protocol and recordings of population spikes, both segments of the ko hippocampus display altered short-term neuronal dynamics. |
2024-02-18 |
2024-02-21 |
rat |
| Sultan Aljuraysi, Mark Platt, Michela Pulix, Harish Poptani, Antonius Plagg. Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice. Neurobiology of disease. 2024-02-08. PMID:38331351. |
microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in trappc9 ko mice. |
2024-02-08 |
2024-02-11 |
mouse |
| Mario O Caracci, Héctor Pizarro, Carlos Alarcón-Godoy, Luz M Fuentealba, Pamela Farfán, Raffaella De Pace, Natacha Santibañez, Viviana A Cavieres, Tammy P Pástor, Juan S Bonifacino, Gonzalo A Mardones, María-Paz Marzol. The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia. Progress in neurobiology. 2024-01-28. PMID:38281682. |
ap4e1- knock-out (ko) hela cells and hippocampal neurons from ap4e1-ko mice display increased co-localization of apoer2 with golgi markers. |
2024-01-28 |
2024-01-31 |
mouse |
| Mario O Caracci, Héctor Pizarro, Carlos Alarcón-Godoy, Luz M Fuentealba, Pamela Farfán, Raffaella De Pace, Natacha Santibañez, Viviana A Cavieres, Tammy P Pástor, Juan S Bonifacino, Gonzalo A Mardones, María-Paz Marzol. The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia. Progress in neurobiology. 2024-01-28. PMID:38281682. |
finally, analyses of reelin signaling in mouse hippocampal and human cortical ko neurons show that ap4 deficiency causes no changes in reelin-dependent activation of the akt pathway and only mild changes in reelin-induced dendritic arborization, but reduces reelin-induced erk phosphorylation, creb activation, and golgi deployment. |
2024-01-28 |
2024-01-31 |
mouse |